Abstract
In recent years, environmentally friendly polymers are gaining considerable interest. Biorenewable polymers are promising materials which fall in this category. Among the biorenewable polymers known, Lignin is one of the most vastly used polymers. It is the most abundant natural polymer after cellulose. Lignin can be an excellent material having a potential of replacing other synthetic polymers in drug delivery and biomedical applications due to its excellent biocompatibility and nontoxic nature. Hence, lignin micro- and nanoparticles are gaining high interest in the research fraternity. Syntheses of a wide range of polymer nanoparticles have been reported. However, the usage of the reports to the synthesis of lignin micro- and nanoparticles is limited due to the physicochemical properties of lignin. The present chapter discusses the various approaches suitable for preparation of lignin micro- or nanoparticles. The effect of different experimental parameters and their physicochemical properties at nanoscale are also thoroughly explored. A brief discussion on the applications of lignin micro- or nanoparticles in drug delivery, biomedical science, nanomedicine, and therapeutics is also explored.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Aadil KR, Jha H (2016) Physico-chemical properties of lignin–alginate based films in the presence of different plasticizers. Iran Polym J 25:661–670. https://doi.org/10.1007/s13726-016-0449-1
Aadil KR, Barapatre A, Sahu S et al (2014) Free radical scavenging activity and reducing power of Acacia nilotica wood lignin. Int J Biol Macromol 67:220–227. https://doi.org/10.1016/J.IJBIOMAC.2014.03.040
Aadil KR, Barapatre A, Jha H (2016a) Synthesis and characterization of Acacia lignin-gelatin film for its possible application in food packaging. Bioresour Bioprocess 3:27. https://doi.org/10.1186/s40643-016-0103-y
Aadil KR, Barapatre A, Meena AS, Jha H (2016b) Hydrogen peroxide sensing and cytotoxicity activity of Acacia lignin stabilized silver nanoparticles. Int J Biol Macromol 82:39–47. https://doi.org/10.1016/J.IJBIOMAC.2015.09.072
Aadil KR, Prajapati D, Jha H (2016c) Improvement of physcio-chemical and functional properties of alginate film by Acacia lignin. Food Packag Shelf Life 10:25–33. https://doi.org/10.1016/J.FPSL.2016.09.002
Aadil KR, Mussatto SI, Jha H (2018a) Synthesis and characterization of silver nanoparticles loaded poly(vinyl alcohol)-lignin electrospun nanofibers and their antimicrobial activity. Int J Biol Macromol 120:763–767. https://doi.org/10.1016/J.IJBIOMAC.2018.08.109
Aadil KR, Nathani A, Sharma CS et al (2018b) Fabrication of biocompatible alginate-poly(vinyl alcohol) nanofibers scaffolds for tissue engineering applications. Mater Technol 33:507–512. https://doi.org/10.1080/10667857.2018.1473234
Ago M, Jakes JE, Johansson L-S et al (2012a) Interfacial properties of lignin-based electrospun nanofibers and films reinforced with cellulose nanocrystals. ACS Appl Mater Interfaces 4:6849–6856. https://doi.org/10.1021/am302008p
Ago M, Okajima K, Jakes JE et al (2012b) Lignin-based electrospun nanofibers reinforced with cellulose nanocrystals. Biomacromol 13:918–926. https://doi.org/10.1021/bm201828g
Ago M, Jakes JE, Rojas OJ (2013) Thermomechanical properties of lignin-based electrospun nanofibers and films reinforced with cellulose nanocrystals: a dynamic mechanical and nanoindentation study. ACS Appl Mater Interfaces 5:11768–11776. https://doi.org/10.1021/am403451w
Ago M, Huan S, Borghei M et al (2016) High-throughput synthesis of lignin particles (∼30 nm to ∼2 μm) via Aerosol Flow Reactor: Size Fractionation and Utilization in Pickering Emulsions. ACS Appl Mater Interfaces 8:23302–23310. https://doi.org/10.1021/acsami.6b07900
Ahmed I, Liu H-Y, Mamiya PC et al (2006) Three-dimensional nanofibrillar surfaces covalently modified with tenascin-C-derived peptides enhance neuronal growthin vitro. J Biomed Mater Res Part A 76A:851–860. https://doi.org/10.1002/jbm.a.30587
Anderson JM, Hiltner A, Schodt K, Woods R (1972) Biopolymers as biomaterials: mechanical properties of?-benzyl-L-glutamate-L-Leucine copolymers. J Biomed Mater Res 6:25–35. https://doi.org/10.1002/jbm.820060405
Anderson DG, Levenberg S, Langer R (2004) Nanoliter-scale synthesis of arrayed biomaterials and application to human embryonic stem cells. Nat Biotechnol 22:863–866. https://doi.org/10.1038/nbt981
Antman-Passig M, Shefi O (2016) Remote magnetic orientation of 3D collagen hydrogels for directed neuronal regeneration. Nano Lett 16:2567–2573. https://doi.org/10.1021/acs.nanolett.6b00131
Antman-Passig M, Levy S, Gartenberg C et al (2017) Mechanically oriented 3D collagen hydrogel for directing neurite growth. Tissue Eng Part A 23:403–414. https://doi.org/10.1089/ten.tea.2016.0185
Ashokkumar M, Lee J, Iida Y et al (2010) Spatial distribution of acoustic cavitation bubbles at different ultrasound frequencies. ChemPhysChem 11:1680–1684. https://doi.org/10.1002/cphc.200901037
Atkins M, Damidot D, Glasser FP (1993) Performance of cementitious systems in the repository. MRS Proc 333:315. https://doi.org/10.1557/PROC-333-315
Babu SG, Karthik P, John MC et al (2019) Synergistic effect of sono-photocatalytic process for the degradation of organic pollutants using CuO-TiO2/rGO. Ultrason Sonochem 50:218–223. https://doi.org/10.1016/J.ULTSONCH.2018.09.021
Baranes K, Shevach M, Shefi O, Dvir T (2016) Gold nanoparticle-decorated scaffolds promote neuronal differentiation and maturation. Nano Lett 16:2916–2920. https://doi.org/10.1021/acs.nanolett.5b04033
Barapatre A, Aadil KR, Tiwary BN, Jha H (2015) In vitro antioxidant and antidiabetic activities of biomodified lignin from Acacia nilotica wood. Int J Biol Macromol 75:81–89. https://doi.org/10.1016/J.IJBIOMAC.2015.01.012
Barapatre A, Aadil KR, Jha H (2016) Synergistic antibacterial and antibiofilm activity of silver nanoparticles biosynthesized by lignin-degrading fungus. Bioresour Bioprocess 3:8. https://doi.org/10.1186/s40643-016-0083-y
Barapatre A, Aadil KR, Jha H (2017) Biodegradation of Malachite Green by the Ligninolytic Fungus Aspergillus flavus. Clean Soil Air Water 45:1600045. https://doi.org/10.1002/clen.201600045
Beisl S, Friedl A, Miltner A et al (2017a) Lignin from micro- to nanosize: applications. Int J Mol Sci 18:2367. https://doi.org/10.3390/ijms18112367
Beisl S, Miltner A, Friedl A et al (2017b) Lignin from micro- to nanosize: production methods. Int J Mol Sci 18:1244. https://doi.org/10.3390/ijms18061244
Bruce RJ, West CA (1989) Elicitation of lignin biosynthesis and isoperoxidase activity by pectic fragments in suspension cultures of castor bean. Plant Physiol 91:889–897. https://doi.org/10.1104/PP.91.3.889
Buesser B, Pratsinis SE (2012) Design of nanomaterial synthesis by aerosol processes. Annu Rev Chem Biomol Eng 3:103–127. https://doi.org/10.1146/annurev-chembioeng-062011-080930
Caicedo HM, Dempere LA, Vermerris W (2012) Template-mediated synthesis and bio-functionalization of flexible lignin-based nanotubes and nanowires. Nanotechnology 23:105605. https://doi.org/10.1088/0957-4484/23/10/105605
Charoenchaitrakool M, Dehghani F, Foster NR, Chan HK (2000) Micronization by rapid expansion of supercritical solutions to enhance the dissolution rates of poorly water-soluble pharmaceuticals. Ind Eng Chem Res 39:4794–4802. https://doi.org/10.1021/IE000151A
Chaudhary A, Dwivedi C, Gupta A, Nandi CK (2015) One pot synthesis of doxorubicin loaded gold nanoparticles for sustained drug release. RSC Adv 5:97330–97334. https://doi.org/10.1039/C5RA12892G
Chawla M, Kumar R, Siril PF (2016) High catalytic activities of palladium nanowires synthesized using liquid crystal templating approach. J Mol Catal A: Chem 423:126–134. https://doi.org/10.1016/J.MOLCATA.2016.06.014
Chawla M, Dubey R, Singh G et al (2017a) Controlling the morphology of layered double hydroxides of Mn and Co and their exceptional catalytic activities. Thermochim Acta 654:130–139. https://doi.org/10.1016/J.TCA.2017.05.017
Chawla M, Randhawa JK, Siril PF (2017b) Calcination temperature as a probe to tune the non-enzymatic glucose sensing activity of Cu–Ni bimetallic nanocomposites. New J Chem 41:4582–4591. https://doi.org/10.1039/C6NJ03920K
Chawla M, Sharma V, Randhawa JK (2017c) Facile one pot synthesis of CuO nanostructures and their effect on Nonenzymatic Glucose Biosensing. Electrocatalysis 8:27–35. https://doi.org/10.1007/s12678-016-0337-7
Chawla M, Kumari A, Siril PF (2018) Exceptional catalytic activities and sensing performance of palladium decorated anisotropic gold nanoparticles. ChemistrySelect 3:9071–9083. https://doi.org/10.1002/slct.201801426
Chen X, Kuo D-H, Lu D et al (2016) Synthesis and photocatalytic activity of mesoporous TiO2 nanoparticle using biological renewable resource of un-modified lignin as a template. Microporous Mesoporous Mater 223:145–151. https://doi.org/10.1016/J.MICROMESO.2015.11.005
Cui H, Hanus R, Kessler MR (2013) Degradation of ROMP-based bio-renewable polymers by UV radiation. Polym Degrad Stab 98:2357–2365. https://doi.org/10.1016/J.POLYMDEGRADSTAB.2013.08.003
Dallmeyer I, Ko F, Kadla JF (2010) Electrospinning of technical lignins for the production of fibrous networks. J Wood Chem Technol 30:315–329. https://doi.org/10.1080/02773813.2010.527782
Dalton L (2002) Nonlinear optical polymeric materials: from chromophore design to commercial applications. Polymers for photonics applications I. Springer, Berlin, Heidelberg, pp 1–86
Dalvi SV, Mukhopadhyay M (2009) A novel process for precipitation of ultra-fine particles using sub-critical CO2. Powder Technol 195:190–195. https://doi.org/10.1016/J.POWTEC.2009.05.029
Dang JM, Leong KW (2006) Natural polymers for gene delivery and tissue engineering. Adv Drug Deliv Rev 58:487–499. https://doi.org/10.1016/J.ADDR.2006.03.001
Davin LB, Lewis NG (2005) Lignin primary structures and dirigent sites. Curr Opin Biotechnol 16:407–415. https://doi.org/10.1016/J.COPBIO.2005.06.011
