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Hormonal Biophysiology of the Uterus

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Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1242)

Abstract

Intrauterine development of the uterus is promoted by the hormonal influence of the maternal steroid sex hormones on the female fetus. The cyclic activity of the endometrium starts at puberty, at menarche, and is controlled by the pituitary hormones (FSH and LH) and steroid ovarian hormones, the latter acting on the target tissue—the endometrium. The proliferative and secretory cyclic changes of the endometrium prepare the uterus for implantation of a fertilized ovum. Ovarian failure to secrete steroid hormones results in the menopausal gradual atrophy of the endometrium.

Keywords

Proliferative endometrium Secretory endometrium Decidua Gonadotropins Receptor-hormone complex GnRH Ovulation Endometrial dating Spiral arterioles Endometrial atrophy 

References

  1. 1.
    Bazer FW, Roberts RM, Thatcher WW. Actions of hormones on the uterus and effect of conceptus development. J Anim Sci. 1979;49(Suppl 2):35–45.CrossRefGoogle Scholar
  2. 2.
    O’Brien Y, Wingfield M, O’Shea LC. Anti-Müllerian hormone and progesterone levels in human follicular fluid are predictors of embryonic development. Reprod Biol Endocrinol. 2019;17(1):47.  https://doi.org/10.1186/s12958-019-0492-9.CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    Brosens I, Benagiano G. The endometrium from the neonate to the adolescent. J Matern Fetal Neonatal Med. 2016;29(8):1195–9.CrossRefGoogle Scholar
  4. 4.
    Fritz MA, Speroff L. The endocrinology of the menstrual cycle: the interaction of folliculogenesis and neuroendocrine mechanisms. Fertil Steril. 1982;38(5):509–29. Review.CrossRefGoogle Scholar
  5. 5.
    Mais V, Kazer RR, Cetel NS, Rivier J, Vale W, Yen SS. The dependency of folliculogenesis and corpus luteum function on pulsatile gonadotropin secretion in cycling women using a gonadotropin-releasing hormone antagonist as a probe. J Clin Endocrinol Metab. 1986;62(6):1250–5.CrossRefGoogle Scholar
  6. 6.
    Kase NG. The normal human ovary. In: Altchek A, editor. Diagnosis and management of ovarian disorders. 3rd ed. Cambridge University Press; 2013.Google Scholar
  7. 7.
    Hansen KR, Knowlton NS, Thyer AC, Charleston JS, Soules MR, Klein NA. A new model of reproductive aging: the decline in ovarian non-growing follicle number from birth to menopause. Hum Reprod. 2008;23(3):699–708.CrossRefGoogle Scholar
  8. 8.
    Gougeon A, Ecochard R, Thalabard JC. Age-related changes of the population of human ovarian follicles: increase in the disappearance rate of non-growing and early-growing follicles in aging women. Biol Reprod. 1994;50(3):653–63.CrossRefGoogle Scholar
  9. 9.
    Kase NG. Menopause. In: Altchek A, editor. Diagnosis and management of ovarian disorders. 3rd ed. Cambridge University Press; 2013.Google Scholar
  10. 10.
    Feldman S, Shapter A, Welch WR, Berkowitz RS. Two-year follow-up of 263 patients with post/perimenopausal vaginal bleeding and negative initial biopsy. Gynecol Oncol. 1994;55(1):56–9.CrossRefGoogle Scholar
  11. 11.
    Deligdisch L, Yedwab G, Persitz A, David MP. Ultrastructural features in normal and hyperplastic postmenopausal endometrium. Acta Obstet Gynecol Scand. 1978;57(5):439–52.CrossRefGoogle Scholar
  12. 12.
    Harlow SD, Gass M, Hall JE, Lobo R, Maki P, Rebar RW, Sherman S, Sluss PM, de Villiers TJ, STRAW + 10 Collaborative Group. Executive summary of the Stages of Reproductive Aging Workshop + 10: addressing the unfinished agenda of staging reproductive aging. Fertil Steril. 2012;97(4):843–51.CrossRefGoogle Scholar
  13. 13.
    McKinlay SM, Bifano NL, McKinlay JB. The normal menopause transition. Maturitas. 1992;14(2):103–15.CrossRefGoogle Scholar
  14. 14.
    Gosden RG, Faddy MJ. Ovarian aging, follicular depletion, and steroidogenesis. Exp Gerontol. 1994;29(3–4):265–74. Review.CrossRefGoogle Scholar
  15. 15.
    Randolph JF Jr, Zheng H, Sowers MR, Crandall C, Crawford S, Gold EB, Vuga M. Change in follicle-stimulating hormone and estradiol across the menopausal transition: effect of age at the final menstrual period. J Clin Endocrinol Metab. 2011;96(3):746–54.CrossRefGoogle Scholar
  16. 16.
    Burger HG, Dudley EC, Cui J, Dennerstein L, Hopper JL. A prospective longitudinal study of serum testosterone, dehydroepiandrosterone sulfate, and sex hormone-binding globulin levels through the menopause transition. J Clin Endocrinol Metab. 2000;85(8):2832–8.PubMedGoogle Scholar
  17. 17.
    Janssen I, Powell LH, Crawford S, Lasley B, Sutton-Tyrrell K. Menopause and the metabolic syndrome: the study of Women’s Health Across the Nation. Arch Intern Med. 2008;168(14):1568–75.CrossRefGoogle Scholar
  18. 18.
    Carr MC. The emergence of the metabolic syndrome with menopause. J Clin Endocrinol Metab. 2003;88(6):2404–11. Review.CrossRefGoogle Scholar
  19. 19.
    Flegal KM. Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999–2010. JAMA. 2012;307(5):491–7.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Professor Emeritus, Department of PathologyIcahn School of Medicine at Mount SinaiNew YorkUSA
  2. 2.Department of Obstetrics-Gynecology and Reproductive ScienceIcahn School of Medicine at Mount SinaiNew YorkUSA
  3. 3.New York Medical College, Westchester Medical CenterValhallaUSA

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