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The Substrate of Ventricular Tachycardia

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Heart Rhythm Disorders

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Abstract

Defibrillation and synchronized cardioversion are capable of summarily stopping ventricular fibrillation (VF) and ventricular tachycardia (VT). However, these interventions developed in the twentieth century did not address the “substrate,” nor could they prevent VT recurrence and sudden cardiac death (SCD). In this chapter the author reviews the history of deciphering the mechanisms of VT in the animal model and in man, including bundle-branch-reentry, and the pioneers behind these discoveries that ultimately resulted in identifying the pathophysiology of the substrate of VT in remote infarcts leading to its surgical treatment. The author also discusses the impact of revascularization (thrombolysis and primary stenting) on the post-infarct substrate, as well as the current status of surgical resection of the VT substrate.

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Authors and Affiliations

  1. Icahn School of Medicine, Mount Sinai Hospital, New York, NY, USA

    J. Anthony Gomes

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Correspondence to J. Anthony Gomes .

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Gomes, J.A. (2020). The Substrate of Ventricular Tachycardia. In: Heart Rhythm Disorders. Springer, Cham. https://doi.org/10.1007/978-3-030-45066-3_13

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  • DOI: https://doi.org/10.1007/978-3-030-45066-3_13

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-45065-6

  • Online ISBN: 978-3-030-45066-3

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