Skip to main content

Cryptoglandular Abscess and Fistula

  • Chapter
  • First Online:
The ASCRS Textbook of Colon and Rectal Surgery

Abstract

Cryptoglandular sepsis is the leading cause of anorectal abscess, and at least one-third of abscess cases progress to anorectal fistula formation. Management of these disorders centers on the control of sepsis, amelioration of symptoms, prevention of recurrence, and preservation of continence. There are numerous techniques and methods that can be employed in disease management, some of which have stood the test of time and some have not. Creative clinicians continue to attempt to expand the treatment armamentarium such that we can arrive at a “perfect” treatment. Unfortunately, this treatment does not currently exist. In this chapter, we attempt to provide background on the majority of methods used to treat cryptoglandular abscess and fistula as well as some insight into the potential treatments of the future.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 139.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Abcarian H. Anorectal infection: abscess–fistula. Clin Colon Rectal Surg. 2011;24(1):14–21. https://doi.org/10.1055/s-0031-1272819.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Sainio P. Fistula-in-ano in a defined population. Incidence and epidemiological aspects. Ann Chir Gynaecol. 1984;73(4):219–24.

    CAS  PubMed  Google Scholar 

  3. Ommer A, Herold A, Berg E, et al. German S3 guidelines: anal abscess and fistula (second revised version). Langenbecks Arch Surg. 2017;402(2):191–201. https://doi.org/10.1007/s00423-017-1563-z.

    Article  PubMed  Google Scholar 

  4. Adamo K, Sandblom G, Brännström F, Strigård K. Prevalence and recurrence rate of perianal abscess—a population-based study, Sweden 1997–2009. Int J Colorectal Dis. 2016;31(3):669–73. https://doi.org/10.1007/s00384-015-2500-7.

    Article  PubMed  Google Scholar 

  5. Eisenhammer S. The internal anal sphincter and the anorectal abscess. Surg Gynecol Obstet. 1956;103(4):501–6.

    CAS  PubMed  Google Scholar 

  6. Parks AG. Pathogenesis and treatment of fistula-in-ano. Br Med J. 1961;1(5224):463–460.2.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. McElwain JW, MacLean MD, Alexander RM, Hoexter B, Guthrie JF. Anorectal problems: experience with primary fistulectomy for anorectal abscess, a report of 1,000 cases. Dis Colon Rectum. 1975;18(8):646–9. https://doi.org/10.1007/bf02604266.

    Article  CAS  PubMed  Google Scholar 

  8. Ramanujam PS, Prasad ML, Abcarian H, Tan AB. Perianal abscesses and fistulas. A study of 1023 patients. Dis Colon Rectum. 1984;27(9):593–7. https://doi.org/10.1007/bf02553848.

    Article  CAS  PubMed  Google Scholar 

  9. Caliste X, Nazir S, Goode T, et al. Sensitivity of computed tomography in detection of perirectal abscess. Am Surg. 2011;77(2):166–8.

    Article  PubMed  Google Scholar 

  10. Hamadani A, Haigh PI, Liu I-LA, Abbas MA. Who is at risk for developing chronic anal fistula or recurrent anal sepsis after initial perianal abscess? Dis Colon Rectum. 2009;52(2):217–21. https://doi.org/10.1007/DCR.0b013e31819a5c52.

    Article  PubMed  Google Scholar 

  11. Lohsiriwat V, Yodying H, Lohsiriwat D. Incidence and factors influencing the development of fistula-in-ano after incision and drainage of perianal abscesses. J Med Assoc Thail Chotmaihet Thangphaet. 2010;93(1):61–5.

    Google Scholar 

  12. Cox SW, Senagore AJ, Luchtefeld MA, Mazier WP. Outcome after incision and drainage with fistulotomy for ischiorectal abscess. Am Surg. 1997;63(8):686–9.

    CAS  PubMed  Google Scholar 

  13. Read DR, Abcarian H. A prospective survey of 474 patients with anorectal abscess. Dis Colon Rectum. 1979;22(8):566–8. https://doi.org/10.1007/bf02587008.

    Article  CAS  PubMed  Google Scholar 

  14. Vasilevsky CA, Gordon PH. The incidence of recurrent abscesses or fistula-in-ano following anorectal suppuration. Dis Colon Rectum. 1984;27(2):126–30. https://doi.org/10.1007/bf02553995.

    Article  CAS  PubMed  Google Scholar 

  15. Schouten WR, van Vroonhoven TJ. Treatment of anorectal abscess with or without primary fistulectomy. Results of a prospective randomized trial. Dis Colon Rectum. 1991;34(1):60–3. https://doi.org/10.1007/bf02050209.

    Article  CAS  PubMed  Google Scholar 

  16. O’Malley GF, Dominici P, Giraldo P, et al. Routine packing of simple cutaneous abscesses is painful and probably unnecessary. Acad Emerg Med. 2009;16(5):470–3. https://doi.org/10.1111/j.1553-2712.2009.00409.x.

    Article  PubMed  Google Scholar 

  17. Perera AP, Howell AM, Sodergren MH, et al. A pilot randomised controlled trial evaluating postoperative packing of the perianal abscess. Langenbecks Arch Surg. 2015;400(2):267–71. https://doi.org/10.1007/s00423-014-1231-5.

    Article  CAS  PubMed  Google Scholar 

  18. Tonkin DM, Murphy E, Brooke-Smith M, et al. Perianal abscess: a pilot study comparing packing with nonpacking of the abscess cavity. Dis Colon Rectum. 2004;47(9):1510–4. https://doi.org/10.1007/s10350-004-0620-1.

    Article  PubMed  Google Scholar 

  19. Vogel J, Johnson E, Morris A, et al. Clinical practice guideline for the management of anorectal abscess, fistula-in-ano, and rectovaginal fistula. Dis Colon Rectum. 2016;59(12):1117–33. https://doi.org/10.1097/DCR.0000000000000733.

