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Protein- and Cell-Based Therapies for Periodontal Regeneration

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Emerging Therapies in Periodontics

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Abstract

To fully regenerate the periodontal tissues remains a challenge in our daily practice. Periodontal regeneration is a complex process involving a series of cellular and molecular events. In the last two decades, significant advances have been made in applying proteins and peptides to treat periodontal osseous defects. Several products are currently available and a few others are under development. Stem cell therapy has also been vigorously investigated for regenerating craniofacial tissues including periodontia. In this chapter, we review the current status of protein- and cell-based therapies for periodontal regeneration, with an emphasis on products that have been tested in clinical studies.

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Acknowledgments

This work has been supported in part by the Osteology Foundation (14-031) and NIH/NIDCR R03DE027146 to ZL and NIH/NIDCR U24 DE026915 to WVG.

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Authors and Affiliations

  1. Department of Periodontics, Virginia Commonwealth University School of Dentistry, Richmond, VA, USA

    Zhao Lin & Jill Beitz

  2. Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, USA

    Young-Dan Cho, Frederic Kauffmann, Lea Sarment, Darnell Kaigler & William V. Giannobile

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  1. Zhao Lin
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  2. Young-Dan Cho
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  3. Frederic Kauffmann
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  4. Lea Sarment
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  5. Jill Beitz
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  7. William V. Giannobile
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Correspondence to Zhao Lin .

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Editors and Affiliations

  1. School of Dental Medicine, Department of Periodontics, University of Pennsylvania, Philadelphia, PA, USA

    Sinem Esra Sahingur

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Lin, Z. et al. (2020). Protein- and Cell-Based Therapies for Periodontal Regeneration. In: Sahingur, S. (eds) Emerging Therapies in Periodontics. Springer, Cham. https://doi.org/10.1007/978-3-030-42990-4_14

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  • DOI: https://doi.org/10.1007/978-3-030-42990-4_14

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