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Cancer of the Brain, Eye, and Other Parts of the Central Nervous System

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Cancer Rehabilitation
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Abstract

Primary central nervous system (CNS) malignancies comprise just 1.4% of all cancers, and benign brain tumors have an incidence more than double that of malignant primary brain tumors. Brain and spinal metastatic disease greatly outnumber primary brain or spinal cord tumors. Tumor types which commonly metastasize to brain include lung, breast, kidney, colorectal, and melanoma, affecting an estimated 20% of cancer patients. In general, 2% of all nonhematologic cancer patients exhibit brain metastasis at the time of diagnosis. Surgery is the mainstay of treatment. Steroids are almost universally used in the treatment of brain tumors, and nearly all brain tumor patients will receive glucocorticoids at some point in their treatment. Inpatient rehabilitation studies of brain tumor patients have consistently reported comparable functional outcomes and discharge to community rates as other brain rehabilitation populations, such as brain injury and stroke patients. Limited outpatient interdisciplinary outcome data for malignant brain tumor patients suggests favorable functional outcomes and cost-effectiveness. Cognitive rehabilitation has been studied in various populations, including those with childhood tumors, and adult glioma patients, and cognitive therapy has been recommended as a practice guideline for children and adolescents treated for brain tumor.

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References

  1. Noone AM, Howlader N, Krapcho M, Miller D, Brest A, Yu M, Ruhl J, Tatalovich Z, Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA, editors. Cancer stat facts: brain and other nervous system cancer. In: SEER cancer statistics review, 1975–2015, National Cancer Institute, Bethesda, https://seer.cancer.gov/csr/1975_2015/, based on Nov 2017 SEER data submission, posted to the SEER web site, Apr 2018.

  2. Ostrom QT, Gittleman H, Truitt G, et al. CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2011–2015. Neuro-Oncology. 2018;20(S4):1–86.

    Article  Google Scholar 

  3. Cagney DN, Martin AM, Catalano PJ, et al. Incidence and prognosis of patients with brain metastases at diagnosis of systemic malignancy: a population-based study. Neuro-Oncology. 2017;19(11):1511–21.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Achrol AS, Rennert RC, Anders C, et al. Brain metastases. Nat Rev Dis Primers. 2019;5(1):5.

    Article  PubMed  Google Scholar 

  5. Yao A, Sarkiss CA, Ladner TR, Jenkins AL. Contemporary spinal oncology treatment paradigms and outcomes for metastatic tumors to the spine: a systematic review of breast, prostate, renal, and lung metastases. J Clin Neurosci. 2017;41:11–23.

    Article  PubMed  Google Scholar 

  6. National Collaborating Centre for Cancer (UK). Metastatic spinal cord compression. Diagnosis and management of patients at risk of or with metastatic spinal cord compression. NICE clinical guidelines, no. 75. Cardiff: National Collaborating Centre for Cancer (UK); 2008, ISBN-13: 978-0-9558265-1-1.

    Google Scholar 

  7. Lehmann J, DeLisa JA, Warren CG, et al. Cancer rehabilitation assessment of need development and education of a model of care. Arch Phys Med Rehabil. 1978;59:410–9.

    CAS  PubMed  Google Scholar 

  8. Mukand JA, Blackinton DD, Crincolli MG, et al. Incidence of neurologic deficits and rehabilitation of patients with brain tumors. Am J Phys Med Rehabil. 2001;80:346–50.

    Article  CAS  PubMed  Google Scholar 

  9. Lustig RH, Post SR, Srivannaboon K, et al. Risk factors for the development of obesity in children surviving brain tumors. J Clin Endocrinol Metab. 2003;88(2):611–6.

    Article  CAS  PubMed  Google Scholar 

  10. Short PF, Vasey JJ, Tunceli K. Employment pathways in a large cohort of adult cancer survivors. Cancer. 2005;103:1292–301.

    Article  PubMed  Google Scholar 

  11. Ellenberg L, Liu Q, Gioia G, et al. Neurocognitive status in long-term survivors of childhood CNS malignancies: a report from the Childhood Cancer Survivor Study. Neuropsychology. 2009;23(6):705–17.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Lonjaret L, Guyonnet M, Berard E, et al. Postoperative complications after craniotomy for brain tumor surgery. Anaesth Crit Care Pain Med. 2017;36:213–8.

    Article  PubMed  Google Scholar 

  13. Sawaya R, Hammoud M, Schoppa D, et al. Neurosurgical outcomes in a modern series of 400 craniotomies for treatment of parenchymal tumors. Neurosurgery. 1998;42(5):1044–55.

    Article  CAS  PubMed  Google Scholar 

  14. Sharpar S, Mhatre PV, Huang ME. Update on brain tumors: new developments in neuro-oncologic diagnosis and treatment, and impact on rehabilitation strategies. PM R. 2016;8:678–89.

    Article  Google Scholar 

  15. Dropcho EJ. Neurotoxicity of radiation therapy. Neurol Clin. 2010;28:217–34.

    Article  PubMed  Google Scholar 

  16. Greene-Schloesser D, Robbins ME, Peiffer AM, et al. Radiation-induced brain injury: a review. Front Oncol. 2012;2:1–18.

