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Cancer of the Respiratory and Intrathoracic Organs

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Cancer Rehabilitation

Abstract

Lung cancer is one of the most common oncological diagnoses in the United States. When diagnosed at an early stage, surgical resection or occasionally stereotactic radiation can be curative. Localized lung cancers can be resected with lobectomy, pneumonectomy, or sleeve resection removing the tumor and bronchus. Almost 40% of patients are not surgical candidates due to comorbidities related to smoking. Lung cancer is frequently diagnosed in its later stages due to many overlapping symptoms from comorbid medical conditions such as tobacco abuse and chronic obstructive pulmonary disease (COPD). Common medical considerations associated with this diagnosis include supplemental oxygen, palliative radiation, and pain management to name a few. Patients who have been treated for lung cancer may present with a variety of impairments and frequently have limited exercise tolerance from dyspnea and pain. These patients can use exercise as well as physical, occupational, and speech therapies throughout the course of their disease to help reduce morbidity and improve their quality of life.

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References

  1. Owonikoko TK, Ragin CC, Belani CP, et al. Lung cancer in elderly patients: an analysis of the surveillance, epidemiology, and end results database. J Clin Oncol. 2007;25:5570–7.

    Article  Google Scholar 

  2. Brunelli A, Kim AW, Berger KI, Adrizzo-Harris DJ. Physiologic evaluation of the patient with lung cancer being considered for resectional surgery: diagnosis and management of lung cancer, 3rd ed. American College of Chest Physicians evidence-based clinical practice guidelines. Chest. 2013;143:e166S–90S.

    Article  CAS  Google Scholar 

  3. National Lung Screening Trial Research Team, Aberle DR, Adams AM, et al. Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med. 2011;365:395–409.

    Article  Google Scholar 

  4. Le Pechoux C, Dunant A, Senan S, et al. Standard-dose versus higher-dose prophylactic cranial irradiation in patients with limited-stage small-cell lung cancer in complete remission after chemotherapy and thoracic radiotherapy: a randomised clinical trial. Lancet Oncol. 2009;10:467–74.

    Article  Google Scholar 

  5. Turrisi AT, Kim K, Blum R, et al. Twice-daily compared with once-daily thoracic radiotherapy in limited small-cell lung cancer treated concurrently with cisplatin and etoposide. N Engl J Med. 1999;340:265–71.

    Article  CAS  Google Scholar 

  6. O’Brien ME, Ciuleanu TE, Tsekov H, et al. Phase III trial comparing supportive care alone with supportive care with oral topotecan in patients with relapsed small-cell lung cancer. J Clin Oncol. 2006;24:5441–7.

    Article  Google Scholar 

  7. Kalemkerian GP, Akerley W, Bogner P, et al. Small cell lung cancer. J Natl Compr Cancer Netw. 2013;11:78–98.

    Article  CAS  Google Scholar 

  8. Sterlacci W, Savic S, Schmid T, et al. Tissue-sparing application of the newly proposed IASLC/ATS/ERS classification of adenocarcinoma of the lung shows practical diagnostic and prognostic impact. Am J Clin Pathol. 2012;137:946–56.

    Article  Google Scholar 

  9. Paci M, Cavazza A, Annessi V, et al. Large cell neuroendocrine carcinoma of the lung: a 10-year clinicopathologic retrospective study. Ann Thorac Surg. 2004;77:1163.

    Article  Google Scholar 

  10. Predina JD, Kunkala M, Aliperti LA, Singhal AK, Singhal S. Sleeve lobectomy: current indications and future directions. Ann Thorac Cardiovasc Surg. 2010;16:310–8.

    PubMed  Google Scholar 

  11. Pignon JP, Tribodet H, Scagliotti GV, et al. Lung adjuvant cisplatin evaluation: a pooled analysis by LACE Collaborative Group. J Clin Oncol. 2008;26:3552–9.

    Article  Google Scholar 

  12. Strauss GM, Wang XF, Maddaus M, et al. Adjuvant chemotherapy in stage IB non-small cell lung cancer (NSCLC): long-term follow-up of Cancer and Leukemia Group B (CALGB) 9633. J Clin Oncol. 2011;29:7015.

