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Brain Metastasis: The Experience of the Burdenko Institute of Neurosurgery

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CyberKnife NeuroRadiosurgery

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Abstract

Brain metastases (BMs) are a heterogeneous group of intracranial neoplasms that differ in origin, histological structure, clinical course, and treatment outcomes and resulting from hematogenous spreading of extracranial malignant tumors.

The goal of radiation treatment for patients with BM is to provide local control of metastatic lesions in order to reduce the risk of death from intracranial progression, preserve the quality of life, and improve overall survival in certain clinical situations.

This chapter will focus on techniques that are implemented using the CyberKnife LINAC for patients with brain metastasis at the Burdenko Institute of Neurosurgery (since 2018—National Medical Research Center of Neurosurgery named after academician N. N. Burdenko (NMRC Burdenko)) as this techniques are the subject of different studies, performed in this institution.

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References

  1. Baschnagel AM, Meyer KD, Chen PY, Krauss DJ, Olson RE, Pieper DR, et al. Tumor volume as a predictor of survival and local control in patients with brain metastases treated with gamma knife surgery. J Neurosurg. 2013;119:1139–44. https://doi.org/10.3171/2013.7.JNS13431.

    Article  PubMed  Google Scholar 

  2. Sheehan JP, Sun M-H, Kondziolka D, Flickinger J, Lunsford LD. Radiosurgery for non-small cell lung carcinoma metastatic to the brain: long-term outcomes and prognostic factors influencing patient survival time and local tumor control. J Neurosurg. 2002;97:1276–81. https://doi.org/10.3171/jns.2002.97.6.1276.

    Article  PubMed  Google Scholar 

  3. Golanov AV, Banov SM, Il’yalov SR, Trunin YY, Maryashev SA, Vetlova ER, et al. Overall survival and intracranial relapse in patients with brain metastases after gamma knife radiosurgery alone. Voprosy Neirokhirurgii Buedenko. 2016;80:35–46. https://doi.org/10.17116/neiro201680235-46.

    Article  CAS  Google Scholar 

  4. Shaw E, Scott C, Souhami L, Dinapoli R, Kline R, Loeffler J, Farnan N. Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases: final report of RTOG protocol 90-05. Int J Radiat Oncol Biol Phys. 2000;47:291–8. https://doi.org/10.1016/S0360-3016(99)00507-6.

    Article  CAS  PubMed  Google Scholar 

  5. Elliott RE, Rush SC, Morsi A, Mehta N, Spriet J, Narayana A, et al. Local control of newly diagnosed and distally recurrent, low-volume brain metastases with fixed-dose (20 gy) gamma knife radiosurgery. Neurosurgery. 2011;68:921–31;. ; discussion 931. https://doi.org/10.1227/NEU.0b013e318208f58e.

    Article  PubMed  Google Scholar 

  6. Schoeggl A, Kitz K, Ertl A, Reddy M, Bavinzski G, Schneider B. Prognostic factor analysis for multiple brain metastases after gamma knife radiosurgery: results in 97 patients. J Neurooncol. 1999;42:169–75. https://doi.org/10.1023/A:1006110631704.

    Article  CAS  PubMed  Google Scholar 

  7. Wiggenraad R, Verbeek-de Kanter A, Kal HB, Taphoorn M, Vissers T, Struikmans H. Dose-effect relation in stereotactic radiotherapy for brain metastases. A systematic review. Radiother Oncol. 2011;98:292–7. https://doi.org/10.1016/j.radonc.2011.01.011.

    Article  PubMed  Google Scholar 

  8. Vogelbaum MA, Angelov L, Lee S-Y, Li L, Barnett GH, Suh JH. Local control of brain metastases by stereotactic radiosurgery in relation to dose to the tumor margin. J Neurosurg. 2006;104:907–12. https://doi.org/10.3171/jns.2006.104.6.907.

    Article  PubMed  Google Scholar 

  9. Kirkpatrick JP, Wang Z, Sampson J, Kelsey C, Allen K, Duffy E, et al. Early results of a randomized trial to identify an optimal PTV in stereotactic radiosurgery of brain metastases. Int J Radiat Oncol Biol Phys. 2013;87:S50. https://doi.org/10.1016/j.ijrobp.2013.06.131.

    Article  Google Scholar 

  10. Choi CYH, Chang SD, Gibbs IC, Adler JR, Harsh GR, Lieberson RE, Soltys SG. Stereotactic radiosurgery of the postoperative resection cavity for brain metastases: prospective evaluation of target margin on tumor control. Int J Radiat Oncol Biol Phys. 2012;84:336–42. https://doi.org/10.1016/j.ijrobp.2011.12.009.

    Article  PubMed  Google Scholar 

  11. Vetlova ER, Golbin AD, Golanov AV, Potapov AA, Banov SM, Antipina NA, et al. Preoperative stereotactic radiosurgery of brain metastases: preliminary results. Cureus. 2017;9:e1987.

    PubMed  PubMed Central  Google Scholar 

  12. Minniti G, D’Angelillo RM, Scaringi C, Trodella LE, Clarke E, Matteucci P, et al. Fractionated stereotactic radiosurgery for patients with brain metastases. J Neurooncol. 2014;117:295–301. https://doi.org/10.1007/s11060-014-1388-3.

    Article  CAS  PubMed  Google Scholar 

  13. Joshi R, Johnson MD, Maitz A, Marvin KS, Olson RE, Grills IS. Utility of graded prognostic assessment in evaluation of patients with brainstem metastases treated with radiosurgery. Clin Neurol Neurosurg. 2016;147:30–3. https://doi.org/10.1016/j.clineuro.2016.05.001.

    Article  PubMed  Google Scholar 

  14. Angelov L, Mohammadi AM, Bennett EE, Abbassy M, Elson P, Chao ST, et al. Impact of 2-staged stereotactic radiosurgery for treatment of brain metastases ≥ 2 cm. J Neurosurg. 2018;129:366–82. https://doi.org/10.3171/2017.3.JNS162532.

    Article  PubMed  Google Scholar 

  15. Murai T, Ogino H, Manabe Y, Iwabuchi M, Okumura T, Matsushita Y, et al. Fractionated stereotactic radiotherapy using CyberKnife for the treatment of large brain metastases: a dose escalation study. Clin Oncol (R Coll Radiol). 2014;26:151–8. https://doi.org/10.1016/j.clon.2013.11.027.

    Article  CAS  Google Scholar 

  16. Jiang X-S, Xiao J-P, Zhang Y, Xu Y-J, Li X-P, Chen X-J, et al. Hypofractionated stereotactic radiotherapy for brain metastases larger than three centimeters. Radiat Oncol. 2012;7:36. https://doi.org/10.1186/1748-717X-7-36.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Kim KH, Kong D-S, Cho KR, Lee MH, Choi J-W, Seol HJ, et al. Outcome evaluation of patients treated with fractionated gamma knife radiosurgery for large (3 cm) brain metastases: a dose-escalation study. J Neurosurg. 2019:1–10. https://doi.org/10.3171/2019.5.JNS19222.

  18. Inoue HK, Sato H, Suzuki Y, Saitoh J-I, Noda S-E, Seto K-I, et al. Optimal hypofractionated conformal radiotherapy for large brain metastases in patients with high risk factors: a single-institutional prospective study. Radiat Oncol. 2014;9:231. https://doi.org/10.1186/s13014-014-0231-5.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Demirci H, Shields CL, Chao A-N, Shields JA. Uveal metastasis from breast cancer in 264 patients. Am J Ophthalmol. 2003;136:264–71. https://doi.org/10.1016/S0002-9394(03)00192-2.

    Article  PubMed  Google Scholar 

  20. Ferry AP, Font RL. Carcinoma metastatic to the eye and orbit. I. A clinicopathologic study of 227 cases. Arch Ophthalmol. 1974;92:276–86. https://doi.org/10.1001/archopht.1974.01010010286003.

    Article  CAS  PubMed  Google Scholar 

  21. Mewis L, Young SE. Breast carcinoma metastatic to the choroid. Ophthalmology. 1982;89:147–51. https://doi.org/10.1016/S0161-6420(82)34838-1.

