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Effect of Short Chain Fatty Acids on Age-Related Disorders

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Reviews on New Drug Targets in Age-Related Disorders

Part of the book series: Advances in Experimental Medicine and Biology ((PMISB,volume 1260))

Abstract

Recent studies have indicated a prominent role of intestinal microbiota in regulation of several physiological aspects of the host including development and activation of the immune system and control of metabolism. In this review, we focused our discussion on bacterial metabolites produced from dietary fiber fermentation called short-chain fatty acids, which act as a link between the microbiota and host cells. Specifically, we described how modifications in their intestinal levels are associated with development of age-related pathologies including metabolic diseases and type 2 diabetes, hypertension, cardiovascular and neurodegenerative diseases. We also highlight their impact on the development of cancer.

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Acknowledgements

Sarah de Oliveira and Patrícia Brito Rodrigues are supported by fellowships from São Paulo Research Foundation (FAPESP #2019/11662-0 and 2019/14342-7). Mariana Portovedo and Mariane Fernandes Font are supported by fellowships from CAPES. This study is also supported by the National Council for Scientific and Technological Development (CNPq) (304433/2018-7) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES)—Finance Code 001.

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  1. Mariane Font Fernandes, Sarah de Oliveira, Mariana Portovedo, Patrícia Brito Rodrigues and Marco Aurélio Ramirez Vinolo contributed equally to the work.

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  1. Laboratory of Immunoinflammation, Department of Genetics, Evolution, Microbiology, and Immunology, Institute of Biology, University of Campinas, Campinas, SP, Brazil

    Mariane Font Fernandes, Sarah de Oliveira, Mariana Portovedo, Patrícia Brito Rodrigues & Marco Aurélio Ramirez Vinolo

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  1. Mariane Font Fernandes
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Correspondence to Marco Aurélio Ramirez Vinolo .

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  1. Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil

    Paul C. Guest

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Fernandes, M.F., de Oliveira, S., Portovedo, M., Rodrigues, P.B., Vinolo, M.A.R. (2020). Effect of Short Chain Fatty Acids on Age-Related Disorders. In: Guest, P. (eds) Reviews on New Drug Targets in Age-Related Disorders. Advances in Experimental Medicine and Biology(), vol 1260. Springer, Cham. https://doi.org/10.1007/978-3-030-42667-5_4

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