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AI-Based Method for Detecting Retinal Haemorrhage in Eyes with Malarial Retinopathy

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Medical Image Understanding and Analysis (MIUA 2019)

Part of the book series: Communications in Computer and Information Science ((CCIS,volume 1065))

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Abstract

Cerebral Malaria (CM) as one of the most common and severe diseases in sub-Saharan Africa, claimed the lives of more than 435,000 people each year. Because Malarial Retinopathy (MR) is as one of the best clinical diagnostic indicators of CM, it may be essential to analysing MR in fundus images for assisting the CM diagnosis as an applicable solution in developing countries. Image segmentation is an essential topic in medical imaging analysis and is widely developed and improved for clinic study. In this paper, we aim to develop an automatic and fast approach to detect/segment MR haemorrhages in colour fundus images. We introduce a deep learning-based haemorrhages detection of MR inspired by Dense-Net based network called one-hundred-layers tiramisu for the segmentation tasks. We evaluate our approach on one MR dataset of 259 annotated colour fundus images. For keeping the originality of raw MR colour fundus images, 6,098 sub-images are extracted and split into a training set (70%), a validation set (10%) and a testing set (20%). After implementation, our experimental results testing on 1,669 annotated sub-images, show that the proposed method outperforms commonly mainstream network architecture U-Net.

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References

  1. Ashraf, A., Akram, M.U., Sheikh, S.A., Abbas, S.: Detection of macular whitening and retinal hemorrhages for diagnosis of malarial retinopathy. In: 2015 IEEE International Conference on Imaging Systems and Techniques (IST), pp. 1–5. IEEE (2015)

    Google Scholar 

  2. Beare, N.A., Taylor, T.E., Harding, S.P., Lewallen, S., Molyneux, M.E.: Malarial retinopathy: a newly established diagnostic sign in severe malaria. Am. J. Trop. Med. Hyg. 75(5), 790–797 (2006)

    Article  Google Scholar 

  3. Coupé, P., Manjón, J.V., Fonov, V., Pruessner, J., Robles, M., Collins, D.L.: Patch-based segmentation using expert priors: application to hippocampus and ventricle segmentation. NeuroImage 54(2), 940–954 (2011)

    Article  Google Scholar 

  4. Essuman, V.A., et al.: Retinopathy in severe malaria in Ghanaian children-overlap between fundus changes in cerebral and non-cerebral malaria. Malaria J. 9(1), 232 (2010)

    Article  Google Scholar 

  5. He, K., Zhang, X., Ren, S., Sun, J.: Deep residual learning for image recognition. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 770–778 (2016)

    Google Scholar 

  6. Huang, G., Liu, Z., Van Der Maaten, L., Weinberger, K.Q.: Densely connected convolutional networks. In: IEEE Conference on Computer Vision and Pattern Recognition, vol. 1, p. 3 (2017)

    Google Scholar 

  7. Jégou, S., Drozdzal, M., Vazquez, D., Romero, A., Bengio, Y.: The one hundred layers tiramisu: fully convolutional densenets for semantic segmentation. In: 2017 IEEE Conference on Computer Vision and Pattern Recognition Workshops (CVPRW), pp. 1175–1183. IEEE (2017)

    Google Scholar 

  8. Joshi, V., et al.: Automated detection of malarial retinopathy in digital fundus images for improved diagnosis in malawian children with clinically defined cerebral malaria. Sci. Rep. 7, 42703 (2017)

    Article  Google Scholar 

  9. Joshi, V.S., et al.: Automated detection of malarial retinopathy-associated retinal hemorrhages. Invest. Ophthalmol. Vis. Sci. 53(10), 6582–6588 (2012)

    Article  Google Scholar 

  10. Kande, G.B., Savithri, T.S., Subbaiah, P.V.: Automatic detection of microaneurysms and hemorrhages in digital fundus images. J. Digit. Imaging 23(4), 430–437 (2010)

