Abstract
Endometrial hyperplasia and endometrial carcinoma are rare in young women, but the incidence is continually increasing in developed countries due to obesity and metabolic diseases. Pregnancies can occur after the diagnosis of endometrial hyperplasia after progestin treatment and careful regular re-evaluation. The risk of progression to endometrial carcinoma is especially high in atypical endometrial hyperplasia. Fertility preservation treatment can be offered to women with endometrial cancer stage I (FIGO IA), well-differentiated tumours and expression of progesterone receptors. Assisted reproductive technologies (ART) are indicated to shorten the time to pregnancy. Genetic counselling for young women with endometrial cancer is recommended to rule out syndromes of hereditary cancer predisposition such as Lynch syndrome.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
GGPO German Guideline program in oncology. Guideline on the diagnosis, treatment, and follow-up of patients with endometrial carcinoma, short version 1.0 2018, AWMF-register no. 032/034-OL.
Gerstl B, Sullivan E, Vallejo M, Koch J, Johnson M, Wand H, et al. Reproductive outcome following treatment for a gynecological cancer diagnosis: a systematic review. J Cancer Surviv. 2019;13:269–81. https://doi.org/10.1007/s11764-019-00749-x.
S2k-Leitlinie. Fertilitätserhalt bei onkologischen Erkrankungen, Langversion V 1.0 2017, AWMF-Registernummer 015/082.
Simpson AN, Feigenberg T, Clarke BA, Gien LT, Ismiil N, Laframboise S, et al. Fertility sparing treatment of complex atypical hyperplasia and low grade endometrial cancer using oral progestin. Gynecol Oncol. 2014;133:229–33. https://doi.org/10.1016/j.ygyno.2014.02.020.
Zhang Q, Qi G, Kanis MJ, Dong R, Cui B, Yang X, et al. Comparison among fertility-sparing therapies for well differentiated early-stage endometrial carcinoma and complex atypical hyperplasie. Oncotarget. 2017;8:57642–53. https://doi.org/10.18632/oncotarget.17588.
Gonthier C, Piel B, Touboul C, Walker F, Cortez A, Luton D, et al. Cancer incidence in patients with atypical endometrial hyperplasia managed by primary hysterectomy of fertility-sparing treatment. Anticancer Res. 2015;35:6799–804.
De Marzi P, Bergamini A, Luchini S, Petrone M, Taccagni GL, Mangili G, et al. Hysteroscopic resection in fertility-sparing surgery for atypical hyperplasia and endometrial cancer: safety and efficacy. J Minim Invasive Gynecol. 2015;22:1178–82. https://doi.org/10.1016/j.jmig.2015.06.004.
Chen M, Jin Y, Li Y, Bi Y, Shan Y, Pan L. Oncologic and reproductive outcomes after fertility-sparing management with oral progestin for women with complex endometrial hyperplasia and endometrial cancer. Int J Gynaecol Obstet. 2016;132:34–8. https://doi.org/10.1016/j.ijgo.2015.06.046.
Pronin SM, Novikova OV, Andreeva JY, Novikova EG. Fertility-sparing treatment of early endometrial cancer and complex atypical hyperplasia in young women of childbearing potential. Int J Gynecol Cancer. 2015;25:1010–4. https://doi.org/10.1097/IGC.0000000000000467.
Zhou R, Yang Y, Lu Q, Wang J, Miao Y, Wang S, et al. Prognostic factors of oncological and reproductive outcomes in fertility-sparing treatment of complex atypical hyperplasia and low-grade endometrial cancer using oral progestin in Chinese patients. Gynecol Oncol. 2015;139:424–8. https://doi.org/10.1016/j.ygyno.2015.09.078.
Yang B, Xu Y, Zhu Q, Xie L, Shan W, Ning C, et al. Treatment efficiency of comprehensive hysteroscopic evaluation and lesion resection combined with progestin therapy in young women with endometrial atypical hyperplasia and endometrial cancer. Gynecol Oncol. 2019;153:55–62. https://doi.org/10.1016/j.ygyno.2019.01.014.
Gu H, Li J, Gu Y, Tu H, Zhou Y, Liu J. Survival impact of ovarian preservation on women with early-stage endometrial cancer: a systematic review and meta-analysis. Int J Gynecol Cancer. 2017;27:77–84. https://doi.org/10.1097/IGC.0000000000000857.
Dogan A, Schultheis B, Rezniczek GA, Hilal Z, Cetin C, Häusler G, et al. Synchronous endometrial and ovarian cancer in young women: case report and review of the literature. Anticancer Res. 2017;37:969–78.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Goeckenjan, M., von Wolff, M., Wimberger, P. (2020). Endometrial Hyperplasia and Endometrial Carcinoma. In: von Wolff, M., Nawroth, F. (eds) Fertility Preservation in Oncological and Non-Oncological Diseases. Springer, Cham. https://doi.org/10.1007/978-3-030-47568-0_11
Download citation
DOI: https://doi.org/10.1007/978-3-030-47568-0_11
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-47567-3
Online ISBN: 978-3-030-47568-0
eBook Packages: MedicineMedicine (R0)