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Radioligand Therapy in Prostate Cancer Using PSMA Ligands

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Clinical Nuclear Medicine

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Abstract

Patients with metastatic castration-resistant prostate cancer (mCRPC) have limited therapeutic options. Following a theranostics strategy, targeting the prostate-specific membrane antigen (PSMA) by diagnostic and therapeutic radioisotopes is an evolving field in the management of mCRPC. Initial results of PSMA ligands that are conjugated with therapeutic radioisotopes show good efficacy and modest side effects. In this chapter, we present a historical outline and current clinical procedure guidelines for PSMA-targeted therapy regimes.

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Author information

Authors and Affiliations

  1. Department of Nuclear Medicine, University Hospital Muenster, Muenster, Germany

    Robert Seifert & Kambiz Rahbar

Authors
  1. Robert Seifert
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  2. Kambiz Rahbar
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Corresponding author

Correspondence to Kambiz Rahbar .

Editor information

Editors and Affiliations

  1. Department of Nuclear Medicine, Klinikum Westfalen - Knappschaftskrankenhaus Academic teaching hospital of the Ruhr University, Dortmund, Nordrhein-Westfalen, Germany

    Hojjat Ahmadzadehfar

  2. Department of Nuclear Medicine, Beta Klinik Bonn, Bonn, Germany

    Hans-Jürgen Biersack

  3. Division of Nuclear Medicine, Department of Radiology, Montefiore Medical Center, Bronx, NY, USA

    Leonard M. Freeman

  4. Albert Einstein College of Medicine, Bronx, NY, USA

    Lionel S. Zuckier

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Seifert, R., Rahbar, K. (2020). Radioligand Therapy in Prostate Cancer Using PSMA Ligands. In: Ahmadzadehfar, H., Biersack, HJ., Freeman, L., Zuckier, L. (eds) Clinical Nuclear Medicine. Springer, Cham. https://doi.org/10.1007/978-3-030-39457-8_40

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  • DOI: https://doi.org/10.1007/978-3-030-39457-8_40

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-39455-4

  • Online ISBN: 978-3-030-39457-8

  • eBook Packages: MedicineMedicine (R0)

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