Nanotechnology-Inspired Bionanosystems for Valorization of Natural Origin Extracts

Part of the Sustainable Agriculture Reviews book series (SARV, volume 44)


Medicinal plants are the richest bioresource of drugs on traditional systems of medicine and their use in treating diseases by ancestral societies has caught the attention of the scientific community. Application of these plants in daily diet, cosmetic and pharmaceutical industries is widely implemented for many years. However, with the increasing need for more sustainable and environmentally friendly techniques, substituting chemical processes by plants in the production and enrichment of nanomaterials is certainly a very appealing alternative.

Studies have shown that among many examples of green synthesized drug delivery systems, those that receive the most attention include nanometallic particles, polymers and biological materials. Nanotechnology has enabled the creation of new drug delivery systems with the ability to increase the efficacy and improve the bioavailability of plant-derived bioactive compounds, promoting their release in a controlled manner, requiring a reduced dose, and reducing side effects while potentiating their activity. This review highlights the use of biosynthesized nanomaterials as a viable alternative to conventional techniques, and values ​​plant extracts as a source of new nanomedicines, acting as an ally or alternative to existing therapies.


Plant extracts Nanotechnology Plant-based nanostructures Green synthesis, eco-friendly nanotherapeutics 



This work was supported by the strategic programme UID/BIA/04050/2019 funded by national funds through the FCT I.P.


  1. Abbasi B, Anjum S (2016) Thidiazuron-enhanced biosynthesis and antimicrobial efficacy of silver nanoparticles via improving phytochemical reducing potential in callus culture of Linum usitatissimum L. Int J Nanomedicine 11:715PubMedPubMedCentralGoogle Scholar
  2. Adil S et al (2016) Apoptosis inducing ability of silver decorated highly reduced graphene oxide nanocomposites in A549 lung cancer. Int J Nanomedicine 11:873PubMedPubMedCentralGoogle Scholar
  3. Afrin S, Jahan I, Nazmul Hasan AHM, Deepa KN (2018) Novel approaches of herbal drug delivery. J Pharm Res Int 21(5):1–11Google Scholar
  4. Ahn S et al (2018) Soy protein/cellulose nanofiber scaffolds mimicking skin extracellular matrix for enhanced wound healing. Adv Healthc Mater 7(9):1–13. Scholar
  5. Ajoumshariati S, Eyedramin P, Eyedeh S, Imia K, Avari Y, Ohammad M, Hokrgozar ALIS (2016) Physical and biological modification of polycaprolactone electrospun nanofiber by Panax ginseng extract for bone tissue engineering application. Ann Biomed Eng 44(5):1808–1820Google Scholar
  6. Al-Huqail AA, Hatata MM, AL-Huqail AA, Ibrahim MM (2018) Preparation, characterization of silver phyto nanoparticles and their impact on growth potential of Lupinus termis L. seedlings. Saudi J Biol Sci 25(2):313–319PubMedGoogle Scholar
  7. Ali MS, Altaf M, Al-Lohedan HA (2017) Green synthesis of biogenic silver nanoparticles using Solanum tuberosum extract and their interaction with human serum albumin: evidence of ‘Corona’ formation through a multi-spectroscopic and molecular docking analysis. J Photochem Photobiol B Biol 173:108–119Google Scholar
  8. Allafchian AR et al (2018) Green synthesis of silver nanoparticles using Glaucium corniculatum (L.) curtis extract and evaluation of its antibacterial activity. IET Nanobiotechnol 12(5):574–578PubMedGoogle Scholar
  9. Ambika S, Sundrarajan M (2015) Antibacterial behaviour of Vitex negundo extract assisted ZnO nanoparticles against pathogenic bacteria. J Photochem Photobiol B Biol 146:52–57Google Scholar
  10. Amiri M, Pardakhti A, Ahmadi-zeidabadi M, Akbari A (2018) Magnetic nickel ferrite nanoparticles: green synthesis by urtica and therapeutic effect of frequency magnetic field on creating cytotoxic response in neural cell lines. Colloids Surf B: Biointerfaces 172:244–253. Scholar
