Skip to main content

Part of the book series: Lecture Notes in Computer Science ((LNIP,volume 13131))

Abstract

Efficient and accurate segmentation of the heart is important for analysis of cardiac magnetic resonance imaging (MRI). Although many convolutional neural networks (CNNs) have been proposed to address cardiac segmentation in cine MRI, the task is still an open and challenging problem due to highly complex and variable cardiac shape in various pathologies and the ill-defined borders, particularly near the base and apex of the heart. Existing methods typically only segment the heart on either short-axis images or long-axis images without employing any complementary information from multi-view images for better segmentation of the ventricles. This can be problematic in the basal region, where the ventricles can be easily confused with the atria. In this paper, we propose a novel framework to jointly segment the ventricles in both short- and long-axis images. The method has two stages: 1) segment the two views independently and then 2) refine their segmentations by fusing the complementary information from the other views. The proposed method was evaluated on the MICCAI 2021 Multi-Disease, Multi-View & Multi-Center Cardiac MR Segmentation Challenge (M&Ms-2) dataset. The result shows improvement on the segmentation of the left and right ventricular cavities and the myocardium for both short-axis and long-axis cardiac MR images compared to the conventional state-of-the-art segmentation methods.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 64.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 84.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Bernard, O., et al.: Deep learning techniques for automatic MRI cardiac multi-structures segmentation and diagnosis: Is the problem solved? IEEE Trans. Med. Imaging 37(11), 2514–2525 (2018)

    Article  Google Scholar 

  2. Campello, V.M., et al.: Multi-centre, multi-vendor and multi-disease cardiac segmentation: the M&Ms challenge. IEEE Trans. Med. Imaging 40, 3543–3554 (2021)

    Google Scholar 

  3. Chang, Q., Yan, Z., Lou, Y., Axel, L., Metaxas, D.N.: Soft-label guided semi-supervised learning for bi-ventricle segmentation in cardiac cine MRI. In: 2020 IEEE 17th International Symposium on Biomedical Imaging (ISBI), pp. 1752–1755. IEEE (2020)

    Google Scholar 

  4. Han, X., Xu, C., Prince, J.L.: A topology preserving deformable model using level sets. In: Proceedings of the 2001 IEEE Computer Society Conference on Computer Vision and Pattern Recognition. CVPR 2001, vol. 2, pp. 2. IEEE (2001)

    Google Scholar 

  5. Isensee, F., Jaeger, P.F., Full, P.M., Wolf, I., Engelhardt, S., Maier-Hein, K.H.: Automatic cardiac disease assessment on cine-MRI via time-series segmentation and domain specific features. In: Pop, M., et al. (eds.) STACOM 2017. LNCS, vol. 10663, pp. 120–129. Springer, Cham (2018). https://doi.org/10.1007/978-3-319-75541-0_13

    Chapter  Google Scholar 

  6. Karamitsos, T.D., Francis, J.M., Myerson, S., Selvanayagam, J.B., Neubauer, S.: The role of cardiovascular magnetic resonance imaging in heart failure. J. Am. Coll. Cardiol. 54(15), 1407–1424 (2009)

    Article  Google Scholar 

  7. Khened, M., Kollerathu, V.A., Krishnamurthi, G.: Fully convolutional multi-scale residual densenets for cardiac segmentation and automated cardiac diagnosis using ensemble of classifiers. Med. Image Anal. 51, 21–45 (2019)

    Article  Google Scholar 

  8. Kong, B., Zhan, Y., Shin, M., Denny, T., Zhang, S.: Recognizing end-diastole and end-systole frames via deep temporal regression network. In: Ourselin, S., Joskowicz, L., Sabuncu, M.R., Unal, G., Wells, W. (eds.) MICCAI 2016. LNCS, vol. 9902, pp. 264–272. Springer, Cham (2016). https://doi.org/10.1007/978-3-319-46726-9_31

