Skip to main content

Specific Gastrointestinal Microbial Infections

  • Chapter
  • First Online:
Pocket Handbook of GI Pharmacotherapeutics

Part of the book series: Clinical Gastroenterology ((CG))

  • 808 Accesses

Abstract

This chapter covers infections by Clostridioides (formerly Clostridium) difficile (C. difficile), Helicobacter pylori (H. pylori), Escherichia coli (E. coli), and conditions oropharyngeal candidiasis, gastroenteritis, Shigella colitis, Salmonella gastroenteritis, Campylobacter gastroenteritis, Whipple disease, Yersinia gastroenteritis, and infections by Vibrio cholerae, Listeria monocytogenes, Cryptosporidium hominis, Cyclospora cayetanensis, Epstein-Barr, cytomegalovirus, Herpes simplex, Helicobacter pylori. This chapter includes drug class, brand/trade names, manufacturer, dosage, indications, contraindications/cautions, adverse effects, drug interactions, pregnancy advice, lactation safety, relative cost of vancomycin, fidaxomicin, metronidazole, clarithromycin, amoxicillin, bismuth, metronidazole, tetracycline, levofloxacin, tinidazole, bactrim, azithromycin, erythromycin, doxycycline, tetracycline, penicillin G, hydroxychloroquine, fluconazole, voriconazole, caspofungin, clotrimazole nitzoxanide, ganciclovir, valganciclovir, foscarnet, tinidazole, albendazole, mebendazole, ivermectin, praziquantel, thiabendazole, pyrantel pamoate, tinidazole, paromomycin, iodoquinol, diethylcarbamazine, benznidazole, and triclabendazole. This chapter also includes a convenient algorithm for the treatment of Clostridioides difficile pseudomembranous colitis, and H. pylori, Whipple’s disease, and antihelminthic therapies.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Suggested Reading

  1. McDonald LC, Gerding DN, Johnson S, et al. Clinical practice guidelines for Clostridium difficile infection in adults and children: 2017 update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA). Clin Infect Dis. 2018;66(7):e1–e48.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Chey WD, Leontiadis GI, Howden CW, et al. ACG clinical guideline: of Helicobacter pylori infection. Am J Gastroenterol. 2017;112(2):212–39.

    Google Scholar 

  3. Cdc.gov. https://www.cdc.gov/parasites/index.html. Accessed 1 Dec 2021.

  4. Samuel D. Cytomegalovirus infection, fulminant hepatitis, and liver transplantation: the sides of the triangle. Liver Transpl. 1997;3(5):552–5.

    Article  Google Scholar 

  5. Norvell JP, Blei AT, Jovanovic BD, Levitsky J. Herpes simplex virus hepatitis: an analysis of the published literature and institutional cases. Liver Transpl. 2007;13(10):1428–34.

    Article  PubMed  Google Scholar 

  6. Bennish ML, Salam MA, Khan WA, Khan AM. Treatment of shigellosis: III. Comparison of one- or two-dose ciprofloxacin with standard 5-day therapy. A randomized, blinded trial. Ann Intern Med. 1992;117(9):727–34.

    Article  CAS  PubMed  Google Scholar 

  7. Onwuezobe IA, Oshun PO, Odigwe CC. Antimicrobials for treating symptomatic non-typhoidal Salmonella infection. Cochrane Database Syst Rev. 2012;11:CD001167.

    PubMed  Google Scholar 

  8. Dryden MS, Gabb RJ, Wright SK. Empirical treatment of severe acute community-acquired gastroenteritis with ciprofloxacin. Clin Infect Dis. 1996;22(6):1019–25.

    Article  CAS  PubMed  Google Scholar 

  9. White AE, Ciampa N, Chen Y, et al. Characteristics of Campylobacter and Salmonella infections and acute gastroenteritis in older adults in Australia, Canada, and the United States. Clin Infect Dis. 2019;69(9):1545–52.

    Article  PubMed  Google Scholar 

  10. Perfect JR, Marr KA, Walsh TJ, et al. Voriconazole treatment for less-common, emerging, or refractory fungal infections. Clin Infect Dis. 2003;36(9):1122–31.

    Article  CAS  PubMed  Google Scholar 

  11. Kuschner RA, Trofa AF, Thomas RJ, et al. Use of azithromycin for the treatment of Campylobacter enteritis in travelers to Thailand, an area where ciprofloxacin resistance is prevalent. Clin Infect Dis. 1995;21(3):536–41.