  11. Amooaghaie R, Reza M, Azizi M (2015) Synthesis, characterization and biocompatibility of silver nanoparticles synthesized from Nigella sativa leaf extract in comparison with chemical silver nanoparticles. Ecotoxicol Environ Saf 120:400–408. Scholar
  12. André C, Kapustikova I, Lethier L (2014) A particulate biochromatographic support for the research of arginase inhibitors doped with nanomaterials: differences observed between carbon and boron nitride nanotubes. Application to three plant extracts. Chromatographia 77(21–22):1521–1527Google Scholar
  13. Arunachalam K, Arun L, Annamalai S, Arunachalam A (2014) Potential anticancer properties of bioactive compounds of Gymnema sylvestre and its biofunctionalized silver nanoparticles. Int J Nanomedicine 10:31–41. Scholar
  14. Atanasov AG et al (2015) Discovery and resupply of pharmacologically active plant-derived natural products : a review. Biotechnol Adv 33(8):1582–1614. Scholar
  15. Balalakshmi C et al (2017) Green synthesis of gold nanoparticles using a cheap Sphaeranthus indicus extract: impact on plant cells and the aquatic crustacean Artemia nauplii. J Photochem Photobiol B Biol 173:598–605Google Scholar
  16. Balamurugan M, Saravanan S, Soga T (2014) Synthesis of Iron oxide nanoparticles by using Eucalyptus globulus plant extract. J Surf Sci Nanotechnol 12:363–367Google Scholar
  17. Balestrin LA et al (2016) Protective effect of a hydrogel containing Achyrocline satureioides extract-loaded nanoemulsion against UV-induced skin damage. J Photochem Photobiol B Biol 163:269–276. Scholar
  18. Banu H et al (2018) Gold and silver nanoparticles biomimetically synthesized using date palm pollen extract-induce apoptosis and regulate P53 and Bcl-2 expression in human breast adenocarcinoma cells. Biol Trace Elem Res 186(1):122–134PubMedGoogle Scholar
  19. Bayrami A, Parvinroo S, Habibi-Yangjeh A, Rahim Pouran S et al (2017) Bio-extract-mediated ZnO nanoparticles: microwave-assisted synthesis, characterization and antidiabetic activity evaluation. Artif Cells Nanomed Biotechnol: 1–10.
  20. Botha TL et al (2019) Cytotoxicity of Ag, Au and Ag-Au bimetallic nanoparticles prepared using golden rod (Solidago canadensis) plant extract. Sci Rep 9(1):1–8Google Scholar
  21. Carvalho SSF, Carvalho NMF (2017) Dye degradation by green heterogeneous Fenton catalysts prepared in presence of Camellia sinensis. J Environ Manag 187:82–88Google Scholar
  22. Charernsriwilaiwat N et al (2013) Electrospun chitosan-based nanofiber mats loaded with Garcinia mangostana extracts. Int J Pharm 452(1–2):333–343PubMedGoogle Scholar
  23. Chintamani RB, Salunkhe KS, Chavan MJ (2018) Emerging use of green synthesis silver nanoparticle: an updated review. Int J Pharm Sci Res 9(10):4029–4055Google Scholar
  24. Choudhary BC et al (2017) Photocatalytic reduction of organic pollutant under visible light by green route synthesized gold nanoparticles. J Environ Sci (China) 55:236–246Google Scholar
  25. Chung IM et al (2016) Plant-mediated synthesis of silver nanoparticles: their characteristic properties and therapeutic applications. Nanoscale Res Lett 11(1):1–14. Scholar
  26. Clemente I, Ristori S, Pierucci F, Muniz-miranda M (2017) Gold nanoparticles from vegetable extracts using different plants from the market: a study on stability, shape and toxicity. ChemistrySelect 2(30):9777–9782Google Scholar
  27. da Silva Gündel S et al (2018) Nanoemulsions containing Cymbopogon flexuosus essential oil: development, characterization, stability study and evaluation of antimicrobial and antibiofilm activities. Microb Pathog 118:268–276PubMedGoogle Scholar
  28. Dai X et al (2017) Nano-formulated curcumin accelerates acute wound healing through Dkk-1-mediated fibroblast mobilization and MCP-1-mediated anti-inflammation. NPG Asia Mater 9(3):368Google Scholar
  29. David B, Wolfender JL, Dias DA (2015) The pharmaceutical industry and natural products: historical status and new trends. Phytochem Rev 14:299–315Google Scholar
  30. Dehghanizade S, Arasteh J, Mirzaie A (2017) Green synthesis of silver nanoparticles using Anthemis atropatana extract: characterization and in vitro biological activities. Artif Cells Nanomed Biotechnol:1–9.
