Abstract
Cerebrovascular disorders (CVDs) remain the leading cause of morbidity and mortality worldwide. Neuropsychiatric symptoms (such as depression and fatigue) and cognitive impairment are common complications in CVD patients which are associated with worse patient-centered health status, adverse clinical outcomes, and worse CVD prognosis. Impairment of normal functioning of the hypothalamic–pituitary–thyroid (HPT) axis (as in the low triiodothyronine syndrome) is also commonly observed in patients with CVDs and is linked to greater neuropsychiatric symptom severity, cognitive impairment, worse quality of life, and shorter survival. However, there are no studies examining whether treatment of subclinical HPT axis dysfunction can improve patient-centered health status of CVD patients. Further studies should attempt to elucidate if treatment of subclinical thyroid dysfunction could improve neuropsychiatric and cognitive symptom severity of CVD survivors and possibly translate into better patient-centered outcomes and longer survival. Evaluation of possible association between genetic polymorphisms of enzymes involved in thyroid hormone transport and metabolism with patient-centered health status could help to more accurately identify high-risk CVD patients and provide with personalized treatment approaches.
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References
Faustino LC, Ortiga-Carvalho TM. Thyroid hormone role on cerebellar development and maintenance: a perspective based on transgenic mouse models. Front Endocrinol. 2014;5:75. https://doi.org/10.3389/fendo.2014.00075.
Gothie JD, Demeneix B, Remaud S. Comparative approaches to understanding thyroid hormone regulation of neurogenesis. Mol Cell Endocrinol. 2017;459:104–15. https://doi.org/10.1016/j.mce.2017.05.020.
Ahmed OM, El-Gareib AW, El-Bakry AM, Abd El-Tawab SM, Ahmed RG. Thyroid hormones states and brain development interactions. Int J Dev Neurosci. 2008;26(2):147–209. https://doi.org/10.1016/j.ijdevneu.2007.09.011.
Kapoor R, Fanibunda SE, Desouza LA, Guha SK, Vaidya VA. Perspectives on thyroid hormone action in adult neurogenesis. J Neurochem. 2015;133(5):599–616. https://doi.org/10.1111/jnc.13093.
Bianco AC, Kim BW. Deiodinases: implications of the local control of thyroid hormone action. J Clin Invest. 2006;116(10):2571–9. https://doi.org/10.1172/jci29812.
Williams AJ, Robson H, Kester MHA, van Leeuwen J, Shalet SM, Visser TJ, et al. Iodothyronine deiodinase enzyme activities in bone. Bone. 2008;43(1):126–34. https://doi.org/10.1016/j.bone.2008.03.019.
Bianco AC, Salvatore D, Gereben B, Berry MJ, Larsen PR. Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocr Rev. 2002;23(1):38–89. https://doi.org/10.1210/edrv.23.1.0455.
Cheng SY, Leonard JL, Davis PJ. Molecular aspects of thyroid hormone actions. Endocr Rev. 2010;31(2):139–70. https://doi.org/10.1210/er.2009-0007.
Davis PJ, Goglia F, Leonard JL. Nongenomic actions of thyroid hormone. Nat Rev Endocrinol. 2016;12(2):111–21. https://doi.org/10.1038/nrendo.2015.205.
Brent GA. The molecular basis of thyroid hormone action. N Engl J Med. 1994;331(13):847–53. https://doi.org/10.1056/nejm199409293311306.
Bernal J, Guadano-Ferraz A, Morte B. Thyroid hormone transporters—functions and clinical implications. Nat Rev Endocrinol. 2015;11(7):406–17. https://doi.org/10.1038/nrendo.2015.66.
Novara F, Groeneweg S, Freri E, Estienne M, Reho P, Matricardi S, et al. Clinical and molecular characteristics of SLC16A2 (MCT8) mutations in three families with the Allan-Herndon-Dudley syndrome. Hum Mutat. 2017;38(3):260–4. https://doi.org/10.1002/humu.23140.
Panicker V, Cluett C, Shields B, Murray A, Parnell KS, Perry JR, et al. A common variation in deiodinase 1 gene DIO1 is associated with the relative levels of free thyroxine and triiodothyronine. J Clin Endocrinol Metab. 2008;93(8):3075–81. https://doi.org/10.1210/jc.2008-0397.
Dayan CM, Panicker V. Novel insights into thyroid hormones from the study of common genetic variation. Nat Rev Endocrinol. 2009;5(4):211–8. https://doi.org/10.1038/nrendo.2009.19.
Brozaitiene J, Skiriute D, Burkauskas J, Podlipskyte A, Jankauskiene E, Serretti A, et al. Deiodinases, organic anion transporter polypeptide polymorphisms, and thyroid hormones in patients with myocardial infarction. Genet Test Mol Biomarkers. 2018;22(4):270–8. https://doi.org/10.1089/gtmb.2017.0283.
Alkemade A. Thyroid hormone and the developing hypothalamus. Front Neuroanat. 2015;9:15. https://doi.org/10.3389/fnana.2015.00015.
Horn S, Heuer H. Thyroid hormone action during brain development: more questions than answers. Mol Cell Endocrinol. 2010;315(1–2):19–26. https://doi.org/10.1016/j.mce.2009.09.008.
Moog NK, Entringer S, Heim C, Wadhwa PD, Kathmann N, Buss C. Influence of maternal thyroid hormones during gestation on fetal brain development. Neuroscience. 2017;342:68–100. https://doi.org/10.1016/j.neuroscience.2015.09.070.
Endendijk JJ, Wijnen HAA, Pop VJM, van Baar AL. Maternal thyroid hormone trajectories during pregnancy and child behavioral problems. Horm Behav. 2017;94:84–92. https://doi.org/10.1016/j.yhbeh.2017.06.007.
Gilbert ME, Lasley SM. Developmental thyroid hormone insufficiency and brain development: a role for brain-derived neurotrophic factor (BDNF)? Neuroscience. 2013;239:253–70. https://doi.org/10.1016/j.neuroscience.2012.11.022.
Preau L, Fini JB, Morvan-Dubois G, Demeneix B. Thyroid hormone signaling during early neurogenesis and its significance as a vulnerable window for endocrine disruption. Biochim Biophys Acta. 2015;1849(2):112–21. https://doi.org/10.1016/j.bbagrm.2014.06.015.
Kapoor R, van Hogerlinden M, Wallis K, Ghosh H, Nordstrom K, Vennstrom B, et al. Unliganded thyroid hormone receptor alpha1 impairs adult hippocampal neurogenesis. FASEB J. 2010;24(12):4793–805. https://doi.org/10.1096/fj.10-161802.
Sanchez-Huerta K, Garcia-Martinez Y, Vergara P, Segovia J, Pacheco-Rosado J. Thyroid hormones are essential to preserve non-proliferative cells of adult neurogenesis of the dentate gyrus. Mol Cell Neurosci. 2016;76:1–10. https://doi.org/10.1016/j.mcn.2016.08.001.
