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Parathyroid Glands in Chronic Kidney Disease pp 143–149Cite as

Parathyroid Hormone as a Uremic Toxin

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Abstract

In chronic kidney disease (CKD) uremia is an elevation of retained toxic metabolic by-products and other compounds in the body related to reduced renal function and ultimately can result in multi-organ dysfunction. Parathyroid hormone (PTH) should be considered one of the uremic toxins associated with progressive CKD. In addition to having multiple effects on mineral metabolism associated with CKD, PTH has multiple systemic effects including myopathy, neurologic abnormalities, anemia, pruritus, and cardiomyopathy. These disorders results in significant morbidity and mortality if left untreated. Thus, clinical practice guidelines recommend frequent measurement of PTH in order to determine trends and implement appropriate treatments.

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Authors and Affiliations

  1. Division of Nephrology, Department of Medicine, University of Chicago Pritzker School of Medicine, Chicago, IL, USA

    Victoria Vo

  2. Division of Nephrology, Department of Medicine, North University Health System – University of Chicago Pritzker School of Medicine, Evanston, IL, USA

    Stuart M. Sprague

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  1. Victoria Vo
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  2. Stuart M. Sprague
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Correspondence to Stuart M. Sprague .

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Editors and Affiliations

  1. Internal Medicine - Nephrology, Grigore T. Popa University of Medicine and Pharmacy, Iași, Romania

    Adrian Covic

  2. Renal Unit, Guy's and St Thomas' NHS Foundation Hospital, London, UK

    David Goldsmith

  3. Nephrology-Dialysis Service, AURA Nord Saint Ouen, Saint Ouen, France

    Pablo A. Ureña Torres

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Vo, V., Sprague, S.M. (2020). Parathyroid Hormone as a Uremic Toxin. In: Covic, A., Goldsmith, D., Ureña Torres, P. (eds) Parathyroid Glands in Chronic Kidney Disease. Springer, Cham. https://doi.org/10.1007/978-3-030-43769-5_9

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  • DOI: https://doi.org/10.1007/978-3-030-43769-5_9

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  • Online ISBN: 978-3-030-43769-5

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