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Development of Optical Sensor Strips for Point-of-Care Testing for Pesticide

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Nanosensors for Environmental Applications

Part of the book series: Environmental Chemistry for a Sustainable World ((ECSW,volume 43))

Abstract

Disposable or point-of-care sensors are a promising tool for low-cost and rapid sensing of analytes including pesticides. They find important applications in pesticide-contaminated food, agro-products, and water quality monitoring. This chapter highlights the implication and significance of pesticide residue identification in foodstuffs and overviews the most frequently engaged analytical techniques, and finally their benefits and limitations are discussed. Disposable strip-based biosensors have their intrinsic advantages and some disadvantages, but their cost-effectiveness and portability have turned them as a potential possibility for point-of-care (POC) testing of various pesticides. The fabrication of robust, low-cost, reliable, and sensitive sensors with the aid of both simple naked eye-based and portable readout-based detectors is the driving factor in this sensor’s technology area. The pending limitations can be overcome by adapting new specific recognition elements and better signal generative particles or systems. The integration of these devices with card readers or smartphones can make them more user-friendly and will provide more accurate quantitative information.

The development of LFAs and paper sensors with multiplexing capabilities will further add to their practical utility. In the future, it is expected that LFAs and portable user-friendly sensors will be made available to the general public for POC testing of complex parameters, e.g., dengue, chikungunya, typhoid, etc. These tools have immense significance toward the screening of food and water samples for pollutants like pesticides, heavy metals, pathogens, etc. In overall, future successes and adoption of LFA paper sensors in a wide range of environmental monitoring application call for the realization of more stable devices capable of handling multiple analytes with high sensitivity without sacrificing the simplicity and cost advantages. The possibilities of future research and development in the field of colorimetric-/fluorescence-based assays are deliberated.

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Abbreviations

2,4,5-T:

2,4,5-Trichlorophenoxyacetic acid

2,4-D:

2-(2,4-Dichlorophenoxy)acetic acid

AChE:

Acetylcholinesterase enzyme

AMP:

p-(Aminomethyl)phenyl

ASE:

Accelerated solvent extraction

ATChI:

Acetylthiocholine iodide

BC:

Before Christ year

BSA:

Bovine serum albumin

C:

Control

CE:

Capillary electrophoresis

CLC:

Capillary liquid chromatography

CNS:

Central nervous system

CPE:

Cloud point extraction

c-SWCNTs:

Carboxyl-functionalized single walled-carbon nanotubes

DDT:

Dichlorodiphenyltrichloroethane

DNA:

Deoxyribonucleic acid

DPV:

Differential pulse voltammetry

dSPE:

Dispersive solid-phase extraction

DTNB:

5,5′-Dithiobis(2-nitrobenzoic) acid

ECD:

Electron capture detectors

ELCD:

Electrolytic conductivity detectors

EPA:

Environmental Protection Agency

EU:

European Union

FAM:

Carboxyfluorescein

FAO:

Agriculture Organization of United Nations

FAO/WHO:

World Health Organization

FID:

Flame ionization detectors

FPD:

Flame photometric detectors

GC:

Gas chromatography

GCE:

Glassy carbon electrode

GCxGC:

Comprehensive two-dimensional gas chromatography

GNPs:

Colloidal gold nanoparticles

GO:

Graphene oxide

GUP:

General use pesticides

hCG:

Human chorionic gonadotropin

HILIC:

Hydrophilic interaction liquid chromatography

HIV:

Human immunodeficiency virus

HPLC:

High-performance liquid chromatography

IAA:

Indole acetic acid

IFE:

Inner-filter effect

LC x LC:

Two-dimensional liquid chromatography

LC:

Liquid chromatography

LD 50:

Lethal dose

LFA:

Lateral flow immunoassay

LFIA:

Lateral flow immunochromatographic assay

LOD:

Limit of detection

LOQ:

Limit of quantification

LP-GC:

Low-pressure gas chromatography

LPME:

Liquid-phase microextraction

MAE:

Microwave-assisted extraction

MB:

Methylene blue

MCPA:

2-(4-Chloro-2-methylphenoxy)acetic acid

MIP:

Molecularly imprinted polymers

μLC:

Micro-liquid chromatography

MRLs:

Maximum residue limits

MS:

Mass spectrophotometers

MW:

Microwave

nano-LC:

Nanoliquid chromatography

NC:

Nitrocellulose

NHS:

N-Hydroxysuccinimide

NIST:

National Institute of Standards and Technology

NPD:

Nitrogen-phosphorus detectors

OPH:

Organophosphate hydrolase

PAHs:

Polyaromatic hydrocarbons

PCR:

Polymerase chain reaction

PID:

Photoionization detectors

PM:

Protamine molecules

POC:

Point-of-care

POP:

Persistent organic pollutant

PTV:

Programmed temperature vaporization

QuEChERS:

Quick, easy, cheap, effective, rugged, and safe

RF-QDs:

Ratiometric fluorescent quantum dots

RNA:

Ribonucleic acid

RPLC:

Reversed-phase liquid chromatography

SBSE:

Stir bar sorptive extraction

SELEX:

Systematic evolution of ligands by exponential enrichment

SERS:

Surface-enhanced Raman scattering

SPE:

Solid-phase extraction

SPME:

Solid-phase microextraction

SPR:

Surface plasmon resonance

ssDNA:

Single-stranded DNA

T:

Test

TCD:

Thermal conductivity detectors

TLC:

Thin-layer chromatography

UHPLC:

Ultrahigh-performance liquid chromatography

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Acknowledgment

Dr. Satish Kumar acknowledges the Council of Scientific and Industrial Research (CSIR), New Delhi, for his research grant. Dr. Akash Deep thanks the Department of Science and Technology, New Delhi, for funding his research project.

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Mohanta, G.C., Bhatt, D., Deep, A., Pandey, S.K. (2020). Development of Optical Sensor Strips for Point-of-Care Testing for Pesticide. In: Kumar Tuteja, S., Arora, D., Dilbaghi, N., Lichtfouse, E. (eds) Nanosensors for Environmental Applications. Environmental Chemistry for a Sustainable World, vol 43. Springer, Cham. https://doi.org/10.1007/978-3-030-38101-1_7

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