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PSMA-Ligand Imaging in the Diagnosis of Prostate Cancer

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Clinical Nuclear Medicine

Abstract

During the past years, the prostate-specific membrane antigen (PSMA) has received increased attention as an excellent target for prostate carcinoma (PC) imaging and therapy. PSMA, also known as glutamate carboxypeptidase II, N-acetyl-α-linked acidic dipeptidase I, or folate hydrolase, is an enzyme which is significantly overexpressed in prostate cancer cells. Another advantages of PSMA are its transmembraneous location with a large extracellular domain and its enzyme activity which allows the development of specific inhibitors and their internalization after ligand binding.

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Author information

Authors and Affiliations

  1. Department of Nuclear Medicine, Bern University Hospital, Bern, Switzerland

    Ali Afshar-Oromieh

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  1. Ali Afshar-Oromieh
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Correspondence to Ali Afshar-Oromieh .

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Editors and Affiliations

  1. Department of Nuclear Medicine, Klinikum Westfalen - Knappschaftskrankenhaus Academic teaching hospital of the Ruhr University, Dortmund, Nordrhein-Westfalen, Germany

    Hojjat Ahmadzadehfar

  2. Department of Nuclear Medicine, Beta Klinik Bonn, Bonn, Germany

    Hans-Jürgen Biersack

  3. Division of Nuclear Medicine, Department of Radiology, Montefiore Medical Center, Bronx, NY, USA

    Leonard M. Freeman

  4. Albert Einstein College of Medicine, Bronx, NY, USA

    Lionel S. Zuckier

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Afshar-Oromieh, A. (2020). PSMA-Ligand Imaging in the Diagnosis of Prostate Cancer. In: Ahmadzadehfar, H., Biersack, HJ., Freeman, L., Zuckier, L. (eds) Clinical Nuclear Medicine. Springer, Cham. https://doi.org/10.1007/978-3-030-39457-8_25

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  • DOI: https://doi.org/10.1007/978-3-030-39457-8_25

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-39455-4

  • Online ISBN: 978-3-030-39457-8

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