Pilhatsch M, Marxen M, Winter C, Smolka MN, Bauer M. Hypothyroidism and mood disorders: integrating novel insights from brain imaging techniques. Thyroid Res. 2011;4(Suppl 1):S3. https://doi.org/10.1186/1756-6614-4-s1-s3.
Pasqualetti G, Caraccio N, Dell Agnello U, Monzani F. Cognitive function and the ageing process: the peculiar role of mild thyroid failure. Recent Pat Endocr Metab Immune Drug Discov. 2016;10(1):4–10.
Aubert CE, Bauer DC, da Costa BR, Feller M, Rieben C, Simonsick EM, et al. The association between subclinical thyroid dysfunction and dementia: the Health, Aging and Body Composition (Health ABC) study. Clin Endocrinol. 2017;87(5):617–26. https://doi.org/10.1111/cen.13458.
Beydoun MA, Beydoun HA, Rostant OS, Dore GA, Fanelli-Kuczmarski MT, Evans MK, et al. Thyroid hormones are associated with longitudinal cognitive change in an urban adult population. Neurobiol Aging. 2015;36(11):3056–66. https://doi.org/10.1016/j.neurobiolaging.2015.08.002.
Bunevicius R, Varoneckas G, Prange AJ Jr, Hinderliter AL, Gintauskiene V, Girdler SS. Depression and thyroid axis function in coronary artery disease: impact of cardiac impairment and gender. Clin Cardiol. 2006;29(4):170–4.
Chatonnet F, Flamant F, Morte B. A temporary compendium of thyroid hormone target genes in brain. Biochim Biophys Acta. 2015;1849(2):122–9. https://doi.org/10.1016/j.bbagrm.2014.05.023.
Krausz Y, Freedman N, Lester H, Newman JP, Barkai G, Bocher M, et al. Regional cerebral blood flow in patients with mild hypothyroidism. J Nucl Med. 2004;45(10):1712–5.
Li L, Zhi M, Hou Z, Zhang Y, Yue Y, Yuan Y. Abnormal brain functional connectivity leads to impaired mood and cognition in hyperthyroidism: a resting-state functional MRI study. Oncotarget. 2017;8(4):6283–94. https://doi.org/10.18632/oncotarget.14060.
Constant EL, de Volder AG, Ivanoiu A, Bol A, Labar D, Seghers A, et al. Cerebral blood flow and glucose metabolism in hypothyroidism: a positron emission tomography study. J Clin Endocrinol Metab. 2001;86(8):3864–70. https://doi.org/10.1210/jcem.86.8.7749.
Begin ME, Langlois MF, Lorrain D, Cunnane SC. Thyroid function and cognition during aging. Curr Gerontol Geriatr Res. 2008;2008:474868. https://doi.org/10.1155/2008/474868.
Szlejf C, Suemoto CK, Santos IS, Lotufo PA, Haueisen Sander Diniz MF, Barreto SM, et al. Thyrotropin level and cognitive performance: baseline results from the ELSA-Brasil study. Psychoneuroendocrinology. 2018;87:152–8. https://doi.org/10.1016/j.psyneuen.2017.10.017.
Brandt F, Thvilum M, Almind D, Christensen K, Green A, Hegedus L, et al. Hyperthyroidism and psychiatric morbidity: evidence from a Danish nationwide register study. Eur J Endocrinol. 2014;170(2):341–8. https://doi.org/10.1530/eje-13-0708.
Baek JH, Kang ES, Fava M, Mischoulon D, Nierenberg AA, Lee D, et al. Thyroid stimulating hormone and serum, plasma, and platelet brain-derived neurotrophic factor during a 3-month follow-up in patients with major depressive disorder. J Affect Disord. 2014;169:112–7. https://doi.org/10.1016/j.jad.2014.08.009.
Jia Y, Zhong S, Wang Y, Liu T, Liao X, Huang L. The correlation between biochemical abnormalities in frontal white matter, hippocampus and serum thyroid hormone levels in first-episode patients with major depressive disorder. J Affect Disord. 2015;180:162–9. https://doi.org/10.1016/j.jad.2015.04.005.
McAloon CJ, Boylan LM, Hamborg T, Stallard N, Osman F, Lim PB, et al. The changing face of cardiovascular disease 2000–2012: an analysis of the world health organisation global health estimates data. Int J Cardiol. 2016;224:256–64.
Roth GA, Johnson CO, Abate KH, Abd-Allah F, Ahmed M, Alam K, et al. The burden of cardiovascular diseases among US states, 1990-2016. JAMA Cardiol. 2018;3(5):375–89.
Nichols M, Townsend N, Luengo-Fernandez R, Leal J, Gray A, Scarborough P, Rayner M. European cardiovascular disease statistics 2012. Brussels/Sophia Antipolis: European Heart Network/European Society of Cardiology; 2012.
Wilkins E, Wilson L, Wickramasinghe K, Bhatnagar P, Leal J, Luengo-Fernandez R, Burns R, Rayner M, Townsend N. European cardiovascular disease statistics 2017. Brussels: European Heart Network; 2017.
Members ATF, Piepoli MF, Hoes AW, Agewall S, Albus C, Brotons C, et al. 2016 European guidelines on cardiovascular disease prevention in clinical practice: developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR). Eur J Prev Cardiol. 2016;23(11):NP1–NP96.
Montalescot G, Sechtem U, Achenbach S, Andreotti F, Arden C, Budaj A, et al. 2013 ESC guidelines on the management of stable coronary artery disease: the task force on the management of stable coronary artery disease of the European Society of Cardiology. Eur Heart J. 2013;34(38):2949–3003. https://doi.org/10.1093/eurheartj/eht296.
Suls J. Toxic affect: are anger, anxiety, and depression independent risk factors for cardiovascular disease? Emot Rev. 2018;10(1):6–17.
Celano CM, Villegas AC, Albanese AM, Gaggin HK, Huffman JC. Depression and anxiety in heart failure: a review. Harv Rev Psychiatry. 2018;26(4):175–84. https://doi.org/10.1097/hrp.0000000000000162.
Huffman JC, Celano CM, Beach SR, Motiwala SR, Januzzi JL. Depression and cardiac disease: epidemiology, mechanisms, and diagnosis. Cardiovasc Psychiatry Neurol. 2013;2013:695925.
Rutledge T, Reis VA, Linke SE, Greenberg BH, Mills PJ. Depression in heart failure a meta-analytic review of prevalence, intervention effects, and associations with clinical outcomes. J Am Coll Cardiol. 2006;48(8):1527–37. https://doi.org/10.1016/j.jacc.2006.06.055.
Moser DK, Dracup K, Evangelista LS, Zambroski CH, Lennie TA, Chung ML, et al. Comparison of prevalence of symptoms of depression, anxiety, and hostility in elderly patients with heart failure, myocardial infarction, and a coronary artery bypass graft. Heart Lung. 2010;39(5):378–85. https://doi.org/10.1016/j.hrtlng.2009.10.017.