    Chapter  Google Scholar 

  9. Li, J., Hu, Z.: Left ventricle full quantification using deep layer aggregation based multitask relationship learning. In: Pop, M., et al. (eds.) STACOM 2018. LNCS, vol. 11395, pp. 381–388. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-12029-0_41

    Chapter  Google Scholar 

  10. Li, Z., et al.: Fully automatic segmentation of short-axis cardiac MRI using modified deep layer aggregation. In: 2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019), pp. 793–797. IEEE (2019)

    Google Scholar 

  11. Metaxas, D.N.: Physics-based Deformable Models: Applications to Computer Vision, Graphics and Medical Imaging, vol. 389. Springer Science & Business Media, Boston (2012)

    Google Scholar 

  12. Ngo, T.A., Lu, Z., Carneiro, G.: Combining deep learning and level set for the automated segmentation of the left ventricle of the heart from cardiac cine magnetic resonance. Med. Image Anal. 35, 159–171 (2017)

    Article  Google Scholar 

  13. Peng, P., Lekadir, K., Gooya, A., Shao, L., Petersen, S.E., Frangi, A.F.: A review of heart chamber segmentation for structural and functional analysis using cardiac magnetic resonance imaging. Mag. Reson. Mater. Phys. Biol. Med. 29(2), 155–195 (2016). https://doi.org/10.1007/s10334-015-0521-4

    Article  Google Scholar 

  14. Petitjean, C., Dacher, J.N.: A review of segmentation methods in short axis cardiac MR images. Med. Image Anal. 15(2), 169–184 (2011)

    Article  Google Scholar 

  15. Poudel, R.P.K., Lamata, P., Montana, G.: Recurrent fully convolutional neural networks for multi-slice MRI cardiac segmentation. In: Zuluaga, M.A., Bhatia, K., Kainz, B., Moghari, M.H., Pace, D.F. (eds.) RAMBO/HVSMR -2016. LNCS, vol. 10129, pp. 83–94. Springer, Cham (2017). https://doi.org/10.1007/978-3-319-52280-7_8

    Chapter  Google Scholar 

  16. Queirós, S., et al.: Fast automatic myocardial segmentation in 4d cine CMR datasets. Med. Image Anal. 18(7), 1115–1131 (2014)

    Google Scholar 

  17. Tan, L.K., Liew, Y.M., Lim, E., McLaughlin, R.A.: Convolutional neural network regression for short-axis left ventricle segmentation in cardiac cine MR sequences. Med. Image Anal. 39, 78–86 (2017)

    Article  Google Scholar 

  18. Yu, C., Wang, J., Peng, C., Gao, C., Yu, G., Sang, N.: Learning a discriminative feature network for semantic segmentation. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 1857–1866 (2018)

    Google Scholar 

  19. Yu, F., Wang, D., Shelhamer, E., Darrell, T.: Deep layer aggregation. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 2403–2412 (2018)

    Google Scholar 

  20. Zhuang, X., Shen, J.: Multi-scale patch and multi-modality atlases for whole heart segmentation of MRI. Med. Image Anal. 31, 77–87 (2016)

    Article  Google Scholar 

Download references

Acknowledgement

The authors declare that the segmentation method implemented for participation in the M&Ms-2 challenge has not used any pre-trained models nor additional MRI datasets other than those provided by the organizers.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Di Liu .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2022 Springer Nature Switzerland AG

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Liu, D., Yan, Z., Chang, Q., Axel, L., Metaxas, D.N. (2022). Refined Deep Layer Aggregation for Multi-Disease, Multi-View & Multi-Center Cardiac MR Segmentation. In: Puyol Antón, E., et al. Statistical Atlases and Computational Models of the Heart. Multi-Disease, Multi-View, and Multi-Center Right Ventricular Segmentation in Cardiac MRI Challenge. STACOM 2021. Lecture Notes in Computer Science(), vol 13131. Springer, Cham. https://doi.org/10.1007/978-3-030-93722-5_34

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-93722-5_34

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-93721-8

  • Online ISBN: 978-3-030-93722-5

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics