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Introduction of Visceral Leishmaniasis (Kala-azar)

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Spatial Mapping and Modelling for Kala-azar Disease

Part of the book series: SpringerBriefs in Medical Earth Sciences ((BRIEFSMEEASC))

Abstract

This chapter begins with a summary of leishmaniasis in parallel with special emphasis on kala-azar. Kala-azar or visceral leishmaniasis (VL) is a slow progressing indigenous disease caused by a protozoan parasite (Leishmania donovani, Leishmania infantum, and Leishmania archibaldi), with a mortality rate 75–95%. The parasite primarily infects the reticuloendothelial system and may be found in abundance in the bone marrow, spleen, and liver. Out of the 88 VL-affected countries, 72 countries are least developed countries, and 90% of kala-azar cases are recorded from India, Bangladesh, Nepal, and Sudan. Approximately 600 Leishmania species have been identified in the Old World and New World. However, the prevalence of P. argentipes is observed throughout the year with two annual peak density. In India, VL is purely anthroponosis. A multifaceted aspect has seen the reemergence and transmission of kala-azar throughout the world.

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References

  • Aagaard-Hansen J, Nombela N, Alvar J (2010) Population movement: a key factor in the epidemiology of neglected tropical diseases. Tropical Med Int Health 15:1281–1288

    Article  Google Scholar 

  • Alvar J, Ve’lez ID, Bern C, Herrero M, Desjeux P et al (2012) WHO Leishmaniasis Control Team. Leishmaniasis worldwide and global estimates of its incidence. PLoS One 7:e35671

    Article  Google Scholar 

  • Andrade-Narvaez FJ, Canto Lara SB, van Wynsberghe NR et al (2003) Seasonal transmission of Leishmania (Leishmania) mexicana in the state of Campeche, Yucatan Peninsula, Mexico. Mem Inst Oswaldo Cruz 98(8):995–998

    Article  Google Scholar 

  • Aversi-Ferreira RAGMF, Galvão JD, da Silva SF, Cavalcante GF, da Silva EV, Bhatia-Dey N, Aversi-Ferreira TA (2015) Geographical and environmental variables of leishmaniasis transmission. INTECH:105–123. https://doi.org/10.5772/57546

  • Awati PR (1922) Survey of biting insects of Assam with reference to kala-azar for the whole year from November 1921 to October 1922. Biting insects found in dwelling-houses. Indian J Med Res 10:579–591

    Google Scholar 

  • Belen A, Alten B (2005) Variation in life table characteristics among populations of Phlebotomus papatasi at different altitudes. J Vector Ecol 31:35–44

    Article  Google Scholar 

  • Bern C, Courtenay O, Alvar J (2010) Of cattle, sand flies and men: a systematic review of risk factor analyses for South Asian visceral leishmaniasis and implications for elimination. PLoS Negl Trop Dis 4:e599

    Article  Google Scholar 

  • Bhunia GS (2014) An appraisal of environmental determinants of the disease visceral leishmaniasis (Kala-azar) using remote sensing and GIS techniques: case studies of Vaishali and Muzaffarpur districts, Bihar. PhD thesis, Submitted to the Department of Geography, University of Calcutta, Kolkata

    Google Scholar 

  • Boelaert M, Meheus F, Sanchez A, Singh SP, Vanlerberghe V, Picado A et al (2009) The poorest of the poor: a poverty appraisal of households affected by visceral leishmaniasis in Bihar, India. Trop Med Int Health 14:639–644

    Article  Google Scholar 

  • Bora D (1999) Epidemiology of visceral leishmaniasis in India. Natl Med J India 12(2):62–68

    Google Scholar 

  • Chakrabarti S, Sarkar S, Goswami BK, Sarkar N, Das S (2013) Clinico-haematological profile of visceral leishmaniasis in immunocompetent patients. Southeast Asian J Trop Med Public Health 44(2):143–149

    Google Scholar 

  • Clarke K, McLafferty S, Tempalski B (1996) On epidemiology and geographic information systems: a review and discussion of future directions. Emerg Infect Dis 2:85–92

    Article  Google Scholar 

  • Cohen C, Corazza F, De Mol P, Brasseur D (1991) Leishmaniasis acquired in Belgium. Lancet 338:128