Bunevicius A, Staniute M, Brozaitiene J, Pop VJ, Neverauskas J, Bunevicius R. Screening for anxiety disorders in patients with coronary artery disease. Health Qual Life Outcomes. 2013;11:37. https://doi.org/10.1186/1477-7525-11-37.
van Montfort E, Denollet J, Vermunt JK, Widdershoven J, Kupper N. The tense, the hostile and the distressed: multidimensional psychosocial risk profiles based on the ESC interview in coronary artery disease patients—the THORESCI study. Gen Hosp Psychiatry. 2017;47:103–11. https://doi.org/10.1016/j.genhosppsych.2017.05.006.
Riegel B, Moser DK, Buck HG, Dickson VV, Dunbar SB, Lee CS, et al. Self-care for the prevention and management of cardiovascular disease and stroke: a scientific statement for healthcare professionals from the American Heart Association. J Am Heart Assoc. 2017;6(9):e006997.
Lichtman JH, Bigger JT Jr, Blumenthal JA, Frasure-Smith N, Kaufmann PG, Lespérance F, et al. Depression and coronary heart disease: recommendations for screening, referral, and treatment: a science advisory from the American Heart Association Prevention Committee of the Council on Cardiovascular Nursing, Council on Clinical Cardiology, Council on Epidemiology and Prevention, and Interdisciplinary Council on Quality of Care and Outcomes Research: endorsed by the American Psychiatric Association. Circulation. 2008;118(17):1768–75.
Thombs BD, Ziegelstein RC, Whooley MA. Optimizing detection of major depression among patients with coronary artery disease using the patient health questionnaire: data from the heart and soul study. J Gen Intern Med. 2008;23(12):2014–7.
Bunevicius A, Deltuva V, Tamasauskas S, Tamasauskas A, Bunevicius R. Screening for psychological distress in neurosurgical brain tumor patients using the patient health questionnaire-2. Psychooncology. 2013;22(8):1895–900. https://doi.org/10.1002/pon.3237.
Albus C, Jordan J, Herrmann-Lingen C. Screening for psychosocial risk factors in patients with coronary heart disease-recommendations for clinical practice. Eur J Cardiovasc Prev Rehabil. 2004;11(1):75–9.
Pedersen SS, von Känel R, Tully PJ, Denollet J. Psychosocial perspectives in cardiovascular disease. Eur J Prev Cardiol. 2017;24(3_suppl):108–15.
Jackson AC, Le Grande MR, Higgins RO, Rogerson M, Murphy BM. Psychosocial screening and assessment practice within cardiac rehabilitation: a survey of cardiac rehabilitation coordinators in Australia. Heart Lung Circ. 2017;26(1):64–72. https://doi.org/10.1016/j.hlc.2016.04.018.
Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001;16(9):606–13.
Beck AT, Steer RA, Brown GK. BDI-II, Beck depression inventory: manual. San Antonio: Psychological Corp; 1996.
Zung WK. A self-rating depression scale. Arch Gen Psychiatry. 1965;12(1):63–70. https://doi.org/10.1001/archpsyc.1965.01720310065008.
Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983;67(6):361–70.
Spitzer RL, Kroenke K, Williams JB, Lowe B. A brief measure for assessing generalized anxiety disorder: the GAD-7. Arch Intern Med. 2006;166(10):1092–7. https://doi.org/10.1001/archinte.166.10.1092.
Spielberger CD, Gorsuch RL, Lushene R, Vagg PR, Jacobs GA. Manual for the state-trait anxiety inventory. Palo Alto: Consulting Psychologist Press; 1983.
Liguori I, Russo G, Curcio F, Sasso G, Della-Morte D, Gargiulo G, et al. Depression and chronic heart failure in the elderly: an intriguing relationship. J Geriatr Cardiol. 2018;15(6):451.
Haring B, Leng X, Robinson J, Johnson KC, Jackson RD, Beyth R, et al. Cardiovascular disease and cognitive decline in postmenopausal women: results from the Women’s Health Initiative memory study. J Am Heart Assoc. 2013;2(6):e000369. https://doi.org/10.1161/jaha.113.000369.
Folstein MF, Folstein SE, McHugh PR. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12(3):189–98.
Spreen O, Benton AL. Neurosensory center comprehensive examination for aphasia (NCCEA), 1977 revision: manual of instructions. Victoria: Neuropsychology Laboratory, University of Victoria; 1977.
Strauss E, Sherman E, Spreen O. A compendium of neuropsychological tests: administration, norms, and commentary. New York: Oxford University Press; 2006.
Benton AL, Hamsher KD, Sivan AB. Multilingual aphasia examination: manual of instructions. AJA Association: Iowa City; 1994.
Brandt J. The Hopkins verbal learning test: development of a new memory test with six equivalent forms. Clin Neuropsychol. 1991;5(2):125–42.
WAIS-III. Wechsler Adult Intelligence Scale; WMS-III: Weschler memory scale: technical manual. 3rd ed. San Antonio: The Psychological Corporation; 1997.
Cummings JL, Mega M, Gray K, Rosenberg-Thompson S, Carusi DA, Gornbein J. The neuropsychiatric inventory: comprehensive assessment of psychopathology in dementia. Neurology. 1994;44(12):2308.
Baker DW, Brown J, Chan KS, Dracup KA, Keeler EB. A telephone survey to measure communication, education, self-management, and health status for patients with heart failure: the improving chronic illness care evaluation (ICICE). J Card Fail. 2005;11(1):36–42.
Friedman MM, King KB. Correlates of fatigue in older women with heart failure. Heart Lung. 1995;24(6):512–8.
Oka RK, Stotts NA, Dae MW, Haskell WL, Gortner SR. Daily physical activity levels in congestive heart failure. Am J Cardiol. 1993;71(11):921–5.
Schaefer KM, Shober Potylycki MJ. Fatigue associated with congestive heart failure: use of Levine’s conservation model. J Adv Nurs. 1993;18(2):260–8.
McNair DM, Heuchert JP. Profile of mood states, POMS2. North Tonawanda: Educational and Industrial Testing System, Multi-Health Systems; 2012.
Smets EM, Garssen B, Bonke B, De Haes JC. The multidimensional fatigue inventory (MFI) psychometric qualities of an instrument to assess fatigue. J Psychosom Res. 1995;39(3):315–25.
Wang Y, Liu G, Gao X, Zhao Z, Li L, Chen W, et al. Prognostic value of type D personality for in-stent restenosis in coronary artery disease patients treated with drug-eluting stent. Psychosom Med. 2018;80(1):95–102. https://doi.org/10.1097/psy.0000000000000532.
Condén E, Rosenblad A, Wagner P, Leppert J, Ekselius L, Åslund C. Is type D personality an independent risk factor for recurrent myocardial infarction or all-cause mortality in post-acute myocardial infarction patients? Eur J Prev Cardiol. 2017;24(5):522–33.
Denollet J. DS14: standard assessment of negative affectivity, social inhibition, and type D personality. Psychosom Med. 2005;67(1):89–97.