  31. Devi GK, Sathishkumar K (2016) Synthesis of gold and silver nanoparticles using Mukia maderaspatna plant extract and its anticancer activity. IET Nanobiotechnol 11(2):143–151Google Scholar
  32. Devi GK, Kumar KS, Parthiban R, Kalishwaralal K (2017) An insight study on HPTLC fingerprinting of Mukia maderaspatna: mechanism of bioactive constituents in metal nanoparticle synthesis and its activity against human pathogens. Microb Pathog 102:120–132PubMedGoogle Scholar
  33. Dobrucka R (2018) Synthesis of MgO nanoparticles using Artemisia abrotanum herba extract and their antioxidant and photocatalytic properties. Iran J Sci Technol Trans A Sci 42(2):547–555Google Scholar
  34. Doddapaneni SJDS et al (2018) Antimicrobial and anticancer activity of AgNPs coated with Alphonsea sclerocarpa extract. 3 Biotech 8(3):1–9. Scholar
  35. Dzoyem JP, Tshikalange E, Kuete V (2013) Medicinal plant research in Africa. In: Medicinal plants market and industry in Africa: pharmacology and chemistry. Elsevier Inc, London. Scholar
  36. Ezhilarasi A et al (2016) Green synthesis of NiO nanoparticles using Moringa oleifera extract and their biomedical applications: cytotoxicity effect of nanoparticles against HT-29 cancer cells. J Photochem Photobiol B Biol 164:352–360. Scholar
  37. Ezhilarasi AA et al (2018) Green synthesis of NiO nanoparticles using Aegle marmelos leaf extract for the evaluation of in vitro cytotoxicity, antibacterial and photocatalytic properties. J Photochem Photobiol B Biol 180:39–50.
  38. Foo ME, Gyun C, Radi A, Yaakub W (2018) Antimicrobial activity of functionalized single – walled carbon nanotube with herbal extract of Hempedu bumi. Surf Interface Anal 2018:354–361Google Scholar
  39. Francis S, Koshy EP, Mathew B (2018) Green synthesis of Stereospermum suaveolens capped silver and gold nanoparticles and assessment of their innate antioxidant, antimicrobial and antiproliferative activities. Bioprocess Biosyst Eng 41(7):939–951. Scholar
  40. Ghayempour S, Montazer M (2018) A modified microemulsion method for fabrication of hydrogel tragacanth nanofibers. Int J Biol Macromol 115:317–323PubMedGoogle Scholar
  41. Gumus ZP et al (2015) Herbal infusions of black seed and wheat germ oil: their chemical profiles, in vitro bio-investigations and effective formulations as phyto-nanoemulsions. Colloids Surf B: Biointerfaces 133:73–80.
  42. Guo R, Guo X (2017) Fabrication and optimization of self-microemulsions to improve the oral bioavailability of total flavones of Hippopha ë Rhamnoides L. J Food Sci 82(7):1–9Google Scholar
  43. Hassanien R, Husein DZ, Al-hakkani MF (2018) Biosynthesis of copper nanoparticles using aqueous Tilia extract: antimicrobial and anticancer activities. Heliyon 4(12):e01077.