    Article  Google Scholar 

  • Cruz I, Morales MA, Noguer I, Rodriguez A, Alvar J (2002) Leishmania in discarded syringes from intravenous drug users. Lancet 359:1124–1125

    Article  Google Scholar 

  • de Almeida AS, de Andrade MR, Werneck GL (2011) Identification of risk areas for visceral Leishmaniasis in Teresina, Piaui State, Brazil. Am J Trop Med Hyg 84(5):681–687

    Article  Google Scholar 

  • Dinesh DS, Ranjan A, Palit A, Kishore K, Kar SK (2001) Seasonal and nocturnal landing/biting behaviour of Phlebotomus argentipes (Diptera: Psychodidae). Ann Trop Med Parasitol 95(2):197–202

    Article  Google Scholar 

  • Feliciangeli MD, Delgado O, Suarez B, Bravo A (2006) Leishmania and sand flies: proximity to woodland as a risk factor for infection in a rural focus of visceral leishmaniasis in west central Venezuela. Tropical Med Int Health 11:1785–1791

    Article  Google Scholar 

  • GBD (2013) Mortality and Causes of Death Collaborators. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 385(9963):117–171

    Google Scholar 

  • Hailu A, Mudawi Musa A, Royce C, Wasunna M (2005) Visceral leishmaniasis: new health tools are needed. PLoS Med 2(7):e211. https://doi.org/10.1371/journal.pmed.0020211

    Article  Google Scholar 

  • Handler MZ, Patel PA, Kapila R, Al-Qubati Y, Schwartz RA (2015) Cutaneous and mucocutaneous leishmaniasis: clinical perspectives. J Am Acad Dermatol 73(6):897–908

    Article  Google Scholar 

  • Jervis S, Chapman LAC, Dwivedi S, Karthick M, Das A, Rutte EAL, Courtenay O, Medley GF, Banerjee I, Mahapatra T, Chaudhuri I, Srikantiah S, Hollingsworth TD (2017) Variations in visceral leishmaniasis burden, mortality and the pathway to care within Bihar, India. Parasit Vectors 10:601

    Article  Google Scholar 

  • Lane RP (1993) Sandflies (Phlebotominae). In: Lane RP, Crosskey RW (eds) Medical insects and arachnids. Chapman and Hall, London, pp 78–119

    Chapter  Google Scholar 

  • Luo EJ, Levitt L (2008) Massive splenomegaly. Hospital Physician, pp 31–38

    Google Scholar 

  • Mackie PF (1914) A flagellate infection of sandflies. Indian J Med Res 2:377–379

    Google Scholar 

  • Maroli M, Feliciangeli MD, Bichaud L, Charrel RN, Gradoni L (2012) Phlebotomine sandflies and the spreading of leishmaniases and other diseases of public health concern. Med Vet Entomol 27:123–147

    Article  Google Scholar 

  • Meinecke CK, Schottelius J, Oskam L, Fleischer B (1999) Congenital transmission of visceral leishmaniasis (kala azar) from an asymptomatic mother to her child. Pediatrics 104:e65

    Article  Google Scholar 

  • Oryan A, Akbari M (2016) Worldwide risk factors in leishmaniasis. Asian Pac J Trop Med 9(10):925–932

    Article  Google Scholar 

  • Picado A, Das ML, Kumar V, Dinesh DS, Rijal S, Singh SP, Das P, Coosemans M, Boelaert M, Davies C (2010a) Phlebotomus argentipes seasonal patterns in India and Nepal. J Med Entomol 47(2):283–286

    Article  Google Scholar 

  • Picado A, Das ML, Kumar V, Kesari S, Dinesh DS, Roy L, Rijal S, Das P, Rowland M, Sundar S, Coosemans M, Boelaert M, Davies CR (2010b) Effect of village-wide use of long-lasting insecticidal nets on visceral leishmaniasis vectors in India and Nepal: a cluster randomized trial. PLoS Negl Trop Dis 4(1):e587. https://doi.org/10.1371/journal.pnt-d.0000587

