Skip to main content

Intraocular Lens Placement in the Setting of Glaucoma

  • Chapter
  • First Online:
  • 299 Accesses

Abstract

Glaucoma following cataract surgery and uveitic glaucoma are the most common clinical scenarios in which glaucoma complicates aphakia. In both of these forms of glaucoma, intraocular pressure control takes precedence and may require medical or surgical intervention prior to considering placement of an intraocular lens (IOL). Evidence of long-term pressure control is imperative for preservation of vision and, especially in young children, accurate lens calculations. In the setting of glaucoma, there are special considerations that need to be assessed when placing a secondary IOL in an aphakic eye. Evaluation of the angle and anterior chamber anatomy and recognition of prior glaucoma surgeries are important when deciding whether to place the IOL in the sulcus or within the capsule. Especially in microphthalmia or eyes with a history of uveitis, debulking of the Soemmering ring and placement of the lens within the capsule should be a priority. Additional procedures in order to preserve a prior glaucoma surgery such as a trabeculectomy or glaucoma drainage device may be required to prevent uncontrolled intraocular pressure postoperatively. Importantly, intraocular pressure control should not be compromised in the process of improving visual function with placement of a secondary IOL.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Sharon Y, Frilling R, Luski M, Campoverde BQ, Amer R, Kramer M. Uveitic glaucoma: long-term clinical outcome and risk factors for progression. Ocul Immunol Inflamm. 2017;25(6):740–7.

    Article  PubMed  Google Scholar 

  2. Groen F, Ramdas W, de Hoog J, Vingerling JR, Rothova A. Visual outcomes and ocular morbidity of patients with uveitis referred to a tertiary center during first year of follow-up. Eye (Lond). 2016;30(3):473–80.

    Article  CAS  Google Scholar 

  3. Bohnsack BL, Freedman SF. Surgical outcomes in childhood uveitic glaucoma. Am J Ophthalmol. 2013;155(1):134–42.

    Article  PubMed  Google Scholar 

  4. Freedman SF, Rodriguez-Rosa RE, Rojas MC, Enyedi LB. Goniotomy for glaucoma secondary to chronic childhood uveitis. Am J Ophthalmol. 2002;133(5):617–21.

    Article  PubMed  Google Scholar 

  5. Ho CL, Wong EY, Walton DS. Goniosurgery for glaucoma complicating chronic childhood uveitis. Arch Ophthalmol. 2004;122(6):838–44.

    Article  PubMed  Google Scholar 

  6. Wang Q, Wang J, Fortin E, Hamel P. Trabeculotomy in the treatment of pediatric uveitic glaucoma. J Glaucoma. 2016;25(9):744–9.

    Article  PubMed  Google Scholar 

  7. Kwon YH, Kong YXG, Tao LW, et al. Surgical outcomes of trabeculectomy and glaucoma drainage implant for uveitic glaucoma and relationship with uveitis activity. Clin Exp Ophthalmol. 2017;45(5):472–80.

    Article  PubMed  Google Scholar 

  8. Eksioglu U, Yakin M, Sungur G, et al. Short- to long-term results of Ahmed glaucoma valve in the management of elevated intraocular pressure in patients with pediatric uveitis. Can J Ophthalmol. 2017;52(3):295–301.

    Article  PubMed  Google Scholar 

  9. Tan AN, Cornelissen MF, Webers CAB, Erckens RJ, Berendschot TTJM, Beckers HJM. Outcomes of severe uveitic glaucoma treated with Baerveldt implant: can blindness be prevented. Acta Ophthalmol. 2018;96(1):24–30.

    Article  PubMed  Google Scholar 

  10. Sng CC, Barton K. Mechanism and management of angle closure in uveitis. Curr Opin Ophthalmol. 2015;26(2):121–7.

    Article  PubMed  Google Scholar 

  11. Voykov B, Dimopoulos S, Leitritz MA, Doycheva D, William A. Long-term results of ab externo trabeculotomy for glaucoma secondary to chronic uveitis. Graefes Arch Clin Exp Ophthalmol. 2016;254(2):355–60.