  44. Hatamipour M et al (2019) Novel nanomicelle formulation to enhance bioavailability and stability of curcuminoids. Iran J Basic Med Sci 22(3):282–289. (11)PubMedPubMedCentralGoogle Scholar
  45. Hoscheid J et al (2015) Development and characterization of Pterodon pubescens oil nanoemulsions as a possible delivery system for the treatment of rheumatoid arthritis. Colloids Surf A Physicochem Eng Asp 484:19–27. Scholar
  46. Hussain M et al (2018) Green synthesis and characterisation of silver nanoparticles and their effects on antimicrobial efficacy and biochemical profiling in Citrus reticulata. IET Nanobiotechnol 12(4):514–519PubMedGoogle Scholar
  47. Ibrar M, Khan MA, Abdullah, Imran M (2018) Evaluation of Paeonia emodi and its gold nanoparticles for cardioprotective and antihyperlipidemic potentials. J Photochem Photobiol B Biol 189:5–13Google Scholar
  48. Islam NU et al (2015) Antinociceptive, muscle relaxant and sedative activities of gold nanoparticles generated by methanolic extract of Euphorbia milii. BMC Complement Altern Med 15:160PubMedPubMedCentralGoogle Scholar
  49. Jafarirad S, Mehrabi M, Divband B, Kosari-nasab M (2016) Biofabrication of zinc oxide nanoparticles using fruit extract of Rosa canina and their toxic potential against bacteria: a mechanistic approach. Mater Sci Eng C 59:296–302.
  50. Jahan N et al (2016) Formulation and characterisation of nanosuspension of herbal extracts for enhanced antiradical potential. J Exp Nanosci 11(1):72–80. Scholar
  51. Jamal L, Umaralikhan M, Jaffar M (2016) Green synthesis of MgO nanoparticles and it antibacterial activity. Iran J Sci Technol Trans A Sci 12:1–9Google Scholar
  52. Jena S et al (2016) Photo-bioreduction of Ag+ ions towards the generation of multifunctional silver nanoparticles: mechanistic perspective and therapeutic potential. J Photochem Photobiol B Biol 164:306–313Google Scholar
  53. Judith Vijaya J et al (2017) Bioreduction potentials of dried root of Zingiber officinale for a simple green synthesis of silver nanoparticles: antibacterial studies. J Photochem Photobiol B Biol 177:62–68Google Scholar
  54. Klekotko M et al (2015) Bio-mediated synthesis, characterization and cytotoxicity of gold nanoparticles. Phys Chem Chem Phys 17(43):29014–29019PubMedGoogle Scholar
  55. Kotakadi VS et al (2014) Biofabrication of silver nanoparticles using Andrographis paniculata. Eur J Med Chem 73:135–140. Scholar
  56. Lediga ME et al (2018) Biosynthesis and characterisation of antimicrobial silver nanoparticles from a selection of fever-reducing medicinal plants of South Africa. S Afr J Bot 119:172–180. Scholar
  57. Li H et al (2018) Folate-targeting annonaceous acetogenins nanosuspensions: significantly enhanced antitumor efficacy in HeLa tumor-bearing mice. Drug Deliv 25(1):880–887. Scholar
  58. Loo C-y et al (2016) Combination of silver nanoparticles and curcumin nanoparticles for enhanced anti-bio film activities. J Agric Food Chem 64(12):2513–2522PubMedGoogle Scholar
  59. Mahendra C et al (2017) Antibacterial and antimitotic potential of bio-fabricated zinc oxide nanoparticles of Cochlospermum religiosum (L.). Microb Pathog 110:620–629. Scholar
  60. Mahmoodi Esfanddarani H, Abbasi Kajani A, Bordbar A-K (2018) Green synthesis of silver nanoparticles using flower extract of Malva sylvestris and investigation of their antibacterial activity. IET Nanobiotechnol 12(4):412–416PubMedGoogle Scholar
  61. Marslin G et al (2015) Antimicrobial activity of cream incorporated with silver nanoparticles biosynthesized from Withania somnifera. Int J Nanomedicine 10:5955–5963PubMedPubMedCentralGoogle Scholar
