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HSF1 and Molecular Chaperones in Biology and Cancer pp 101–111Cite as

The Role of HSF1 and the Chaperone Network in the Tumor Microenvironment

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1243))

Abstract

Tumors are stressful environments. As tumors evolve from single mutated cancer cells into invasive malignancies they must overcome various constraints and barriers imposed by a hostile microenvironment. To achieve this, cancer cells recruit and rewire cells in their microenvironment to become pro-tumorigenic. We propose that chaperones are vital players in this process, and that activation of stress responses helps tumors adapt and evolve into aggressive malignancies, by enabling phenotypic plasticity in the tumor microenvironment (TME). In this chapter we will review evidence supporting non-cancer-cell-autonomous activity of chaperones in human patients and mouse models of cancer, discuss the mechanisms by which this non-cell-autonomous activity is mediated and provide an evolutionary perspective on the basis of this phenomenon.

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Acknowledgements

N.G. is supported by the Israel cancer research foundation. O.L.G. is supported by the Minerva foundation and the Thompson family foundation. R.S.S is supported by the Israel Science Foundation (grants No. 401/17 and 1384/1), the European Research Council (ERC grant agreement 754320), the Laura Gurwin Flug Family Fund, the Peter and Patricia Gruber Awards, the Comisaroff Family Trust, the Estate of Annice Anzelewitz, and the Estate of Mordecai M. Roshwal. R.S.S is the incumbent of the Ernst and Kaethe Ascher Career Development Chair in Life Sciences.

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Authors and Affiliations

  1. Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel

    Nil Grunberg, Oshrat Levi-Galibov & Ruth Scherz-Shouval

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  1. Nil Grunberg
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  2. Oshrat Levi-Galibov
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  3. Ruth Scherz-Shouval
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Correspondence to Ruth Scherz-Shouval .

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Editors and Affiliations

  1. Northwestern University Feinberg School of Medicine, Chicago, IL, USA

    Marc Laurence Mendillo

  2. University of Chicago, Chicago, IL, USA

    David Pincus

  3. Weizmann Institute of Science, Rehovot, Israel

    Ruth Scherz-Shouval

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Grunberg, N., Levi-Galibov, O., Scherz-Shouval, R. (2020). The Role of HSF1 and the Chaperone Network in the Tumor Microenvironment. In: Mendillo, M.L., Pincus, D., Scherz-Shouval, R. (eds) HSF1 and Molecular Chaperones in Biology and Cancer. Advances in Experimental Medicine and Biology, vol 1243. Springer, Cham. https://doi.org/10.1007/978-3-030-40204-4_7

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