Staniute M, Brozaitiene J, Burkauskas J, Kazukauskiene N, Mickuviene N, Bunevicius R. Type D personality, mental distress, social support and health-related quality of life in coronary artery disease patients with heart failure: a longitudinal observational study. Health Qual Life Outcomes. 2015;13(1):1. https://doi.org/10.1186/s12955-014-0204-2.
Gremigni P, Sommaruga M. Type D personality, a relevant construct in cardiology. Preliminary validation study of the Italian questionnaire. Psicot Cogn Comport. 2005;11:7–18.
Williams L, O’Connor RC, Howard S, Hughes BM, Johnston DW, Hay JL, et al. Type-D personality mechanisms of effect: the role of health-related behavior and social support. J Psychosom Res. 2008;64(1):63–9.
Bunevicius A, Staniute M, Brozaitiene J, Stropute D, Bunevicius R, Denollet J. Type D (distressed) personality and its assessment with the DS14 in Lithuanian patients with coronary artery disease. J Health Psychol. 2013;18(9):1242–51. https://doi.org/10.1177/1359105312459098.
Spielberger CD, Jacobs GA, Russell S, Crane RS. Assessment of anger: the state-trait anger scale. Advances in personality assessment. Hillsdale: Lawrence Erlbaum Associates; 1983.
Cook WW, Medley DM. Proposed hostility and pharisaic-virtue scales for the MMPI. J Appl Psychol. 1954;38(6):414–8. https://doi.org/10.1037/h0060667.
Enhancing recovery in coronary heart disease patients (ENRICHD): study design and methods. The ENRICHD investigators. Am Heart J. 2000;139(1 Pt 1):1–9.
Zimet GD, Dahlem NW, Zimet SG, Farley GK. The multidimensional scale of perceived social support. J Pers Assess. 1988;52(1):30–41. https://doi.org/10.1207/s15327752jpa5201_2.
Hagström E, Norlund F, Stebbins A, Armstrong P, Chiswell K, Granger C, et al. Psychosocial stress and major cardiovascular events in patients with stable coronary heart disease. J Intern Med. 2018;283(1):83–92.
Karasek R, Brisson C, Kawakami N, Houtman I, Bongers P, Amick B. The job content questionnaire (JCQ): an instrument for internationally comparative assessments of psychosocial job characteristics. J Occup Health Psychol. 1998;3(4):322–55. https://doi.org/10.1037/1076-8998.3.4.322.
Siegrist J, Starke D, Chandola T, Godin I, Marmot M, Niedhammer I, et al. The measurement of effort–reward imbalance at work: European comparisons. Soc Sci Med. 2004;58(8):1483–99. https://doi.org/10.1016/S0277-9536(03)00351-4.
Denollet J, van Felius RA, Lodder P, Mommersteeg PM, Goovaerts I, Possemiers N, et al. Predictive value of type D personality for impaired endothelial function in patients with coronary artery disease. Int J Cardiol. 2018;259:205–10.
Wang Y, Zhao Z, Gao X, Li L, Liu G, Chen W, et al. Type D personality and coronary plaque vulnerability in patients with coronary artery Disease: an optical coherence tomography study. Psychosom Med. 2016;78(5):583–92. https://doi.org/10.1097/psy.0000000000000307.
Jackson AC, Ski CF, Murphy BM, Fernandez E, Alvarenga ME, Le Grande MR, et al. What role does personality play in cardiovascular disease? Br J Card Nurs. 2018;13(7):330–7.
Busch LY, Pössel P, Valentine JC. Meta-analyses of cardiovascular reactivity to rumination: a possible mechanism linking depression and hostility to cardiovascular disease. Psychol Bull. 2017;143(12):1378.
Kupper N, Denollet J. Type D personality as a risk factor in coronary heart Disease: a review of current evidence. Curr Cardiol Rep. 2018;20(11):104.
Pedersen SS, Denollet J. Is type D personality here to stay? Emerging evidence across cardiovascular disease patient groups. Curr Cardiol Rev. 2006;2(3):205–13.
Eckhardt AL, Devon HA, Piano MR, Ryan CJ, Zerwic JJ. Fatigue in the presence of coronary heart disease. Nurs Res. 2014;63(2):83–93. https://doi.org/10.1097/NNR.0000000000000019.
Ter Hoeve N, Sunamura M, Stam HJ, van Domburg RT, van den Berg-Emons RJ. Extended cardiac rehabilitation improves aerobic capacity and fatigue: a randomized controlled trial. Optim Card Rehabil. 2018:189.
Staniute M, Bunevicius A, Brozaitiene J, Bunevicius R. Relationship of health-related quality of life with fatigue and exercise capacity in patients with coronary artery disease. Eur J Cardiovasc Nurs. 2014;13(4):338–44. https://doi.org/10.1177/1474515113496942.
Irvine J, Basinski A, Baker B, Jandciu S, Paquette M, Cairns J, et al. Depression and risk of sudden cardiac death after acute myocardial infarction: testing for the confounding effects of fatigue. Psychosom Med. 1999;61(6):729–37.
Bunevicius A, Brozaitiene J, Stankus A, Bunevicius R. Specific fatigue-related items in self-rating depression scales do not bias an association between depression and fatigue in patients with coronary artery disease. Gen Hosp Psychiatry. 2011;33(5):527–9. https://doi.org/10.1016/j.genhosppsych.2011.06.009.
Shavelle RM, Paculdo DR, Strauss DJ, Kush SJ. Cognitive impairment and mortality in the Cardiovascular Health Study. J Insur Med. 2009;41(2):110–6.
Fried LP, Kronmal RA, Newman AB, Bild DE, Mittelmark MB, Polak JF, et al. Risk factors for 5-year mortality in older adults: the cardiovascular health study. JAMA. 1998;279(8):585–92.
Freiheit EA, Hogan DB, Eliasziw M, Patten SB, Demchuk AM, Faris P, et al. A dynamic view of depressive symptoms and neurocognitive change among patients with coronary artery disease. Arch Gen Psychiatry. 2012;69(3):244–55. https://doi.org/10.1001/archgenpsychiatry.2011.1361.
Satizabal C, Beiser AS, Seshadri S. Incidence of dementia over three decades in the Framingham heart study. N Engl J Med. 2016;375(1):93–4. https://doi.org/10.1056/NEJMc1604823.
Duijndam S, Denollet J, Nyklicek I, Kupper N. Perceived cognition after percutaneous coronary intervention: association with quality of life, mood and fatigue in the THORESCI study. Int J Behav Med. 2017;24(4):552–62. https://doi.org/10.1007/s12529-016-9624-1.
Burkauskas J, Brozaitiene J, Kazukauskiene N, Fineberg NA, Mickuviene NP. Cognitive functioning and health-related quality of life in coronary artery disease patients with heart failure: a longitudinal observational study. Eur Neuropsychopharmacol. 2016;26:S339. https://doi.org/10.1016/S0924-977X(16)31262-7.
Hachinski V, Iadecola C, Petersen RC, Breteler MM, Nyenhuis DL, Black SE, et al. National Institute of Neurological Disorders and Stroke–Canadian stroke network vascular cognitive impairment harmonization standards. Stroke. 2006;37(9):2220–41.
Burkauskas J, Noreikaite A, Bunevicius A, Brozaitiene J, Neverauskas J, Mickuviene N, et al. Beta-1-selective beta-blockers and cognitive functions in patients with coronary artery disease: a cross-sectional study. J Neuropsychiatry Clin Neurosci. 2015;28(2):143–6. https://doi.org/10.1176/appi.neuropsych.15040088.
Lanctot KL, O’Regan J, Schwartz Y, Swardfager W, Saleem M, Oh PI, et al. Assessing cognitive effects of anticholinergic medications in patients with coronary artery disease. Psychosomatics. 2014;55(1):61–8. https://doi.org/10.1016/j.psym.2013.04.004.
Burkauskas J, Lang P, Bunevicius A, Neverauskas J, Buciute-Jankauskiene M, Mickuviene N. Cognitive function in patients with coronary artery disease: a literature review. J Int Med Res. 2018;46(10):4019–31. https://doi.org/10.1177/0300060517751452.
Valenza G, Toschi N, Barbieri R. Uncovering brain-heart information through advanced signal and image processing. Philos Transact A Math Phys Eng Sci. 2016;374(2067). https://doi.org/10.1098/rsta.2016.0020.
Kim MS, Kim JJ. Heart and brain interconnection—clinical implications of changes in brain function during heart failure. Circ J. 2015;79(5):942–7. https://doi.org/10.1253/circj.CJ-15-0360.
Woo MA, Kumar R, Macey PM, Fonarow GC, Harper RM. Brain injury in autonomic, emotional, and cognitive regulatory areas in patients with heart failure. J Card Fail. 2009;15(3):214–23. https://doi.org/10.1016/j.cardfail.2008.10.020.
Dublin S, Anderson ML, Heckbert SR, Hubbard RA, Sonnen JA, Crane PK, et al. Neuropathologic changes associated with atrial fibrillation in a population-based autopsy cohort. J Gerontol Ser A Biol Sci Med Sci. 2014;69(5):609–15. https://doi.org/10.1093/gerona/glt141.
Meissner A. Hypertension and the brain: a risk factor for more than heart disease. Cerebrovasc Dis. 2016;42(3–4):255–62. https://doi.org/10.1159/000446082.
Roy B, Woo MA, Wang DJJ, Fonarow GC, Harper RM, Kumar R. Reduced regional cerebral blood flow in patients with heart failure. Eur J Heart Fail. 2017;19(10):1294–302. https://doi.org/10.1002/ejhf.874.
von Rhein M, Buchmann A, Hagmann C, Huber R, Klaver P, Knirsch W, et al. Brain volumes predict neurodevelopment in adolescents after surgery for congenital heart disease. Brain J Neurol. 2014;137(Pt 1):268–76. https://doi.org/10.1093/brain/awt322.
Ogren JA, Fonarow GC, Woo MA. Cerebral impairment in heart failure. Curr Heart Fail Rep. 2014;11(3):321–9. https://doi.org/10.1007/s11897-014-0211-y.
Pan A, Kumar R, Macey PM, Fonarow GC, Harper RM, Woo MA. Visual assessment of brain magnetic resonance imaging detects injury to cognitive regulatory sites in patients with heart failure. J Card Fail. 2013;19(2):94–100. https://doi.org/10.1016/j.cardfail.2012.12.001.
Kumar R, Nguyen HD, Ogren JA, Macey PM, Thompson PM, Fonarow GC, et al. Global and regional putamen volume loss in patients with heart failure. Eur J Heart Fail. 2011;13(6):651–5. https://doi.org/10.1093/eurjhf/hfr012.
Alosco ML, Brickman AM, Spitznagel MB, Garcia SL, Narkhede A, Griffith EY, et al. Cerebral perfusion is associated with white matter hyperintensities in older adults with heart failure. Congest Heart Fail. 2013;19(4):E29–34. https://doi.org/10.1111/chf.12025.
Alosco ML, Brickman AM, Spitznagel MB, Griffith EY, Narkhede A, Raz N, et al. Independent and interactive effects of blood pressure and cardiac function on brain volume and white matter hyperintensities in heart failure. J Am Soc Hypertens. 2013;7(5):336–43. https://doi.org/10.1016/j.jash.2013.04.011.
Woo MA, Ogren JA, Abouzeid CM, Macey PM, Sairafian KG, Saharan PS, et al. Regional hippocampal damage in heart failure. Eur J Heart Fail. 2015;17(5):494–500. https://doi.org/10.1002/ejhf.241.
Menteer J, Macey PM, Woo MA, Panigrahy A, Harper RM. Central nervous system changes in pediatric heart failure: a volumetric study. Pediatr Cardiol. 2010;31(7):969–76. https://doi.org/10.1007/s00246-010-9730-9.
Park B, Roy B, Woo MA, Palomares JA, Fonarow GC, Harper RM, et al. Lateralized resting-state functional brain network organization changes in heart failure. PLoS One. 2016;11(5):e0155894. https://doi.org/10.1371/journal.pone.0155894.
Bernard C, Catheline G, Dilharreguy B, Couffinhal T, Ledure S, Lassalle-Lagadec S, et al. Cerebral changes and cognitive impairment after an ischemic heart disease: a multimodal MRI study. Brain Imaging Behav. 2016;10(3):893–900. https://doi.org/10.1007/s11682-015-9483-4.
Harper RM, Kumar R, Macey PM, Woo MA, Ogren JA. Affective brain areas and sleep-disordered breathing. Prog Brain Res. 2014;209:275–93. https://doi.org/10.1016/b978-0-444-63274-6.00014-x.
Tummala S, Palomares J, Kang DW, Park B, Woo MA, Harper RM, et al. Global and regional brain non-Gaussian diffusion changes in newly diagnosed patients with obstructive sleep apnea. Sleep. 2016;39(1):51–7. https://doi.org/10.5665/sleep.5316.
Bernal J. Thyroid hormones in brain development and function. In: De Groot LJ, Chrousos G, Dungan K, Feingold KR, Grossman A, Hershman JM, et al., editors. Endotext. South Dartmouth: MDText.com; 2000.
Ritchie M, Yeap BB. Thyroid hormone: influences on mood and cognition in adults. Maturitas. 2015;81(2):266–75. https://doi.org/10.1016/j.maturitas.2015.03.016.
Villar HCCE, Saconato H, Valente O, Atallah ÁN. Thyroid hormone replacement for subclinical hypothyroidism. Cochrane Database Syst Rev. 2007;(3):CD003419.
Samuels MH. Psychiatric and cognitive manifestations of hypothyroidism. Curr Opin Endocrinol Diabetes Obes. 2014;21(5):377–83. https://doi.org/10.1097/med.0000000000000089.