De Oliveira W, Glasser WG (1994) Multiphase materials with lignin. XII. Blends of poly(vinyl chloride) with lignin–caprolactone copolymers. J Appl Polym Sci 51:563–571. https://doi.org/10.1002/app.1994.070510320
del Agua I, Marina S, Pitsalidis C et al (2018) Conducting polymer scaffolds based on Poly(3,4-ethylenedioxythiophene) and Xanthan Gum for live-cell monitoring. ACS Omega 3:7424–7431. https://doi.org/10.1021/acsomega.8b00458
Didenko YT, McNamara WB, Suslick KS (1999) Hot spot conditions during cavitation in water. https://doi.org/10.1021/ja9844635
Dubey R, Chawla M, Siril PF, Singh G (2013) Bi-metallic nanocomposites of Mn with very high catalytic activity for burning rate enhancement of composite solid propellants. Thermochim Acta 572:30–38. https://doi.org/10.1016/J.TCA.2013.09.005
Dutt S, Sharma R (2017) Controlling the polypyrrole microstructures using swollen liquid crystals as structure directing agent. Mater Res Express 4:105305. https://doi.org/10.1088/2053-1591/aa9192
Dutt S, Siril PF (2014a) A novel approach for the synthesis of polyaniline nanostructures using swollen liquid crystal templates. Mater Lett 124:50–53. https://doi.org/10.1016/J.MATLET.2014.03.068
Dutt S, Siril PF (2014b) Morphology controlled synthesis of polyaniline nanostructures using swollen liquid crystal templates. J Appl Polym Sci 131. https://doi.org/10.1002/app.40800
Dutt S, Siril PF (2015) Controlling the morphology of polyaniline–platinum nanocomposites using swollen liquid crystal templates. Synth Met 209:82–90. https://doi.org/10.1016/J.SYNTHMET.2015.07.012
Dutt S, Kumar R, Siril PF (2015) Green synthesis of a palladium–polyaniline nanocomposite for green Suzuki-Miyaura coupling reactions. RSC Adv 5:33786–33791. https://doi.org/10.1039/C5RA05007C
Dutt S, Siril PF, Remita S (2017) Swollen liquid crystals (SLCs): a versatile template for the synthesis of nano structured materials. RSC Adv 7:5733–5750. https://doi.org/10.1039/C6RA26390A
Dutt S, Vats T, Siril PF (2018) Synthesis of polyaniline–magnetite nanocomposites using swollen liquid crystal templates for magnetically separable dye adsorbent applications. New J Chem 42:5709–5719. https://doi.org/10.1039/C7NJ04637E
Duval A, Lawoko M (2014) A review on lignin-based polymeric, micro- and nano-structured materials. React Funct Polym 85:78–96. https://doi.org/10.1016/J.REACTFUNCTPOLYM.2014.09.017
Dwivedi C, Gupta A, Chaudhary A, Nandi CK (2014) Gold nanoparticle chitosan composite hydrogel beads show efficient removal of methyl parathion from waste water. RSC Adv 4:39830. https://doi.org/10.1039/C4RA03870C
Edgar KJ, Buchanan CM, Debenham JS et al (2001) Advances in cellulose ester performance and application. Prog Polym Sci 26:1605–1688. https://doi.org/10.1016/S0079-6700(01)00027-2
Eerikäinen H, Watanabe W, Kauppinen EI, Ahonen PP (2003) Aerosol flow reactor method for synthesis of drug nanoparticles. Eur J Pharm Biopharm 55:357–360. https://doi.org/10.1016/S0939-6411(03)00005-5
Felix SP, Singh G, Sikder AK, Aggrawal JP (2005) Studies on energetic compounds: Part 33: thermolysis of keto-RDX and its plastic bonded explosives containing thermally stable polymers. Thermochim Acta 426:53–60. https://doi.org/10.1016/J.TCA.2004.06.020
Figueiredo P, Lintinen K, Kiriazis A et al (2017) In vitro evaluation of biodegradable lignin-based nanoparticles for drug delivery and enhanced antiproliferation effect in cancer cells. Biomaterials 121:97–108. https://doi.org/10.1016/J.BIOMATERIALS.2016.12.034
Figueiredo P, Lintinen K, Hirvonen JT et al (2018) Properties and chemical modifications of lignin: towards lignin-based nanomaterials for biomedical applications. Prog Mater Sci 93:233–269. https://doi.org/10.1016/J.PMATSCI.2017.12.001
Fitz Patrick M, Champagne P, Cunningham MF, Whitney RA (2010) A biorefinery processing perspective: treatment of lignocellulosic materials for the production of value-added products. Bioresour Technol 101:8915–8922. https://doi.org/10.1016/J.BIORTECH.2010.06.125
Flannigan DJ, Suslick KS (2005) Plasma formation and temperature measurement during single-bubble cavitation. Nature 434:52–55. https://doi.org/10.1038/nature03361
Francis Suh J-K, Matthew HW (2000) Application of chitosan-based polysaccharide biomaterials in cartilage tissue engineering: a review. Biomaterials 21:2589–2598. https://doi.org/10.1016/S0142-9612(00)00126-5
Frangville C, Rutkevičius M, Richter AP et al (2012) Fabrication of environmentally biodegradable lignin nanoparticles. ChemPhysChem 13:4235–4243. https://doi.org/10.1002/cphc.201200537
Furusawa Y, Fujiwara Y, Campbell P et al (2012) DNA double-strand breaks induced by cavitational mechanical effects of ultrasound in cancer cell lines. PLoS One 7:e29012. https://doi.org/10.1371/journal.pone.0029012
Gedanken A (2004) Using sonochemistry for the fabrication of nanomaterials. Ultrason Sonochem 11:47–55. https://doi.org/10.1016/J.ULTSONCH.2004.01.037
Ghosh D, Khastgir D (2018) Degradation and stability of polymeric high-voltage insulators and prediction of their service life through environmental and accelerated aging processes. ACS Omega 3:11317–11330. https://doi.org/10.1021/acsomega.8b01560
Gilca IA, Popa VI, Crestini C (2015) Obtaining lignin nanoparticles by sonication. Ultrason Sonochem 23:369–375. https://doi.org/10.1016/J.ULTSONCH.2014.08.021
Gross SK, Sarkanen K, Schuerch C (1958) Determinations of molecular weight of lignin degradation products by three methods. Anal Chem 30:518–521. https://doi.org/10.1021/ac60136a020
Gupta A, Nandi CK (2017) PC12 live cell ultrasensitive neurotransmitter signaling using high quantum yield sulphur doped carbon dots and its extracellular Ca2 + ion dependence. Sensors Actuators B Chem 245:137–145. https://doi.org/10.1016/J.SNB.2017.01.145
Gupta AK, Mohanty S, Nayak SK (2014) Synthesis, characterization and application of Lignin Nanoparticles (LNPs). Mater Focus 3:444–454. https://doi.org/10.1166/mat.2014.1217
Gupta A, Chaudhary A, Mehta P et al (2015) Nitrogen-doped, thiol-functionalized carbon dots for ultrasensitive Hg(ii) detection. Chem Commun 51:10750–10753. https://doi.org/10.1039/C5CC03019F
Gupta A, Verma NC, Khan S et al (2016a) Paper strip based and live cell ultrasensitive lead sensor using carbon dots synthesized from biological media. Sensors Actuators B Chem 232:107–114. https://doi.org/10.1016/J.SNB.2016.03.110
Gupta A, Verma NC, Khan S, Nandi CK (2016b) Carbon dots for naked eye colorimetric ultrasensitive arsenic and glutathione detection. Biosens Bioelectron 81:465–472. https://doi.org/10.1016/J.BIOS.2016.03.018
Gutiérrez MC, Ferrer ML, del Monte F (2008) Ice-templated materials: sophisticated structures exhibiting enhanced functionalities obtained after unidirectional freezing and ice-segregation-induced self-assembly. Chem Mater 20:634–648. https://doi.org/10.1021/cm702028z
Hafeez HY, Lakhera SK, Ashokkumar M, Neppolian B (2019) Ultrasound assisted synthesis of reduced graphene oxide (rGO) supported InVO4-TiO2 nanocomposite for efficient hydrogen production. Ultrason Sonochem 53:1–10. https://doi.org/10.1016/J.ULTSONCH.2018.12.009
Han T, Sophonrat N, Tagami A et al (2019) Characterization of lignin at pre-pyrolysis temperature to investigate its melting problem. Fuel 235:1061–1069. https://doi.org/10.1016/J.FUEL.2018.08.120
Hatfield RD, Jung H-JG, Ralph J et al (1994) A comparison of the insoluble residues produced by the Klason lignin and acid detergent lignin procedures. J Sci Food Agric 65:51–58. https://doi.org/10.1002/jsfa.2740650109
Hosseini M, Fazelian N, Fakhri A et al (2019) Preparation, and structural of new NiS-SiO2 and Cr2S3-TiO2 nano-catalyst: photocatalytic and antimicrobial studies. J Photochem Photobiol B Biol 194:128–134. https://doi.org/10.1016/J.JPHOTOBIOL.2019.03.016
Huang L, McMillan RA, Apkarian RP et al (2000) Generation of synthetic elastin-mimetic small diameter fibers and fiber networks. https://doi.org/10.1021/ma991858f
Huebsch N, Mooney DJ (2009) Inspiration and application in the evolution of biomaterials. Nature 462:426–432. https://doi.org/10.1038/nature08601
Iden R, Schrof W, Hadeler J, Lehmann S (2003) Combinatorial materials research in the polymer industry: speed versus flexibility. Macromol Rapid Commun 24:63–72. https://doi.org/10.1002/marc.200390019
Jin G-Z, Kim M, Shin US, Kim H-W (2011) Neurite outgrowth of dorsal root ganglia neurons is enhanced on aligned nanofibrous biopolymer scaffold with carbon nanotube coating. Neurosci Lett 501:10–14. https://doi.org/10.1016/J.NEULET.2011.06.023
Jung YJ, Kar S, Talapatra S et al (2006) Aligned Carbon nanotube − polymer hybrid architectures for diverse flexible electronic applications. https://doi.org/10.1021/nl052238x
Kabanov AV (2006) Polymer genomics: an insight into pharmacology and toxicology of nanomedicines. Adv Drug Deliv Rev 58:1597–1621. https://doi.org/10.1016/J.ADDR.2006.09.019
Kogan G, Šoltés L, Stern R, Gemeiner P (2006) Hyaluronic acid: a natural biopolymer with a broad range of biomedical and industrial applications. Biotechnol Lett 29:17–25. https://doi.org/10.1007/s10529-006-9219-z
Košíková B, Gregorová A, Osvald A, Krajčovičová J (2007) Role of lignin filler in stabilization of natural rubber–based composites. J Appl Polym Sci 103:1226–1231. https://doi.org/10.1002/app.24530
Klossner RR, Queen HA, Coughlin AJ, Krause WE (2008) Correlation of chitosan’s rheological properties and its ability to electrospin. Biomacromolcules, 2009, 9(10):2947–2953. https://doi.org/10.1021/bm800738u
Kumar R (2016) Repositioning of Non-Steroidal Anti Inflammatory Drug (NSAIDs) for cancer treatment: promises and challenges. J Nanomed Nanotechnol 7:e140. https://doi.org/10.4172/2157-7439.1000e140
Kumar R (2019a) Lipid-based nanoparticles for drug-delivery systems. Nanocarriers Drug Deliv 249–284. https://doi.org/10.1016/B978-0-12-814033-8.00008-4
Kumar R (2019b) Nanotechnology based approaches to enhance aqueous solubility and bioavailability of griseofulvin: a literature survey. J Drug Deliv Sci Tec 53:101221. https://doi.org/10.1016/j.jddst.2019.101221
Kumar R (2020) Solubility and Bioavailability of Fenofibrate Nanoformulations. ChemistrySelect, 5(4):1478–1490. https://doi.org/10.1002/slct.201903647
