Fabrication of Antibacterial Electrospun Chitosan-Polyethylene Oxide Nanocomposite Nanofibrous Mats

Abstract

Antimicrobial chitosan–polyethylene oxide (CS-PEO) nanofibrous mats were developed by electrospinning technique for wound dressing applications. A green method was used to achieve antibacterial mats loaded with 0.25 and 0.50 w/w% of bioactive silver nanoparticles (Ag NPs, ~70 nm diameter) reduced by Falcaria vulgaris herbal extract. All of the nanofibers had an average ~200 nm diameter. Interestingly, both of the CS-PEO mats containing 0.25 and 0.50% bioactive F. vulgaris-Ag NPs revealed 100% bactericidal activities against both S. aureus and E. coli bacteria. The improved properties of CS-PEO-0.50% F. vulgaris-Ag NPs relative to those of the CS-PEO 0.25% F. vulgaris-Ag NPs suggested that the former was superior for biomedical applications.