Abstract
The study of tracts—bundles of nerve fibers that are organized together and have a similar function—is of major interest in neurology and related areas of science. Tractography is the medical imaging technique that provides the information to estimate these tracts, which is crucial for clinical applications and scientific research. This is a complex task due to the nature of the nerve fibers, also known as streamlines, and requires human interaction with prior knowledge. In this paper, we propose an automatic volumetric segmentation architecture based on the 3D U-Net architecture to segment each tract individually from streamlines data. We evaluate the impact of different data pre-processing techniques namely Rescaled Density Map (RDM), Gaussian Filter Mask (GFM), and Closing Opening Mask (COM) on the final segmentation results using the Tractoinferno dataset. In our experiments, the average DICE and IoU average performance was 62.2% and 72.2% respectively. Our results show that proper data pre-processing can significantly enhance segmentation performance. Moreover, we achieve similar levels of accuracy for all segmented tracts, despite shape disparity and an unequal number of occurrences in the tract dataset. Overall, this work contributes to the field of neuroimaging by providing a reliable approach for accurately segmenting individual tracts.
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References
De Santis, S., Sommer, W.H., Canals, S.: Detecting alcohol-induced brain damage noninvasively using diffusion tensor imaging. ACS Chem. Neurosci. 10(10), 4187–4189 (2019)
De Santis, S., et al.: Chronic alcohol consumption alters extracellular space geometry and transmitter diffusion in the brain. Sci. Adv. 6(26), eaba0154 (2020)
Assaf, Y., Pasternak, O.: Diffusion tensor imaging (DTI)-based white matter mapping in brain research: a review. J. Mol. Neurosci. 34(1), 51–61 (2008)
Jeurissen, B., et al.: Diffusion MRI fiber tractography of the brain. NMR Biomed. 32(4), e3785 (2019)
Poulin, P., et al.: Tractography and machine learning: current state and open challenges. Magn. Reson. Imaging 64, 37–48 (2019)
Zhang, F., et al.: Quantitative mapping of the brain’s structural connectivity using diffusion MRI tractography: a review. Neuroimage 249, 118870 (2022)
Hosseini, S., et al.: CTtrack: a CNN+transformer-based framework for fiber orientation estimation & tractography. Neurosci. Inform. 2(4), 100099 (2022)
Li, B., et al.: Neuro4Neuro: a neural network approach for neural tract segmentation using large-scale population-based diffusion imaging. Neuroimage 218, 116993 (2020)
Wasserthal, J., Neher, P., Maier-Hein, K.H.: TractSeg - Fast and accurate white matter tract segmentation. Neuroimage 183, 239–253 (2018)
Zhang, F., et al.: Deep white matter analysis (DeepWMA): fast and consistent tractography segmentation. Med. Image Anal. 65, 101761 (2020)
Lu, Q., Li, Y., Ye, C.: Volumetric white matter tract segmentation with nested self-supervised learning using sequential pretext tasks. Med. Image Anal. 72, 102094 (2021)
Liu, W., et al.: Volumetric segmentation of white matter tracts with label embedding. Neuroimage 250, 118934 (2022)
Lu, Q., et al.: A transfer learning approach to few-shot segmentation of novel white matter tracts. Med. Image Anal. 79, 102454 (2022)
Ronneberger, O., Fischer, P., Brox, T.: U-Net: convolutional networks for biomedical image segmentation. In: International Conference on Medical Image Computing and Computer-Assisted Intervention - MICCAI 2015, pp. 234–241 (2015)
Zhang, Y., et al.: Bridging 2D and 3D segmentation networks for computation-efficient volumetric medical image segmentation: an empirical study of 2.5D solutions. Comput. Med. Imaging Graph. 99, 102088 (2022)
Burdescu, D.D., et al.: Efficient volumetric segmentation method. In: 2014 Federated Conference on Computer Science and Information Systems, pp. 659–668 (2014)
Milletari, F., Navab, N., Ahmadi, S.-A.: V-Net: fully convolutional neural networks for volumetric medical image segmentation. In: 2016 Fourth International Conference on 3D Vision (3DV), pp. 565–571. IEEE (2016)
Çiçek, Ö., Abdulkadir, A., Lienkamp, S.S., Brox, T., Ronneberger, O.: 3D U-Net: learning dense volumetric segmentation from sparse annotation. In: Ourselin, S., Joskowicz, L., Sabuncu, M.R., Unal, G., Wells, W. (eds.) MICCAI 2016. LNCS, vol. 9901, pp. 424–432. Springer, Cham (2016). https://doi.org/10.1007/978-3-319-46723-8_49
Qamar, S., et al.: A variant form of 3D-UNet for infant brain segmentation. Futur. Gener. Comput. Syst. 108, 613–623 (2020)
Mukherjee, P., et al.: Diffusion tensor MR imaging and fiber tractography: technical considerations. Am. J. Neuroradiol. 29(5), 843–852 (2008)
Xu, K., et al.: Optimization of graph neural networks: Implicit acceleration by skip connections and more depth. In: Meila, M., Zhang, T. (eds.) Proceedings of the 38th International Conference on Machine Learning, vol. 139 of Proceedings of Machine Learning Research, pp. 11592–11602, PMLR (2021)
Ioffe, S., Szegedy, C.: Batch normalization: accelerating deep network training by reducing internal covariate shift (2015)
Im, D., et al.: DT-CNN: an energy-efficient dilated and transposed convolutional neural network processor for region of interest based image segmentation. IEEE Trans. Circuits Syst. I Regul. Pap. 67(10), 3471–3483 (2020)
Abadi, M., et al.: TensorFlow: large-scale machine learning on heterogeneous systems (2015). software available from tensorflow.org, https://www.tensorflow.org/
Garyfallidis, E., et al.: Dipy, a library for the analysis of diffusion MRI data. Front. Neuroinform. 8(FEB), 8 (2014)
Kingma, D.P., Ba, J.L.: Adam: a method for stochastic optimization. In: 3rd International Conference on Learning Representations, ICLR 2015 - Conference Track Proceedings (2014)
Poulin, P., et al.: TractoInferno: a large-scale, open-source, multi-site database for machine learning dMRI tractography. bioRxiv, 2021.11.29.470422 (2021)
Basser, P.J., et al.: In Vivo Fiber Tractography Using DT-MRI Data, Technical report (2000)
Tournier, J.-D., Calamante, F., Connelly, A.: MRtrix: diffusion tractography in crossing fiber regions. Int. J. Imaging Syst. Technol. 22(1), 53–66 (2012)
Girard, G., et al.: Towards quantitative connectivity analysis: reducing tractography biases. Neuroimage 98, 266–278 (2014)
St-Onge, E., et al.: Surface-enhanced tractography (set). Neuroimage 169, 524–539 (2018)
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Rocamora-García, P., Saval-Calvo, M., Villena-Martinez, V., Gallego, A.J. (2023). A Deep Approach for Volumetric Tractography Segmentation. In: Pertusa, A., Gallego, A.J., Sánchez, J.A., Domingues, I. (eds) Pattern Recognition and Image Analysis. IbPRIA 2023. Lecture Notes in Computer Science, vol 14062. Springer, Cham. https://doi.org/10.1007/978-3-031-36616-1_46
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