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Overload Disorders

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Pocket Handbook of GI Pharmacotherapeutics

Part of the book series: Clinical Gastroenterology ((CG))

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Abstract

This chapter covers the following conditions: hereditary and secondary hemochromatosis, Wilson’s disease, Gaucher’s disease. This chapter includes drug class, brand/trade names, manufacturer, dosage, indications, contraindications/cautions, adverse effects, drug Interactions, pregnancy advice, lactation safety, relative cost of deferoxamine, deferasirox, penicillamine, trientine, tetrathiomolybdate, zinc sulfate, imiglucerase (glucocerebrosidase), velaglucerase alfa (glucocerebrosidase), taliglucerase alfa, miglustat, eliglustat. This chapter also includes a convenient algorithm for the treatment of hemochromatosis, and Gaucher’s disease.

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Abbreviations

EM:

Extensive metabolizer

IM:

Intermediate metabolizer

PM:

Poor metabolizer

Suggested Reading

  1. ACG clinical guideline: hereditary hemochromatosis. Am J Gastroenterol. 2019;114:1202–8

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  2. Bacon BR, et al. Diagnosis and management of hemochromatosis: 2011 Practice Guideline by the American Association for the Study of Liver Diseases. Hepatology. 2011;54(1):328–43.

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  3. Kawabata H. The mechanisms of systemic iron homeostasis and etiology, diagnosis, and treatment of hereditary hemochromatosis. Int J Hematol. 2018;107(1):31–43.

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  4. Gary SE, et al. Recent advances in the diagnosis and management of Gaucher disease. Expert Rev Endocrinol Metabol. 2018;13(2):107–18.

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  5. American Association for Study of Liver Diseases (AASLD). Diagnosis and treatment of Wilson disease: an update. Hepatology. 2008;47(6):2089–111.

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  6. https://pubchem.ncbi.nlm.nih.gov/compound/Deferoxamine-mesylate. Accessed Aug 2020.

  7. https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/016267s044lbl.pdf. Acessed Aug 2020.

  8. https://pubchem.ncbi.nlm.nih.gov/compound/Trientine-hydrochloride#section=3D-Conformer. Accessed Sept 2020.

  9. https://pubchem.ncbi.nlm.nih.gov/compound/Penicillamine. Accessed Sept 2020.

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  11. UpToDate/Lexicom

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  12. Package Inserts of medications, including Zin sulfate, Imiglucerase, Velaglucerase, Taliglucerase, Miglustat, Eliglustat

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  13. Bath R. Overload disorders. In: Wu GY, editor. Pocket handbook of GI pharmacotherapeutics. 2nd ed. Humana Press; 2016. p. 154.

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Author information

Authors and Affiliations

  1. Gastroenterology-Hepatology Fellowship Program, University of Connecticut Health Center, Farmington, CT, USA

    Jennifer Onwochei

  2. Division of Gastroenterology & Hepatology, University of Connecticut Health Center, Farmington, CT, USA

    Roopjeet K. Bath

Authors
  1. Jennifer Onwochei
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  2. Roopjeet K. Bath
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Corresponding author

Correspondence to Jennifer Onwochei .

Editor information

Editors and Affiliations

  1. Medicine, Division of Gastroenterology-Hepatology, University of Connecticut Health Center, Farmington, CT, USA

    Marianna G. Mavilia

  2. Medicine, Division of Gastroenterology-Hepatology, University of Connecticut Health Center, Farmington, CT, USA

    George Y. Wu

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© 2021 The Author(s), under exclusive license to Springer Nature Switzerland AG

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Onwochei, J., Bath, R.K. (2021). Overload Disorders. In: Mavilia, M.G., Wu, G.Y. (eds) Pocket Handbook of GI Pharmacotherapeutics. Clinical Gastroenterology. Humana, Cham. https://doi.org/10.1007/978-3-030-72592-1_13

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  • DOI: https://doi.org/10.1007/978-3-030-72592-1_13

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  • Publisher Name: Humana, Cham

  • Print ISBN: 978-3-030-72591-4

  • Online ISBN: 978-3-030-72592-1

  • eBook Packages: MedicineMedicine (R0)

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