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Hypothermia Post-Cardiac Arrest

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Heart Rhythm Disorders

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Abstract

The lack of blood flow to the brain during a cardiac arrest can cause irreparable damage; consequently, after restoring normal rhythm and circulation, patients can end up with a beating heart in a brain-dead or a severely damaged body. Thus, preservation of the brain from hypoxic-ischemic encephalopathy has assumed paramount importance post-cardiac arrest. In this chapter, the author discusses the history of hypothermia for brain preservation since ancient times, the mechanisms of neuroprotection, temporal trends in therapeutic hypothermia use in the USA, and survival in non-shockable and inhospital cardiac arrest as well as outcome assessment.

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References

  1. Ewy GA. Cardiocerebral resuscitation the new cardiopulmonary resuscitation. Circulation. 2005;111:2134–42.

    Article  Google Scholar 

  2. Cyril P. Bryan, trans Ebers Papyrus. London: Geoffrey Bles; 1930. https://web.archive.org/web/20130921055114/http://oilib.uchicago.edu/books/bryan_the_papyrus_ebers_1930.pdf

    Google Scholar 

  3. Neuroprotective therapy for stroke and ischemic disease. In Lepchak PL, Zang JH, editors. Springer International Publishing Switzerland, 2017.

    Google Scholar 

  4. Varon J, Acosta P. Therapeutic hypothermia: past, present, and future. Chest. 2008;133(5):1267–74. [PubMed]

    Article  Google Scholar 

  5. Karnatovskaia LV, Wartenberg KE, Freeman WD. Therapeutic hypothermia for neuroprotection: history, mechanisms, risks, and clinical applications. Neurohospitalist. 2014;4(3):153–63. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056415/

    Article  Google Scholar 

  6. Forrester JM. The origins and fate of James Currie’s cold water treatment for fever. Med His. 2000;44:57.

    Article  CAS  Google Scholar 

  7. Dominique Jean Larrey (1766–1842) Memoirs of Military Surgery, and Campaigns of the French Armies. Baltimore, MD: Published by Joseph Cushing, 6, North Howard street, 1814.

    Google Scholar 

  8. Fay T. Early experiences with local and generalized refrigeration of the human brain. J Neurosurg. 1959;16:239–59.

    Article  CAS  Google Scholar 

  9. Bigelow WG, Mcbirnie JE. Further experiences with hypothermia for intracardiac surgery in monkeys and groundhogs. Ann Surg. 1953;137(3):361–5. [PubMed]

    Article  CAS  Google Scholar 

  10. Shumway NE, Lewis FJ. 1916–1993. Ann Thorac Surg. 1996;61:250–1orman.

    Google Scholar 

  11. Lewis FJ, Taufic M. Closure of atrial septal defects with the aid of hypothermia; experimental accomplishments and the report of one successful case. Surgery. 1953;33(1):52–59. [PubMed] [Google Scholar].

    Google Scholar 

  12. Rainey Williams G Jr, Spencer FC. The clinical use of hypothermia following cardiac arrest. Ann Surg. 1958;148(3):462–6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1450838/pdf/annsurg01227-0170.pdf

    Article  Google Scholar 

  13. Benson DW, Williams GR, Spencer FC, et al. The use of hypothermia after cardiac arrest. Anesth Analg. 1959;38:423–8.

    Article  CAS  Google Scholar 

  14. Rosomoff H.L. Safar P. Management of the comatose patient. In: Safar P., editor. Respiratory therapy F.A. Davis Co.; Philadelphia, pps: 1965. pp. 244–258.

    Google Scholar 

  15. Safar PJ, Kochanek PM. Therapeutic hypothermia after cardiac arrest. N Engl J Med. 2002;346:612–3.

    Article  Google Scholar 

  16. Kochanek PM, Drabeck T, Tishweman SA. Therapeutic hypothermia: the Safar vision. J Neurotrauma. 2009;26(3):417–20.

    Article  Google Scholar 

  17. Newsweek Staff: Back to Life: the Science of Reviving the Dead 7/22/07 AT 8:00 PM EDT.

    Google Scholar 

  18. Bushak L. Induced hypothermia: how freezing people after heart attacks could save lives. Newsweek, December 20, 2014. http://www.newsweek.com/2015/01/02/induced-hypothermia-how-freezing-people-after-heart-attacks-could-save-lives-293598.html.

  19. MacDonald F. This is how a Norwegian woman survived the lowest body temperature ever recorded. Science Alert, October 14, 2016, https://www.sciencealert.com/this-woman-survived-the-lowest-body-temperature-ever-recorded.

  20. The Hypothermia after Cardiac Arrest Study Group: Hypothermia after Cardiac Arrest Study Group. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med. 2002;346:549–56.

    Google Scholar 

  21. Bernard SA, Gray TW, Buist MD, et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med. 2002;346:557–63.

    Article  Google Scholar 

  22. Safar PJ, Kochanek PM. Therapeutic hypothermia after cardiac arrest. N Engl J Med. 2002;346:612–3.

    Article  Google Scholar 

  23. Nolan JP, Morley PT, Vanden Hock TL, Hickey RW. ILCOR Advisory Statement. Therapeutic Hypothermia After Cardiac Arrest. An Advisory Statement by the Advanced Life Support Task Force of the International Liaison Committee on Resuscitation. Circulation. 2003;108:118–21.

    Article  CAS  Google Scholar 

  24. Hazinski MF, Nadkarni VM, Hickey RW, et al. Major changes in the 2005 AHA guidelines for CPR and ECC. Reaching the tipping point for change. Circulation. 2005;112:IV-206–IV-211.

    Google Scholar 

  25. Callaway CW, Donnino MW, Fink EL, et al. Part 8: post-cardiac arrest care. 2015 American Heart Association guidelines update for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation. 2015;132(suppl 1):S465–82.

    Article  Google Scholar 

  26. Nielsen N, Wetterslev J, Cronberg T, et al. Targeted temperature management at 33°C versus 36°C after cardiac arrest. N Engl J Med. 2013;369:2197–206.

    Google Scholar 

  27. Sadaka F, Patel D, Lakshmanan R. The Four score predicts outcome in patients after traumatic brain injury. Neurocritical Care. 2012;16(1):95–101. [PubMed] [Google Scholar].

    Google Scholar 

  28. Jalali R, Rezaei M. A comparison of the Glasgow coma scale score with full outline of unresponsiveness scale to predict patients’ traumatic brain injury outcomes in intensive care units. Crit Care Res Pract. 2014; 2014: 289803. Published online 2014 Jun 10. https://doi.org/10.1155/2014/289803

  29. Yenari MA, Han HS. Neuroprotective mechanisms of hypothermia in brain ischaemia. Nat Rev Neurosci. 2012;13(4):267–78. [PubMed]

    Article  CAS  Google Scholar 

  30. Kuffler DP. Maximizing neuroprotection: where do we stand? Ther Clin Risk Manag. 2012;8:185–194 [PMC free article] [PubMed].

    Google Scholar 

  31. Polderman KH. Mechanisms of action, physiological effects, and complications of hypothermia. Crit Care Med. 2009;37(7 suppl):S186–202. [PubMed]

    Article  Google Scholar 

  32. Erecinska M, Thoresen M, Silver IA. Effects of hypothermia on energy metabolism in mammalian central nervous system. J Cereb Blood Flow Metab. 2003;23(5):513–30. [PubMed]

    Article  CAS  Google Scholar 

  33. Rosomoff HL, Holaday DA. Cerebral blood flow and cerebral oxygen consumption during hypothermia. Am J Phys. 1954;179(1):85–8. [PubMed]

    Article  CAS  Google Scholar 

  34. Zhao QJ, Zhang XG, Wang LX. Mild hypothermia therapy reduces blood glucose and lactate and improves neurologic outcomes in patients with severe traumatic brain injury. J Crit Care. 2011;26(3):311–5. [PubMed]

    Article  CAS  Google Scholar 

  35. Nakashima K, Todd MM. Effects of hypothermia on the rate of excitatory amino acid release after ischemic depolarization. Stroke. 1996;27(5):913–8. [PubMed]

    Article  CAS  Google Scholar 

  36. Wang D, Zhao Y, Zhang Y, et al. Hypothermia protects against oxygen-glucose deprivation-induced neuronal injury by down-regulating the reverse transport of glutamate by astrocytes as mediated by neurons. Neuroscience. 2013;237:130–8. [PubMed]

    Article  CAS  Google Scholar 

  37. Mueller Burke D, Koehler RC, Martin LJ. Rapid NMDA receptor phosphorylation and oxidative stress precede striatal neurodegeneration after hypoxic ischemia in newborn piglets and are attenuated with hypothermia. Int J Dev Neurosci. 2008;26(1):67–76 [PMC free article] [PubMed].

    Google Scholar 

  38. Yenari MA, Han HS. Neuroprotective mechanisms of hypothermia in brain ischaemia. Nat Rev Neurosci. 2012;13(4):267–78. [PubMed].

    Google Scholar 

  39. Takino M, Okada Y. Hyperthermia following cardiopulmonary resuscitation. Intensive Care Med. 1991;17:4190420.

    Article  Google Scholar 

  40. Bradley SM, Liu W, McNally B, et al. Temporal trends in the use of therapeutic hypothermia for out-of-hospital cardiac arrest. JAMA Netw Open. 2018;1(7):e184511.

    Article  Google Scholar 

  41. Dumas F, Grimaldi D, Zuber B, et al. Iss hypothermia after cardiac arrest effective in both shockable and nonshockable patients? Insights from a large registry. Circulation. 2011;123:877–86.

    Article  Google Scholar 

  42. Kima Y-M, Yimb H-W, Jeongc S-H, et al. Does therapeutic hypothermia benefit adult cardiac arrest patients presenting with non-shockable initial rhythms?: a systematic review and meta-analysis of randomized and non-randomized studies. Resuscitation. 2012;83:188–96.

    Article  Google Scholar 

  43. Chan PS, Berg RA, Tang Y, et al. Association between therapeutic hypothermia and survival after in-hospital cardiac arrest. JAMA. 2016;316(13):1375–82.

    Article  Google Scholar 

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Authors and Affiliations

  1. Icahn School of Medicine, Mount Sinai Hospital, New York, NY, USA

    J. Anthony Gomes

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  1. J. Anthony Gomes
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Correspondence to J. Anthony Gomes .

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Gomes, J.A. (2020). Hypothermia Post-Cardiac Arrest. In: Heart Rhythm Disorders. Springer, Cham. https://doi.org/10.1007/978-3-030-45066-3_20

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  • DOI: https://doi.org/10.1007/978-3-030-45066-3_20

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-45065-6

  • Online ISBN: 978-3-030-45066-3

  • eBook Packages: MedicineMedicine (R0)

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