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Recurrent Respiratory Papillomatosis

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Textbook of Surgery of Larynx and Trachea

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Abstract

Recurrent respiratory papillomatosis (RRP) is a condition caused by human papillomavirus (HPV) that occurs in both children and adults, characterized by recurrent growths of intraluminal papillomas in the airway, usually in the larynx. Patients present with dysphonia (both roughness and breathiness), coughing, and eventually airway obstruction. The most common causative HPV types are HPV6 and HPV11. RRP has a significant adverse effect on quality of life. In the absence of a curative treatment, patients have to undergo frequent surgical procedures. Some patients require more than a 100 procedures. Several adjuvant therapies have been proposed to reduce the severity of disease and the number of surgical interventions. The introduction of vaccines against HPV6 and HPV11 can reduce the incidence of RRP.

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Authors and Affiliations

  1. Department of Otorhinolaryngology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands

    Frederik G. Dikkers

  2. Department of Otorhinolaryngology, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa

    Riaz Y. Seedat

  3. Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Groningen, Groningen, The Netherlands

    Michel R. M. San Giorgi

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  1. Frederik G. Dikkers
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Correspondence to Frederik G. Dikkers .

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  1. Department of Oto-Rhino-Laryngology, Centre Hospitalier de Luxembourg (CHL), Luxembourg, Luxembourg

    Marc Remacle

  2. Department of Oto-Rhino-Laryngology, A.ö. Landeskrankenhaus Klagenfurt, HNO, Klagenfurt, Austria

    Hans Edmund Eckel

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Dikkers, F.G., Seedat, R.Y., San Giorgi, M.R.M. (2022). Recurrent Respiratory Papillomatosis. In: Remacle, M., Eckel, H.E. (eds) Textbook of Surgery of Larynx and Trachea. Springer, Cham. https://doi.org/10.1007/978-3-031-09621-1_14

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