    Article  PubMed  Google Scholar 

  20. Ghahramani L, Minaie MR, Arasteh P, et al. Antibiotic therapy for prevention of fistula in-ano after incision and drainage of simple perianal abscess: a randomized single blind clinical trial. Surgery. 2017;162(5):1017–25. https://doi.org/10.1016/j.surg.2017.07.001.

    Article  PubMed  Google Scholar 

  21. Mocanu V, Dang JT, Ladak F, et al. Antibiotic use in prevention of anal fistulas following incision and drainage of anorectal abscesses: a systematic review and meta-analysis. Am J Surg. 2019;217(5):910–7. https://doi.org/10.1016/j.amjsurg.2019.01.015.

    Article  PubMed  Google Scholar 

  22. Sözener U, Gedik E, Aslar AK, et al. Does adjuvant antibiotic treatment after drainage of anorectal abscess prevent development of anal fistulas? A randomized, placebo-controlled, double-blind, multicenter study. Dis Colon Rectum. 2011;54(8):923–9. https://doi.org/10.1097/DCR.0b013e31821cc1f9.

    Article  PubMed  Google Scholar 

  23. Parks AG, Gordon PH, Hardcastle JD. A classification of fistula-in-ano. Br J Surg. 1976;63(1):1–12. https://doi.org/10.1002/bjs.1800630102.

    Article  CAS  PubMed  Google Scholar 

  24. Sileri P, Cadeddu F, D’Ugo S, et al. Surgery for fistula-in-ano in a specialist colorectal unit: a critical appraisal. BMC Gastroenterol. 2011;11:120. https://doi.org/10.1186/1471-230X-11-120.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Subasinghe D, Samarasekera DN. Comparison of preoperative endoanal ultrasonography with intraoperative findings for fistula in ano. World J Surg. 2010;34(5):1123–7. https://doi.org/10.1007/s00268-010-0478-4.

    Article  PubMed  Google Scholar 

  26. Gonzalez-Ruiz C, Kaiser AM, Vukasin P, Beart RW, Ortega AE. Intraoperative physical diagnosis in the management of anal fistula. Am Surg. 2006;72(1):11–5.

    Article  PubMed  Google Scholar 

  27. Barwood N, Clarke G, Levitt S, Levitt M. Fistula-in-ano: a prospective study of 107 patients. Aust N Z J Surg. 1997;67(2–3):98–102. https://doi.org/10.1111/j.1445-2197.1997.tb01911.x.

    Article  CAS  PubMed  Google Scholar 

  28. Pomerri F, Dodi G, Pintacuda G, Amadio L, Muzzio PC. Anal endosonography and fistulography for fistula-in-ano. Radiol Med (Torino). 2010;115(5):771–83. https://doi.org/10.1007/s11547-010-0524-1.

    Article  CAS  PubMed  Google Scholar 

  29. Williams G, Williams A, Tozer P, et al. The treatment of anal fistula: second ACPGBI position statement – 2018. Colorectal Dis. 2018;20(S3):5–31. https://doi.org/10.1111/codi.14054.

    Article  PubMed  Google Scholar 

  30. Liang C, Jiang W, Zhao B, Zhang Y, Du Y, Lu Y. CT imaging with fistulography for perianal fistula: does it really help the surgeon? Clin Imaging. 2013;37(6):1069–76. https://doi.org/10.1016/j.clinimag.2013.04.014.

    Article  PubMed  Google Scholar 

  31. Soker G, Gulek B, Yilmaz C, et al. The comparison of CT fistulography and MR imaging of perianal fistulae with surgical findings: a case-control study. Abdom Radiol N Y. 2016;41(8):1474–83. https://doi.org/10.1007/s00261-016-0722-y.

    Article  Google Scholar 

  32. Lunniss PJ, Armstrong P, Barker PG, Reznek RH, Phillips RK. Magnetic resonance imaging of anal fistulae. Lancet Lond Engl. 1992;340(8816):394–6. https://doi.org/10.1016/0140-6736(92)91472-k.

    Article  CAS  Google Scholar 

  33. Joyce M, Veniero JC, Kiran RP. Magnetic resonance imaging in the management of anal fistula and anorectal sepsis. Clin Colon Rectal Surg. 2008;21(3):213–9. https://doi.org/10.1055/s-2008-1081000.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Halligan S. Magnetic resonance imaging of fistula-in-ano. Magn Reson Imaging Clin N Am. 2020;28(1):141–51. https://doi.org/10.1016/j.mric.2019.09.006.

    Article  PubMed  Google Scholar 

  35. Konan A, Onur MR, Özmen MN. The contribution of preoperative MRI to the surgical management of anal fistulas. Diagn Interv Radiol. 2018;24(6):321–7. https://doi.org/10.5152/dir.2018.18340.

    Article  PubMed  PubMed Central  Google Scholar 

  36. deSouza NM, Gilderdale DJ, Coutts GA, Puni R, Steiner RE. MRI of fistula-in-ano: a comparison of endoanal coil with external phased array coil techniques. J Comput Assist Tomogr. 1998;22(3):357–63. https://doi.org/10.1097/00004728-199805000-00004.

    Article  CAS  PubMed  Google Scholar 

  37. West RL, Zimmerman DDE, Dwarkasing S, et al. Prospective comparison of hydrogen peroxide-enhanced three-dimensional endoanal ultrasonography and endoanal magnetic resonance imaging of perianal fistulas. Dis Colon Rectum. 2003;46(10):1407–15. https://doi.org/10.1007/s10350-004-6758-z.

    Article  CAS  PubMed  Google Scholar 

  38. Halligan S, Bartram CI. MR imaging of fistula in ano: are endoanal coils the gold standard? AJR Am J Roentgenol. 1998;171(2):407–12. https://doi.org/10.2214/ajr.171.2.9694465.

    Article  CAS  PubMed  Google Scholar 

  39. Buchanan GN, Halligan S, Bartram CI, Williams AB, Tarroni D, Cohen CRG. Clinical examination, endosonography, and MR imaging in preoperative assessment of fistula in ano: comparison with outcome-based reference standard. Radiology. 2004;233(3):674–81. https://doi.org/10.1148/radiol.2333031724.