    Article  CAS  PubMed  Google Scholar 

  12. Nelson EJ, Nelson DS, Salam MA, Sack DA. Antibiotics for both moderate and severe cholera. N Engl J Med. 2011;364(1):5–7.

    Article  CAS  PubMed  Google Scholar 

  13. Thønnings S, Knudsen JD, Schønheyder HC, et al. Antibiotic treatment and mortality in patients with Listeria monocytogenes meningitis or bacteraemia. Clin Microbiol Infect. 2016;22(8):725–30.

    Article  PubMed  CAS  Google Scholar 

  14. Ooi ST, Lorber B. Gastroenteritis due to Listeria monocytogenes. Clin Infect Dis. 2005;40(9):1327–32.

    Article  PubMed  Google Scholar 

  15. Pappas PG, Kauffman CA, Andes DR, et al. Executive summary: clinical practice guideline for the management of candidiasis: 2016 update by the infectious diseases society of America. Clin Infect Dis. 2016;62(4):409–17.

    Article  PubMed  Google Scholar 

  16. Goldman M, Cloud GA, Wade KD, et al. A randomized study of the use of fluconazole in continuous versus episodic therapy in patients with advanced HIV infection and a history of oropharyngeal candidiasis: AIDS Clinical Trials Group Study 323/Mycoses Study Group Study 40. Clin Infect Dis. 2005;41(10):1473–80.

    Article  CAS  PubMed  Google Scholar 

  17. Spanakis EK, Aperis G, Mylonakis E. New agents for the treatment of fungal infections: clinical efficacy and gaps in coverage. Clin Infect Dis. 2006;43(8):1060–8.

    Article  CAS  PubMed  Google Scholar 

  18. Wilcox CM, Darouiche RO, Laine L, Moskovitz BL, Mallegol I, Wu J. A randomized, double-blind comparison of itraconazole oral solution and fluconazole tablets in the treatment of esophageal candidiasis. J Infect Dis. 1997;176(1):227–32.

    Article  CAS  PubMed  Google Scholar 

  19. Rossignol JF, Ayoub A, Ayers MS. Treatment of diarrhea caused by Cryptosporidium parvum: a prospective randomized, double-blind, placebo-controlled study of Nitazoxanide. J Infect Dis. 2001;184(1):103–6.

    Article  CAS  PubMed  Google Scholar 

  20. Fox LM, Saravolatz LD. Nitazoxanide: a new thiazolide antiparasitic agent. Clin Infect Dis. 2005;40(8):1173–80.

    Article  CAS  PubMed  Google Scholar 

  21. Smith HV, Corcoran GD. New drugs and treatment for cryptosporidiosis. Curr Opin Infect Dis. 2004;17(6):557–64.

    Article  CAS  PubMed  Google Scholar 

  22. Gandhi MK, Khanna R. Human cytomegalovirus: clinical aspects, immune regulation, and emerging treatments. Lancet Infect Dis. 2004;4(12):725–38.

    Article  CAS  PubMed  Google Scholar 

  23. Kotton CN, Kumar D, Caliendo AM. Updated international consensus guidelines on the management of cytomegalovirus in solid organ transplantation. Transplantation. 2013;96(4):333–60

    Google Scholar 

  24. Nih.gov. http://aidsinfo.nih.gov/contentfiles/lvguidelines/adult_oi.pdf. Accessed 1 Dec 2020.

  25. Canalejo E, Durán FG, Cabello N, Martínez JG. Herpes esophagitis in healthy adults and adolescents: report of 3 cases and review of the literature. Medicine (Baltimore). 2010;89(4):204–10.

    Google Scholar 

  26. Shirley D-AT, Farr L, Watanabe K, Moonah S. A review of the global burden, new diagnostics, and current therapeutics for amebiasis. Open Forum Infect Dis. 2018;5(7):ofy161.

    Google Scholar 

  27. Bercu TE, Petri WA, Behm JW. Amebic colitis: new insights into pathogenesis and treatment. Curr Gastroenterol Rep. 2007;9(5):429–33.

    Article  PubMed  Google Scholar 

  28. Gardner TB, Hill DR. Treatment of giardiasis. Clin Microbiol Rev. 2001;14(1):114–28.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Minetti C, Chalmers RM, Beeching NJ, Probert C, Lamden K. Giardiasis. BMJ. 2016;355:i5369.

    Article  PubMed  Google Scholar 

  30. Granados CE, Reveiz L, Uribe LG, Criollo CP. Drugs for treating giardiasis. Cochrane Database Syst Rev. 2012;12:CD007787.

