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Spatiotemporal Controls of Tooth-Supportive Structure Neogenesis by 3D Printing Technology

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Emerging Therapies in Periodontics

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Abstract

At present, various tissue engineering strategies in the regenerative medicine have been developed for multiple tissue regeneration and integrative structure formations in musculoskeletal system. However, the regenerations of dental tissues or tooth-supportive structures are still challenging due to the micro-interfacial compartmentalization of multiple tissues, their integrations for systematic responses, and spatiotemporal organizations of engineered fibrous tissues. In particular, the biomaterial-based approaches are limitedly investigated for spatiotemporal controls of periodontal regenerations and challenging to promote micron-scaled interfacial tissue compartmentalization with their integrations for functioning restorations. This chapter demonstrates biomaterial applications for periodontal tissue engineering and the advanced 3D fabrication technologies for preclinical applications and the limited clinical trial using 3D scaffolding systems.

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Acknowledgments

This work was supported by the Osteology Foundation (#16-173) and National Research Foundation of Korea (NRF-2014R1A1A2059301) to CHP, the Osteology Foundation to YDC, and the NIH/NIDCR U24 DE026915 to WVG.

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Authors and Affiliations

  1. Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI, USA

    Young-Dan Cho, William V. Giannobile & Lea Sarment

  2. Department of Periodontology, School of Dentistry, Seoul National University, Seoul, Republic of Korea

    Young-Dan Cho

  3. Department of Biomedical Engineering, College of Engineering, University of Michigan, Ann Arbor, MI, USA

    William V. Giannobile

  4. Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA

    William V. Giannobile

  5. Department of Dental Biomaterials, School of Dentistry, Kyungpook National University, Daegu, Republic of Korea

    Chan Ho Park

  6. Institute for Biomaterials Research and Development, Kyungpook National University, Daegu, Republic of Korea

    Chan Ho Park

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  1. Young-Dan Cho
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  2. William V. Giannobile
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  4. Chan Ho Park
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Correspondence to Chan Ho Park .

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  1. School of Dental Medicine, Department of Periodontics, University of Pennsylvania, Philadelphia, PA, USA

    Sinem Esra Sahingur

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Cho, YD., Giannobile, W.V., Sarment, L., Park, C.H. (2020). Spatiotemporal Controls of Tooth-Supportive Structure Neogenesis by 3D Printing Technology. In: Sahingur, S. (eds) Emerging Therapies in Periodontics. Springer, Cham. https://doi.org/10.1007/978-3-030-42990-4_16

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