    Article  PubMed  Google Scholar 

  40. Brillantino A, Iacobellis F, Reginelli A, et al. Preoperative assessment of simple and complex anorectal fistulas: tridimensional endoanal ultrasound? Magnetic resonance? Both? Radiol Med (Torino). 2019;124(5):339–49. https://doi.org/10.1007/s11547-018-0975-3.

    Article  PubMed  Google Scholar 

  41. Cho DY. Endosonographic criteria for an internal opening of fistula-in-ano. Dis Colon Rectum. 1999;42(4):515–8. https://doi.org/10.1007/bf02234179.

    Article  CAS  PubMed  Google Scholar 

  42. Ratto C, Grillo E, Parello A, Costamagna G, Doglietto GB. Endoanal ultrasound-guided surgery for anal fistula. Endoscopy. 2005;37(8):722–8. https://doi.org/10.1055/s-2005-870155.

    Article  CAS  PubMed  Google Scholar 

  43. Tsankov T, Tankova L, Deredjan H, Kovatchki D. Contrast-enhanced endoanal and transperineal sonography in perianal fistulas. Hepatogastroenterology. 2008;55(81):13–6.

    PubMed  Google Scholar 

  44. Kim Y, Park YJ. Three-dimensional endoanal ultrasonographic assessment of an anal fistula with and without H2O2 enhancement. World J Gastroenterol WJG. 2009;15(38):4810–5. https://doi.org/10.3748/wjg.15.4810.

    Article  PubMed  Google Scholar 

  45. Bleier JI, Moloo H. Current management of cryptoglandular fistula-in-ano. World J Gastroenterol WJG. 2011;17(28):3286–91. https://doi.org/10.3748/wjg.v17.i28.3286.

    Article  PubMed  Google Scholar 

  46. Davis BR, Kasten KR. Anorectal abscess and fistula. In: Steele SR, Hull TL, Read TE, Saclarides TJ, Senagore AJ, Whitlow CB, editors. The ASCRS textbook of colon and rectal surgery. 3rd ed. Cham: Springer International Publishing; 2016. https://doi.org/10.1007/978-3-319-25970-3.

    Chapter  Google Scholar 

  47. Maternini M, Guttadauro A, Ripamonti L, Chiarelli M, Gabrielli F. Malignant transformation of a chronic anorectal fistula. Ann Ital Chir. 2018;7:S2239253X18029109.

    PubMed  Google Scholar 

  48. Garcia-Aguilar J, Belmonte C, Wong WD, Goldberg SM, Madoff RD. Anal fistula surgery. Factors associated with recurrence and incontinence. Dis Colon Rectum. 1996;39(7):723–9. https://doi.org/10.1007/bf02054434.

    Article  CAS  PubMed  Google Scholar 

  49. Cheong DM, Nogueras JJ, Wexner SD, Jagelman DG. Anal endosonography for recurrent anal fistulas: image enhancement with hydrogen peroxide. Dis Colon Rectum. 1993;36(12):1158–60. https://doi.org/10.1007/bf02052266.

    Article  CAS  PubMed  Google Scholar 

  50. Navarro-Luna A, García-Domingo MI, Rius-Macías J, Marco-Molina C. Ultrasound study of anal fistulas with hydrogen peroxide enhancement. Dis Colon Rectum. 2004;47(1):108–14. https://doi.org/10.1007/s10350-003-0015-8.

    Article  PubMed  Google Scholar 

  51. Buchanan GN, Bartram CI, Williams AB, Halligan S, Cohen CRG. Value of hydrogen peroxide enhancement of three-dimensional endoanal ultrasound in fistula-in-ano. Dis Colon Rectum. 2005;48(1):141–7. https://doi.org/10.1007/s10350-004-0752-3.

    Article  PubMed  Google Scholar 

  52. Abou-Zeid AA. Anal fistula: intraoperative difficulties and unexpected findings. World J Gastroenterol WJG. 2011;17(28):3272–6. https://doi.org/10.3748/wjg.v17.i28.3272.

    Article  PubMed  Google Scholar 

  53. Whiteford MH, Kilkenny J, Hyman N, et al. Practice parameters for the treatment of perianal abscess and fistula-in-ano (revised). Dis Colon Rectum. 2005;48(7):1337–42. https://doi.org/10.1007/s10350-005-0055-3.

    Article  PubMed  Google Scholar 

  54. van Tets WF, Kuijpers HC. Continence disorders after anal fistulotomy. Dis Colon Rectum. 1994;37(12):1194–7. https://doi.org/10.1007/bf02257781.

    Article  PubMed  Google Scholar 

  55. Ho Y-H, Tan M, Leong AFPK, Seow-Choen F. Marsupialization of fistulotomy wounds improves healing: a randomized controlled trial. BJS Br J Surg. 1998;85(1):105–7. https://doi.org/10.1046/j.1365-2168.1998.00529.x.

    Article  CAS  Google Scholar 

  56. Pescatori M, Ayabaca SM, Cafaro D, Iannello A, Magrini S. Marsupialization of fistulotomy and fistulectomy wounds improves healing and decreases bleeding: a randomized controlled trial. Colorectal Dis. 2006;8(1):11–4. https://doi.org/10.1111/j.1463-1318.2005.00835.x.

    Article  CAS  PubMed  Google Scholar 

  57. Kronborg O. To lay open or excise a fistula-in-ano: a randomized trial. Br J Surg. 1985;72(12):970. https://doi.org/10.1002/bjs.1800721211.

    Article  CAS  PubMed  Google Scholar 

  58. Belmonte Montes C, Ruiz Galindo GH, Montes Villalobos JL, Decanini TC. Fistulotomy vs fistulectomy. Ultrasonographic evaluation of lesion of the anal sphincter function. Rev Gastroenterol Mex. 1999;64(4):167–70.