  62. Mazzarino L et al (2017) Jaboticaba (Plinia peruviana) extract nanoemulsions: development, stability, and in vitro antioxidant activity. Drug Dev Ind Pharm 44(4):1–27Google Scholar
  63. Miftahul M (2018) Mangosteen pericarp extract embedded in electrospun PVP nanofiber mats: physicochemical properties and release mechanism of α -mangostin. Int J Nanomedicine 13:4927–4941Google Scholar
  64. Mittal AK, Chisti Y, Banerjee UC (2013) Synthesis of metallic nanoparticles using plant extracts. Biotechnol Adv 31(2):346–356. Scholar
  65. Murad U et al (2018) Synthesis of silver and gold nanoparticles from leaf of Litchi chinensis and its biological activities. Asian Pac J Trop Biomed 8(3):142–149Google Scholar
  66. Nadeem M et al (2018) The current trends in the green syntheses of titanium oxide nanoparticles and their applications. Green Chem Lett Rev 11(4):492–502. Scholar
  67. Nambiar S et al (2018) Synthesis of curcumin – functionalized gold nanoparticles and cytotoxicity studies in human prostate cancer cell line. Appl Nanosci 8(3):347–357. Scholar
  68. Nasiri J, Motamedi E, Naghavi MR, Ghafoori M (2019) Removal of crystal violet from water using Β-cyclodextrin functionalized biogenic zero-valent iron nanoadsorbents synthesized via aqueous root extracts of Ferula persica. J Hazard Mater 367:325–338PubMedGoogle Scholar
  69. Nazar N et al (2018) Cu nanoparticles synthesis using biological molecule of P. Granatum seeds extract as reducing and capping agent: growth mechanism and photo-catalytic activity. Int J Biol Macromol 106:1203–1210. Scholar
  70. Newman DJ, Cragg GM (2016) Natural products as sources of new drugs from 1981 to 2014. J Nat Prod 79(3):629–661Google Scholar
  71. Ocsoy I et al (2017) A green approach for formation of silver nanoparticles on magnetic graphene oxide and highly effective antimicrobial activity and reusability. J Mol Liq 227:147–152. Scholar
  72. Ocsoy I, Tasdemir D, Mazicioglu S, Tan W (2018) Nanotechnology in plants. Adv Biochem Eng Biotechnol 164:263–275. Scholar
  73. Odei-Addo F et al (2017) Nanoformulation of Leonotis leonurus to improve its bioavailability as a potential antidiabetic drug. 3 Biotech 7(5):344PubMedPubMedCentralGoogle Scholar
  74. Oh KH et al (2018) Biosynthesized gold and silver nanoparticles by aqueous fruit extract of Chaenomeles sinensis and screening of their biomedical activities. Artif Cells Nanomed Biotechnol 46(3):599–606PubMedGoogle Scholar
  75. Ouda Sahar M (2014) Some nanoparticles effects on Proteus Sp. and KLebsiella Sp. isolated from water. Am J Infect Dis Microbiol 2(1):4–10Google Scholar
  76. Ovais M (2017) Sageretia thea (Osbeck.) mediated synthesis of zinc oxide nanoparticles and its biological applications. Nanomedicine 12(15):1767–1789PubMedGoogle Scholar
  77. Pansambal S et al (2017) Phytosynthesis and biological activities of fluorescent CuO nanoparticles using Acanthospermum hispidum L. extract. J Nanostruct 7(3):165–174Google Scholar
  78. Parveen K, Banse V, Ledwani L (2016) Green synthesis of nanoparticles: their advantages and disadvantages. In: AIP conference proceedings 1724Google Scholar
  79. Periasamy VS, Athinarayanan J, Alshatwi AA (2016) Anticancer activity of an ultrasonic nanoemulsion formulation of Nigella sativa L. essential oil on human breast cancer cells. Ultrason Sonochem 31:449–455. Scholar
  80. Pires PR et al (2016) Systemic treatment with resveratrol and/or curcumin reduces the progression of experimental periodontitis in rats. J Periodont Res 55(11).
