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Oxidative Stress Mediated by Reactive Intermediates

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Xenobiotic Metabolic Enzymes: Bioactivation and Antioxidant Defense

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Abstract

Reactive intermediates generated from activation metabolism are associated with inflammation and carcinogenesis. Oxidative stress occurs as the productions of reactive oxygen species, free radicals, or other reactive intermediates are not balanced by the capability of body’s defense systems. Oxidative stress-mediated cellular damages play a crucial role in the pathogenesis processes that can attribute to cardiovascular disorder, neurodegeneration, pulmonary injury, and cancers. An elevated level of chemically reactive intermediates requires an overwhelming response from detoxification enzymes and endogenous antioxidants. An imbalance between oxidants and antioxidants is the underlying basis of oxidative stress.

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Authors and Affiliations

  1. Institute for Health and the Environment and Department of Biomedical Sciences, University at Albany, State University of New York, 5 University Place, Rensselaer, NY, USA

    Chang-Hwei Chen

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  1. Chang-Hwei Chen
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Chen, CH. (2020). Oxidative Stress Mediated by Reactive Intermediates. In: Xenobiotic Metabolic Enzymes: Bioactivation and Antioxidant Defense. Springer, Cham. https://doi.org/10.1007/978-3-030-41679-9_11

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