Abstract
The concept of merging enamine activation catalysis with transition metal catalysis is an important strategy, which allows for selective chemical transformations not accessible without this combination. The amine catalyst activates the carbonyl compounds through the formation of a reactive nucleophilic enamine intermediate and, in parallel, the transition metal activates a wide range of functionalities such as allylic substrates through the formation of reactive electrophilic π-allyl-metal complex. Since the first report of this strategy in 2006, considerable effort has been devoted to the successful advancement of this technology. In this chapter, these findings are highlighted and discussed.
Chapter PDF
Similar content being viewed by others
Author information
Authors and Affiliations
Corresponding authors
Editor information
Editors and Affiliations
Rights and permissions
Open Access This chapter is licensed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence and indicate if changes were made.
Copyright information
© 2020 The Author(s)
About this chapter
Cite this chapter
Afewerki, S., Córdova, A. (2020). Enamine/Transition Metal Combined Catalysis: Catalytic Transformations Involving Organometallic Electrophilic Intermediates. In: Arndtsen, B., Gong, LZ. (eds) Asymmetric Organocatalysis Combined with Metal Catalysis. Topics in Current Chemistry Collections. Springer, Cham. https://doi.org/10.1007/978-3-030-43851-7_1
Download citation
DOI: https://doi.org/10.1007/978-3-030-43851-7_1
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-43850-0
Online ISBN: 978-3-030-43851-7
eBook Packages: Chemistry and Materials ScienceChemistry and Material Science (R0)