Pasqualetti G, Pagano G, Rengo G, Ferrara N, Monzani F. Subclinical Hypothyroidism and cognitive impairment: systematic review and meta-analysis. J Clin Endocrinol Metabol. 2015;100(11):4240–8. https://doi.org/10.1210/jc.2015-2046.
Akintola A, Jansen S, van Bodegom D, van der Grond J, Westendorp R, de Craen A, et al. Subclinical hypothyroidism and cognitive function in people over 60 years: a systematic review and meta-analysis. Front Aging Neurosci. 2015;7:150. https://doi.org/10.3389/fnagi.2015.00150.
Cooper DS, Biondi B. Subclinical thyroid disease. Lancet. 2012;379(9821):1142–54. https://doi.org/10.1016/S0140-6736(11)60276-6.
Chaker L, Baumgartner C, Den Elzen WP, Ikram MA, Blum MR, Collet T-H, et al. Subclinical hypothyroidism and the risk of stroke events and fatal stroke: an individual participant data analysis. J Clin Endocrinol Metabol. 2015;100(6):2181–91.
Pasqualetti G, Tognini S, Polini A, Caraccio N, Monzani F. Is subclinical hypothyroidism a cardiovascular risk factor in the elderly? J Clin Endocrinol Metab. 2013;98(6):2256–66. https://doi.org/10.1210/jc.2012-3818.
Surks MI, Hollowell JG. Age-specific distribution of serum thyrotropin and antithyroid antibodies in the U.S. population: implications for the prevalence of subclinical hypothyroidism. J Clin Endocrinol Metabol. 2007;92(12):4575–82. https://doi.org/10.1210/jc.2007-1499.
Ross DS. Serum thyroid-stimulating hormone measurement for assessment of thyroid function and disease. Endocrinol Metab Clin North Am. 2001;30(2):245–64, vii.
Pearce EN. Subclinical hyperthyroidism with serum TSH< 0.1 mIU/L is associated with increased dementia risk in older adults. Clin Thyroidol. 2017;29(10):382–4.
Collet TH, Gussekloo J, Bauer DC, den Elzen WP, Cappola AR, Balmer P, et al. Subclinical hyperthyroidism and the risk of coronary heart disease and mortality. Arch Intern Med. 2012;172(10):799–809. https://doi.org/10.1001/archinternmed.2012.402.
Selmer C, Olesen JB, Hansen ML, Lindhardsen J, Olsen AM, Madsen JC, et al. The spectrum of thyroid disease and risk of new onset atrial fibrillation: a large population cohort study. BMJ. 2012;345:e7895. https://doi.org/10.1136/bmj.e7895.
Gencer B, Collet TH, Virgini V, Bauer DC, Gussekloo J, Cappola AR, et al. Subclinical thyroid dysfunction and the risk of heart failure events: an individual participant data analysis from 6 prospective cohorts. Circulation. 2012;126(9):1040–9. https://doi.org/10.1161/circulationaha.112.096024.
Nishtala A, Piers RJ, Himali JJ, Beiser AS, Davis-Plourde KL, Saczynski JS, et al. Atrial fibrillation and cognitive decline in the Framingham heart study. Heart Rhythm. 2018;15(2):166–72.
Lutski M, Weinstein G, Goldbourt U, Tanne D. Cardiovascular health and cognitive decline 2 decades later in men with preexisting coronary artery disease. Am J Cardiol. 2018;121(4):410–5.
Ottens TH, Hendrikse J, Nathoe HM, Biessels GJ, van Dijk D. Brain volume and cognitive function in patients with revascularized coronary artery disease. Int J Cardiol. 2017;230:80–4. https://doi.org/10.1016/j.ijcard.2016.12.079.
Myserlis PG, Malli A, Kalaitzoglou DK, Kalaitzidis G, Miligkos M, Kokkinidis DG, et al. Atrial fibrillation and cognitive function in patients with heart failure: a systematic review and meta-analysis. Heart Fail Rev. 2017;22(1):1–11.
Yudiarto FL, Muliadi L, Moeljanto D, Hartono B. Neuropsychological findings in hyperthyroid patients. Acta Med Indones. 2006;38(1):6–10.
Yuan L, Tian Y, Zhang F, Ma H, Chen X, Dai F, et al. Decision-making in patients with hyperthyroidism: a neuropsychological study. PLoS One. 2015;10(6):e0129773. https://doi.org/10.1371/journal.pone.0129773.
Samuels MH. Cognitive function in untreated hypothyroidism and hyperthyroidism. Curr Opin Endocrinol Diabetes Obes. 2008;15(5):429–33. https://doi.org/10.1097/MED.0b013e32830eb84c.
Vogel A, Elberling TV, Hording M, Dock J, Rasmussen AK, Feldt-Rasmussen U, et al. Affective symptoms and cognitive functions in the acute phase of Graves’ thyrotoxicosis. Psychoneuroendocrinology. 2007;32(1):36–43. https://doi.org/10.1016/j.psyneuen.2006.09.012.
Lillevang-Johansen M, Petersen I, Christensen K, Hegedüs L, Brix TH. Is previous hyperthyroidism associated with long-term cognitive dysfunction? A twin study. Clin Endocrinol. 2014;80(2):290–5.
Constant EL, Adam S, Seron X, Bruyer R, Seghers A, Daumerie C. Anxiety and depression, attention, and executive functions in hypothyroidism. J Int Neuropsychol Soc. 2005;11(5):535–44. https://doi.org/10.1017/s1355617705050642.
Davis JD, Tremont G. Neuropsychiatric aspects of hypothyroidism and treatment reversibility. Minerva Endocrinol. 2007;32(1):49–65.
Osterweil D, Syndulko K, Cohen SN, Pettler-Jennings PD, Hershman JM, Cummings JL, et al. Cognitive function in non-demented older adults with hypothyroidism. J Am Geriatr Soc. 1992;40(4):325–35.
Smith CD, Grondin R, LeMaster W, Martin B, Gold BT, Ain KB. Reversible cognitive, motor, and driving impairments in severe hypothyroidism. Thyroid. 2015;25(1):28–36.
Correia N, Mullally S, Cooke G, Tun TK, Phelan N, Feeney J, et al. Evidence for a specific defect in hippocampal memory in overt and subclinical hypothyroidism. J Clin Endocrinol Metab. 2009;94(10):3789–97. https://doi.org/10.1210/jc.2008-2702.
Miller KJ, Parsons TD, Whybrow PC, Van Herle K, Rasgon N, Van Herle A, et al. Verbal memory retrieval deficits associated with untreated hypothyroidism. J Neuropsychiatry Clin Neurosci. 2007;19(2):132–6. https://doi.org/10.1176/jnp.2007.19.2.132.
Burmeister LA, Ganguli M, Dodge HH, Toczek T, Dekosky ST, Nebes RD. Hypothyroidism and cognition: preliminary evidence for a specific defect in memory. Thyroid. 2001;11(12):1177–85.