Kumar R, Siril PF (2014) Ultrafine carbamazepine nanoparticles with enhanced water solubility and rate of dissolution. RSC Adv 4:48101–48108. https://doi.org/10.1039/C4RA08495K
Kumar R, Siril PF (2015) Controlling the size and morphology of griseofulvin nanoparticles using polymeric stabilizers by evaporation-assisted solvent–antisolvent interaction method. J Nanoparticle Res 17:256. https://doi.org/10.1007/s11051-015-3066-6
Kumar R, Siril PF (2016) Preparation and characterization of polyvinyl alcohol stabilized griseofulvin nanoparticles. Mater Today Proc 3:2261–2267. https://doi.org/10.1016/J.MATPR.2016.04.135
Kumar R, Siril PF (2018) Enhancing the solubility of fenofibrate by nanocrystal formation and encapsulation. AAPS PharmSciTech 19:284–292. https://doi.org/10.1208/s12249-017-0840-z
Kumar R, Siril PF (2020) Drop-by-drop solvent hot antisolvent interaction method for engineering nanocrystallization of sulfamethoxazole to enhanced water solubility and bioavailablility. J Drug Deliv Sci Tec 55:101359. https://doi.org/10.1016/j.jddst.2019.101359
Kumar R, Siril PF, Soni P (2014) Preparation of Nano-RDX by evaporation assisted solvent antisolvent interaction. Propellants Explos Pyrotech 39:383–389. https://doi.org/10.1002/prep.201300104
Kumar R, Siril PF, Soni P (2015a) Tuning the particle size and morphology of high energetic material nanocrystals. Def Technol 11:382–389. https://doi.org/10.1016/J.DT.2015.07.002
Kumar R, Siril PF, Soni P (2015b) Optimized synthesis of HMX nanoparticles using antisolvent precipitation method. J Energ Mater 33:277–287. https://doi.org/10.1080/07370652.2014.988774
Kumar R, Siril PF, Javid F (2016) Unusual anti-leukemia activity of nanoformulated naproxen and other non-steroidal anti-inflammatory drugs. Mater Sci Eng C 69:1335–1344. https://doi.org/10.1016/j.msec.2016.08.024
Kumar R, Singh A, Garg N, Siril PF (2018a) Solid lipid nanoparticles for the controlled delivery of poorly water soluble non-steroidal anti-inflammatory drugs. Ultrason Sonochem 40:686–696. https://doi.org/10.1016/J.ULTSONCH.2017.08.018
Kumar VB, Kumar R, Gedanken A, Shefi O (2018b) Fluorescent metal-doped carbon dots for neuronal manipulations. Ultrason Sonochem, 2019, 52:205–213. https://doi.org/10.1016/j.ultsonch.2018.11.017
Kumar R, Kumar VB, Marcus M (2019a) Elements (B, N, P) doped carbon dots interaction with neural cells: promising results and future prospective. In: Proceedings SPIE 10892, colloidal nanoparticles for biomedical applications XIV, p 1089214. https://doi.org/10.1117/12.2509610
Kumar R, Soni P, Siril PF (2019b) Engineering the morphology and particle size of high energetic compounds using drop-by-drop and drop-to-drop solvent-antisolvent interaction methods. ACS Omega 4:5424–5433. https://doi.org/10.1021/acsomega.8b03214
Kumar VB, Kumar R, Friedman O et al (2019c) One-pot hydrothermal synthesis of elements (B, N, P)-doped fluorescent Carbon dots for cell labelling, differentiation and outgrowth of neuronal cells. ChemistrySelect 4:4222–4232. https://doi.org/10.1002/slct.201900581
Kumar R, Singh A, Garg N (2019d) Acoustic cavitation-assisted formulation of solid lipid nanoparticles using different Stabilizers. ACS Omega 4 (8):13360–13370. https://doi.org/10.1021/acsomega.9b01532
Kumar R, Singh A, Garg N (2019e) Acoustic cavitation assisted hot melt mixing technique for solid lipid nanoparticles formulation, characterization, and controlled delivery of poorly water soluble drugs. J Drug Deliv Sci Tec 54:101277. https://doi.org/10.1016/j.jddst.2019.101277
Kumar R, Kumar VB, Gedanken A (2020a) The sonochemical synthesis of carbon dots: Synthetic route, effect of parameters, and catalytic, energy, biomedical and tissue engineering applications. Ultrason Sonochem 105009. https://doi.org/10.1016/j.ultsonch.2020.105009
Kumar R, Singh A, Sharma K, Dhasmana D, Garg N, Siril PF (2020b) Preparation, characterization and in vitro cytotoxicity of Fenofibrate and Nabumetone loaded solid lipid nanoparticles. Mater Sci Eng: C 106:110184. https://doi.org/10.1016/j.msec.2019.110184
Li Y, Sarkanen S (2005) Miscible blends of kraft lignin derivatives with low-Tg polymers. Macromolecules, 2005, 38(6):2296–2306. https://doi.org/10.1021/ma047546g
Li J, Gellerstedt G, Toven K (2009) Steam explosion lignins; their extraction, structure and potential as feedstock for biodiesel and chemicals. Bioresour Technol 100:2556–2561. https://doi.org/10.1016/J.BIORTECH.2008.12.004
Lievonen M, Valle-Delgado JJ, Mattinen M-L et al (2016) A simple process for lignin nanoparticle preparation. Green Chem 18:1416–1422. https://doi.org/10.1039/C5GC01436K
Lopes MS, Jardini AL, Filho RM (2012) Poly (Lactic Acid) production for tissue engineering applications. Procedia Eng 42:1402–1413. https://doi.org/10.1016/J.PROENG.2012.07.534
Lu Q, Zhu M, Zu Y et al (2012) Comparative antioxidant activity of nanoscale lignin prepared by a Supercritical Antisolvent (SAS) process with non-nanoscale lignin. Food Chem 135:63–67. https://doi.org/10.1016/J.FOODCHEM.2012.04.070
Marcus M, Baranes K, Park M et al (2017) Interactions of Neurons with physical environments. Adv Healthc Mater 6:1700267
Martín A, Cocero MJ (2008) Micronization processes with supercritical fluids: fundamentals and mechanisms. Adv Drug Deliv Rev 60:339–350. https://doi.org/10.1016/J.ADDR.2007.06.019
McNamara WB, Didenko YT, Suslick KS (1999) Sonoluminescence temperatures during multi-bubble cavitation. Nature 401:772–775. https://doi.org/10.1038/44536
Meziani MJ, Pathak P, Hurezeanu R et al (2004) Supercritical-fluid processing technique for nanoscale polymer particles. Angew Chemie Int Ed 43:704–707. https://doi.org/10.1002/anie.200352834
Mogoşanu GD, Grumezescu AM (2014) Natural and synthetic polymers for wounds and burns dressing. Int J Pharm 463:127–136. https://doi.org/10.1016/J.IJPHARM.2013.12.015
Montero GA, Smith CB, Hendrix WA, Butcher DL (2000) Supercritical fluid technology in textile processing: an overview. Ind Eng Chem Res 39:4806–4812. https://doi.org/10.1021/IE0002475
Mukhopadhyay M, Dalvi SV (2004) Partial molar volume fraction of solvent in binary (CO2–solvent) solution for solid solubility predictions. J Supercrit Fluids 29:221–230. https://doi.org/10.1016/S0896-8446(03)00087-1
Myint AA, Lee HW, Seo B et al (2016) One pot synthesis of environmentally friendly lignin nanoparticles with compressed liquid carbon dioxide as an antisolvent. Green Chem 18:2129–2146. https://doi.org/10.1039/C5GC02398J
Naik SN, Goud VV, Rout PK, Dalai AK (2010) Production of first and second generation biofuels: a comprehensive review. Renew Sustain Energy Rev 14:578–597. https://doi.org/10.1016/J.RSER.2009.10.003
Nair SS, Sharma S, Pu Y et al (2014) High shear homogenization of lignin to nanolignin and thermal stability of Nanolignin-Polyvinyl Alcohol blends. Chemsuschem 7:3513–3520. https://doi.org/10.1002/cssc.201402314
Nie H, He A, Wu W et al (2009) Effect of poly(ethylene oxide) with different molecular weights on the electrospinnability of sodium alginate. Polymer (Guildf) 50:4926–4934. https://doi.org/10.1016/J.POLYMER.2009.07.043
Nitz H, Semke H, Mülhaupt R (2001) Influence of lignin type on the mechanical properties of lignin based compounds. Macromol Mater Eng 286:737. https://doi.org/10.1002/1439-2054(20011201)286:12%3c737:AID-MAME737%3e3.0.CO;2-2
Pathak P, Meziani MJ, Desai T, Sun YP (2004) Nanosizing drug particles in supercritical fluid processing. J Am Chem Soc 126:10842–10843. https://doi.org/10.1021/JA046914T
Paul DR, Robeson LM (2008) Polymer nanotechnology: nanocomposites. Polymer (Guildf) 49:3187–3204. https://doi.org/10.1016/J.POLYMER.2008.04.017
Pilloni M, Kumar VB, Ennas G et al (2018) Formation of metallic silver and copper in non-aqueous media by ultrasonic radiation. Ultrason Sonochem 47:108–113. https://doi.org/10.1016/J.ULTSONCH.2018.04.018
Rana RK, Mastai Y, Gedanken A (2002) Acoustic cavitation leading to the morphosynthesis of mesoporous silica vesicles. Adv Mater 14:1414–1418. https://doi.org/10.1002/1521-4095(20021002)14:19%3c1414:AID-ADMA1414%3e3.0.CO;2-F
Reddy N, Yang Y (2005) Biofibers from agricultural byproducts for industrial applications. Trends Biotechnol 23:22–27. https://doi.org/10.1016/J.TIBTECH.2004.11.002
Reddy N, Reddy R, Jiang Q (2015) Crosslinking biopolymers for biomedical applications. Trends Biotechnol 33:362–369. https://doi.org/10.1016/J.TIBTECH.2015.03.008
Reverchon E, Adami R (2006) Nanomaterials and supercritical fluids. J Supercrit Fluids 37:1–22. https://doi.org/10.1016/J.SUPFLU.2005.08.003
Reverchon E, Adami R, De Marco I et al (2005) Pigment Red 60 micronization using supercritical fluids based techniques. J Supercrit Fluids 35:76–82. https://doi.org/10.1016/J.SUPFLU.2004.10.010
Richter AP, Bharti B, Armstrong HB et al (2016) Synthesis and characterization of biodegradable lignin nanoparticles with tunable surface properties. Langmuir 32:6468–6477. https://doi.org/10.1021/acs.langmuir.6b01088
Rogowska-Tylman J, Locs J, Salma I et al (2019) In vivo and in vitro study of a novel nanohydroxyapatite sonocoated scaffolds for enhanced bone regeneration. Mater Sci Eng C 99:669–684. https://doi.org/10.1016/J.MSEC.2019.01.084
Sahoo S, Misra M, Mohanty AK (2013) Effect of compatibilizer and fillers on the properties of injection molded lignin-based hybrid green composites. J Appl Polym Sci 127:4110–4121. https://doi.org/10.1002/app.37667
Sameni J, Krigstin S, Sain M (2016) Characterization of Lignins isolated from industrial residues and their beneficial uses. BioResources 11(4):8435–8456. https://doi.org/10.15376/biores.11.4.8435-8456
Sarkanen S, Chen Y, Wang Y-Y (2016) Journey to polymeric materials composed exclusively of simple lignin derivatives. ACS Sustain Chem Eng 4:5223–5229. https://doi.org/10.1021/acssuschemeng.6b01700
Savy D, Nebbioso A, Mazzei P et al (2015) Molecular composition of water-soluble lignins separated from different non-food biomasses. Fuel Process Technol 131:175–181. https://doi.org/10.1016/J.FUPROC.2014.11.011
