Abstract
This chapter discusses motor evoked potentials (MEPs) recorded by transcranial electrical stimulation (TCES) and transcranial magnetic stimulation (TCMS). It describes anatomy of the central motor pathways and physiology of the D and I waves. Intraoperative monitoring of MEPs using TCES is now widely used for spinal cord and posterior fossa surgeries. Anesthetic considerations, TCES parameters, stimulation derivations, muscles utilized for MEP recordings, alarm criteria, and safety issues are discussed in detail. Even though TCMS is approved in the United States only for the treatment of depression, it has extensive diagnostic and therapeutic applications worldwide. Various diagnostic parameters of MEPs elicited by TCMS including central motor conduction time, MEP latency and amplitude, triple stimulation technique, magnetic stimulation threshold, silent period, evaluation of cortical inhibition and facilitation, long-interval intracortical inhibition, and use of paired stimuli are discussed. The TCMS parameters applied as diagnostic tools in clinical conditions such as multiple sclerosis, motor neuron disease, strokes, and myelopathies are described. Finally, some of the therapeutic applications of TCMS particularly in psychiatric disorders are discussed.
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References
Abalkhail TM, MacDonald DB, AlThubaiti I, AlOtaibi F, et al. Intraoperative direct cortical stimulation motor evoked potentials: stimulus parameter recommendation based on rheobase and chronaxie. Clin Neurophysiol. 2017;128:2300–8.
Barker AT, Jalinous R, Freeston IL. Non-invasive magnetic stimulation of human motor cortex. Lancet. 1985;1:1106–7.
Britton TC, Meyer B-U, Benecke R. Variability of cortically evoked motor responses in multiple sclerosis. Electroencephalogr Clin Neurophysiol. 1991;81:186–94.
Bühler R, Magistris MR, Truffert A, et al. The triple stimulation technique to study central motor conduction to the lower limbs. Clin Neurophysiol. 2001;112:938–49.
Cantello R. Applications of transcranial magnetic stimulation in movement disorders. J Clin Neurophysiol. 2002;19:272–93.
Caramia MD, Cicinelli P, Paradiso C, et al. Excitability changes of muscular responses to magnetic brain stimulation in patients with central motor disorders. Electroencephalogr Clin Neurophysiol. 1991;81:243–50.
Caramia MD, Gigli G, Iani C, et al. Distinguishing forms of generalized epilepsy using magnetic brain stimulation. Electroencephalogr Clin Neurophysiol. 1996;98:14–9.
Chen X, Sterio D, Ming X, et al. Success rate of motor evoked potentials for intraoperative neurophysiologic monitoring; effects of age, lesion location, and preoperative neurological deficits. J Clin Neurophysiol. 2007;24:281–5.
Chen R, Cros D, Curra A, et al. The clinical diagnostic utility of transcranial magnetic stimulation: report of an IFCN committee. Clin Neurophysiol. 2008;119:504–32.
Claus D, Brunhölzl C, Kerling FP, et al. Transcranial magnetic stimulation as a diagnostic and prognostic test in amyotrophic lateral sclerosis. J Neurol Sci. 1995;129(Suppl):30–4.
Eisen A, Shytbel W, Murphy K, et al. Cortical magnetic stimulation in amyotrophic lateral sclerosis. Muscle Nerve. 1990;13:146–51.
Emerson RG. NIOM for spinal deformity surgery: there are more than one way to skin a cat. J Clin Neurophysiol. 2012;29:149–50.
Garnaat SL, Yuan S, Wang H, et al. Updates on transcranial magnetic stimulation therapy for major depressive disorder. Psychiatr Clin North Am. 2018;41:419–31.
Garvey MA, Mall V. Transcranial magnetic stimulation in children. Clin Neurophysiol. 2008;119:973–84.
Groppa S, Oliviero A, Eisen A, et al. A practical guide to diagnostic transcranial magnetic stimulation: report of an IFCN committee. Clin Neurophysiol. 2012;123:858–82.
Guo LJ, Li Y, Han R, et al. The correlation between recordable MEPs and motor function during spinal surgery for resection of thoracic spinal cord tumor. J Neurosurg Anesthesiol. 2018;30:39–43.
Hendricks HT, Pasman JW, Merx JL, et al. Analysis of recovery processes after stroke by means of transcranial magnetic stimulation. J Clin Neurophysiol. 2003;20:188–95.
Hess CW, Mills KR, Murray NMF, et al. Magnetic brain stimulation: central motor conduction studies in multiple sclerosis. Ann Neurol. 1987;22:744–52.
Humm AM, Magistris MR, Truffert A, et al. Central motor conduction differs between acute relapsing-remitting and chronic progressive multiple sclerosis. Clin Neurophysiol. 2003;114:2196–203.
Jones SJ, Harrison R, Koh KF, et al. Motor evoked potential monitoring during spinal surgery: responses of distal limb muscles to transcranial cortical stimulation with pulse trains. Electroencephalogr Clin Neurophysiol. 1996;100:375–83.
Legatt AD, Emerson RG, Epstein CM, et al. ACNS guideline: transcranial electrical stimulation motor evoked potential monitoring. J Clin Neurophysiol. 2016;33:42–50.
Lo YL, Chan LL, Lim W, et al. Transcranial magnetic stimulation screening for cord compression in cervical spondylosis. J Neurol Sci. 2006;244:17–21.
MacDonald DB. Safety of intraoperative transcranial electrical stimulation motor evoked potential monitoring. J Clin Neurophysiol. 2002;19:416–29.
MacDonald DB, Skinner S, Chils J, et al. Guidelines: intraoperative motor evoked potential monitoring- a position statement by the American Society of Neurophysiological Monitoring. Clin Neurophysiol. 2013;124:2291–316.
Magistris MR, Rosler KM, Truffert A, et al. A clinical study of motor evoked potentials using a triple stimulation technique. Brain. 1999;122:265–79.
Merton PA, Morton HB. Stimulation of the cerebral cortex in the intact human subject. Nature. 1980;285:287.
Minahan RE, Sepkuty JP, Lesser RP, et al. Anterior spinal cord injury with preserved neurogenic “motor” evoked potentials. Clin Neurophysiol. 2001;112:1442–50.
Nuwer MR, Dawson EG, Carlson LG, et al. Somatosensory evoked potential spinal cord monitoring reduces neurologic deficits after scoliosis surgery: results of a large multicenter survey. Electroencephalogr Clin Neurophysiol. 1995;96:6–11.
Nuwer MR, Emerson RG, Galloway G, et al. Evidence-based guideline update: intraoperative spinal monitoring with somatosensory and transcranial electrical motor evoked potentials. J Clin Neurophysiol. 2012;29:101–8.
Owen JH, Laschinger J, Bridwell K, et al. Sensitivity and specificity of somatosensory and neurogenic motor-evoked potentials in animals and humans. Spine. 1988;13:1111–8.
Patton HD, Amassian VE. Single and multiple-unit analysis of cortical stage of pyramidal tract activation. J Neurophysiol. 1954;17:345–63.
Pillai JJ, Markind S, Streletz LJ, et al. Motor evoked potentials in psychogenic paralysis. Neurology. 1992;42:935–6.
Rossini PM, Rossi S. Clinical applications of motor evoked potentials. Electroencephalogr Clin Neurophysiol. 1998;106:180–94.
Rossini PM, Rossi S. Transcranial magnetic stimulation: diagnostic therapeutic and research potentials. Neurology. 2007;113:1680–7.
Rossini PM, Barker AT, Berardelli A, et al. Non-invasive electrical and magnetic stimulation of the brain, spinal cord and roots: basic principles and procedures for routine clinical application. Report of an IFCN committee. Electroencephalogr Clin Neurophysiol. 1994;91:79–92.
Schönfeldt-Lecuona C, Connemann BJ, Viviani R, et al. Transcranial magnetic stimulation in motor conversion disorder: a short case series. J Clin Neurophysiol. 2006;23:472–5.
Schriefer TN, Hess CW, Mills KR, et al. Central motor conduction studies in motor neuron disease using magnetic brain stimulation. Electroencephalogr Clin Neurophysiol. 1989;74:431–7.
Schulte-Mattler WJ, Müller T, Zierz S. Transcranial magnetic stimulation compared with upper motor neuron signs in patients with amyotrophic lateral sclerosis. J Neurol Sci. 1999;170:51–6.
Su CF, Haghighi SS, Oro JJ, et al. “Backfiring” in spinal cord monitoring. High thoracic spinal cord stimulation evokes sciatic response by antidromic sensory pathway conduction, not motor tract conduction. Spine. 1992;17:504–8.
Toleikis JR, Skelly JP, Carlvin AO, et al. Spinally elicited peripheral nerve responses are sensory rather than motor. Clin Neurophysiol. 2000;111:736–42.
Travlos A, Pant B, Eisen A. Transcranial magnetic stimulation for detection of preclinical cervical spondylotic myelopathy. Arch Phys Med Rehabil. 1992;73:442–6.
Triggs WJ, Menkes D, Onorato J, et al. Transcranial magnetic stimulation identifies upper motor neuron involvement in motor neuron disease. Neurology. 1999;53:605–11.
Trompetto C, Assini A, Buccolieri A, et al. Motor recovery following stroke: a transcranial magnetic stimulation study. Clin Neurophysiol. 2000;111:1860–7.
Uozumi T, Tsuji S, Murai Y. Motor potentials evoked by magnetic stimulation of the motor cortex in normal subjects and patients with motor disorders. Electroencephalogr Clin Neurophysiol. 1991;81:251–6.
Wang Y, Wang H, Cui L-Y. Triple stimulation technique in amyotrophic lateral sclerosis. J Clin Neurophysiol. 2019;36:87–92.
Wasserman EM. Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the international workshop on the safety of repetitive transcranial magnetic stimulation, June 5–7, 1996. Electroencephalogr Clin Neurophysiol. 1998;108:1–16.
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Markand, O.N. (2020). Motor Evoked Potentials. In: Clinical Evoked Potentials. Springer, Cham. https://doi.org/10.1007/978-3-030-36955-2_5
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DOI: https://doi.org/10.1007/978-3-030-36955-2_5
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