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Immunotherapy for Melanoma

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Immunotherapy

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1244))

Abstract

While melanoma is less common than some other skin cancers, it is responsible for nearly 10,000 deaths in the USA each year alone. For many decades, very limited treatment options were available for patients with metastatic melanoma. However, recent breakthroughs have brought new hopes for patients and providers. While targeted therapy with BRAF and MEK inhibitors represents an important cornerstone in the treatment of metastatic melanoma, this chapter carefully reviews the past and current therapy options available, with a significant focus on immunotherapy-based approaches. In addition, we provide an overview of the results of recent advances in the adjuvant setting for patients with resected stage III and stage IV melanoma, as well as in patients with melanoma brain metastases. Finally, we provide a quick overview over the current research efforts in the field of immuno-oncology and melanoma.

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Author information

Authors and Affiliations

  1. Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Aya A. Albittar

  2. Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Omar Alhalabi

  3. Department of Melanoma Medical Oncology, UT MD Anderson Cancer Center, Houston, TX, USA

    Isabella C. Glitza Oliva

Authors
  1. Aya A. Albittar
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  2. Omar Alhalabi
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  3. Isabella C. Glitza Oliva
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Correspondence to Isabella C. Glitza Oliva .

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Editors and Affiliations

  1. MD Anderson Cancer Center, University of Texas, Houston, TX, USA

    Aung Naing

  2. Baylor College of Medicine, Texas Children’s Hospital, Houston, TX, USA

    Joud Hajjar

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Albittar, A.A., Alhalabi, O., Glitza Oliva, I.C. (2020). Immunotherapy for Melanoma. In: Naing, A., Hajjar, J. (eds) Immunotherapy. Advances in Experimental Medicine and Biology, vol 1244. Springer, Cham. https://doi.org/10.1007/978-3-030-41008-7_3

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