Seidlits SK, Lee JY, Schmidt CE (2008) Nanostructured scaffolds for neural applications. Nanomedicine 3:183–199. https://doi.org/10.2217/17435889.3.2.183
Shah S, Yin PT, Uehara TM et al (2014) Guiding stem cell differentiation into oligodendrocytes using graphene-nanofiber hybrid scaffolds. Adv Mater 26:3673–3680. https://doi.org/10.1002/adma.201400523
Sharma V, Sinha N, Dutt S et al (2016) Tuning the surface enhanced Raman scattering and catalytic activities of gold nanorods by controlled coating of platinum. J Colloid Interface Sci 463:180–187. https://doi.org/10.1016/J.JCIS.2015.10.036
Shi X, Karachi A, Hosseini M et al (2019) Ultrasound wave assisted removal of Ceftriaxone sodium in aqueous media with novel nano composite g-C3N4/MWCNT/Bi2WO6 based on CCD-RSM model. Ultrason Sonochem. https://doi.org/10.1016/J.ULTSONCH.2019.01.018
Singh G, Kapoor IPS, Dubey S, Siril PF (2009) Preparation, characterization and catalytic activity of transition Metal Oxide nanocrystals. J Sci Conf Proc 1:11–17. https://doi.org/10.1166/jcp.2009.002
Singh K, Gupta SP, Kumar A, Kumar A (2019) The effect of High Intensity Ultrasound (HIU) on the kinetics of crystallization of sucrose: elimination of latent period. Ultrason Sonochem 52:19–24. https://doi.org/10.1016/J.ULTSONCH.2018.05.030
Siril PF, Lehoux A, Ramos L et al (2012) Facile synthesis of palladium nanowires by a soft templating method. New J Chem 36:2135. https://doi.org/10.1039/c2nj40342k
Son Y, Lee D, Lee W et al (2019) Cavitational activity in heterogeneous systems containing fine particles. Ultrason Sonochem 58:104599. https://doi.org/10.1016/J.ULTSONCH.2019.05.016
Song M, Seo J, Kim H, Kim Y (2017) Flexible thermal sensors based on organic field-effect transistors with polymeric channel/gate-insulating and light-blocking layers. ACS Omega 2:4065–4070. https://doi.org/10.1021/acsomega.7b00494
Spender J, Demers AL, Xie X et al (2012) Method for production of polymer and carbon nanofibers from water-soluble polymers. Nano Lett 12:3857–3860. https://doi.org/10.1021/nl301983d
Stewart D (2008) Lignin as a base material for materials applications: Chemistry, application and economics. Ind Crops Prod 27:202–207. https://doi.org/10.1016/J.INDCROP.2007.07.008
Sun Y-P, Meziani MJ, Pathak P, Qu L (2005) Polymeric nanoparticles from rapid expansion of supercritical fluid solution. Chem A Eur J 11:1366–1373. https://doi.org/10.1002/chem.200400422
Suslick KS, Price GJ (1999) Applications of ultrasound to materials Chemistry. Annu Rev Mater Sci 29:295–326. https://doi.org/10.1146/annurev.matsci.29.1.295
Suslick KS, Hammerton DA, Cline RE (1986) Sonochemical hot spot. J Am Chem Soc 108:5641–5642. https://doi.org/10.1021/ja00278a055
Suslick KS, McNamara WB, Didenko Y (1999) Hot spot conditions during multi-bubble cavitation. Sonochemistry and sonoluminescence. Springer, Netherlands, Dordrecht, pp 191–204
Suyama K, Shirai M (2009) Photobase generators: recent progress and application trend in polymer systems. Prog Polym Sci 34:194–209. https://doi.org/10.1016/J.PROGPOLYMSCI.2008.08.005
Ten E, Ling C, Wang Y et al (2014) Lignin nanotubes as vehicles for gene delivery into human cells. Biomacromol 15:327–338. https://doi.org/10.1021/bm401555p
Thakur VK, Thakur MK (2014) Processing and characterization of natural cellulose fibers/thermoset polymer composites. Carbohydr Polym 109:102–117. https://doi.org/10.1016/J.CARBPOL.2014.03.039
Thakur VK, Thakur MK, Raghavan P, Kessler MR (2014) Progress in green polymer composites from lignin for multifunctional applications: a review. ACS Sustain Chem Eng 2:1072–1092. https://doi.org/10.1021/sc500087z
Thorat AA, Dalvi SV (2012) Liquid antisolvent precipitation and stabilization of nanoparticles of poorly water soluble drugs in aqueous suspensions: recent developments and future perspective. Chem Eng J 181–182:1–34. https://doi.org/10.1016/J.CEJ.2011.12.044
Thunga M, Chen K, Grewell D, Kessler MR (2014) Bio-renewable precursor fibers from lignin/polylactide blends for conversion to carbon fibers. Carbon 68:159–166. https://doi.org/10.1016/J.CARBON.2013.10.075 (N Y)
Topaz M, Motiei M, Assia E et al (2002) Acoustic cavitation in phacoemulsification: chemical effects, modes of action and cavitation index. Ultrasound Med Biol 28:775–784. https://doi.org/10.1016/S0301-5629(02)00514-8
Tortora M, Cavalieri F, Mosesso P et al (2014) Ultrasound driven assembly of lignin into microcapsules for storage and delivery of hydrophobic molecules. Biomacromol 15:1634–1643. https://doi.org/10.1021/bm500015j
Uggla C, Mellerowicz EJ, Sundberg B et al (1998) Indole-3-Acetic acid controls cambial growth in scots pine by positional signaling. Plant Physiol 117:113–121. https://doi.org/10.1104/pp.117.1.113
Varesano A, Aluigi A, Vineis C, Tonin C (2008) Study on the shear viscosity behavior of keratin/PEO blends for nanofibre electrospinning. J Polym Sci Part B: Polym Phys 46:1193–1201. https://doi.org/10.1002/polb.21452
Vats T, Siril PF (2017) A dataset for preparing pristine graphene-palladium nanocomposites using swollen liquid crystal templates. Sci Data 4:170196. https://doi.org/10.1038/sdata.2017.196