  81. Pirtarighat S, Ghannadnia M, Baghshahi S (2019) Green synthesis of silver nanoparticles using the plant extract of Salvia spinosa grown in vitro and their antibacterial activity assessment. J Nanostruct Chem 9(1):1–9. Scholar
  82. Preshaw PM (2015) Detection and diagnosis of periodontal conditions amenable to prevention. BMC Oral Health 15(Suppl 1):S5PubMedPubMedCentralGoogle Scholar
  83. Rasheed T, Bilal M, Iqbal HMN, Li C (2017) Green biosynthesis of silver nanoparticles using leaves extract of Artemisia vulgaris and their potential biomedical applications. Colloids Surf B: Biointerfaces 158:408–415. Scholar
  84. Riaz M et al (2018) Biogenic synthesis of AgNPs with Saussurea lappa C.B. Clarke and studies on their biochemical properties. J Nanosci Nanotechnol 18(12):8392–8398Google Scholar
  85. Rijo P, Ascensão L, Roberto A, Sofia A (2016) Bioproduction of gold nanoparticles for photothermal therapy. Ther Deliv 7:287–304PubMedGoogle Scholar
  86. Sadegh S et al (2019) Neuroprotective potential of curcumin- loaded nanostructured lipid carrier in an animal model of Alzheimer’ s disease : behavioral and biochemical evidence. J Alzheimers Dis 69:671–686Google Scholar
  87. Sahni G, Panwar A, Kaur B (2015) Controlled green synthesis of silver nanoparticles by Allium cepa and Musa acuminata with strong antimicrobial activity. Int Nano Lett 5:93–100. Scholar
  88. Saleem S, Ahmed B, Saghir M, Al-shaeri M (2017) Inhibition of growth and bio film formation of clinical bacterial isolates by NiO nanoparticles synthesized from Eucalyptus globulus plants. Microb Pathog 111:375–387. Scholar
  89. Santhoshkumar T et al (2014) Green synthesis of titanium dioxide nanoparticles using Psidium guajava extract and its antibacterial and antioxidant properties. Asian Pac J Trop Med 7(12):968–976. Scholar
  90. Saran M, Vyas S, Mathur M, Bagaria A (2018) Green synthesis and characterisation of CuNPs : insights into their potential bioactivity. IET Nanobiotechnol 12(3):357–364Google Scholar
  91. Saravanan A, Kumar PS, Karthiga Devi G, Arumugam T (2016) Synthesis and characterization of metallic nanoparticles impregnated onto activated carbon using leaf extract of Mukia maderasapatna: evaluation of antimicrobial activities. Microb Pathog 97:198–203PubMedGoogle Scholar
  92. Sathishkumar P et al (2016) Anti-acne, anti-dandruff and anti-breast cancer efficacy of green synthesised silver nanoparticles using Coriandrum sativum leaf extract. J Photochem Photobiol B Biol 163:69–76. Scholar
  93. Sathishkumar G et al (2018) Green synthesis of magnetic Fe 3 O 4 nanoparticles using Couroupita guianensis Aubl. fruit extract for their antibacterial and cytotoxicity activities. Artif Cells Nanomed Biotechnol 46(3):589–598PubMedGoogle Scholar
  94. Sathya K, Saravanathamizhan R, Baskar G (2018) Ultrasonic assisted green synthesis of Fe and Fe/Zn bimetallic nanoparticles for in vitro cytotoxicity study against HeLa cancer cell line. Mol Biol Rep 45(5):1397–1404Google Scholar
  95. Selvam K, Sudhakar C, Govarthanan M (2017) Eco-friendly biosynthesis and characterization of silver nanoparticles using Tinospora cordifolia (Thunb.) miers and evaluate its antibacterial, antioxidant potential. J Radiat Res Appl Sci 10(1):6–12. Scholar
  96. Suman TY et al (2016) GC-MS analysis of bioactive components and biosynthesis of silver nanoparticles using Hybanthus enneaspermus at room temperature evaluation of their stability and its larvicidal activity. Environ Sci Pollut Res 23(3):2705–2714Google Scholar
  97. Suman TY et al (2018) Toxicity of biogenic gold nanoparticles fabricated by Hybanthus enneaspermus aqueous extract against Anopheles stephensi and Culex tritaeniorhynchus. Res J Biotechnol 13(9):26–34Google Scholar
  98. Suresh D, Nethravathi PC, Rajanaika H (2015) Green synthesis of multifunctional zinc oxide (ZnO) nanoparticles using Cassia fistula plant extract and their photodegradative, antioxidant and antibacterial activities. Mater Sci Semicond Process 31:446–454.
