Abstract
How an animal responds to environmental stressors and threats is essential for survival. These responses are governed through an interconnected circuit in the brain dubbed the limbic system. Three main structures of the limbic system are the amygdala, bed nucleus of the stria terminalis (BNST), and hypothalamus. Together these structures define a central stress-threat circuit. This chapter describes the most up to date knowledge of how these structures function in regulating responses to stressors and how each of these structures is formed from embryonic development. This knowledge of the underlying biology of these regions is essential to design rational therapeutic approaches for conditions, such as post-traumatic stress disorder (PTSD) that are characterized by dysregulation of the stress-threat system. In this chapter, we also describe the critical unanswered questions in the field of stress-threat research and potential future research directions.
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Key References
Key References
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Choi et al. (2005)—This article identifies subcircuits of the medial amygdala that are genetically identifiable by expression of the LIM-family of transcription factors and posits that these subcircuits control different innate behaviors.
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Gross and Canteras (2012)—This review nicely describes the brain circuits controlling innate and learned fear.
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Hirata et al. (2009)—Using genetic tracing techniques this study revealed that there are progenitor zones in the developing telencephalon that are dedicated to generate neuronal diversity in the amygdala.
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Hashikawa et al. (2016)—This review eloquently describes the olfactory to deeper brain circuits that translate odor information to innate behavioral output.
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Lebow and Chen (2016)—This review provides an excellent summary the anatomy, function and role of the bed nucleus of the stria terminalis in psychiatric disorders.
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Luo, et al. (2018)—This review provides an very comprehensive description of the state of the art tools of modern neuroscience.
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Motta et al. (2009)—Using a combination of approaches, this study revealed that there are distinct hypothalamic circuits for processing different fear behaviors.
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Canteras, N.S., Lin, D., Corbin, J.G. (2020). Development of Limbic System Stress-Threat Circuitry. In: Wray, S., Blackshaw, S. (eds) Developmental Neuroendocrinology. Masterclass in Neuroendocrinology, vol 9. Springer, Cham. https://doi.org/10.1007/978-3-030-40002-6_12
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