    Article  CAS  PubMed  Google Scholar 

  22. Shields CL, Shields JA, Gross NE, Schwartz GP, Lally SE. Survey of 520 eyes with uveal metastases. Ophthalmology. 1997;104:1265–76. https://doi.org/10.1016/S0161-6420(97)30148-1.

    Article  CAS  PubMed  Google Scholar 

  23. Shah SU, Mashayekhi A, Shields CL, Walia HS, Hubbard GB, Zhang J, Shields JA. Uveal metastasis from lung cancer: clinical features, treatment, and outcome in 194 patients. Ophthalmology. 2014;121:352–7. https://doi.org/10.1016/j.ophtha.2013.07.014.

    Article  PubMed  Google Scholar 

  24. de Potter P, Shields CL, Shields JA, Tardio DJ. Uveal metastasis from prostate carcinoma. Cancer. 1993;71:2791–6. https://doi.org/10.1002/1097-0142(19930501)71:9<2791::AID-CNCR2820710917>3.0.CO;2-Y.

    Article  PubMed  Google Scholar 

  25. Dieckert JP, Berger BB. Prostatic carcinoma metastatic to choroid. Br J Ophthalmol. 1982;66:234–9. https://doi.org/10.1136/bjo.66.4.234.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Mathis T, Jardel P, Loria O, Delaunay B, Nguyen A-M, Lanza F, et al. New concepts in the diagnosis and management of choroidal metastases. Prog Retin Eye Res. 2019;68:144–76. https://doi.org/10.1016/j.preteyeres.2018.09.003.

    Article  PubMed  Google Scholar 

  27. Bellmann C, Fuss M, Holz FG, Debus J, Rohrschneider K, Völcker HE, Wannenmacher M. Stereotactic radiation therapy for malignant choroidal tumors. Ophthalmology. 2000;107:358–65. https://doi.org/10.1016/S0161-6420(99)00081-0.

    Article  CAS  PubMed  Google Scholar 

  28. Cho KR, Lee KM, Han G, Kang SW, Lee J-I. Gamma knife radiosurgery for cancer metastasized to the ocular choroid. J Korean Neurosurg Soc. 2018;61:60–5. https://doi.org/10.3340/jkns.2016.0606.003.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. National Medical Research Center of Neurosurgery named after Burdenko, Moscow, Russia

    Elena R. Vetlova, Andrey V. Golanov, Sergey M. Banov, Natalia A. Antipina, Amayak A. Durgaryan, Elena N. Igoshina, Mikhail V. Galkin & Elena I. Butenko

  2. Moscow Gamma Knife Center, Moscow, Russia

    Andrey V. Golanov & Sergey M. Banov

Authors
  1. Elena R. Vetlova
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  2. Andrey V. Golanov
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  3. Sergey M. Banov
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  4. Natalia A. Antipina
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  5. Amayak A. Durgaryan
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  6. Elena N. Igoshina
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  7. Mikhail V. Galkin
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  8. Elena I. Butenko
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Corresponding author

Correspondence to Andrey V. Golanov .

Editor information

Editors and Affiliations

  1. Associate Professor of Neurosurgery, Alma Mater Studiorum University of Bologna, Bologna, Italy

    Alfredo Conti

  2. Scientific Director, AB Medica, Milano, Italy

    Pantaleo Romanelli

  3. Assistant Professor, Medical Physics Laboratory, Medical School, National and Kapodistrian University of Athens, Athens, Greece

    Evangelos Pantelis

  4. Associate Professor, Department of Radiation Oncology, Stanford University Cancer Center, Stanford, CA, USA

    Scott G. Soltys

  5. Associate Professor, Department of Neurosurgery and Radiosurgery Center, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, Korea (Republic of)

    Young Hyun Cho

  6. Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Michael Lim

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Vetlova, E.R. et al. (2020). Brain Metastasis: The Experience of the Burdenko Institute of Neurosurgery. In: Conti, A., Romanelli, P., Pantelis, E., Soltys, S., Cho, Y., Lim, M. (eds) CyberKnife NeuroRadiosurgery . Springer, Cham. https://doi.org/10.1007/978-3-030-50668-1_15

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