Vats T, Dutt S, Kumar R, Siril PF (2016) Facile synthesis of pristine graphene-palladium nanocomposites with extraordinary catalytic activities using swollen liquid crystals. Sci Rep 6:33053. https://doi.org/10.1038/srep33053
Wang X, Zhang Y, Hao C et al (2014) Solid-phase synthesis of Mesoporous ZnO using Lignin-Amine template and its photocatalytic properties. Ind Eng Chem Res 53:6585–6592. https://doi.org/10.1021/ie404179f
Xu H, Zeiger BW, Suslick KS (2013) Sonochemical synthesis of nanomaterials. Chem Soc Rev 42:2555–2567. https://doi.org/10.1039/C2CS35282F
Yang W, Fortunati E, Dominici F et al (2015a) Effect of processing conditions and lignin content on thermal, mechanical and degradative behavior of lignin nanoparticles/polylactic (acid) bionanocomposites prepared by melt extrusion and solvent casting. Eur Polym J 71:126–139. https://doi.org/10.1016/J.EURPOLYMJ.2015.07.051
Yang W, Kenny JM, Puglia D (2015b) Structure and properties of biodegradable wheat gluten bionanocomposites containing lignin nanoparticles. Ind Crops Prod 74:348–356. https://doi.org/10.1016/J.INDCROP.2015.05.032
Yang W, Fortunati E, Dominici F et al (2016a) Synergic effect of cellulose and lignin nanostructures in PLA based systems for food antibacterial packaging. Eur Polym J 79:1–12. https://doi.org/10.1016/J.EURPOLYMJ.2016.04.003
Yang W, Owczarek JS, Fortunati E et al (2016b) Antioxidant and antibacterial lignin nanoparticles in polyvinyl alcohol/chitosan films for active packaging. Ind Crops Prod 94:800–811. https://doi.org/10.1016/J.INDCROP.2016.09.061
Ye X, Wai CM (2003) Making nanomaterials in supercritical fluids: a review. J Chem Educ 80:198. https://doi.org/10.1021/ed080p198
Yearla SR, Padmasree K (2016) Preparation and characterisation of lignin nanoparticles: evaluation of their potential as antioxidants and UV protectants. J Exp Nanosci 11:289–302. https://doi.org/10.1080/17458080.2015.1055842
Zhang X, Li C, Luo Y (2011) Aligned/unaligned conducting polymer Cryogels with three-dimensional macroporous architectures from ice-segregation-induced self-assembly of PEDOT-PSS. Langmuir 27:1915–1923. https://doi.org/10.1021/la1044333
Zhang C, Gao Q, Zhou B, Bhargava G (2017) Preparation, characterization, and surface conductivity of nanocomposites with hollow graphitic carbon nanospheres as fillers in polymethylmethacrylate matrix. J Nanoparticle Res 19:269. https://doi.org/10.1007/s11051-017-3976-6
Zhao W, Liu L, Zhang F et al (2019) Shape memory polymers and their composites in biomedical applications. Mater Sci Eng C 97:864–883. https://doi.org/10.1016/J.MSEC.2018.12.054
Zhong J-F, Xu L, Qin X-L (2015) Efficient antibacterial silver nanoparticles composite using lignin as a template. J Compos Mater 49:2329–2335. https://doi.org/10.1177/0021998314545192
Zhou L, Kamyab H, Surendar A et al (2019) Novel Z-scheme composite Ag2CrO4/NG/polyimide as high performance nano catalyst for photoreduction of CO2: design, fabrication, characterization and mechanism. J Photochem Photobiol A Chem 368:30–40. https://doi.org/10.1016/J.JPHOTOCHEM.2018.09.006
Zimniewska M, Kozłowski R, Batog J (2008) Nanolignin modified linen fabric as a multifunctional product. Mol Cryst Liq Cryst 484:43[409]–50[416]. https://doi.org/10.1080/15421400801903395
Acknowledgements
All authors express their gratitude to the book editors Dr. Swati Sharma and Dr. Ashok Kumar Nadda for giving an opportunity for the contribution of book chapter and reviewer for their kind review process, comments, and suggestions to uplift the quality of book chapter. Dr. Raj Kumar is thankful to Council of Higher Education, Israel, for awarding Planning and Budget Committee Postdoctoral Fellowship. Dr. Abhishek Gupta is thankful to postdoctoral fellowships from the Jacob Blaustein Center for Scientific Cooperation, Ben-Gurion University of the Negev, Israel. Dr. Vijay Bhooshan Kumar, Dr. Abhishek Chaudhary, and Dr. Sunil Dutt are thankful to directors and departments of respective institutes viz., Bar Ilan University, Israel; Jaypee University Institute of Technology, India; and Himachal Pradesh Higher Education Department, Himachal Pradesh, India, respectively, for proving support and necessary facilities. Dr. Mohit Chawla thanks IIT Mandi and Gyan Sankul, Kullu for kind encouragement. Dr. Keshaw Ram Aadil thanks to Science and Engineering Research Board (SERB), India for awarding National Postdoctoral Fellowship (NPDF) (NPDF/2016/001156).
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Kumar, R. et al. (2020). Advances in Nanotechnology based Strategies for Synthesis of Nanoparticles of Lignin. In: Sharma, S., Kumar, A. (eds) Lignin. Springer Series on Polymer and Composite Materials. Springer, Cham. https://doi.org/10.1007/978-3-030-40663-9_7
Download citation
DOI: https://doi.org/10.1007/978-3-030-40663-9_7
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-40662-2
Online ISBN: 978-3-030-40663-9
eBook Packages: Chemistry and Materials ScienceChemistry and Material Science (R0)