    Article  Google Scholar 

  13. Spiro SG, Rudd RM, Souhami RL, et al. Chemotherapy versus supportive care in advanced non-small cell lung cancer: improved survival without detriment to quality of life. Thorax. 2004;59:828–36.

    Article  CAS  Google Scholar 

  14. Sandler A, Gray R, Perry MC, et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med. 2006;355(24):2542–50.

    Article  CAS  Google Scholar 

  15. Price B, Ware A. Time trend of mesothelioma incidence in the United States and projection of future cases: an update based on SEER data for 1973-2005. Crit Rev Toxicol. 2009;39(7):576–88.

    Article  Google Scholar 

  16. Robinson B. Malignant pleural mesothelioma: an epidemiological perspective. Ann Cardiothorac Surg. 2012;1(4):491–6.

    PubMed  PubMed Central  Google Scholar 

  17. Rusch VW, Giroux D, Kennedy C, et al. Initial analysis of the international association for the study of lung cancer mesothelioma database. J Thorac Oncol. 2012;7(11):1631–9.

    Article  Google Scholar 

  18. Adams RF, Gleeson FV. Percutaneous image-guided cutting-needle biopsy of the pleura in the presence of a suspected malignant effusion. Radiology. 2001;219(2):510–4.

    Article  CAS  Google Scholar 

  19. Zhao S, Chen F, Wang D, et al. Effect of preoperative smoking cessation on postoperative pain outcomes in elderly patients with high nicotine dependence. Medicine (Baltimore). 2019;98(3):e14209. https://doi.org/10.1097/MD.0000000000014209.

    Article  Google Scholar 

  20. Kendall F, Abreu P, Pinho J, et al. The role of physiotherapy in patients undergoing pulmonary surgery for lung cancer: a literature review. Rev Port Pneumol. 2017;23(6):343–51. https://doi.org/10.1016/j.rppnen/2017.05.003. Accessed 1/14/19.

    Article  CAS  PubMed  Google Scholar 

  21. Smith SR, Khanna A, Wisotzky EM. An evolving role for cancer rehabilitation in the era of low-dose lung computed tomography screening. PMR. 2017;9:S407–14.

    Article  Google Scholar 

  22. Iyer S, Roughley A, Rider A, et al. The symptom burden of non-small cell lung cancer in the USA: a real-world cross-sectional study. Support Care Cancer. 2014;22:181–7.

    Article  Google Scholar 

  23. Chen J, Lu JJ, Ma N, et al. Early stage non-small cell lung cancer treated with pencil beam scanning particle therapy: retrospective analysis of early results on safety and efficacy. Radiat Oncol. 2019;14(1):16. https://doi.org/10.1186/s13014-019-1216-1.

    Article  PubMed  PubMed Central  Google Scholar 

  24. New P. Radiation injury to the nervous system. Curr Opin Neurol. 2001;14:725–34.

    Article  CAS  Google Scholar 

  25. Shulman RM, Meyer JE, Li T, Howell KJ. External beam radiation therapy (EBRT) for asymptomatic bone metastases in patients with solid tumors reduces the risk of skeletal-related events (SREs). Ann Palliat Med. 2018. pii: apm.2018.10.04; https://doi.org/10.21037/apm.2018.10.04.

    Article  Google Scholar 

  26. den Otter LA, Kaza E, Kierkels RGJ, et al. Reproducibility of the lung anatomy under active breathing coordinator control: dosimetric consequences for scanned proton treatment. Med Phys. 2018;45(12):5525–34.

    Article  Google Scholar 

  27. Kaza E, Dunlop A, Panek R, et al. Lung volume reproducibility under ABC control and self-sustained breath holding. J Appl Clin Med Phys. 2017;18(2):154–62. https://doi.org/10.1002/acm2.12034.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Butts CA, Ding K, Seymour L, et al. Randomized phase III trial of vinorelbine plus cisplatin compared with observation in completely resected stage IB and II non-small-cell lung cancer: updated survival analysis of JBR-10. J Clin Oncol. 2010;28(1):29–34.

    Article  CAS  Google Scholar 

  29. Cheng X, Huo J, Wang D, et al. Herbal medicine AC591 prevents oxaliplatin-induced peripheral neuropathy in animal model and cancer patients. Front Pharmacol. 2017;8:344.

