Brain Recovery in Childhood: The Interaction Between Developmental Plasticity and Regenerative Mechanisms

Costanzo, Floriana; Fucà, Elisa; Menghini, Deny; Vicari, Stefano

doi:10.1007/978-3-031-24930-3_13

Floriana Costanzo³,
Elisa Fucà³,
Deny Menghini³ &
…
Stefano Vicari^3,4

Part of the book series: Contemporary Clinical Neuroscience ((CCNE))

418 Accesses

Abstract

Stroke is one of the ten leading causes of death in children and adolescents ages 1–18. Pediatric stroke has some specific characteristics that make it very different from the stroke that occurs in adulthood, such as causes, symptoms, and outcomes. The clinical manifestations of pediatric stroke can vary depending on the site and type of brain damage, with symptoms ranging from early seizures to speech and motor impairment.

Despite the increased ability to discriminate pediatric strokes, there are some factors that still result in a delay in diagnosis, such as recognition of clinical signs and radiographic investigations. Proper differential diagnosis is another crucial step in the early recognition of pediatric stroke. Clinical outcomes of pediatric stroke include movement (e.g., hemiparesis) and language impairment, as well as cognitive and behavioral problems.

Recovery after an early brain insult is determined by several dynamically interacting factors, such as aspects related to the injury (e.g., age at stroke, nature, severity of injury), premorbid characteristics, and environment.

The application of a number of non-pharmacological interventions can improve motor and cognitive outcomes. Several non-pharmacological interventions can improve motor and cognitive outcomes.

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Child and Adolescent Neuropsychiatry Unit, Department of Neuroscience, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
Floriana Costanzo, Elisa Fucà, Deny Menghini & Stefano Vicari
Department of Life Science and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy
Stefano Vicari

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Costanzo, F., Fucà, E., Menghini, D., Vicari, S. (2023). Brain Recovery in Childhood: The Interaction Between Developmental Plasticity and Regenerative Mechanisms. In: Petrosini, L. (eds) Neurobiological and Psychological Aspects of Brain Recovery. Contemporary Clinical Neuroscience. Springer, Cham. https://doi.org/10.1007/978-3-031-24930-3_13

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