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International Conference on Computational Advances in Bio and Medical Sciences

ICCABS 2019: Computational Advances in Bio and Medical Sciences pp 90–101Cite as

Effects of Various Alpha-1 Antitrypsin Supplement Dosages on the Lung Microbiome and Metabolome

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Part of the book series: Lecture Notes in Computer Science ((LNBI,volume 12029))

Abstract

Patients with Alpha-1 Antitrypsin Deficiency (A1AD) have abnormally low levels of the protein Alpha-1 Antitrypsin (AAT) in their blood, because of a double mutation that makes the protein misfold and instead collect in the liver (sometimes even causing cirrhosis). The currently accepted single dosage (SD) of AAT supplements does not produce AAT blood concentrations anywhere near normal levels; they typically only reach the effect of having a single mutation. Some have therefore advocated for a double dosage (DD) of these treatments, which generally would be enough to approach these normal concentrations. Levels of cytokines, produced by the immune system in response to an attack, have already been observed to drop dramatically when A1AD patients consuming single dosage started taking double dosage, and then either remain the same or increase again upon return to a single dosage regimen. In this study we administer the same dosage sequence to A1AD patients (SD, DD, SD) for one month each and view the effects on their lung microbiome and metabolome. We analyze both at the end of each stage, comparing and contrasting and discovering potential biomarkers for each stage, and concluding with a discussion of potential implications.

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Acknowledgment

GN and KM were supported by National Institute of Health (580 #1R15AI128714-01). GN was also supported by Department of Defense (581 #W911NF-16-1-0494) and the National Institute of Justice (582 #2017-NE-BX-0001). GN, KM and MC were supported by the Florida Department of Health (FDOH 09KW-10) and the Alpha-One Foundation. TC received support from NVIDIA and Florida International University. The authors also thank colleagues from the BioRG for many useful discussions.

Author information

Authors and Affiliations

  1. Bioinformatics Research Group (BioRG), Florida International University, Miami, FL, USA

    Trevor Cickovski & Giri Narasimhan

  2. Center for Precision Health, University of Texas Health Science Center, Houston, TX, USA

    Astrid Manuel

  3. Human and Molecular Genetics, Florida International University, Miami, FL, USA

    Kalai Mathee

  4. Miller School of Medicine, University of Miami, Miami, FL, USA

    Michael Campos

Authors
  1. Trevor Cickovski
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  2. Astrid Manuel
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  3. Kalai Mathee
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  4. Michael Campos
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  5. Giri Narasimhan
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Corresponding author

Correspondence to Trevor Cickovski .

Editor information

Editors and Affiliations

  1. University of Connecticut, Storrs, CT, USA

    Ion Măndoiu

  2. Virginia Tech, Blacksburg, VA, USA

    T. M. Murali

  3. Florida International University, Miami, FL, USA

    Giri Narasimhan

  4. University of Connecticut, Storrs, CT, USA

    Sanguthevar Rajasekaran

  5. Georgia State University, Atlanta, GA, USA

    Pavel Skums

  6. Georgia State University, Atlanta, GA, USA

    Alexander Zelikovsky

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Cickovski, T., Manuel, A., Mathee, K., Campos, M., Narasimhan, G. (2020). Effects of Various Alpha-1 Antitrypsin Supplement Dosages on the Lung Microbiome and Metabolome. In: Măndoiu, I., Murali, T., Narasimhan, G., Rajasekaran, S., Skums, P., Zelikovsky, A. (eds) Computational Advances in Bio and Medical Sciences. ICCABS 2019. Lecture Notes in Computer Science(), vol 12029. Springer, Cham. https://doi.org/10.1007/978-3-030-46165-2_8

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  • DOI: https://doi.org/10.1007/978-3-030-46165-2_8

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-46164-5

  • Online ISBN: 978-3-030-46165-2

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