    Article  CAS  Google Scholar 

  17. Dietrich J, Rao K, Pastorino S, Kesari S. Corticosteroids in brain cancer patients: benefits and pitfalls. Expert Rev Clin Pharmacol. 2011;4(2):233–42.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Vargo M. Brain tumors and metastases. Phys Med Rehabil Clin N Am. 2017;28:115–41.

    Article  PubMed  Google Scholar 

  19. Marciniak CM, Sliwa JA, Heinemann AW, Semik PE. Functional outcomes of persons with brain tumors after inpatient rehabilitation. Arch Phys Med Rehabil. 2001;82:457–63.

    Article  CAS  PubMed  Google Scholar 

  20. Khan F, Amatya B, Drummond K, et al. Effectiveness of integrated multidisciplinary rehabilitation in primary brain cancer survivors in an Australian community cohort: a controlled clinical trial. J Rehabil Med. 2014;46:754–60.

    Article  PubMed  Google Scholar 

  21. McCarty S, Keeshin S, Eickmeyer SM, et al. Evaluation of the cost of comprehensive outpatient therapies in patients with malignant brain tumors. Am J Phys Med Rehabil. 2017;96:341–6.

    Article  PubMed  Google Scholar 

  22. Langenbahn DM, Ashman T, Cantor J, et al. An evidence-based review of cognitive rehabilitation in medical conditions affecting cognitive function. Arch Phys Med Rehabil. 2013;94:271–86.

    Article  PubMed  Google Scholar 

  23. Ruden E, Reardon DA, Coan AD, et al. Exercise behavior, functional capacity, and survival in adults with malignant recurrent glioma. J Clin Oncol. 2011;29:2918–23.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Williams PT. Reduced risk of brain cancer mortality from walking and running. Med Sci Sports Exerc. 2014;46(5):927–32.

    Article  PubMed  Google Scholar 

  25. Roberts PS, Nuño M, Sherman D, et al. The impact of inpatient rehabilitation on function and survival of newly diagnosed patients with glioblastoma. PM R. 2014;6:514–21.

    Article  PubMed  Google Scholar 

  26. Hansen A, Søgaard K, Minet LR, Jarden JO. A 12-week interdisciplinary rehabilitation trial in patients with gliomas – a feasibility study. Disabil Rehabil. 2018;40(12):1379–85.

    Article  PubMed  Google Scholar 

  27. Jones LW, Guill B, Keir ST. Exercise interest and preferences among patients diagnosed with primary brain cancer. Support Care Cancer. 2007;15:47–55.

    Article  PubMed  Google Scholar 

  28. Englot DJ, Chang EF, Vecht CJ. Epilepsy and brain tumors. Handb Clin Neurol. 2016;134:267–85.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Vecht CJ, van Breemen M. Optimizing therapy of seizures in patients with brain tumors. Neurology. 2006;67(Suppl 4):S10–3.

    Article  PubMed  Google Scholar 

  30. Benit CP, Kerkhof M, Duran-Peña A, Vecht CJ. Seizures as complications in cancer. In: Cancer neurology in clinical practice. Cham: Springer; 2018. p. 153–69.

    Chapter  Google Scholar 

  31. Bourg V, Lebrun C, Chichmanian RM, Thomas P, Frenay M. Nitroso-urea-cisplatin-based chemotherapy associated with valproate: increase of haematologic toxicity. Ann Oncol. 2001;12(2):217–9.

    Article  CAS  PubMed  Google Scholar 

  32. Semrad TJ, O’Donnell R, Wun T, Chew H, Harvey D, Zhou H, White RH. Epidemiology of venous thromboembolism in 9489 patients with malignant glioma. J Neurosurg. 2007;106(4):601–8.

    Article  PubMed  Google Scholar 

  33. Marras LC, Geerts WH, Perry JR. The risk of venous thromboembolism is increased throughout the course of malignant glioma: an evidence-based review. Cancer. 2000;89(3):640–6.

    Article  CAS  PubMed  Google Scholar 

  34. Lyman GH, Bohlke K, Khorana AA, Kuderer NM, Lee AY, Arcelus JI, Balaban EP, Clarke JM, Flowers CR, Francis CW, Gates LE. Venous thromboembolism prophylaxis and treatment in patients with cancer: American Society of Clinical Oncology clinical practice guideline update 2014. J Clin Oncol. 2015;33(6):654.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Siegel C, Armstrong TS. Nursing guide to management of major symptoms in patients with malignant glioma. Seminars in oncology nursing. 2018; 34(5):513–27.

    Article  PubMed  Google Scholar 

  36. Armstrong TS, Cron SG, Bolanos EV, Gilbert MR, Kang DH. Risk factors for fatigue severity in primary brain tumor patients. Cancer. 2010;116:2707–15.

    PubMed  Google Scholar 

  37. Rooney AG, Brown PD, Reijneveld JC, Grant R. Depression in glioma: a primer for clinicians and researchers. J Neurol Neurosurg Psychiatry. 2014;85:230–5.

