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Multidisciplinary Treatment: Influence on Outcomes

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Multidisciplinary Treatment of Colorectal Cancer

Abstract

Background. Colorectal cancer is the most common cancer in the western world. Although different treatment modalities are available, many patients suffer from poor functional outcomes, recurrent disease and/or death.

Methods. In 1993, the first national educational programme was launched in Norway in order to improve standards of treatment for rectal cancer and, thus, the prognosis of this disease. Several multidisciplinary workshops were arranged. Simultaneously, a national rectal cancer registry was established. In 1995, a similar programme started in Sweden; later several countries have followed. The aim of this chapter is to describe how these projects were developed, how they were run, what were the problems and what were the results and the consequences.

Results. A few years after starting the projects, the prognosis of rectal cancer improved at national levels. There was a considerable variation of results between hospitals. Patients treated by health-care professionals having attended multidisciplinary workshops had better prognosis than other patients. Multidisciplinary teams have been developed in order to secure workup, decision-making and treatment. During the last years, colon cancer has been included into the same projects. The treatment of colorectal cancer has been increasingly multimodal and tailored according to stage of the disease and the status of the patient.

Conclusions. The lesson to learn is that colorectal cancer treatment is no more a matter of a single surgeon working alone in a small hospital. Modern colorectal cancer treatment is advanced medicine that has to be performed by multidisciplinary teams (MDTs). Multimodal-tailored treatment has been developed and should be offered to every patient with colorectal cancer. Standards of care can only be evaluated within national audits. Quality assurance of cancer care should be mandatory.

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References

  1. McCall JL, Cox MR, Wattchow DA. Analysis of local recurrence rates after surgery alone for rectal cancer. Int J Color Dis. 1995;10:126–32.

    Article  CAS  Google Scholar 

  2. Abulafi AM, Williams NS. Local recurrence of colorectal cancer: the problem, mechanisms, management and adjuvant therapy. Br J Surg. 1994;81:7–19.

    Article  CAS  PubMed  Google Scholar 

  3. Cohen AM, Winawer SJ, Friedman MA, Gunderson LL, editors. Cancer of the colon, rectum and anus. New York: McGraw-Hill; 1995.

    Google Scholar 

  4. [No authors listed]. Adjuvant therapy for patients with colon and rectal cancer. JAMA. 1990;264:1444–50.

    Google Scholar 

  5. Heald RJ, Husband EM, Ryall RDH. The mesorectum in rectal cancer surgery-the clue to pelvic recurrence? Br J Surg. 1982;69:613–6.

    Article  CAS  PubMed  Google Scholar 

  6. Heald RJ, Ryall RDH. Recurrence and survival after total mesorectal excision for rectal cancer. Lancet. 1986;327:1479–82.

    Article  Google Scholar 

  7. Wibe A, Møller B, Norstein J, Carlsen E, Wiig JN, Heald RJ, Langmark F, Myrvold HE, Søreide O, Norwegian Rectal Cancer Group. A national strategic change in treatment policy for rectal cancer—implementation of total mesorectal excision (TME) as routine treatment in Norway. A national audit. Dis Colon Rectum. 2002;45:857–66.

    Article  PubMed  Google Scholar 

  8. Isbister WH. Basingstoke revisited. Aust N Z J Surg. 1990;60:243–6.

    Article  CAS  PubMed  Google Scholar 

  9. McCall JL, Wattchow DA. Failure after curative surgery alone. In: Søreide O, Norstein J, editors. Rectal cancer surgery: optimisation, standardisation, documentation. Berlin: Springer; 1997. p. 29–45.

    Chapter  Google Scholar 

  10. Dahl O, Horn A, Morild I, Halvorsen JF, Odland G, Reinertsen S, Reisaeter A, Kavli H, Thunold J. Low-dose preoperative radiation postpones recurrences in operable rectal cancer. Results of a randomized multicenter trial in western Norway. Cancer. 1990;66:2286–94.

    Article  CAS  PubMed  Google Scholar 

  11. Rein KA, Wiig JN, Sæther OD, Myrvold HE. Local recurrence in patients with rectal cancer. Tidsskr Nor Laegeforen. 1987;107:2318–20. In Norwegian.

    CAS  PubMed  Google Scholar 

  12. Norstein J, Langmark F. Results of rectal cancer treatment: a national experience. In: Søreide O, Norstein J, editors. Rectal cancer surgery: optimisation, standardisation, documentation. Berlin: Springer; 1997. p. 17–28.

    Chapter  Google Scholar 

  13. Bjerkeset T, Edna TH. Rectal cancer: the influence of type of operation on local recurrence and survival. Eur J Surg. 1996;162:643–8.

