Abstract
The pancreas is located deeply in the retroperitoneum, in close association with several vital structures, which complicates access to the organ for diagnostic and therapeutic procedures. Equally complex is the histology of the pancreas, which is characterized by the unusual combination of exocrine and endocrine tissue within the same organ. This chapter focuses on the description of anatomical, histological, and embryological features that are of diagnostic relevance for lesions and diseases of both the exocrine and endocrine pancreas. Where appropriate, reference will be made to the various book chapters in which a particular anatomical or histological feature is part of diagnostic considerations.
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References
Vikram R, Balachandran A, Bhosale PR, Tamm EP, Marcal LP, Chamsangavej C. Pancreas: peritoneal reflections, ligamentous connections, and pathways of disease spread. Radiographics. 2009;29:e34.
Horiguchi S-I, Kamisawa T. Major duodenal papilla and its normal anatomy. Dig Surg. 2010;27:90–3.
Strobel O, Rosow DE, Rakhlin EY, Lauwers GY, Trainor AG, Alsina J, Fernandez-Del Castillo C, Warschaw AL, Thayer SP. Pancreatic duct glands are distinct ductal compartments that react to chronic injury and mediate Shh-induced metaplasia. Gastroenterology. 2010;138:1166–77.
Sakata N, Yoshimatsu G, Kodama S. Development and characteristics of pancreatic epsilon cells. Int J Mol Sci. 2019;20:1867.
Verbeke C, Löhr M, Severin Karlsson J, Del Chiaro M. Pathology reporting of pancreatic cancer following neoadjuvant therapy: Challenges and uncertainties. Cancer Treat Rev. 2015;41:17–26.
Suda K. Histopathology of the minor duodenal papilla. Dig Surg. 2010;27:137–9.
Further Reading
Pan FC, Wright C. Pancreas organogenesis: from bud to plexus to gland. Dev Dyn. 2011;240:530–65.
Reichert M, Rustgi AK. Pancreatic ductal cells in development, regeneration, and neoplasia. J Clin Invest. 2011;121:4572–8.
Klimstra DS, Hruban RH, Pitman MB. Pancreas. In: Mills SE, editor. Histology for pathologists, 3rd edn, Chapt 30. Philadelphia: Lippincott Williams & Wilkins; 2007. p. 723–56.
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Campbell, F., Verbeke, C.S. (2021). Embryology, Anatomy, and Histology. In: Pathology of the Pancreas. Springer, Cham. https://doi.org/10.1007/978-3-030-49848-1_1
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DOI: https://doi.org/10.1007/978-3-030-49848-1_1
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