    Article  PubMed  Google Scholar 

  38. Salander P, Bergenheim T, Henriksson R. The creation of protection and hope in patients with malignant brain tumours. Soc Sci Med. 1996;42(7):985–96.

    Article  CAS  PubMed  Google Scholar 

  39. Vargo M, Henriksson R, Salander P. Rehabilitation of patients with glioma. Handb Clin Neurol. 2016;134:287–304.

    Article  PubMed  Google Scholar 

  40. Dimaras H, Corson TW, Cobrinik D, et al. Retinoblastoma. Nat Rev Dis Primers. 2015;1:15021. https://doi.org/10.1038/nrdp.2015.21.

    Article  PubMed  PubMed Central  Google Scholar 

  41. Amaro A, Gangemi R, Piaggio F, et al. The biology of uveal melanoma. Cancer Metastasis Rev. 2017;36:109–40.

    Article  PubMed  PubMed Central  Google Scholar 

  42. Singh M, Durairaj P, Yeung J. Uveal melanoma: a review of the literature. Oncol Ther. 2018;6:87–10.4.

    Article  Google Scholar 

  43. Mishra KK, Chiu-Tsao ST, Orton CG. Particle therapy is ideal for the treatment of ocular melanomas. Point counterpoint. Med Phys. 2016;43(2):631–4.

    Article  PubMed  Google Scholar 

  44. Rundle P (2017) Photodynamic therapy for eye cancer. Biomedicine 5(4) pii E69; doi:https://doi.org/10.3390/biomedicines5040069.

    Article  PubMed Central  Google Scholar 

  45. Samartzis D, Gillis CC, Shih P, et al. Intramedullary spinal cord tumors: part i—epidemiology, pathophysiology, and diagnosis. Global Spine J. 2015;5:425–35.

    Article  PubMed  PubMed Central  Google Scholar 

  46. Byrne TN. Spinal cord compression from epidural metastases. NEJM. 1992;327:614–9.

    Article  CAS  PubMed  Google Scholar 

  47. Barcena A, et al. Spinal metastatic disease. An analysis of factors determining functional prognosis and the choice of treatment. Neurosurgery. 1984;15:820–7.

    CAS  PubMed  Google Scholar 

  48. Feng JT, Yang XG, Wang F, et al. Prognostic discrepancy on overall survival between ambulatory and nonambulatory patients with metastatic spinal cord compression. World Neurosurg. 2019;121:e322–32.

    Article  PubMed  Google Scholar 

  49. Fisher CG, DiPaola CP, Ryken TC, et al. A novel classification system for spinal instability in neoplastic disease: an evidence-based approach and expert consensus from the Spine Oncology Study Group. Spine. 2010;35:E1221–9.

    Article  PubMed  Google Scholar 

  50. Wright E, Ricciardi F, Arts M, et al. Metastatic spine tumor epidemiology: comparison of trends in surgery across two decades and three continents. World Neurosurg. 2018;114:e809–17.

    Article  PubMed  Google Scholar 

  51. McKinley WO, Huang E, Brunsvold KT. Neoplastic vs traumatic spinal cord injury: an outcome comparison after acute rehabilitation. Arch Phys Med Rehabil. 1999;80(10):1253–7.

    Article  CAS  PubMed  Google Scholar 

  52. Alam E, Wilson RD, Vargo M. Inpatient cancer rehabilitation: a retrospective comparison of transfer back to acute care between patients with neoplasm and other rehabilitation patients. Arch Phys Med Rehabil. 2008;89(7):1284–9.

    Article  PubMed  Google Scholar 

  53. New PW, Marshall R, Stubblefield MD, Scivoletto G. Rehabilitation of people with spinal cord damage due to tumor: literature review, international survey and practical recommendations for optimizing their rehabilitation. J Spinal Cord Med. 2017;40(2):213–21.

    Article  PubMed  Google Scholar 

  54. Hausheer FH, Schilsky RL, Bain S, et al. Diagnosis, management and evaluation of chemotherapy induced peripheral neuropathy. Semin Oncol. 2006;33(1):15–49.

    Article  CAS  PubMed  Google Scholar 

  55. Kolb NA, Trevino CR, Waheed W, et al. Neuromuscular complications of immune checkpoint inhibitor therapy. Muscle Nerve. 2018;58:10–22.

    Article  Google Scholar 

  56. Harper CM, Thomas JE, Cascino TL, Litchy WJ. Distinction between neoplastic and radiation-induced brachial plexopathy, with emphasis on the role of EMG. Neurology. 1989;39(4):502–6.

    Article  PubMed  Google Scholar 

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Correspondence to Mary Vargo .

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Vargo, M. (2020). Cancer of the Brain, Eye, and Other Parts of the Central Nervous System. In: Baima, J., Khanna, A. (eds) Cancer Rehabilitation . Springer, Cham. https://doi.org/10.1007/978-3-030-44462-4_4

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  • DOI: https://doi.org/10.1007/978-3-030-44462-4_4

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