    CAS  PubMed  Google Scholar 

  14. Quirke P, Dixon MF, Durdey P, Williams NS. Local recurrence of rectal adenocarcinoma due to inadequate surgical resection. Histopathological Study of Lateral Tumour Spread and Surgical Excision. Lancet. 1986;2:996–9.

    Article  CAS  PubMed  Google Scholar 

  15. Wibe A. Rectal cancer treatment in Norway. Standardisation of surgery and quality assurance. Publication from the Norwegian University of Science and Technology (NTNU) 2003. ISSN no. 1503 3465. Thesis no. 234.

    Google Scholar 

  16. Wibe A, Carlsen E, Dahl O, Tveit KM, Weedon-Fekjaer H, Hestvik UE, Wiig JN, Norwegian Rectal Cancer Group. Nationwide quality assurance of rectal cancer treatment. Color Dis. 2006;8(3):224–9.

    Article  CAS  Google Scholar 

  17. Wibe A, Eriksen MT, Syse A, Myrvold HE, Søreide O, Norwegian Rectal Cancer Group. Total mesorectal excision for rectal cancer—what can be achieved by a national audit? Color Dis. 2003;5(5):471–7.

    Article  CAS  Google Scholar 

  18. Wibe A, Eriksen MT, Syse A, Tretli S, Myrvold HE, Søreide O, Norwegian Rectal Cancer Group. Effect of hospital caseload on long-term outcome after standardization of rectal cancer surgery at a national level. Br J Surg. 2005;92(2):217–24.

    Article  CAS  PubMed  Google Scholar 

  19. National guidelines for work-up, treatment and follow-up of colorectal cancer. www.helsedirektoratet.no/kreft/publikasjoner (in Norwegian).

  20. Moen A-C, Hansen PEH, Ott M. Rectal cancer surgery in Haugesund. Norwegian Association of Surgeons 2008, abstract no. 116. (In Norwegian).

    Google Scholar 

  21. Holm T, Rutqvist LE, Johansson H, Cedermark B. Abdominoperineal resection and anterior resection in the treatment of rectal cancer: results in relation to adjuvant preoperative radiotherapy. Br J Surg. 1995;82:1213–6.

    Article  CAS  PubMed  Google Scholar 

  22. [No authors listed]. Improved survival with preoperative radiotherapy in resectable rectal cancer. Swedish Rectal Cancer Trial. N Engl J Med. 1997;336:980–7.

    Google Scholar 

  23. Colorectal Cancer Collaborative Group. Adjuvant radiotherapy for rectal cancer: a systematic overview of 8,507 patients from 22 randomised trials. Lancet. 2001;358:1291–304.

    Article  Google Scholar 

  24. Folkesson J, Engholm G, Ehrnrooth E, Kejs AM, Påhlman L, Harling H, Wibe A, Gaard M, Thornorvaldur J, Tryggvadottir L, Brewster DH, Hakulinen T, Storm HH. Rectal cancer survival in the Nordic countries and Scotland. Int J Cancer. 2009;125(10):2406–12.

    Article  CAS  PubMed  Google Scholar 

  25. Bülow S, Harling H, Iversen LH, Ladelund S, Danish Colorectal Cancer Group. Improved survival after rectal cancer in Denmark. Color Dis. 2010;12(7 Online):e37–42. https://doi.org/10.1111/j.1463-1318.2009.02012. Epub 2009 Jul 15.

  26. Penninckx F, Van Eycken L, Michiels G, Mertens R, Bertrand C, De Coninck D, Haustermans K, Jouret A, Kartheuser A, Tinton N, PROCARE Working Group. Survival of rectal cancer patients in Belgium 1997-98 and the potential benefit of a national project. Acta Chir Belg. 2006;106(2):149–57.

    Article  CAS  PubMed  Google Scholar 

  27. Ortiz H. Total mesorectal excision: a teaching and audited initiative of the Spanish Association of Surgeons. Cir Esp. 2007;82(4):193–4. (In Spanish).

    Article  PubMed  Google Scholar 

  28. Mroczkowski P, Kube R, Schmidt U, Gastinger I, Lippert H. Quality assessment of colorectal cancer care—an international online model. Color Dis. 2011;13(8):890–5.

    Google Scholar 

  29. van Gijn W, Wouters MW, Peeters KC, van de Velde CJ. Nationwide outcome registrations to improve quality of care in rectal surgery. An initiative of the European Society of Surgical Oncology. J Surg Oncol. 2009;99(8):491–6.

    Article  PubMed  Google Scholar 

  30. Tilney H, Lovegrove RE, Smith JJ, Thompson MR, Tekkis PP, Association of Coloproctology of Great Britain and Ireland. The National Bowel Cancer Project: social deprivation is an independent predictor of nonrestorative rectal cancer surgery. Dis Colon Rectum. 2009;52(6):1046–53.