    Article  Google Scholar 

  • Quinnell RJ, Courtenay O (2009) Transmission, reservoir hosts and control of zoonotic visceral leishmaniasis. Parasitology 136(14):1915–1934

    Article  Google Scholar 

  • Ready PD (2013) Biology of phlebotomine sand flies as vectors of disease agents. Annu Rev Entomol 58:227–250

    Article  Google Scholar 

  • Rijal S, Uranw S, Chappuis F, Picado A, Khanal B, Paudel IS, Andersen EW, Meheus F, Ostyn B, Das ML, Davies C, Boelaert M (2010) Epidemiology of Leishmania donovani infection in high-transmission foci in Nepal. Tropical Med Int Health 15:21–28

    Article  Google Scholar 

  • Rogers DJ, Randolph SE, Snow RW, Hay SI (2002a) Satellite imagery in the study and forecast of malaria. Nature 415:710–715

    Article  Google Scholar 

  • Rogers ME, Chance ML, Bates PA (2002b) The role of promastigote secretory gel in the origin and transmission of the infective stage of Leishmania mexicana by the sandfly Lutzomyia longipalpis. Parasitology 124:495–508

    Article  Google Scholar 

  • Salomon OD, Orellano PW, Quintana MG, Pérez S, Sosa Estani S, Acardi S, Lamfri M (2006) Transmisión de la leishmaniasis tegumentaria en Argentina. Medicina (B Aires) 66:211–219

    Google Scholar 

  • Sanyal RK (1985) Leishmaniasis in the Indian subcontinent. In: Chang KP, Bray RS (eds) Leishmaniasis. Elsevier Science. Publishers, Amsterdam, pp 443–467

    Google Scholar 

  • Sanyal RK, Alam SN, Kaul SM, Wattal BL (1979a) Some observations on epidemiology of current outbreak of kala-azar in Bihar. J Commun Disord 11(4):170–182

    Google Scholar 

  • Sanyal RK, Banerjee DP, Ghosh TK, Ghosh IN, Misra BS, Roy YP, Rao OK (1979b) A longitudinal review of kala-azar in Bihar. J Commun Disord 11(4):149–169

    Google Scholar 

  • Short HE, Barraud PJ, Craighead AC (1927) Studies on methods of transmission of kala-azar. Indian J Med Res 14(3):589–600

    Google Scholar 

  • Shortt HE, Swaminath CS (1928) The method of feeding of Phlebotomus argentipes with relation to its bearing on the transmission of kala-azar. Indian J Med Res 15:827–836

    Google Scholar 

  • Torres-Guerrero E, Quintanilla-Cedillo MR, Ruiz-Esmenjaud J, Arenas R (2017) Leishmaniasis: a review. F1000Res 6:750. Published 2017 May 26. https://doi.org/10.12688/f1000research.11120.1

  • Williams P (1993) Relationships of Phlebotomine sand flies (Diptera). Mem Inst Oswaldo Cruz 88:177–183

    Article  Google Scholar 

  • World Health Organization (2004) Report of the scientific working group meeting on leishmaniasis. World Health Organization, Geneva

    Google Scholar 

  • World Health Organization (2016) End in sight accelerating the end of HIV, Tuberculosis, Malaria and Neglected Tropical diseases in the southeast Asia region. World Health Organization, Regional Office for South-East Asia, New Delhi

    Google Scholar 

  • World Health Organization (WHO) (2000a) The leishmaniasis and Leishmania/HIV co-infections. Fact sheet number 116. Geneva: World Health Organization

    Google Scholar 

  • World Health Organization (WHO) (2000b) The leishmaniasis and Leishmania/HIV co-infections. Fact sheet number 116. Geneva: World Health Organization

    Google Scholar 

  • World Health Organization (WHO) (2002) Urbanization: an increasing risk factor for leishmaniasis. Wkly Epidemiol Rec 77:365–372

    Google Scholar 

Download references

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Bhunia, G.S., Shit, P.K. (2020). Introduction of Visceral Leishmaniasis (Kala-azar). In: Spatial Mapping and Modelling for Kala-azar Disease. SpringerBriefs in Medical Earth Sciences. Springer, Cham. https://doi.org/10.1007/978-3-030-41227-2_1

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