Abstract
Exfoliative cytology is a rapid, relatively simple, and cost-effective procedure that can be used as an alternative to biopsy in certain situations. In exfoliative cytology, cells are harvested after their spontaneous release from body surfaces or obtained by use of brushing or scraping procedures. Brushes are used for obtaining cells from the urinary (urethra, urinary bladder, ureters, renal pelvis), respiratory (tracheobronchial tree), digestive (oral mucosa, esophagus, stomach, duodenum, colon), pancreatobiliary, and genital tracts. In this chapter, we briefly describe the cytomorphology and broadly cover the immunostainings applied to exfoliative cytology that can be used in the differential diagnosis of processes affecting these organs. Moreover, we summarize the cytology and immunocytochemistry of peritoneal washings.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Suggested Reading
Auger M, et al. A practical guide for ancillary studies in pulmonary cytologic specimens. Cancer Cytopathol. 2018;126(S8):599–614.
Botti G, et al. ProEx C as diagnostic marker for detection of urothelial carcinoma in urinary samples: a review. Int J Med Sci. 2017;14(6):554–9.
Chandra A, et al. The BSCC code of practice: exfoliative cytopathology (excluding gynecological cytopathology). Cytopathology. 2009;20:211–23.
Chawla N, et al. Role of urine cytology in bladder neoplasm: cytopathological correlation and review of literature. J Mar Med Soc. 2018;20:27–30.
Fowler LJ, Lachar WA. Application of immunohistochemistry to cytology. Arch Pathol Lab Med. 2008;132:373–83.
Idowu MO, Powers CN. Lung cancer cytology: potential pitfalls and mimics - a review. Int J Clin Exp Pathol. 2010;3(4):367–85.
Kim HJ, Yoo JH. Cytokeratin 20/p53 dual immunocytochemistry for improving the diagnostic accuracy of urine liquid-based cytology in the detection of urothelial neoplasm: a retrospective study. Cyto Journal. 2017;14:27.
Michael C. Exfoliative pulmonary cytology. In: Gattuso P, Reddy V, Masood S, editors. Differential diagnosis in cytopathology: Cambridge University Press; 2014. p. 40–86.
Norimatsu Y, et al. The role of liquid-based preparation in the evaluation of endometrial cytology. Acta Cytol. 2013;57:423–35.
Papanicolaou Society of Cytopathology Task Force on Standards of Practice. Guidelines of the papanicolaou society of cytopathology for the examination of cytologic specimens obtained from the respiratory tract. Diagn Cytopathol. 1999;21(1):61–9.
Powers CN. Diagnosis of infectious diseases: a cytopathologist’s perspective. Clin Microbiol Rev. 1998;11(2):341–65.
Sun H, et al. Progress in immunocytochemical staining for cervical cancer screening. Cancer Manag Res. 2019;11:1817–27.
Zakowski MF. Cytology nomenclature and 2015 World Health Organization classification of lung cancer. Cancer Cytopathol. 2016;124(2):81–8.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Leonardo, E., Bardales, R.H. (2020). Exfoliative Cytology. In: Practical Immunocytochemistry in Diagnostic Cytology. Springer, Cham. https://doi.org/10.1007/978-3-030-46656-5_3
Download citation
DOI: https://doi.org/10.1007/978-3-030-46656-5_3
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-46655-8
Online ISBN: 978-3-030-46656-5
eBook Packages: MedicineMedicine (R0)