Changes in Prefrontal Cortex and Skeletal Muscle Metabolism Associated with Muscle Fatigue: An FNIRS Study
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One of the effective interventions to improve paralysis hand following stroke attack is repetitive exercise. This is a pilot study to confirm changes in brain response when performing the repetitive exercise to the fatigue limit. In this study, a participant flexed and extended his left elbow repeatedly at the 0.5 Hz with a 6.0 kg dumbbell as long as he can continue till the fatigued point. During the exercise, the left biceps and the right prefrontal cortex (rPFC) were recorded and measured simultaneously using functional near-infrared spectroscopy (fNIRS). The corresponding changes in metabolic responses were observed for oxy-hemoglobin (HbO) and deoxy-hemoglobin (HbR) in the biceps, the results shows an increase in HbR and a decrease in HbO due to the task and HbR increases more with muscle fatigue. The recordings in the rPFC show an increase in HbO and a decrease in HbR in the early stages, but HbR increased around the area as the exercise reaches fatigue point (failure to continue). The HbR increase is caused by an increased in neural activity and oxygen supply in the fatigued area. Therefore, this finding also suggests that the rPFC activation is enhanced when exercise load increases.
KeywordsRepetitive arm exercise Biceps Muscle fatigue Prefrontal cortex (PFC) PFC activation Functional near-infrared spectroscopy (fNIRS)
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