    CAS  PubMed  Google Scholar 

  59. Browder LK, Sweet S, Kaiser AM. Modified Hanley procedure for management of complex horseshoe fistulae. Tech Coloproctol. 2009;13(4):301–6. https://doi.org/10.1007/s10151-009-0539-6.

    Article  CAS  PubMed  Google Scholar 

  60. Raslan SM, Aladwani M, Alsanea N. Evaluation of the cutting seton as a method of treatment for perianal fistula. Ann Saudi Med. 2016;36(3):210–5. https://doi.org/10.5144/0256-4947.2016.210.

    Article  PubMed  PubMed Central  Google Scholar 

  61. Kamrava A, Collins JC. A decade of selective use of adjustable cutting seton combined with fistulotomy for anal fistula. Am Surg. 2011;77(10):1377–80.

    Article  PubMed  Google Scholar 

  62. Memon AA, Murtaza G, Azami R, Zafar H, Chawla T, Laghari AA. Treatment of complex fistula in ano with cable-tie seton: a prospective case series. ISRN Surg. 2011;2011. https://doi.org/10.5402/2011/636952.

  63. Hammond TM, Knowles CH, Porrett T, Lunniss PJ. The Snug Seton: short and medium term results of slow fistulotomy for idiopathic anal fistulae. Colorectal Dis. 2006;8(4):328–37. https://doi.org/10.1111/j.1463-1318.2005.00926.x.

    Article  CAS  PubMed  Google Scholar 

  64. Izadpanah A, Rezazadehkermani M, Hosseiniasl SM, et al. Pulling seton: combination of mechanisms. Adv Biomed Res. 2016;5. https://doi.org/10.4103/2277-9175.180637.

  65. Ritchie RD, Sackier JM, Hodde JP. Incontinence rates after cutting seton treatment for anal fistula. Colorectal Dis. 2009;11(6):564–71. https://doi.org/10.1111/j.1463-1318.2008.01713.x.

    Article  CAS  PubMed  Google Scholar 

  66. Vial M, Parés D, Pera M, Grande L. Faecal incontinence after seton treatment for anal fistulae with and without surgical division of internal anal sphincter: a systematic review. Colorectal Dis. 2010;12(3):172–8. https://doi.org/10.1111/j.1463-1318.2009.01810.x.

    Article  CAS  PubMed  Google Scholar 

  67. Daodu OO, O’Keefe J, Heine JA. Draining setons as definitive management of fistula-in-ano. Dis Colon Rectum. 2018;61(4):499–503. https://doi.org/10.1097/DCR.0000000000001045.

    Article  PubMed  Google Scholar 

  68. Emile SH, Elfeki H, Thabet W, et al. Predictive factors for recurrence of high trans sphincteric anal fistula after placement of seton. J Surg Res. 2017;213:261–8. https://doi.org/10.1016/j.jss.2017.02.053.

    Article  PubMed  Google Scholar 

  69. Kelly ME, Heneghan HM, McDermott FD, et al. The role of loose seton in the management of anal fistula: a multicenter study of 200 patients. Tech Coloproctol. 2014;18(10):915–9. https://doi.org/10.1007/s10151-014-1186-0.

    Article  CAS  PubMed  Google Scholar 

  70. Omar W, Alqasaby A, Abdelnaby M, et al. Drainage seton versus external anal sphincter-sparing seton after rerouting of the fistula tract in the treatment of complex anal fistula: a randomized controlled trial. Dis Colon Rectum. 2019;62(8):980–7. https://doi.org/10.1097/DCR.0000000000001416.

    Article  PubMed  Google Scholar 

  71. Hjortrup A, Moesgaard F, Kjaergård J. Fibrin adhesive in the treatment of perineal fistulas. Dis Colon Rectum. 1991;34(9):752–4. https://doi.org/10.1007/bf02051064.

    Article  CAS  PubMed  Google Scholar 

  72. Singer M, Cintron J, Nelson R, et al. Treatment of fistulas-in-ano with fibrin sealant in combination with intra-adhesive antibiotics and/or surgical closure of the internal fistula opening. Dis Colon Rectum. 2005;48(4):799–808. https://doi.org/10.1007/s10350-004-0898-z.

    Article  PubMed  Google Scholar 

  73. Buchanan GN, Bartram CI, Phillips RKS, et al. Efficacy of fibrin sealant in the management of complex anal fistula: a prospective trial. Dis Colon Rectum. 2003;46(9):1167–74. https://doi.org/10.1007/s10350-004-6708-9.

    Article  PubMed  Google Scholar 

  74. Adams T, Yang J, Kondylis LA, Kondylis PD. Long-term outlook after successful fibrin glue ablation of cryptoglandular trans sphincteric fistula-in-ano. Dis Colon Rectum. 2008;51(10):1488–90. https://doi.org/10.1007/s10350-008-9405-2.

    Article  PubMed  Google Scholar 

  75. Loungnarath R, Dietz DW, Mutch MG, Birnbaum EH, Kodner IJ, Fleshman JW. Fibrin glue treatment of complex anal fistulas has low success rate. Dis Colon Rectum. 2004;47(4):432–6. https://doi.org/10.1007/s10350-003-0076-8.

    Article  PubMed  Google Scholar 

  76. Cintron JR, Park JJ, Orsay CP, et al. Repair of fistulas-in-ano using fibrin adhesive: long-term follow-up. Dis Colon Rectum. 2000;43(7):944–9; discussion 949–950. https://doi.org/10.1007/bf02237355.

    Article  CAS  PubMed  Google Scholar 

  77. Swinscoe MT, Ventakasubramaniam AK, Jayne DG. Fibrin glue for fistula-in-ano: the evidence reviewed. Tech Coloproctol. 2005;9(2):89–94. https://doi.org/10.1007/s10151-005-0204-7.

    Article  CAS  PubMed  Google Scholar 

  78. Johnson EK, Gaw JU, Armstrong DN. Efficacy of anal fistula plug vs. fibrin glue in closure of anorectal fistulas. Dis Colon Rectum. 2006;49(3):371–6. https://doi.org/10.1007/s10350-005-0288-1.