    Article  PubMed  Google Scholar 

  12. Law SK, Bui D, Caprioli J. Serial axial length measurements in congenital glaucoma. Am J Ophthalmol. 2001;132(6):926–8.

    Article  CAS  PubMed  Google Scholar 

  13. Cronemberger S, Calixto N, Avellar Milhomens TG, et al. Effect of intraocular pressure control on central corneal thickness, horizontal corneal diameter, and axial length in primary congenital glaucoma. J AAPOS. 2014;18(5):433–6.

    Article  PubMed  Google Scholar 

  14. Nakhli FR, Emarah K, Jeddawi L. Accuracy of formulae for secondary intraocular lens power calculations in pediatric aphakia. J Curr Ophthalmol. 2017;29(3):199–203.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Kun L, Szigeti A, Bausz M, Nagy ZZ, Maka E. Preoperative biometry data of eyes with unilateral congenital cataract. J Cataract Refract Surg. 2018;44(10):1198–202.

    Article  PubMed  Google Scholar 

  16. Freedman SF, Lynn MJ, Beck AD, et al. Glaucoma-related adverse events in the first 5 years after unilateral cataract removal in the infant aphakia treatment study. JAMA Ophthalmol. 2015;133(8):907–14.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Wong IB, Sukthankar VD, Cortina-Borja M, Nischal KK. Incidence of early-onset glaucoma after infant cataract extraction with and without intraocular lens implantation. Br J Ophthalmol. 2009;93(9):1200–3.

    Article  CAS  PubMed  Google Scholar 

  18. Chak M, Rahi JS, Group BCCI. Incidence of and factors associated with glaucoma after surgery congenital cataract: findings from the British Congenital Cataract Study. Ophthalmology. 2008;115(6):1013–8.

    Article  PubMed  Google Scholar 

  19. Trivedi RH, Wilson MEJ, Golub RL. Incidence and risk factors for glaucoma after pediatric cataract surgery with and without intraocular lens implantation. J AAPOS. 2006;10(2):117–23.

    Article  PubMed  Google Scholar 

  20. Chen TC, Walton DS, Bhatia LS. Aphakic glaucoma after congenital cataract surgery. Arch Ophthalmol. 2004;122(12):1819–25.

    Article  PubMed  Google Scholar 

  21. Walton DS. Pediatric aphakic glaucoma: a study of 65 patients. Trans Am Ophthalmol Soc. 1995;93:403–13.

    CAS  PubMed  PubMed Central  Google Scholar 

  22. Michael I, Shmoish M, Walton DS, Levenberg S. Interactions between trabecular meshwork cells and lens epithelial cells: a possible mechanism in infantile aphakic glaucoma. Invest Ophthalmol Vis Sci. 2008;49(9):3981–7.

    Article  PubMed  Google Scholar 

  23. Lam DS, Fan DS, Ng JS, Yu CB, Wong CY, Cheung AY. Ocular hypertensive and anti-inflammatory responses to different dosages of topical dexamethasone in children: a randomized trial. Clin Exp Ophthalmol. 2005;33(3):252–8.

    Article  PubMed  Google Scholar 

  24. Baris M, Biler ED, Yimaz SG, Ates H, Uretmen O, Kose S. Treatment results in aphakic patients with glaucoma following congenital cataract surgery. Int Ophthalmol. 2019;39(1):11–9.

    Article  PubMed  Google Scholar 

  25. Kirwan C, Lanigan B, O’Keefe M. Glaucoma in aphakic and pseudophakic eyes following surgery for congenital cataract in the first year of life. Acta Ophthalmol. 2010;88(1):53–9.

