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Skeletal Muscle Aging Atrophy: Assessment and Exercise-Based Treatment

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Reviews on New Drug Targets in Age-Related Disorders

Part of the book series: Advances in Experimental Medicine and Biology ((PMISB,volume 1260))

Abstract

In the ordinary course of aging, individuals change their body composition, mainly reducing their skeletal muscle mass and increasing their fat mass. In association, muscle strength and functionality also decrease. The geriatric assessment allows knowing the baseline situation of the patients, determines the impact of diseases, and defines specific treatments. There are various tools to evaluate the health condition of older people. These tools include the assessment scales of necessary Activities of Daily Living (ADL) and Instrumental Activities of Daily Living (IADL), physical and functional assessment scales, and instruments that assess the cognitive state of the person. There are several strategies that have been proposed to combat skeletal muscle atrophy due to aging, such as physical exercise, nutritional supplements, or drugs. Some researchers have highlighted the efficacy of the combination of the mentioned strategies. In this chapter, we will focus only on physical exercise as a strategy to reduce skeletal muscle loss during aging.

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Funding

Supported by FONDECYT - Chile (Grant Number 11180949) and Dirección de Investigación (DIUFRO) of Universidad de La Frontera (Grant Number DI18-0068). FAPESP, CNPq, and CAPES support the Rui Curi Research team.

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Authors and Affiliations

  1. Departamento de Medicina Interna, Facultad de Medicina, Universidad de La Frontera, Temuco, Chile

    Gabriel Nasri Marzuca-Nassr

  2. Magíster en Terapia Física con menciones, Facultad de Medicina, Universidad de La Frontera, Temuco, Chile

    Gabriel Nasri Marzuca-Nassr, Yuri SanMartín-Calísto, Pablo Guerra-Vega, Macarena Artigas-Arias & Andrea Alegría

  3. Escuela de Kinesiología, Facultad de Ciencias de la Salud, Universidad San Sebastián, Puerto Montt, Chile

    Pablo Guerra-Vega

  4. Interdisciplinary Post-Graduate Program in Health Sciences, Cruzeiro do Sul University, Sao Paulo, Brazil

    Rui Curi

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  1. Gabriel Nasri Marzuca-Nassr
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Correspondence to Gabriel Nasri Marzuca-Nassr .

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  1. Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil

    Paul C. Guest

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Marzuca-Nassr, G.N., SanMartín-Calísto, Y., Guerra-Vega, P., Artigas-Arias, M., Alegría, A., Curi, R. (2020). Skeletal Muscle Aging Atrophy: Assessment and Exercise-Based Treatment. In: Guest, P. (eds) Reviews on New Drug Targets in Age-Related Disorders. Advances in Experimental Medicine and Biology(), vol 1260. Springer, Cham. https://doi.org/10.1007/978-3-030-42667-5_6

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