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Total Marrow Irradiation pp 111–121Cite as

Total Marrow/Lymphoid Irradiation in the Conditioning Regimen for Haploidentical T-Cell-Depleted Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia: The Perugia Experience

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Abstract

This chapter briefly outlines Perugia University’s experience with haploidentical hematopoietic stem cell transplantation (HSCT) for acute myeloid leukemia (AML). It describes modifications to the conditioning regimens over time, focusing on the contribution from radiation oncology and the changes to the haploidentical graft. It reports outcomes in a subset of elderly or unfit young patients with AML who received an immunosuppressive, myeloablative, low-toxic total marrow/lymphoid irradiation (TMLI)-based conditioning regimen and a CD34+ inoculum with Treg/Tcon adoptive immunotherapy. Finally, perspectives and future directions of TMLI are illustrated.

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Author information

Authors and Affiliations

  1. Radiation Oncology Section, Department of Surgical and Biomedical Science, University of Perugia and Perugia General Hospital, Perugia, Italy

    Cynthia Aristei & Gianluca Ingrosso

  2. Radiation Oncology Section, Perugia General Hospital, Perugia, Italy

    Simonetta Saldi

  3. Hematology and Clinical Immunology Section, Department of Medicine, University of Perugia, Perugia, Italy

    Antonio Pierini, Sara Piccinelli, Massimo Fabrizio Martelli & Andrea Velardi

  4. Hematology and Clinical Immunology Section, Perugia General Hospital, Perugia, Italy

    Loredana Ruggeri

Authors
  1. Cynthia Aristei
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  2. Simonetta Saldi
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  3. Antonio Pierini
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  4. Loredana Ruggeri
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  5. Sara Piccinelli
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  6. Gianluca Ingrosso
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  7. Massimo Fabrizio Martelli
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  8. Andrea Velardi
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Corresponding author

Correspondence to Cynthia Aristei .

Editor information

Editors and Affiliations

  1. Department of Radiation Oncology, City Of Hope National Medical Center, Duarte, CA, USA

    Jeffrey Y. C. Wong

  2. Department of Radiation Oncology, City Of Hope National Medical Center, Duarte, CA, USA

    Susanta K. Hui

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Aristei, C. et al. (2020). Total Marrow/Lymphoid Irradiation in the Conditioning Regimen for Haploidentical T-Cell-Depleted Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia: The Perugia Experience. In: Wong, J., Hui, S. (eds) Total Marrow Irradiation. Springer, Cham. https://doi.org/10.1007/978-3-030-38692-4_7

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  • DOI: https://doi.org/10.1007/978-3-030-38692-4_7

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-38691-7

  • Online ISBN: 978-3-030-38692-4

  • eBook Packages: MedicineMedicine (R0)

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