    PubMed  Google Scholar 

  31. Conterno LO, Turchi MD, Corrêa I, Monteiro de Barros Almeida RA. Anthelmintic drugs for treating ascariasis. Cochrane Database Syst Rev. 2020;4:CD010599.

    PubMed  Google Scholar 

  32. Albanese G, Venturi C, Galbiati G. Treatment of larva migrans cutanea (creeping eruption): a comparison between albendazole and traditional therapy: treatment of larva migrans cutanea. Int J Dermatol. 2001;40(1):67–71.

    Article  CAS  PubMed  Google Scholar 

  33. Steinmann P, Utzinger J, Du Z-W, et al. Efficacy of single-dose and triple-dose albendazole and mebendazole against soil-transmitted helminths and Taenia spp.: a randomized controlled trial. PLoS One. 2011;6(9):e25003.

    Google Scholar 

  34. Palmeirim MS, Hürlimann E, Knopp S, et al. Efficacy and safety of co-administered ivermectin plus albendazole for treating soil-transmitted helminths: a systematic review, meta-analysis and individual patient data analysis. PLoS Negl Trop Dis. 2018;12(4):e0006458.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  35. King CL, Suamani J, Sanuku N, et al. A trial of a triple-drug treatment for lymphatic filariasis. N Engl J Med. 2018;379(19):1801–10.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Mahanty S, Maclean JD, Cross JH. Liver, lung, and intestinal fluke infections. In: Tropical infectious diseases: principles, pathogens and practice. Amsterdam: Elsevier; 2011. p. 854–67.

    Chapter  Google Scholar 

  37. Liu LX, Harinasuta KT. Liver and intestinal flukes. Gastroenterol Clin N Am. 1996;25(3):627–36.

    Article  CAS  Google Scholar 

  38. Shane AL, Mody RK, Crump JA, et al. 2017 infectious diseases society of America clinical practice guidelines for the diagnosis and management of infectious diarrhea. Clin Infect Dis. 2017;65(12):e45–80.

    Article  PubMed  PubMed Central  Google Scholar 

  39. Horton J. Albendazole: a review of anthelmintic efficacy and safety in humans. Parasitology. 2000;121(Suppl):S113–32.

    Article  PubMed  Google Scholar 

  40. Mellinger JL, Rossaro L, Naugler WE, et al. Epstein-Barr virus (EBV) related acute liver failure: a case series from the US Acute Liver Failure Study Group. Dig Dis Sci. 2014;59(7):1630–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Zahid M, Ali N, Saad M, Kelly P, Ortiz A. Acute Cytomegalovirus (CMV) hepatitis in an immunocompetent adult. Am J Case Rep. 2020;21:e925495.

    PubMed  PubMed Central  Google Scholar 

  42. DuPont HL. Azithromycin for the self-treatment of traveler’s diarrhea. Clin Infect Dis. 2007;44(3):347–9.

    Article  CAS  PubMed  Google Scholar 

  43. Leibovici-Weissman Y, Neuberger A, Bitterman R, Sinclair D, Salam MA, Paul M. Antimicrobial drugs for treating cholera. Cochrane Database Syst Rev. 2014;(6):CD008625.

    Google Scholar 

  44. Feldman M, Friedman LS, Brandt LJ. Preface. In: Sleisenger and Fordtran’s gastrointestinal and liver disease. Philadelphia: Elsevier; 2010. p. xix–xx.

    Chapter  Google Scholar 

  45. Darouiche RO. Oropharyngeal and esophageal candidiasis in immunocompromised patients: treatment issues. Clin Infect Dis. 1998;26(2):259–72; quiz 273–274.

    Article  CAS  PubMed  Google Scholar 

  46. Vazquez JA. Management of oropharyngeal and esophageal candidiasis in patients with HIV infection. HIV Ther. 2010;4(3):325–43.

    Article  Google Scholar 

  47. Deresinski SC, Stevens DA. Caspofungin. Clin Infect Dis. 2003;36(11):1445–57.

    Article  CAS  PubMed  Google Scholar 

  48. Aslam S, Rotstein C, AST Infectious Disease Community of Practice. Candida infections in solid organ transplantation: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. Clin Transplant. 2019;33(9):e13623.