    Article  Google Scholar 

  30. Garja A, Karim NA, Mulford D, et al. nab-Paclitaxel–based therapy in underserved patient populations: the ABOUND.PS2 study in patients with NSCLC and a performance status of 2. Front Oncol. 2018;8(253) https://doi.org/10.3389/fonc.2018.00253.

  31. Fodeh SJ, Lazenby M, Bai M, et al. Functional impairments as symptoms in the symptom cluster analysis of patients newly diagnosed with advanced cancer. J Pain Symptom Manag. 2013;46(4):500–10. https://doi.org/10.1016/j.jpainsymman.2012.09.011.

    Article  Google Scholar 

  32. Ostroff JS, Krebs P, Coups EJ, et al. Health-related quality of life among early-stage, non-small cell, lung cancer survivors. Lung Cancer. 2011;71(1):103–8. https://doi.org/10.1016/j.lungcan.2010.04.011.

    Article  PubMed  Google Scholar 

  33. Wiskermann J, Hummler S, Diepold C, et al. POSITIVE study: physical exercise program in non-operable lung cancer patients undergoing palliative treatment. BMC Cancer. 2016;16:499.

    Article  Google Scholar 

  34. American Cancer Society ACS Guidelines for Physical Activity and the Cancer Patient. [Accessed January 31, 2019]. Available from: https://www.cancer.org/treatment/survivorship-during-and-after-treatment/staying-active/physical-activity-and-the-cancer-patient.html.

  35. Silver JK, Baima J, Mayer RS. Impairment-driven cancer rehabilitation: an essential component of quality care and survivorship. CA Cancer J Clin. 2013;63(5):295–317.

    Article  Google Scholar 

  36. Morano MT, Araujo AS, Nascimento FB, et al. Preoperative pulmonary rehabilitation versus chest physical therapy in patients undergoing lung cancer resection: a pilot randomized controlled trial. Arch Phys Med Rehabil. 2013;94:53–8.

    Article  Google Scholar 

  37. Jones LW, Peddle CJ, Eves ND, Haykowsky MJ, Courneya KS, Mackey JR, Joy AA, Kumar V, Winton TW, Reiman T. Cancer. 2007;110(3):590–8.

    Article  Google Scholar 

  38. Divisi D, Di Francesco C, Di Leonardo G, Crisci R. Preoperative pulmonary rehabilitation in patients with lung cancer and chronic obstructive pulmonary disease. Eur J Cardiothorac Surg. 2013;43:293–6.

    Article  Google Scholar 

  39. Quist M, Rorth M, Langer S, et al. Safety and feasibility of a combined exercise intervention for inoperable lung cancer patients undergoing chemotherapy: a pilot study. Lung Cancer. 2012;75:203–8.

    Article  Google Scholar 

  40. Zhang LL, Wang SZ, Chen HL, Yuan AZ. Tai Chi exercise for cancer-related fatigue in patients with lung cancer undergoing chemotherapy: a randomized controlled trial. J Pain Symptom Manag. 2016;51(3):504–11.

    Article  Google Scholar 

  41. Cheville AL, Kollasch J, Vandenberg J, et al. A home-based exercise program to improve function, fatigue, and sleep quality in patients with stage IV lung and colorectal cancer: a randomized controlled trial. J Pain Symptom Manag. 2013;45(5):811–21.

    Article  Google Scholar 

  42. Henshall CL, Allin L, Aveyard H. A systematic review and narrative synthesis to explore the effectiveness of exercise-based interventions in improving fatigue, dyspnea, and depression in lung cancer survivors. Cancer Nurs. 2018;42(4):295–306. https://doi.org/10.1097/NCC.0000000000000605.

    Article  Google Scholar 

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Correspondence to Charles Mitchell .

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Mitchell, C., Raj, V., Pugh, T. (2020). Cancer of the Respiratory and Intrathoracic Organs. In: Baima, J., Khanna, A. (eds) Cancer Rehabilitation . Springer, Cham. https://doi.org/10.1007/978-3-030-44462-4_9

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  • DOI: https://doi.org/10.1007/978-3-030-44462-4_9

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-44461-7

  • Online ISBN: 978-3-030-44462-4

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