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Role of Liver Stiffness in the Management of Liver Transplantation: First Experience and Clinical Practice

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Abstract

Liver stiffness has been evaluated in any context of the liver transplantation (LTX) as this organ is subject to both transplant-related diseases and those of the general population. So far, however, studies with limited case numbers have been published. Most experience has been gained with transient elastography and in the context of recurrent hepatitis C after transplantation. Periodic measurement of liver stiffness has a well-defined role in the life-long follow-up of the transplanted liver, and it has become part of the usual clinical practice as an easy-to-use and repeatable monitoring tool in the individual management of patients with the highest need of attention.

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Abbreviations

AIH:

Autoimmune hepatitis

ALD:

Alcoholic liver disease

ALP:

Alkaline phosphatase

ALT:

Alanine aminotransferase

APRI:

AST to platelet ratio index

ARFI:

Acoustic radiation force impulse

AST:

Aspartate aminotransferase

AUROC:

Area under receiver operating characteristic

BMI:

Body mass index

CAP:

Controlled attenuation parameter

CI:

Confidence interval

HCC:

Hepatocellular carcinoma

HE:

Hepatic steatosis

INR:

International normalized ratio

LB:

Liver biopsy

LDLT:

Living donor liver transplantation

LS:

Liver stiffness

LSM:

Liver stiffness measurement

MELD:

Model for end-stage liver disease

MRE:

Magnetic resonance elastography

NAFLD:

Non-alcoholic fatty liver disease

PBC:

Primary biliary cirrhosis

PSC:

Primary sclerosing cholangitis

p-SWE:

Point shear wave elastography

SWE:

Shear wave elastography

TE:

Transient elastography

ULN:

Upper limit of normal

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Author information

Authors and Affiliations

  1. Department of Medical Sciences, Liver Unit for Transplant Management—SATTE, AORN Sant’Anna e San Sebastiano, Caserta, Italy

    Guido Piai & Giovanna Valente

  2. Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Naples, Italy

    Luca Rinaldi

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  1. Guido Piai
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  2. Giovanna Valente
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  1. Department of Medicine and Center for Alcohol Research and Liver Diseases, Salem Medical Center, University of Heidelberg, Heidelberg, Germany

    Sebastian Mueller

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Piai, G., Valente, G., Rinaldi, L. (2020). Role of Liver Stiffness in the Management of Liver Transplantation: First Experience and Clinical Practice. In: Mueller, S. (eds) Liver Elastography. Springer, Cham. https://doi.org/10.1007/978-3-030-40542-7_36

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