    Google Scholar 

  49. Jacobson MA. Review of the toxicities of foscarnet. J Acquir Immune Defic Syndr. 1992;5(Suppl 1):S11–7.

    PubMed  Google Scholar 

  50. Wendt S, Trawinski H, Schubert S, Rodloff AC, Mössner J, Lübbert C. The diagnosis and treatment of pinworm infection. Dtsch Arztebl Int. 2019;116(13):213–19. Lagier JC, Fenollar F, Lepidi H, Giorgi R, Million M, Raoult D. Treatment of classic Whipple’s disease: from in vitro results to clinical outcome. J Antimicrob Chemother. 2013;69(1):219–27. https://doi.org/10.1093/jac/dkt310.

    Article  CAS  Google Scholar 

  51. United States Centers for Disease Control and Prevention. Parasites – lymphatic filariasis. http://www.cdc.gov/parasites/lymphaticfilariasis/treatment.html. Accessed on Dec 2020.

  52. World Health Organizaiton. World Health Organizaiton model prescribing information: drugs used in parasitic diseases. 2nd ed. Helminths; 1995.

    Google Scholar 

  53. Drugs for parasitic infections. 3rd ed. New Rochelle: The Medical Letter; 2013.

    Google Scholar 

  54. Bierer DW. Bismuth subsalicylate: history, chemistry, and safety. Rev Infect Dis. 1990;12(Suppl 1):S3–8.

    Article  CAS  PubMed  Google Scholar 

  55. Centers for Disease Control and Prevention (CDC). Parasites – cysticercosis. Centers for Disease Control and Prevention.

    Google Scholar 

  56. Centers for Disease Control and Prevention (CDC). Parasites – clonorchiasis. Centers for Disease Control and Prevention website. https://www.cdc.gov/parasites/clonorchis/health_professionals/index.html. Updated March 1, 2018. Accessed Dec 2020.

  57. HHS Panel on Opportunistic Infections in Adults and Adolescents with HIV. Guidelines for the prevention and treatment of opportunistic infections in adults and adolescents with HIV: recommendations from the Centers for Disease Control and Prevention, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America. http://aidsinfo.nih.gov/contentfiles/lvguidelines/adult_oi.pdf. Accessed Nov 2020.

  58. US Department of Health and Human Services (HHS) Panel on Adult and Adolescent Opportunistic Infection. Guidelines for the prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: recommendations from the Centers for Disease Control and Prevention, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America. http://aidsinfo.nih.gov/contentfiles/lvguidelines/adult_oi.pdf. Updated November 21, 2019. Accessed Dec 2020.

  59. Centers for Disease Control and Prevention. DPDx: fascioliasis. https://www.cdc.gov/dpdx/fascioliasis/index.html. Accessed on 29 Nov 2020.

  60. World Health Organizaiton model prescribing information: drugs used in parasitic diseases. 2nd ed. Helminths.

    Google Scholar 

  61. Rezaizadeh H, Olson E. Specific GI infections. In: Wu GY, editor. Pocket handbook of GI pharmacotherapeutics. 2nd ed. Totowa: Humana Press; 2016. p. 100.

    Google Scholar 

  62. Lagier J-C, Fenollar F, Lepidi H, Giorgi R, Million M, Raoult D. Treatment of classic Whipple’s disease: from in vitro results to clinical outcome. J Antimicrob Chemother. 2013;69(1):219–27.

    Article  PubMed  CAS  Google Scholar 

  63. Boulos A, Rolain J-M, Raoult D. Antibiotic susceptibility of tropheryma Whipplei in MRC5 cells. Antimicrob Agents Chemother. 2004;48(3):747–52.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  64. Feurle GE, Junga NS, Marth T. Efficacy of ceftriaxone or meropenem as initial therapies in Whipple’s disease. Gastroenterology. 2010;138(2):478–86.

    Article  CAS  PubMed  Google Scholar 

  65. Clifford McDonald L, Gerding DN, Johnson S, et al. Jurate Ivanaviciene, Julia Kostka based on clinical practice guideline for Clostridium difficile infection in adults and children. 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA). Clin Infect Dis. 2018;66:987–94.

    Article  PubMed  CAS  Google Scholar 

  66. Feldman M, et al. Sleisenger & Fordtran gastrointestinal and liver disease. 8th ed. Philadelphia: Saunders; 2006.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2021 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Pakala, T. (2021). Specific Gastrointestinal Microbial Infections. In: Mavilia, M.G., Wu, G.Y. (eds) Pocket Handbook of GI Pharmacotherapeutics. Clinical Gastroenterology. Humana, Cham. https://doi.org/10.1007/978-3-030-72592-1_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-72592-1_7

  • Published:

  • Publisher Name: Humana, Cham

  • Print ISBN: 978-3-030-72591-4

  • Online ISBN: 978-3-030-72592-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics