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Eukaryome: Emerging Field with Profound Translational Potential

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Eukaryome Impact on Human Intestine Homeostasis and Mucosal Immunology

Abstract

The human intestinal eukaryome comprises a diverse set of eukaryotic organisms living in the intestinal lumen. These are in permanent or transient interaction with commensal organisms such as bacteria. This interaction has a direct impact on human well-being. The eukaryome remains one of the least understood components of the gut microbiota despite its permanent association with the host during the natural selection of species. The emerging work hypothesis is that eukaryome and bacteria in synergy influence the complex mechanism underlying the microbial crosstalk with the human gut during health or disease. New microbiota studies should therefore include the characterization of the components and function of the eukaryome to discover its role in homeostasis and intestinal diseases.

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Notes

  1. 1.

    Microbiota is the complex community of microorganisms including bacteria but also viruses (including bacteriophages), Archaea, eukaryotes such as fungi and protozoa living in consortia in sites such as the gastrointestinal tract (Lokmer et al. 2019).

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Acknowledgements

NG work was supported by European ERA-NET Infect-ERA program AMOEBAC (French National Agency for Research grant ANR-14-IFEC-0001-02).

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  1. Institut Pasteur, Centre National de la Recherche Scientifique-ERL9195, 25 Rue du Dr Roux, 75015, Paris, France

    Nancy Guillen

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    Nancy Guillen

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Guillen, N. (2020). Eukaryome: Emerging Field with Profound Translational Potential. In: Guillen, N. (eds) Eukaryome Impact on Human Intestine Homeostasis and Mucosal Immunology. Springer, Cham. https://doi.org/10.1007/978-3-030-44826-4_1

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