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Combination Cancer Chemoprevention by Targeting the Epigenome

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Natural Products for Cancer Chemoprevention

Abstract

The past 15 years have provided a wealth of information on the influence of natural products and dietary agents on epigenetic mechanisms, including DNA methylation, histone acetylation and methylation, and miRNAs. This chapter will give an overview of studies which have investigated potential additive or synergistic effects of chemopreventive agents targeting the epigenome when used in combination. These studies have focused mainly on breast and colon cancer and investigated green tea catechins and soy isoflavones, quercetin, resveratrol and pterostilbene, withaferin A, the short chain fatty acid butyrate, sulforaphane, selenium, curcumin, synthetic triterpenoids, and docosahexaenoic acid (DHA). Up to now, investigations were limited to in vitro cell culture and animal models. The most promising finding might be the reactivation of the estrogen receptor in estrogen receptor-negative breast cancer by various combinations of DNA demethylating and histone-modifying compounds, increasing susceptibility to anti-hormonal therapy.

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Authors and Affiliations

  1. Workgroup Cancer Chemoprevention and Epigenomics, Division Cancer Epigenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany

    Clarissa Gerhauser

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  1. Clarissa Gerhauser
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Correspondence to Clarissa Gerhauser .

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  1. Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY, USA

    John M. Pezzuto

  2. Department of Science, Systems & Models, Roskilde University, Roskilde, Denmark

    Ole Vang

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Gerhauser, C. (2020). Combination Cancer Chemoprevention by Targeting the Epigenome. In: Pezzuto, J., Vang, O. (eds) Natural Products for Cancer Chemoprevention. Springer, Cham. https://doi.org/10.1007/978-3-030-39855-2_18

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