  99. Surface, OF, Modified Zinc, Oxide Nanoparticles, and Human Pathogenic Bacteria (2018) Exploiting in vitro potential and characterization of surface modified zinc oxide nanoparticles of isodon rugosus extract: their clinical potential towards hepg2 cell line and human pathogenic bacteria. EXCLI J 17:671–687Google Scholar
  100. Sushma NJ, Swathi DPG, Deva TMB, Raju P (2016) Facile approach to synthesize magnesium oxide nanoparticles by using Clitoria ternatea – characterization and in vitro antioxidant studies. Appl Nanosci 6(3):437–444Google Scholar
  101. Thatoi P et al (2016) Photo-mediated green synthesis of silver and zinc oxide nanoparticles using aqueous extracts of two mangrove plant species, Heritiera fomes and Sonneratia apetala and investigation of their biomedica. J Photochem Photobiol B 163:311–318. Scholar
  102. Tostado-plascencia MM, Sanchez-tizapa M, Zamudio-ojeda A (2018) Synthesis and characterization of multiwalled carbon nanotubes functionalized with chlorophyll-derivatives compounds extracted from Hibiscus tiliaceus. Diam Relat Mater 89:151–162. Scholar
  103. Tripathi N, Pavelyev V, Islam SS (2017) Synthesis of carbon nanotubes using green plant extract as catalyst: unconventional concept and its realization. Appl Nanosci 7(8):557–566Google Scholar
  104. Vijayakumar S et al (2018) Green synthesis of zinc oxide nanoparticles using Atalantia monophylla leaf extracts : characterization and antimicrobial analysis. Mater Sci Semicond Process 82:39–45. Scholar
  105. Vijayaraghavan K, Ashokkumar T (2017) Plant-mediated biosynthesis of metallic nanoparticles: a review of literature, factors affecting synthesis, characterization techniques and applications. J Environ Chem Eng 5(5):4866–4883. Scholar
  106. Yadi M et al (2018) Current developments in green synthesis of metallic nanoparticles using plant extracts: a review. Artif Cells Nanomed Biotechnol 46(Suppl 3):S336–S343PubMedGoogle Scholar
  107. Yallappa S et al (2015) Phytosynthesis of gold nanoparticles using Mappia foetida leaves extract and their conjugation with folic acid for delivery of doxorubicin to cancer cells. J Mater Sci Mater Med 26(9):1–12Google Scholar
  108. Yallapu MM, Jaggi M, Chauhan SC (2013) Curcumin nanomedicine: a road to cancer therapeutics. Curr Pharm Des 19(11):1994–2010PubMedPubMedCentralGoogle Scholar
  109. Youse I, Pakravan M, Rahimi H, Bahador A (2017) An investigation of Electrospun henna leaves extract-loaded chitosan based nano fibrous mats for skin tissue engineering. Mater Sci Eng C Mater Biol Appl 75:433–444Google Scholar
  110. Yugandhar P, Vasavi T, Uma P, Devi M (2017) Bioinspired green synthesis of copper oxide nanoparticles from Syzygium alternifolium (Wt.) Walp : characterization and evaluation of its synergistic antimicrobial and anticancer activity. Appl Nanosci 7(7):417–427Google Scholar
  111. Zambrano LMG et al (2018) Local administration of curcumin- loaded nanoparticles effectively inhibits inflammation and bone resorption associated with experimental periodontal disease. Sci Rep 8(1):1–11Google Scholar
  112. Zhao X, Wang J, Song Y, Chen X (2018) Synthesis of nanomedicines by nanohybrids conjugating ginsenosides with auto-targeting and enhanced MRI contrast for liver cancer therapy. Drug Dev Ind Pharm 44(8):1307–1316PubMedGoogle Scholar
  113. Zhou Y, Tang RC (2018) Facile and eco-friendly fabrication of AgNPs coated silk for antibacterial and antioxidant textiles using honeysuckle extract. J Photochem Photobiol B Biol 178:463–471Google Scholar
  114. Zhou TE et al (2013) Curcumin inhibits in Fl ammatory response and bone loss during experimental periodontitis in rats. Acta Odontol Scand 71(2):349–356PubMedGoogle Scholar
  115. Zorzi GK, Carvalho ELS, Von Poser GL, Teixeira HF (2015) On the use of nanotechnology-based strategies for association of complex matrices from plant extracts. Braz J Pharm 25(4):426–436. Scholar

Copyright information

© The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.CBMA – Centre of Molecular and Environmental Biology, Department of BiologyUniversity of Minho, Campus of GualtarBragaPortugal
  2. 2.IB-S Institute of Science and Innovation for SustainabilityUniversity of Minho, Campus of GualtarBragaPortugal
  3. 3.INL – International Iberian Nanotechnology LaboratoryBragaPortugal

Personalised recommendations