    Article  Google Scholar 

  11. Kingma, D.P., Ba, J.: Adam: a method for stochastic optimization. arXiv:1412.6980 (2014)

  12. Krizhevsky, A., Sutskever, I., Hinton, G.E.: Imagenet classification with deep convolutional neural networks. In: Advances in Neural Information Processing Systems, pp. 1097–1105 (2012)

    Google Scholar 

  13. LeCun, Y., Bengio, Y., Hinton, G.: Deep learning. Nature 521(7553), 436 (2015)

    Article  Google Scholar 

  14. LeCun, Y., et al.: Comparison of learning algorithms for handwritten digit recognition. In: International Conference on Artificial Neural Networks, Perth, Australia, vol. 60, pp. 53–60 (1995)

    Google Scholar 

  15. Lewallen, S., Taylor, T.E., Molyneux, M.E., Wills, B.A., Courtright, P.: Ocular fundus findings in malawian children with cerebral malaria. Ophthalmology 100(6), 857–861 (1993)

    Article  Google Scholar 

  16. Li, X., Chen, H., Qi, X., Dou, Q., Fu, C.W., Heng, P.A.: H-DenseUNet: Hybrid densely connected UNet for liver and liver tumor segmentation from CT volumes. arXiv:1709.07330 (2017)

  17. Looareesuwan, S., et al.: Retinal hemorrhage, a common sign of prognostic significance in cerebral malaria. Am. J. Trop. Med. Hyg. 32(5), 911–915 (1983)

    Article  Google Scholar 

  18. Maude, R.J., Dondorp, A.M., Sayeed, A.A., Day, N.P., White, N.J., Beare, N.A.: The eye in cerebral malaria: what can it teach us? Trans. R. Soc. Trop. Med. Hyg. 103(7), 661–664 (2009)

    Article  Google Scholar 

  19. Maude, R.J., Hassan, M.U., Beare, N.A.: Severe retinal whitening in an adult with cerebral malaria. Am. J. Trop. Med. Hyg. 80(6), 881 (2009)

    Article  Google Scholar 

  20. Organization, W.H.: World malaria report 2018. World HealthOrganization (2018)

    Google Scholar 

  21. Ronneberger, O., Fischer, P., Brox, T.: U-Net: convolutional networks for biomedical image segmentation. In: Navab, N., Hornegger, J., Wells, W.M., Frangi, A.F. (eds.) MICCAI 2015. LNCS, vol. 9351, pp. 234–241. Springer, Cham (2015). https://doi.org/10.1007/978-3-319-24574-4_28

    Chapter  Google Scholar 

  22. Simonyan, K., Zisserman, A.: Very deep convolutional networks for large-scale image recognition. arXiv:1409.1556 (2014)

  23. Tang, L., Niemeijer, M., Abramoff, M.D.: Splat feature classification: detection of the presence of large retinal hemorrhages. In: 2011 IEEE International Symposium on Biomedical Imaging: From Nano to Macro, pp. 681–684. IEEE (2011)

    Google Scholar 

  24. Tran, P.V.: A fully convolutional neural network for cardiac segmentation in short-axis MRI. arXiv:1604.00494 (2016)

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Acknowledgments

Xu Chen would like to acknowledge the PhD funding from Institute of Ageing and Chronic Disease at University of Liverpool and Liverpool Vascular Research Fund.

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Chen, X., Leak, M., Harding, S.P., Zheng, Y. (2020). AI-Based Method for Detecting Retinal Haemorrhage in Eyes with Malarial Retinopathy. In: Zheng, Y., Williams, B., Chen, K. (eds) Medical Image Understanding and Analysis. MIUA 2019. Communications in Computer and Information Science, vol 1065. Springer, Cham. https://doi.org/10.1007/978-3-030-39343-4_37

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  • DOI: https://doi.org/10.1007/978-3-030-39343-4_37

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  • Publisher Name: Springer, Cham

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  • Online ISBN: 978-3-030-39343-4

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