    Article  PubMed  Google Scholar 

  26. Dao JB, Sarkisian SRJ, Freedman SF. Illuminated microcatheter-facilitated 360-degree trabeculotomy for refractory aphakic and juvenile open-angle glaucoma. J Glaucoma. 2014;23(7):449–54.

    Article  PubMed  Google Scholar 

  27. Grover DS, Smith O, Fellman RL, et al. Gonioscopy assisted transluminal trabeculotomy: an ab interno circumferential trabeculotomy for the treatment of primary congenital glaucoma and juvenile open angle glaucoma. Br J Ophthalmol. 2015;99(8):1092–6.

    Article  PubMed  Google Scholar 

  28. Kjer B, Kessing SV. Trabeculotomy in juvenile open-angle glaucoma. Ophthalmic Surg. 1993;24(10):663–8.

    CAS  PubMed  Google Scholar 

  29. Lim ME, Dao JB, Freedman SF. 360-degree trabeculotomy for medically refractory glaucoma following cataract surgery and juvenile open-angle glaucoma. Am J Ophthalmol. 2017;175:1–7.

    Article  PubMed  Google Scholar 

  30. Yeung HH, Walton DS. Goniotomy for juvenile open-angle glaucoma. J Glaucoma. 2010;19(1):1–4.

    Article  PubMed  Google Scholar 

  31. Chang I, Caprioli J, Ou Y. Surgical management of pediatric glaucoma. Dev Ophthalmol. 2017;59:165–78.

    Article  PubMed  Google Scholar 

  32. Pakravan M, Esfandiari H, Yazdani S, et al. Clinical outcomes of Ahmed glaucoma valve implantation in pediatric glaucoma. Eur J Ophthalmol. 2019;29(1):44–51.

    Article  PubMed  Google Scholar 

  33. Ozgonul C, Besirli CG, Bohnsack BL. Combined vitrectomy and glaucoma drainage device implantation surgical approach for complex pediatric glaucomas. J AAPOS. 2017;21(2):121–6.

    Article  PubMed  Google Scholar 

  34. Elshatory YM, Gauger EH, Kwon YH, et al. Management of pediatric aphakic glaucoma with vitrectomy and tube shunts. J Pediatr Ophthalmol Strabismus. 2016;53(6):339–43.

    Article  PubMed  Google Scholar 

  35. Bannitt MR, Sidoti PA, Gentile RC, et al. Pars plana Baerveldt implantation for refractory childhood glaucomas. J Glaucoma. 2009;18(5):412–7.

    Article  Google Scholar 

  36. DeBry PW, Perkins TW, Heatley G, Kaufman P, Brumback LC. Incidence of late-onset bleb-related complications following trabeculectomy. Arch Ophthalmol. 2002;120(3):297–300.

    Article  CAS  PubMed  Google Scholar 

  37. Waheed S, Ritterband DC, Greenfield DS, Liebmann JM, Sidoti PA, Ritch R. Bleb-related ocular infection in children after trabeculectomy with mitomycin C. Ophthalmology. 1997;104(12):2117–20.

    Article  CAS  PubMed  Google Scholar 

  38. Cantor AJ, Wang J, Li S, Neely DE, Plager DA. Long-term efficacy of endoscopic cyclophotocoagulation in the management of glaucoma following cataract surgery in children. J AAPOS. 2018;22(3):188–91.

    Article  PubMed  Google Scholar 

  39. Tooke F. Dislocation of the ring of Soemmering, its removal. With some notes on its pathology. Br J Ophthalmol. 1933;17(8):466–76.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Suwan Y, Purevdorj B, Teekhasaenee C, Supakontanasan W, Simaroj P. Pseudophakic angle-closure from a Soemmering ring. BMC Ophthalmol. 2016;17(16):91.

    Article  Google Scholar 

  41. Kung Y, Park SC, Liebmann JM, Ritch R. Progressive synechial angle closure from an enlarging Soemmering ring. Arch Ophthalmol. 2011;129(12):1631–2.

    Article  PubMed  Google Scholar 

  42. Gimbel HV, Venkataraman A. Secondary in-the-bag intraocular lens implantation following removal of Soemmering ring contents. J Cataract Refract Surg. 2008;34(8):1246–9.

    Article  PubMed  Google Scholar 

  43. Nihalani BR, Vanderveen DK. Secondary intraocular lens implantation after pediatric aphakia. J AAPOS. 2011;15(5):435–40.

    Article  PubMed  Google Scholar 

  44. Koch CR, Kara-Junior N, Serra A, Morales M. Long-term results of secondary intraocular lens implantation in children under 30 months of age. Eye (Lond). 2018;32(12):1858–63.

    Article  Google Scholar 

  45. Vinod K, Panarelli JF, Gentile RC, Sidoti PA. Long-term outcomes and complications of pars plana Baerveldt implantation in children. J Glaucoma. 2017;26(3):266–71.

    Article  PubMed  Google Scholar 

  46. Holland GN, Stiehm ER. Special considerations in the evaluation and management of uveitis in children. Am J Ophthalmol. 2003;135(6):867–78.

    Article  PubMed  Google Scholar 

  47. Paroli MP, Spinucci G, Liverani M, Monte R, Pezzi PP. Uveitis in childhood: an Italian clinical and epidemiological study. Ocul Immunol Inflamm. 2009;17(4):238–42.

    Article  PubMed  Google Scholar 

  48. de Boer J, Wulffraat N, Rothova A. Visual loss in uveitis of childhood. Br J Ophthalmol. 2003;87(7):879–84.

    Article  PubMed  PubMed Central  Google Scholar 

  49. Sung VC, Barton K. Management of inflammatory glaucomas. Curr Opin Ophthalmol. 2004;15(2):136–40.

    Article  PubMed  Google Scholar 

  50. Kanski JJ. Juvenile arthritis and uveitis. Surv Ophthalmol. 1990;34(4):253–67.

    Article  CAS  PubMed  Google Scholar 

  51. Angeles-Han S, Yeh S. Prevention and management of cataracts in children with juvenile idiopathic-arthritis associated uveitis. Curr Rheumatol Rep. 2012;14(2):142–9.

    Article  PubMed  PubMed Central  Google Scholar 

  52. Blum-Hareuveni T, Seguin-Greenstein S, Kramer M, et al. Risk factors for the development of cataract in children with uveitis. Am J Ophthalmol. 2017;177:139–43.

    Article  PubMed  Google Scholar 

  53. Mehta S, Linton MM, Kempen JH. Outcomes of cataract surgery in patients with uveitis: a systemic review and meta-analysis. Am J Ophthalmol. 2014;158(4):676–92.

    Article  PubMed  Google Scholar 

  54. Ladas JG, Yu F, Loo R, et al. Relationship between aqueous humor protein level and outflow facility in patients with uveitis. Invest Ophthalmol Vis Sci. 2001;42(11):2584–8.

    CAS  PubMed  Google Scholar 

  55. Toris CB, Pederson JE. Aqueous humor dynamics in experimental iridocyclitis. Invest Ophthalmol Vis Sci. 1987;28(3):477–81.

    CAS  PubMed  Google Scholar 

  56. Peretz WL, Tomasi TB. Aqueous humor proteins in uveitis. Immunoelectrophoretic and gel diffusion studies on normal and pathological human aqueous humor. Arch Ophthalmol. 1961;65:20–3.

    Article  CAS  PubMed  Google Scholar 

  57. Vuori M-L. Molteno aqueous shunt as a primary surgical intervention for uveitis glaucoma: long term results. Acta Ophthalmol. 2010;88(1):33–6.

    Article  PubMed  Google Scholar 

  58. Papadaki TG, Zacharopoulos JP, Pasquale LR, Christen WB, Netland PA, Foster CS. Long-term results of Ahmed glaucoma valve implantation for uveitic glaucoma. Am J Ophthalmol. 2007;144(1):62–9.

    Article  PubMed  Google Scholar 

  59. Ozdal PC, Vianna RNG, Deschenes J. Long-term results of Ahmed glaucoma valve implantation for uveitic glaucoma. Am J Ophthalmol. 2006;144(1):178–83.

    Google Scholar 

  60. O'Malley Schotthoefer E, Yanovitch TL, Freedman SF. Aqueous drainage device surgery in refractory pediatric glaucomas: II. Ocular motility consequences. J AAPOS. 2008;12(1):40–5.

    Article  PubMed  Google Scholar 

  61. O'Malley Schotthoefer E, Yanovitch TL, Freedman SF. Aqueous drainage device surgery in refractory pediatric glaucomas: I. Long-term outcomes. J AAPOS. 2008;12(1):33–9.

    Article  PubMed  Google Scholar 

  62. Netland PA, Walton DS. Glaucoma drainage implants in pediatric patients. Ophthalmic Surg. 1993;24(11):723–9.

    CAS  PubMed  Google Scholar 

  63. Kafkala C, Hynes A, Choi J, Tpalkara A, Foster CS. Ahmed valve implantation for uncontrolled pediatric uveitic glaucoma. J AAPOS. 2005;9(4):336–40.

    Article  PubMed  Google Scholar 

  64. De Mata A, Burk SE, Netland PA, Baltazis S, Christen WB, Foster CS. Management of uveitic glaucoma with Ahmed glaucoma valve implantation. Ophthalmology. 1999;106(11):2168–72.

    Article  PubMed  Google Scholar 

  65. Carreno E, Vallaron S, Portero A, Herraras JM, Maquet JA, Calonge M. Surgical outcomes of uveitic glaucoma. J Ophthalmol Inflamm Infect. 2011;1(2):43–53.

    Article  Google Scholar 

  66. Beauchamp GR, Parks MM. Filtering surgery in children: barriers to success. Ophthalmology. 1979;86(1):170–80.

    Article  CAS  PubMed  Google Scholar 

  67. Nuyen B, Weinreb RN, Robbins SL. Steroid-induced glaucoma in the pediatric population. J AAPOS. 2017;21(1):1–6.

    Article  PubMed  Google Scholar 

  68. Gupta S, Shah P, Grewal S, Chaurasia AK, Gupta V. Steroid-induced glaucoma and childhood blindness. Br J Ophthalmol. 2015;99(11):1454–6.

    Article  PubMed  Google Scholar 

  69. Sihota R, Konkal VL, Dada T, Agarwal HC, Singh R. Prospective, long-term evaluation of steroid-induced glaucoma. Eye (Lond). 2008;22(1):26–30.

    Article  CAS  Google Scholar 

  70. Magli A, Forte R, Rombetto L, Alessio M. Cataract management in juvenile idiopathic arthritis: simultaneous versus secondary intraocular lens implantation. Ocul Immunol Inflamm. 2014;22(2):133–7.

    Article  PubMed  Google Scholar 

  71. Mercieca K, Drury B, Bhargava A, Fenerty C. Trabeculectomy bleb needling and antimetabolitic administration practices in the UK: a glaucoma specialist national survey. Br J Ophthalmol. 2018;102(9):1244–7.

    Article  PubMed  Google Scholar 

  72. Than JYL, Al-Mugheiry TS, Gale J, Martin KR. Factors predicting the success of trabeculectomy bleb enhancement with needling. Br J Ophthalmol. 2018;102(12):1667–71.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Brenda L. Bohnsack .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Zepeda, E.M., Bohnsack, B.L. (2020). Intraocular Lens Placement in the Setting of Glaucoma. In: Kraus, C. (eds) Pediatric Cataract Surgery and IOL Implantation. Springer, Cham. https://doi.org/10.1007/978-3-030-38938-3_22

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-38938-3_22

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-38937-6

  • Online ISBN: 978-3-030-38938-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics