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Noise-Induced Hearing Loss and Drug Therapy: Basic and Translational Science

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New Therapies to Prevent or Cure Auditory Disorders

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Abstract

Noise-induced hearing loss is the second leading cause of hearing impairment. The purpose of this chapter is to familiarize the reader with the anatomical, physiological, and perceptual consequences of noise trauma, as well as emerging treatments to attenuate these effects. The relationship between anatomical damage and functional deficits is complex and highly dependent on the type of noise, duration of the noise exposure, and the metric used to assess deficits. Recent studies have now identified potential early subclinical markers of noise-induced trauma that open opportunities for early identification and treatment. The chapter includes discussion of the current state of these findings, their limitations, and avenues for further research. Finally, the chapter reviews current pharmacological interventions, their targeted pathways, and mechanisms of action that may hold promise for future treatment.

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Authors and Affiliations

  1. School of Behavioral and Brain Sciences, The University of Texas at Dallas, Callier Center for Communication Disorders, Dallas, TX, USA

    Celia Escabi, Monica Trevino & Edward Lobarinas

  2. Department of Speech and Hearing Science, The Ohio State University, Columbus, OH, USA

    Eric Bielefeld

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  1. Celia Escabi
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  2. Monica Trevino
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  3. Eric Bielefeld
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  4. Edward Lobarinas
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Correspondence to Edward Lobarinas .

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  1. CILcare, Advanced Solution for Drug Development in Hearing Disorder, Montpellier, France

    Sylvie Pucheu

  2. Center for Hearing and Deafness, University at Buffalo, Buffalo, NY, USA

    Kelly E. Radziwon

  3. Center for Hearing and Deafness, University at Buffalo, Buffalo, NY, USA

    Richard Salvi

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Escabi, C., Trevino, M., Bielefeld, E., Lobarinas, E. (2020). Noise-Induced Hearing Loss and Drug Therapy: Basic and Translational Science. In: Pucheu, S., Radziwon, K., Salvi, R. (eds) New Therapies to Prevent or Cure Auditory Disorders. Springer, Cham. https://doi.org/10.1007/978-3-030-40413-0_2

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