    Article  PubMed  Google Scholar 

  79. Limura E, Giordano P. Modern management of anal fistula. World J Gastroenterol WJG. 2015;21(1):12–20. https://doi.org/10.3748/wjg.v21.i1.12.

    Article  PubMed  Google Scholar 

  80. Kleif J, Hagen K, Wille-Jørgensen P. Acceptable results using plug for the treatment of complex anal fistulas. Dan Med Bull. 2011;58(3):A4254.

    PubMed  Google Scholar 

  81. Champagne BJ, O’Connor LM, Ferguson M, Orangio GR, Schertzer ME, Armstrong DN. Efficacy of anal fistula plug in closure of cryptoglandular fistulas: long-term follow-up. Dis Colon Rectum. 2006;49(12):1817–21. https://doi.org/10.1007/s10350-006-0755-3.

    Article  PubMed  Google Scholar 

  82. El-Gazzaz G, Zutshi M, Hull T. A retrospective review of chronic anal fistulae treated by anal fistulae plug. Colorectal Dis. 2010;12(5):442–7. https://doi.org/10.1111/j.1463-1318.2009.01802.x.

    Article  CAS  PubMed  Google Scholar 

  83. Kodner IJ, Mazor A, Shemesh EI, Fry RD, Fleshman JW, Birnbaum EH. Endorectal advancement flap repair of rectovaginal and other complicated anorectal fistulas. Surgery. 1993;114(4):682–9; discussion 689–690.

    CAS  PubMed  Google Scholar 

  84. Jones IT, Fazio VW, Jagelman DG. The use of transanal rectal advancement flaps in the management of fistulas involving the anorectum. Dis Colon Rectum. 1987;30(12):919–23. https://doi.org/10.1007/bf02554276.

    Article  CAS  PubMed  Google Scholar 

  85. Uribe N, Millán M, Minguez M, et al. Clinical and manometric results of endorectal advancement flaps for complex anal fistula. Int J Colorectal Dis. 2007;22(3):259–64. https://doi.org/10.1007/s00384-006-0172-z.

    Article  PubMed  Google Scholar 

  86. Uribe N, Balciscueta Z, Mínguez M, et al. “Core out” or “curettage” in rectal advancement flap for cryptoglandular anal fistula. Int J Colorectal Dis. 2015;30(5):613–9. https://doi.org/10.1007/s00384-015-2133-x.

    Article  PubMed  Google Scholar 

  87. Jarrar A, Church J. Advancement flap repair: a good option for complex anorectal fistulas. Dis Colon Rectum. 2011;54(12):1537–41. https://doi.org/10.1097/DCR.0b013e31822d7ddd.

    Article  PubMed  Google Scholar 

  88. Hall JF, Bordeianou L, Hyman N, et al. Outcomes after operations for anal fistula: results of a prospective, multicenter, regional study. Dis Colon Rectum. 2014;57(11):1304–8. https://doi.org/10.1097/DCR.0000000000000216.

    Article  PubMed  Google Scholar 

  89. Lee C-L, Lu J, Lim T-Z, et al. Long-term outcome following advancement flaps for high anal fistulas in an Asian population: a single institution’s experience. Int J Colorectal Dis. 2015;30(3):409–12. https://doi.org/10.1007/s00384-014-2100-y.

    Article  PubMed  Google Scholar 

  90. Mitalas LE, Gosselink MP, Oom DMJ, Zimmerman DDE, Schouten WR. Required length of follow-up after transanal advancement flap repair of high trans sphincteric fistulas. Colorectal Dis. 2009;11(7):726–8. https://doi.org/10.1111/j.1463-1318.2008.01666.x.

    Article  CAS  PubMed  Google Scholar 

  91. van Koperen PJ, Wind J, Bemelman WA, Bakx R, Reitsma JB, Slors JFM. Long-term functional outcome and risk factors for recurrence after surgical treatment for low and high perianal fistulas of cryptoglandular origin. Dis Colon Rectum. 2008;51(10):1475–81. https://doi.org/10.1007/s10350-008-9354-9.

    Article  PubMed  Google Scholar 

  92. Balciscueta Z, Uribe N, Balciscueta I, Andreu-Ballester JC, García-Granero E. Rectal advancement flap for the treatment of complex cryptoglandular anal fistulas: a systematic review and meta-analysis. Int J Colorectal Dis. 2017;32(5):599–609. https://doi.org/10.1007/s00384-017-2779-7.

    Article  PubMed  Google Scholar 

  93. Ellis CN, Clark S. Effect of tobacco smoking on advancement flap repair of complex anal fistulas. Dis Colon Rectum. 2007;50(4):459–63. https://doi.org/10.1007/s10350-006-0829-2.

    Article  PubMed  Google Scholar 

  94. Zimmerman DDE, Delemarre JBVM, Gosselink MP, Hop WCJ, Briel JW, Schouten WR. Smoking affects the outcome of transanal mucosal advancement flap repair of trans-sphincteric fistulas. Br J Surg. 2003;90(3):351–4. https://doi.org/10.1002/bjs.4044.

    Article  CAS  PubMed  Google Scholar 

  95. Mizrahi N, Wexner SD, Zmora O, et al. Endorectal advancement flap: are there predictors of failure? Dis Colon Rectum. 2002;45(12):1616–21. https://doi.org/10.1097/01.DCR.0000037654.01119.CD.

    Article  PubMed  Google Scholar 

  96. van Onkelen RS, Gosselink MP, Thijsse S, Schouten WR. Predictors of outcome after transanal advancement flap repair for high trans sphincteric fistulas. Dis Colon Rectum. 2014;57(8):1007–11. https://doi.org/10.1097/DCR.0000000000000154.

    Article  PubMed  Google Scholar 

  97. Boenicke L, Karsten E, Zirngibl H, Ambe P. Advancement flap for treatment of complex cryptoglandular anal fistula: prediction of therapy success or failure using anamnestic and clinical parameters. World J Surg. 2017;41(9):2395–400. https://doi.org/10.1007/s00268-017-4006-7.

