Abstract
Cardiac shape and deformation are two relevant descriptors for the characterization of cardiovascular diseases. It is also known that strong interactions exist between them depending on the disease. In clinical routine, these high dimensional descriptors are reduced to scalar values (ventricular ejection fraction, volumes, global strains...), leading to a substantial loss of information. Methods exist to better integrate these high-dimensional data by reducing the dimension and mixing heterogeneous descriptors. Nevertheless, they usually do not consider the interactions between the descriptors. In this paper, we propose to apply dimensionality reduction on high dimensional cardiac shape and deformation descriptors and take into account their interactions. We investigated two unsupervised linear approaches, an individual analysis of each feature (Principal Component Analysis), and a joint analysis of both features (Partial Least Squares) and related their output to the main characteristics of the studied pathology. We experimented both methods on right ventricular meshes from a population of 254 cases tracked along the cycle (154 with pulmonary hypertension, 100 controls). Despite similarities in the output space obtained by the two methods, substantial differences are observed in the reconstructed shape and deformation patterns along the principal modes of variation, in particular in regions of interest for the studied disease.
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Acknowledgements
The authors acknowledge the partial support from the French ANR (LABEX PRIMES of Université de Lyon [ANR-11-LABX-0063], within the program Investissements d’Avenir [ANR-11-IDEX-0007]), and from the EEA doctoral school.
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Di Folco, M., Clarysse, P., Moceri, P., Duchateau, N. (2020). Learning Interactions Between Cardiac Shape and Deformation: Application to Pulmonary Hypertension. In: Pop, M., et al. Statistical Atlases and Computational Models of the Heart. Multi-Sequence CMR Segmentation, CRT-EPiggy and LV Full Quantification Challenges. STACOM 2019. Lecture Notes in Computer Science(), vol 12009. Springer, Cham. https://doi.org/10.1007/978-3-030-39074-7_13
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DOI: https://doi.org/10.1007/978-3-030-39074-7_13
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