Cooke GE, Mullally S, Correia N, O'Mara SM, Gibney J. Hippocampal volume is decreased in adults with hypothyroidism. Thyroid. 2014;24(3):433–40. https://doi.org/10.1089/thy.2013.0058.
He XS, Ma N, Pan ZL, Wang ZX, Li N, Zhang XC, et al. Functional magnetic resource imaging assessment of altered brain function in hypothyroidism during working memory processing. Eur J Endocrinol. 2011;164(6):951–9. https://doi.org/10.1530/eje-11-0046.
Miller KJ, Parsons TD, Whybrow PC, van Herle K, Rasgon N, van Herle A, et al. Memory improvement with treatment of hypothyroidism. Int J Neurosci. 2006;116(8):895–906. https://doi.org/10.1080/00207450600550154.
Goyal S, Dixit A, Vaney N, Madhu S. Cognitive status in hypothyroid patients before & after attainment of euthyroid state. Indian J Physiol Pharmacol. 2018;62(1):113–9.
Capet C, Jego A, Denis P, Noel D, Clerc I, Cornier AC, et al. [Is cognitive change related to hypothyroidism reversible with replacement therapy?]. La Revue de medecine interne. 2000;21(8):672–8.
Prinz PN, Scanlan JM, Vitaliano PP, Moe KE, Borson S, Toivola B, et al. Thyroid hormones: positive relationships with cognition in healthy, euthyroid older men. J Gerontol A Biol Sci Med Sci. 1999;54(3):M111–6.
Beydoun MA, Beydoun HA, Kitner-Triolo MH, Kaufman JS, Evans MK, Zonderman AB. Thyroid hormones are associated with cognitive function: moderation by sex, race, and depressive symptoms. J Clin Endocrinol Metab. 2013;98(8):3470–81. https://doi.org/10.1210/jc.2013-1813.
Hogervorst E, Huppert F, Matthews FE, Brayne C. Thyroid function and cognitive decline in the MRC cognitive function and ageing study. Psychoneuroendocrinology. 2008;33(7):1013–22. https://doi.org/10.1016/j.psyneuen.2008.05.008.
Grigorova M, Sherwin BB. Thyroid hormones and cognitive functioning in healthy, euthyroid women: a correlational study. Horm Behav. 2012;61(4):617–22. https://doi.org/10.1016/j.yhbeh.2012.02.014.
Bojar I, Bejga P, Witczak M, Łyszcz R, Makara-Studzinska M. Standards for thyroid laboratory testing, and cognitive functions after menopause. Prz Menopauzalny. 2014;13(4):233–41. https://doi.org/10.5114/pm.2014.44999.
Burkauskas J, Bunevicius A, Brozaitiene J, Neverauskas J, Lang P, Duwors R, et al. Cognitive functioning in coronary artery disease patients: associations with thyroid hormones, N-terminal pro-B-type natriuretic peptide and high-sensitivity C-reactive protein. Arch Clin Neuropsychol. 2017;32(2):245–51. https://doi.org/10.1093/arclin/acx004.
Shabani S, Sarkaki A, Ali Mard S, Ahangarpour A, Khorsandi L, Farbood Y. Central and peripheral administrations of levothyroxine improved memory performance and amplified brain electrical activity in the rat model of Alzheimer’s disease. Neuropeptides. 2016;59:111–6. https://doi.org/10.1016/j.npep.2016.09.003.
Ma J, Yang X, Yin H, Wang Y, Chen H, Liu C, et al. Effect of thyroid hormone replacement therapy on cognition in long-term survivors of aneurysmal subarachnoid hemorrhage. Exp Ther Med. 2015;10(1):369–73. https://doi.org/10.3892/etm.2015.2475.
Bauer M, Silverman DH, Schlagenhauf F, London ED, Geist CL, van Herle K, et al. Brain glucose metabolism in hypothyroidism: a positron emission tomography study before and after thyroid hormone replacement therapy. J Clin Endocrinol Metab. 2009;94(8):2922–9. https://doi.org/10.1210/jc.2008-2235.
Sangun O, Demirci S, Dundar N, Pirgon O, Koca T, Dogan M, et al. The effects of six-month L-thyroxine treatment on cognitive functions and event-related brain potentials in children with subclinical hypothyroidism. J Clin Res Pediatr Endocrinol. 2015;7(2):102–8. https://doi.org/10.4274/jcrpe.1684.
Kim EY, Kim SH, Rhee SJ, Huh I, Ha K, Kim J, et al. Relationship between thyroid-stimulating hormone levels and risk of depression among the general population with normal free T4 levels. Psychoneuroendocrinology. 2015;58:114–9. https://doi.org/10.1016/j.psyneuen.2015.04.016.
Duntas LH, Maillis A. Hypothyroidism and depression: salient aspects of pathogenesis and management. Minerva Endocrinol. 2013;38(4):365–77.
Berent D, Zboralski K, Orzechowska A, Galecki P. Thyroid hormones association with depression severity and clinical outcome in patients with major depressive disorder. Mol Biol Rep. 2014;41(4):2419–25. https://doi.org/10.1007/s11033-014-3097-6.
Brouwer JP, Appelhof BC, Hoogendijk WJ, Huyser J, Endert E, Zuketto C, et al. Thyroid and adrenal axis in major depression: a controlled study in outpatients. Eur J Endocrinol. 2005;152(2):185–91. https://doi.org/10.1530/eje.1.01828.
Wei J, Sun G, Zhao L, Liu X, Lin D, Li T, et al. Hair thyroid hormones concentration in patients with depression changes with disease episodes in female Chinese. Psychiatry Res. 2014;220(1–2):251–3. https://doi.org/10.1016/j.psychres.2014.07.029.
Pae CU, Mandelli L, Han C, Ham BJ, Masand PS, Patkar AA, et al. Thyroid hormones affect recovery from depression during antidepressant treatment. Psychiatry Clin Neurosci. 2009;63(3):305–13. https://doi.org/10.1111/j.1440-1819.2009.01938.x.
Pan T, Zhong M, Zhong X, Zhang Y, Zhu D. Levothyroxine replacement therapy with vitamin E supplementation prevents oxidative stress and cognitive deficit in experimental hypothyroidism. Endocrine. 2013;43(2):434–9. https://doi.org/10.1007/s12020-012-9801-1.
Saravanan P, Visser TJ, Dayan CM. Psychological well-being correlates with free thyroxine but not free 3,5,3′-triiodothyronine levels in patients on thyroid hormone replacement. J Clin Endocrinol Metab. 2006;91(9):3389–93. https://doi.org/10.1210/jc.2006-0414.
Kelly T, Denmark L, Lieberman DZ. Elevated levels of circulating thyroid hormone do not cause the medical sequelae of hyperthyroidism. Prog Neuropsychopharmacol Biol Psychiatry. 2016;71:1–6. https://doi.org/10.1016/j.pnpbp.2016.06.001.