    Article  PubMed  Google Scholar 

  31. Peeters KC, Marijnen CA, Nagtegaal ID, Kranenbarg EK, Putter H, Wiggers T, Rutten H, Pahlman L, Glimelius B, Leer JW, van de Velde CJ, Dutch Colorectal Cancer Group. The TME trial after a median follow-up of 6 years: increased local control but no survival benefit in irradiated patients with resectable rectal carcinoma. Ann Surg. 2007;246(5):693–701.

    Article  PubMed  Google Scholar 

  32. Porter GA, Soskolne CL, Yakimetz WW, Newman SC. Surgeon-related factors and outcome in rectal cancer. Ann Surg. 1998;227(2):157–67.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Penninckx F. Surgeon-related aspects of the treatment and outcome after radical resection for rectal cancer. Acta Gastroenterol Belg. 2001;64:258–62.

    CAS  PubMed  Google Scholar 

  34. Daniels IR, Fisher SE, Heald RJ, Moran BJ. Accurate staging, selective preoperative therapy and optimal surgery improves outcome in rectal cancer: a review of the recent evidence. Color Dis. 2007;9:290–301.

    Article  CAS  Google Scholar 

  35. Martling A, Cedermark B, Johansson H, Rutqvist LE, Holm T. The surgeon as a prognostic factor after the introduction of total mesorectal excision in the treatment of rectal cancer. Br J Surg. 2002;89(8):1008–13.

    Article  CAS  PubMed  Google Scholar 

  36. Harling H, Bülow S, Kronborg O, et al. Survival of rectal cancer patients in Denmark during 1994-99. Color Dis. 2004;6(3):153–7.

    Article  CAS  Google Scholar 

  37. Kapiteijn E, Putter H, van de Velde CJ, Cooperative Investigators of the Dutch ColoRectal Cancer Group. Impact of the introduction of training of total mesorectal excision on recurrence and survival in rectal cancer patients in The Netherlands. Br J Surg. 2002;89(9):1142–9.

    Article  CAS  PubMed  Google Scholar 

  38. Sharma A, Sharp DM, Walker LG, Monson JR. Colorectal MDTs: the team’s perspective. Color Dis. 2007;10(1):63–8.

    Google Scholar 

  39. Wood JJ, Metcalfe C, Paes A, et al. An evaluation of treatment decisions at a colorectal cancer multi-disciplinary team. Color Dis. 2008;10(8):769–72.

    Article  CAS  Google Scholar 

  40. MacDermid E, Hooton G, MacDonald M, McKay G, Grose D, Mohammed N, Porteous C. Improving patient survival with the colorectal cancer multi-disciplinary team. Color Dis. 2009;11(3):291–5.

    Article  CAS  Google Scholar 

  41. Segelman J, Singnomklao T, Hellborg H, et al. Differences in multidisciplinary team assessment and treatment between patients with stage IV colon and rectal cancer. Color Dis. 2009;11(7):768–74.

    Article  CAS  Google Scholar 

  42. Lordan JT, Karanjia ND, Quiney N, et al. A 10-year study on outcome following hepatic resection for colorectal liver metastases—the effect of evaluation in a multidisciplinary team setting. Eur J Surg Oncol. 2009;35(3):302–6.

    Article  CAS  PubMed  Google Scholar 

  43. Burton S, Brown G, Daniels IR, et al. MRI directed multidisciplinary team preoperative treatment strategy: the way to eliminate positive circumferential margins? Br J Cancer. 2006;94(3):351–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Hsu YH, Kung PT, Wang ST, Fang CY, Tsai WC. Improved patient survivals with colorectal cancer under multidisciplinary team care: a nationwide cohort study of 25,766 patients in Taiwan. Health Policy. 2016;120(6):674–81. https://doi.org/10.1016/j.healthpol.2016.04.001. Epub 2016 Apr 23.

    Article  PubMed  Google Scholar 

  45. Munro A, Brown M, Niblock P, Steele R, Carey F. Do Multidisciplinary Team (MDT) processes influence survival in patients with colorectal cancer? A population-based experience. BMC Cancer. 2015;15:686. https://doi.org/10.1186/s12885-015-1683-1.

    Article  PubMed  PubMed Central  Google Scholar 

  46. Cancer in Norway 2008. www.kreftregisteret.no. (In Norwegian).

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Wibe, A. (2021). Multidisciplinary Treatment: Influence on Outcomes. In: Baatrup, G. (eds) Multidisciplinary Treatment of Colorectal Cancer. Springer, Cham. https://doi.org/10.1007/978-3-030-58846-5_2

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  • DOI: https://doi.org/10.1007/978-3-030-58846-5_2

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