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PTH Regulation by Phosphate and miRNAs

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Parathyroid Glands in Chronic Kidney Disease

Abstract

From far, clinical and experimental data pointed to phosphate as a modulator of the parathyroid function. However, it has resulted highly difficult to state clearly a mechanism of action for phosphate on PTH secretion . Twenty-five years ago, the physiological constraints associated with the concomitant changes in serum factors related to mineral metabolism occurring in vivo were overcame through in vitro studies with whole parathyroid glands to show a direct effect. This was shown to be post-transcriptional and then, the responsible cis and trans-acting elements were deciphered throughout the next decade. But to find out a specific phosphate sensor in the parathyroid cells has remained quite elusive. Recent data, however, appears to shed new light on the sensing mechanism, which, amazingly, seems to operate at the very core of the regulation of the parathyroid function since it concerns to the calcium sensing receptor (CaSR) itself. This chapter will cover these mechanisms whereby phosphate modulates the secretion of PTH. And it will also cope with the role of microRNAs (miRNAs), perhaps the last guest star mechanism found to regulate PTH secretion . Through interfering RNAs, specific miRNAs can exert a fine-tuning of gene expression and thus might open new therapeutic prospects.

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Authors and Affiliations

  1. Department of Integrated Sciences/Centro de investigacion RENSMA, University of Huelva, Huelva, Spain

    Antonio Canalejo

  2. Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Reina Sofia University Hospital/University of Córdoba, Córdoba, Spain

    Mariano Rodríguez

  3. Unidad de Gestión Clinica Medicina Interna. Lipid and Atherosclerosis Unit, Department of Internal Medicine/IMIBIC/Reina, Sofia University Hospital/University of Córdoba, CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Córdoba, Spain

    Yolanda Almadén

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  1. Antonio Canalejo
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  2. Mariano Rodríguez
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  3. Yolanda Almadén
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Correspondence to Mariano Rodríguez .

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Editors and Affiliations

  1. Internal Medicine - Nephrology, Grigore T. Popa University of Medicine and Pharmacy, Iași, Romania

    Adrian Covic

  2. Renal Unit, Guy's and St Thomas' NHS Foundation Hospital, London, UK

    David Goldsmith

  3. Nephrology-Dialysis Service, AURA Nord Saint Ouen, Saint Ouen, France

    Pablo A. Ureña Torres

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Canalejo, A., Rodríguez, M., Almadén, Y. (2020). PTH Regulation by Phosphate and miRNAs. In: Covic, A., Goldsmith, D., Ureña Torres, P. (eds) Parathyroid Glands in Chronic Kidney Disease. Springer, Cham. https://doi.org/10.1007/978-3-030-43769-5_5

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  • DOI: https://doi.org/10.1007/978-3-030-43769-5_5

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