Hormonal Biophysiology of the Uterus

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1242)


Intrauterine development of the uterus is promoted by the hormonal influence of the maternal steroid sex hormones on the female fetus. The cyclic activity of the endometrium starts at puberty, at menarche, and is controlled by the pituitary hormones (FSH and LH) and steroid ovarian hormones, the latter acting on the target tissue—the endometrium. The proliferative and secretory cyclic changes of the endometrium prepare the uterus for implantation of a fertilized ovum. Ovarian failure to secrete steroid hormones results in the menopausal gradual atrophy of the endometrium.


Proliferative endometrium Secretory endometrium Decidua Gonadotropins Receptor-hormone complex GnRH Ovulation Endometrial dating Spiral arterioles Endometrial atrophy 


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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Professor Emeritus, Department of PathologyIcahn School of Medicine at Mount SinaiNew YorkUSA
  2. 2.Department of Obstetrics-Gynecology and Reproductive ScienceIcahn School of Medicine at Mount SinaiNew YorkUSA
  3. 3.New York Medical College, Westchester Medical CenterValhallaUSA

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