    Article  PubMed  Google Scholar 

  98. Ozuner G, Hull TL, Cartmill J, Fazio VW. Long-term analysis of the use of transanal rectal advancement flaps for complicated anorectal/vaginal fistulas. Dis Colon Rectum. 1996;39(1):10–4. https://doi.org/10.1007/bf02048261.

    Article  CAS  PubMed  Google Scholar 

  99. Yellinek S, Krizzuk D, Moreno Djadou T, Lavy D, Wexner SD. Endorectal advancement flap for complex anal fistula: does flap configuration matter? Colorectal Dis. 2019;21(5):581–7. https://doi.org/10.1111/codi.14564.

    Article  CAS  PubMed  Google Scholar 

  100. Stremitzer S, Riss S, Swoboda P, et al. Repeat endorectal advancement flap after flap breakdown and recurrence of fistula-in-ano--is it an option? Colorectal Dis. 2012;14(11):1389–93. https://doi.org/10.1111/j.1463-1318.2012.02990.x.

    Article  CAS  PubMed  Google Scholar 

  101. Mitalas LE, Gosselink MP, Zimmerman DDE, Schouten WR. Repeat transanal advancement flap repair: impact on the overall healing rate of high trans sphincteric fistulas and on fecal continence. Dis Colon Rectum. 2007;50(10):1508–11. https://doi.org/10.1007/s10350-007-9015-4.

    Article  PubMed  PubMed Central  Google Scholar 

  102. Soltani A, Kaiser AM. Endorectal advancement flap for cryptoglandular or Crohn’s fistula-in-ano. Dis Colon Rectum. 2010;53(4):486–95. https://doi.org/10.1007/DCR.0b013e3181ce8b01.

    Article  PubMed  Google Scholar 

  103. van Koperen PJ, Wind J, Bemelman WA, Slors JFM. Fibrin glue and transanal rectal advancement flap for high trans sphincteric perianal fistulas; is there any advantage? Int J Colorectal Dis. 2008;23(7):697–701. https://doi.org/10.1007/s00384-008-0460-x.

    Article  PubMed  PubMed Central  Google Scholar 

  104. Göttgens KW, Vening W, van der Hagen SJ, et al. Long-term results of mucosal advancement flap combined with platelet-rich plasma for high cryptoglandular perianal fistulas. Dis Colon Rectum. 2014;57(2):223–7. https://doi.org/10.1097/DCR.0000000000000023.

    Article  PubMed  Google Scholar 

  105. Dubsky PC, Stift A, Friedl J, Teleky B, Herbst F. Endorectal advancement flaps in the treatment of high anal fistula of cryptoglandular origin: full-thickness vs. mucosal-rectum flaps. Dis Colon Rectum. 2008;51(6):852–7. https://doi.org/10.1007/s10350-008-9242-3.

    Article  PubMed  Google Scholar 

  106. Lewis P, Bartolo DC. Treatment of trans-sphincteric fistulae by full thickness anorectal advancement flaps. Br J Surg. 1990;77(10):1187–9. https://doi.org/10.1002/bjs.1800771033.

    Article  CAS  PubMed  Google Scholar 

  107. Jun SH, Choi GS. Anocutaneous advancement flap closure of high anal fistulas. Br J Surg. 1999;86(4):490–2. https://doi.org/10.1046/j.1365-2168.1999.01077.x.

    Article  CAS  PubMed  Google Scholar 

  108. Amin SN, Tierney GM, Lund JN, Armitage NC. V-Y advancement flap for treatment of fistula-in-ano. Dis Colon Rectum. 2003;46(4):540–3. https://doi.org/10.1007/s10350-004-6596-z.

    Article  CAS  PubMed  Google Scholar 

  109. Del Pino A, Nelson RL, Pearl RK, Abcarian H. Island flap anoplasty for treatment of trans sphincteric fistula-in-ano. Dis Colon Rectum. 1996;39(2):224–6. https://doi.org/10.1007/bf02068080.

    Article  PubMed  Google Scholar 

  110. Rojanasakul A, Pattanaarun J, Sahakitrungruang C, Tantiphlachiva K. Total anal sphincter saving technique for fistula-in-ano; the ligation of intersphincteric fistula tract. J Med Assoc Thail Chotmaihet Thangphaet. 2007;90(3):581–6.

    Google Scholar 

  111. Malakorn S, Sammour T, Khomvilai S, et al. Ligation of intersphincteric fistula tract for fistula in ano: lessons learned from a decade of experience. Dis Colon Rectum. 2017;60(10):1065–70. https://doi.org/10.1097/DCR.0000000000000880.

    Article  PubMed  Google Scholar 

  112. Hong KD, Kang S, Kalaskar S, Wexner SD. Ligation of intersphincteric fistula tract (LIFT) to treat anal fistula: systematic review and meta-analysis. Tech Coloproctol. 2014;18(8):685–91. https://doi.org/10.1007/s10151-014-1183-3.

    Article  CAS  PubMed  Google Scholar 

  113. Sirany A-ME, Nygaard RM, Morken JJ. The ligation of the intersphincteric fistula tract procedure for anal fistula: a mixed bag of results. Dis Colon Rectum. 2015;58(6):604–12. https://doi.org/10.1097/DCR.0000000000000374.

    Article  PubMed  Google Scholar 

  114. Alasari S, Kim NK. Overview of anal fistula and systematic review of ligation of the intersphincteric fistula tract (LIFT). Tech Coloproctol. 2014;18(1):13–22. https://doi.org/10.1007/s10151-013-1050-7.

    Article  CAS  PubMed  Google Scholar 

  115. Vergara-Fernandez O, Espino-Urbina LA. Ligation of intersphincteric fistula tract: what is the evidence in a review? World J Gastroenterol. 2013;19(40):6805–13. https://doi.org/10.3748/wjg.v19.i40.6805.

    Article  PubMed  PubMed Central  Google Scholar 

  116. Zirak-Schmidt S, Perdawood SK. Management of anal fistula by ligation of the intersphincteric fistula tract - a systematic review. Dan Med J. 2014;61(12):A4977.

    PubMed  Google Scholar 

  117. Liu WY, Aboulian A, Kaji AH, Kumar RR. Long-term results of ligation of intersphincteric fistula tract (LIFT) for fistula-in-ano. Dis Colon Rectum. 2013;56(3):343–7. https://doi.org/10.1097/DCR.0b013e318278164c.

    Article  PubMed  Google Scholar 

  118. Tan K-K, Tan IJ, Lim FS, Koh DC, Tsang CB. The anatomy of failures following the ligation of intersphincteric tract technique for anal fistula: a review of 93 patients over 4 years. Dis Colon Rectum. 2011;54(11):1368–72. https://doi.org/10.1097/DCR.0b013e31822bb55e.

    Article  PubMed  Google Scholar 

  119. van Onkelen RS, Gosselink MP, Schouten WR. Ligation of the intersphincteric fistula tract in low trans sphincteric fistulae: a new technique to avoid fistulotomy. Colorectal Dis. 2013;15(5):587–91. https://doi.org/10.1111/codi.12030.

    Article  PubMed  Google Scholar 

  120. van Onkelen RS, Gosselink MP, Schouten WR. Is it possible to improve the outcome of transanal advancement flap repair for high trans sphincteric fistulas by additional ligation of the intersphincteric fistula tract? Dis Colon Rectum. 2012;55(2):163–6. https://doi.org/10.1097/DCR.0b013e31823c0f74.

    Article  PubMed  Google Scholar 

  121. Madbouly KM, El Shazly W, Abbas KS, Hussein AM. Ligation of intersphincteric fistula tract versus mucosal advancement flap in patients with high trans sphincteric fistula-in-ano: a prospective randomized trial. Dis Colon Rectum. 2014;57(10):1202–8. https://doi.org/10.1097/DCR.0000000000000194.

    Article  PubMed  Google Scholar 

  122. Stellingwerf ME, van Praag EM, Tozer PJ, Bemelman WA, Buskens CJ. Systematic review and meta-analysis of endorectal advancement flap and ligation of the intersphincteric fistula tract for cryptoglandular and Crohn’s high perianal fistulas. BJS Open. 2019;3(3):231–41. https://doi.org/10.1002/bjs5.50129.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  123. Lau YC, Brown KGM, Cheong J, Byrne C, Lee PJ. LIFT and BioLIFT: a 10-year single-centre experience of treating complex fistula-in-ano with ligation of intersphincteric fistula tract procedure with or without bio-prosthetic reinforcement (BioLIFT). J Gastrointest Surg. 2019. https://doi.org/10.1007/s11605-019-04305-x.

  124. Han JG, Wang ZJ, Zheng Y, et al. Ligation of intersphincteric fistula tract vs ligation of the intersphincteric fistula tract plus a bioprosthetic anal fistula plug procedure in patients with transsphincteric anal fistula: early results of a multicenter prospective randomized trial. Ann Surg. 2016;264(6):917–22. https://doi.org/10.1097/SLA.0000000000001562.

    Article  PubMed  Google Scholar 

  125. Sirikurnpiboon S, Awapittaya B, Jivapaisarnpong P. Ligation of intersphincteric fistula tract and its modification: results from treatment of complex fistula. World J Gastrointest Surg. 2013;5(4):123–8. https://doi.org/10.4240/wjgs.v5.i4.123.

    Article  PubMed  PubMed Central  Google Scholar 

  126. Wilhelm A. A new technique for sphincter-preserving anal fistula repair using a novel radial emitting laser probe. Tech Coloproctol. 2011;15(4):445–9. https://doi.org/10.1007/s10151-011-0726-0.

    Article  CAS  PubMed  Google Scholar 

  127. Giamundo P, Geraci M, Tibaldi L, Valente M. Closure of fistula-in-ano with laser--FiLaC™: an effective novel sphincter-saving procedure for complex disease. Colorectal Dis. 2014;16(2):110–5. https://doi.org/10.1111/codi.12440.

    Article  CAS  PubMed  Google Scholar 

  128. Oztürk E, Gülcü B. Laser ablation of fistula tract: a sphincter-preserving method for treating fistula-in-ano. Dis Colon Rectum. 2014;57(3):360–4. https://doi.org/10.1097/DCR.0000000000000067.

    Article  PubMed  Google Scholar 

  129. Lauretta A, Falco N, Stocco E, Bellomo R, Infantino A. Anal fistula laser closure: the length of fistula is the Achilles’ heel. Tech Coloproctol. 2018;22(12):933–9. https://doi.org/10.1007/s10151-018-1885-z.

    Article  CAS  PubMed  Google Scholar 

  130. Giamundo P, Esercizio L, Geraci M, Tibaldi L, Valente M. Fistula-tract laser closure (FiLaC™): long-term results and new operative strategies. Tech Coloproctol. 2015;19(8):449–53. https://doi.org/10.1007/s10151-015-1282-9.

    Article  CAS  PubMed  Google Scholar 

  131. Wilhelm A, Fiebig A, Krawczak M. Five years of experience with the FiLaC™ laser for fistula-in-ano management: long-term follow-up from a single institution. Tech Coloproctol. 2017;21(4):269–76. https://doi.org/10.1007/s10151-017-1599-7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  132. Meinero P, Mori L. Video-assisted anal fistula treatment (VAAFT): a novel sphincter-saving procedure for treating complex anal fistulas. Tech Coloproctol. 2011;15(4):417–22. https://doi.org/10.1007/s10151-011-0769-2.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  133. Garg P, Singh P. Video-assisted anal fistula treatment (VAAFT) in cryptoglandular fistula-in-ano: a systematic review and proportional meta-analysis. Int J Surg. 2017;46:85–91. https://doi.org/10.1016/j.ijsu.2017.08.582.

    Article  PubMed  Google Scholar 

  134. Emile SH, Elfeki H, Shalaby M, Sakr A. A systematic review and meta-analysis of the efficacy and safety of video-assisted anal fistula treatment (VAAFT). Surg Endosc. 2018;32(4):2084–93. https://doi.org/10.1007/s00464-017-5905-2.

    Article  PubMed  Google Scholar 

  135. Ratto C, Litta F, Donisi L, Parello A. Fistulotomy or fistulectomy and primary sphincteroplasty for anal fistula (FIPS): a systematic review. Tech Coloproctol. 2015;19(7):391–400. https://doi.org/10.1007/s10151-015-1323-4.

    Article  CAS  PubMed  Google Scholar 

  136. Litta F, Parello A, De Simone V, Grossi U, Orefice R, Ratto C. Fistulotomy and primary sphincteroplasty for anal fistula: long-term data on continence and patient satisfaction. Tech Coloproctol. 2019;23(10):993–1001. https://doi.org/10.1007/s10151-019-02093-9.

    Article  CAS  PubMed  Google Scholar 

  137. Ratto C, Litta F, Parello A, Zaccone G, Donisi L, De Simone V. Fistulotomy with end-to-end primary sphincteroplasty for anal fistula: results from a prospective study. Dis Colon Rectum. 2013;56(2):226–33. https://doi.org/10.1097/DCR.0b013e31827aab72.

    Article  PubMed  Google Scholar 

  138. Farag AFA, Elbarmelgi MY, Mostafa M, Mashhour AN. One stage fistulectomy for high anal fistula with reconstruction of anal sphincter without fecal diversion. Asian J Surg. 2019;42(8):792–6. https://doi.org/10.1016/j.asjsur.2018.12.005.

    Article  PubMed  Google Scholar 

  139. Garcia-Olmo D, Herreros D, Pascual I, et al. Expanded adipose-derived stem cells for the treatment of complex perianal fistula: a phase II clinical trial. Dis Colon Rectum. 2009;52(1):79–86. https://doi.org/10.1007/DCR.0b013e3181973487.

    Article  PubMed  Google Scholar 

  140. Herreros MD, Garcia-Arranz M, Guadalajara H, De-La-Quintana P, Garcia-Olmo D, FATT Collaborative Group. Autologous expanded adipose-derived stem cells for the treatment of complex cryptoglandular perianal fistulas: a phase III randomized clinical trial (FATT 1: fistula advanced therapy trial 1) and long-term evaluation. Dis Colon Rectum. 2012;55(7):762–72. https://doi.org/10.1097/DCR.0b013e318255364a.

    Article  CAS  PubMed  Google Scholar 

  141. Amor IB, Lainas P, Kassir R, Chenaitia H, Dagher I, Gugenheim J. Treatment of complex recurrent fistula-in-ano by surgery combined to autologous bone marrow-derived mesenchymal stroma cells and platelet-rich plasma injection. Int J Colorectal Dis. 2019;34(10):1795–9. https://doi.org/10.1007/s00384-019-03367-2.

    Article  PubMed  Google Scholar 

  142. de la Portilla F, Muñoz-Cruzado MVD, Maestre MV, et al. Platelet-rich plasma (PRP) versus fibrin glue in cryptogenic fistula-in-ano: a phase III single-center, randomized, double-blind trial. Int J Colorectal Dis. 2019;34(6):1113–9. https://doi.org/10.1007/s00384-019-03290-6.

    Article  PubMed  Google Scholar 

  143. Dozois EJ, Lightner AL, Mathis KL, et al. Early results of a phase I trial using an adipose-derived mesenchymal stem cell-coated fistula plug for the treatment of transsphincteric cryptoglandular fistulas. Dis Colon Rectum. 2019;62(5):615–22. https://doi.org/10.1097/DCR.0000000000001333.

    Article  PubMed  Google Scholar 

  144. Prosst RL, Ehni W. The OTSC® proctology clip system for anorectal fistula closure: the “anal fistula claw”: case report. Minim Invasive Ther Allied Technol. 2012;21(4):307–12. https://doi.org/10.3109/13645706.2012.692690.

    Article  PubMed  Google Scholar 

  145. Prosst RL, Joos AK, Ehni W, Bussen D, Herold A. Prospective pilot study of anorectal fistula closure with the OTSC proctology. Colorectal Dis. 2015;17(1):81–6. https://doi.org/10.1111/codi.12762.

    Article  CAS  PubMed  Google Scholar 

  146. Prosst RL, Joos AK. Short-term outcomes of a novel endoscopic clipping device for closure of the internal opening in 100 anorectal fistulas. Tech Coloproctol. 2016;20(11):753–8. https://doi.org/10.1007/s10151-016-1537-0.

    Article  CAS  PubMed  Google Scholar 

  147. Mascagni D, Pironi D, Grimaldi G, et al. OTSC® Proctology vs. fistulectomy and primary sphincter reconstruction as a treatment for low trans-sphincteric anal fistula in a randomized controlled pilot trial. Minerva Chir. 2019;74(1):1–6. https://doi.org/10.23736/S0026-4733.18.07617-4.

    Article  PubMed  Google Scholar 

  148. Marinello F, Kraft M, Ridaura N, Vallribera F, Espín E. Treatment of fistula-in-ano with OTSC® proctology clip device: short-term results. Cir Esp. 2018;96(6):369–74. https://doi.org/10.1016/j.ciresp.2018.02.003.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2022 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Johnson, E.K., Bernier, G. (2022). Cryptoglandular Abscess and Fistula. In: Steele, S.R., Hull, T.L., Hyman, N., Maykel, J.A., Read, T.E., Whitlow, C.B. (eds) The ASCRS Textbook of Colon and Rectal Surgery. Springer, Cham. https://doi.org/10.1007/978-3-030-66049-9_13

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-66049-9_13

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-66048-2

  • Online ISBN: 978-3-030-66049-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics