Abstract
A corneal ulcer is one of the most frequently appearing diseases that may affect eye health. The proper measurement of corneal ulcer lesions enables the physician to evaluate the treatment effectiveness and assist in decision-making. This article presents the solution for ulcer segmentation as a pixel-wise classification task, and proposes a novel coarse-to-fine method to extract corneal ulcers from ocular staining images. This study combines two classical convolutional neural networks (CNNs), known as U-net and DexiNed, following Morphological Geodesic Active Contour as a post-processing operation. We trained the CNNs using 358 point-flaky corneal ulcer images and evaluated its performance in 91 flaky corneal ulcer images. Our approach achieved 70.50% of Dice Coefficient on average, 87.4% of Recall, and 99.0% of Specificity, and True Dice Coefficient of 63.7%. These results corroborate our approach’s efficacy and efficiency.
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References
Caselles, V., Kimmel, R., Sapiro, G.: Geodesic active contours. Int. J. Comput. Vision 22(1), 61–79 (1997)
Chaurasia, A., Culurciello, E.: LinkNet: exploiting encoder representations for efficient semantic segmentation. In: 2017 IEEE Visual Communications and Image Processing (VCIP), pp. 1–4. IEEE (2017)
Cohen, E.J., Laibson, P.R., Arentsen, J.J., Clemons, C.S.: Corneal ulcers associated with cosmetic extended wear soft contact lenses. Ophthalmology 94(2), 109–114 (1987)
Deng, L., Huang, H., Yuan, J., Tang, X.: Automatic segmentation of corneal ulcer area based on ocular staining images. In: Medical Imaging 2018: Biomedical Applications in Molecular, Structural, and Functional Imaging, vol. 10578, p. 105781D. International Society for Optics and Photonics (2018). https://doi.org/10.1117/12.2293270
Deng, L., Huang, H., Yuan, J., Tang, X.: Superpixel based automatic segmentation of corneal ulcers from ocular staining images. In: 2018 IEEE 23rd International Conference on Digital Signal Processing (DSP), pp. 1–5. IEEE (2018)
Deng, L., Lyu, J., Huang, H., Deng, Y., Yuan, J., Tang, X.: The SUSTech-SYSU dataset for automatically segmenting and classifying corneal ulcers. Sci. Data 7(1), 1–7 (2020)
Gençtav, A., Aksoy, S., Onder, S.: Unsupervised segmentation and classification of cervical cell images. Pattern Recogn. 45(12), 4151–4168 (2012). https://doi.org/10.1016/j.patcog.2012.05.006
Gross, J., Breitenbach, J., Baumgartl, H., Buettner, R.: High-performance detection of corneal ulceration using image classification with convolutional neural networks. In: Proceedings of the 54th Hawaii International Conference on System Sciences, p. 3416 (2021)
Hezekiah, J.D., Chacko, S.: A review on cornea imaging and processing techniques. Current Med. Imaging 16(3), 181–192 (2020)
Lima, P.V., et al.: A semiautomatic segmentation approach to corneal lesions. Comput. Electr. Eng. 84, 106625 (2020)
Liu, Z., Shi, Y., Zhan, P., Zhang, Y., Gong, Y., Tang, X.: Automatic corneal ulcer segmentation combining Gaussian mixture modeling and Otsu method. In: 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), pp. 6298–6301. IEEE (2019)
Patel, T.P., et al.: Novel image-based analysis for reduction of clinician-dependent variability in measurement of the corneal ulcer size. Cornea 37(3), 331–339 (2018). https://doi.org/10.1097/ICO.0000000000001488
Poma, X.S., Riba, E., Sappa, A.: Dense extreme inception network: towards a robust CNN model for edge detection. In: The IEEE Winter Conference on Applications of Computer Vision, pp. 1923–1932 (2020)
Ronneberger, O., Fischer, P., Brox, T.: U-net: convolutional networks for biomedical image segmentation. In: Navab, N., Hornegger, J., Wells, W.M., Frangi, A.F. (eds.) MICCAI 2015. LNCS, vol. 9351, pp. 234–241. Springer, Cham (2015). https://doi.org/10.1007/978-3-319-24574-4_28
Sun, Q., Deng, L., Liu, J., Huang, H., Yuan, J., Tang, X.: Patch-based deep convolutional neural network for corneal ulcer area segmentation. In: Cardoso, M.J., et al. (eds.) FIFI/OMIA -2017. LNCS, vol. 10554, pp. 101–108. Springer, Cham (2017). https://doi.org/10.1007/978-3-319-67561-9_11
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Portela, H.M.B.F. et al. (2021). A Coarse to Fine Corneal Ulcer Segmentation Approach Using U-net and DexiNed in Chain. In: Tavares, J.M.R.S., Papa, J.P., González Hidalgo, M. (eds) Progress in Pattern Recognition, Image Analysis, Computer Vision, and Applications. CIARP 2021. Lecture Notes in Computer Science(), vol 12702. Springer, Cham. https://doi.org/10.1007/978-3-030-93420-0_2
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DOI: https://doi.org/10.1007/978-3-030-93420-0_2
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