Kelly T. An examination of myth: a favorable cardiovascular risk-benefit analysis of high-dose thyroid for affective disorders. J Affect Disord. 2015;177:49–58. https://doi.org/10.1016/j.jad.2015.01.016.
Mohagheghi A, Arfaie A, Amiri S, Nouri M, Abdi S, Safikhanlou S. Preventive effect of liothyronine on electroconvulsive therapy-induced memory deficit in patients with major depressive disorder: a double-blind controlled clinical trial. Biomed Res Int. 2015;2015:503918. https://doi.org/10.1155/2015/503918.
Kalra S, Balhara YP. Euthyroid depression: the role of thyroid hormone. Recent Pat Endocr Metab Immune Drug Dis. 2014;8(1):38–41.
Baumgartner C, Blum MR, Rodondi N. Subclinical hypothyroidism: summary of evidence in 2014. Swiss Med Wkly. 2014;144:w14058. https://doi.org/10.4414/smw.2014.14058.
Samuels MH, Kolobova I, Smeraglio A, Niederhausen M, Janowsky JS, Schuff KG. Effect of thyroid function variations within the laboratory reference range on health status, mood, and cognition in levothyroxine-treated subjects. Thyroid. 2016;26(9):1173–84. https://doi.org/10.1089/thy.2016.0141.
Baethge C, Reischies FM, Berghofer A, Baur H, Schlattmann P, Whybrow PC, et al. Effects of supraphysiological doses of L-thyroxine on cognitive function in healthy individuals. Psychiatry Res. 2002;110(2):117–23.
Kraemer S, Danker-Hopfe H, Pilhatsch M, Bes F, Bauer M. Effects of supraphysiological doses of levothyroxine on sleep in healthy subjects: a prospective polysomnography study. J Thyroid Res. 2011;2011:420580. https://doi.org/10.4061/2011/420580.
Panicker V, Saravanan P, Vaidya B, Evans J, Hattersley AT, Frayling TM, et al. Common variation in the DIO2 gene predicts baseline psychological well-being and response to combination thyroxine plus triiodothyronine therapy in hypothyroid patients. J Clin Endocrinol Metab. 2009;94(5):1623–9. https://doi.org/10.1210/jc.2008-1301.
Xue C, Bian L, Xie YS, Yin ZF, Xu ZJ, Chen QZ, et al. Low fT3 is associated with diminished health-related quality of life in patients with acute coronary syndrome treated with drug-eluting stent: a longitudinal observational study. Oncotarget. 2017;8(55):94580–90. https://doi.org/10.18632/oncotarget.21811.
Bunevicius A, Laws ER, Deltuva V, Tamasauskas A. Association of thyroid hormone concentrations with quality of life of primary brain tumor patients: a pilot study. J Neurooncol. 2017;131(2):385–91. https://doi.org/10.1007/s11060-016-2311-x.
Klaver EI, van Loon HC, Stienstra R, Links TP, Keers JC, Kema IP, et al. Thyroid hormone status and health-related quality of life in the LifeLines Cohort Study. Thyroid. 2013;23(9):1066–73. https://doi.org/10.1089/thy.2013.0017.
Kazukauskiene N, Burkauskas J, Macijauskiene J, Mickuviene N, Brozaitiene J. Exploring potential biomarkers associated with health-related quality of life in patients with coronary artery disease and heart failure. Eur J Cardiovasc Nurs. 2018;17(7):645–51.
Wouters HJ, van Loon HC, van der Klauw MM, Elderson MF, Slagter SN, Kobold AM, et al. No effect of the Thr92Ala polymorphism of deiodinase-2 on thyroid hormone parameters, health-related quality of life, and cognitive functioning in a large population-based cohort study. Thyroid. 2017;27(2):147–55. https://doi.org/10.1089/thy.2016.0199.
Wekking EM, Appelhof BC, Fliers E, Schene AH, Huyser J, Tijssen JG, et al. Cognitive functioning and well-being in euthyroid patients on thyroxine replacement therapy for primary hypothyroidism. Eur J Endocrinol. 2005;153(6):747–53. https://doi.org/10.1530/eje.1.02025.
Djurovic M, Pereira AM, Smit JWA, Vasovic O, Damjanovic S, Jemuovic Z, et al. Cognitive functioning and quality of life in patients with Hashimoto thyroiditis on long-term levothyroxine replacement. Endocrine. 2018;62(1):136–43. https://doi.org/10.1007/s12020-018-1649-6.
Nygaard B, Jensen EW, Kvetny J, Jarlov A, Faber J. Effect of combination therapy with thyroxine (T4) and 3,5,3′-triiodothyronine versus T4 monotherapy in patients with hypothyroidism, a double-blind, randomised cross-over study. Eur J Endocrinol. 2009;161(6):895–902. https://doi.org/10.1530/eje-09-0542.
Brozaitiene J, Mickuviene N, Podlipskyte A, Burkauskas J, Bunevicius R. Relationship and prognostic importance of thyroid hormone and N-terminal pro-B-type natriuretic peptide for patients after acute coronary syndromes: a longitudinal observational study. BMC Cardiovasc Disord. 2016;16(1):45. https://doi.org/10.1186/s12872-016-0226-2.
Fontana M, Passino C, Poletti R, Zyw L, Prontera C, Scarlattini M, et al. Low triiodothyronine and exercise capacity in heart failure. Int J Cardiol. 2012;154(2):153–7. https://doi.org/10.1016/j.ijcard.2010.09.002.
Molinaro S, Iervasi G, Lorenzoni V, Coceani M, Landi P, Srebot V, et al. Persistence of mortality risk in patients with acute cardiac diseases and mild thyroid dysfunction. Am J Med Sci. 2012;343(1):65–70. https://doi.org/10.1097/MAJ.0b013e31822846bd.
Rothberger GD, Gadhvi S, Michelakis N, Kumar A, Calixte R, Shapiro LE. Usefulness of serum triiodothyronine (T3) to predict outcomes in patients hospitalized with acute heart failure. Am J Cardiol. 2017;119(4):599–603. https://doi.org/10.1016/j.amjcard.2016.10.045.
Kowalczuk-Wieteska A, Baranska-Kosakowska A, Zakliczynski M, Lindon S, Zembala M. Do thyroid disorders affect the postoperative course of patients in the early post-heart transplant period? Ann Transplant. 2011;16(3):77–81.
Sousa PA, Providencia R, Albenque JP, Khoueiry Z, Combes N, Combes S, et al. Impact of free thyroxine on the outcomes of left atrial ablation procedures. Am J Cardiol. 2015;116(12):1863–8. https://doi.org/10.1016/j.amjcard.2015.09.028.
Pingitore A, Iervasi G, Barison A, Prontera C, Pratali L, Emdin M, et al. Early activation of an altered thyroid hormone profile in asymptomatic or mildly symptomatic idiopathic left ventricular dysfunction. J Card Fail. 2006;12(7):520–6. https://doi.org/10.1016/j.cardfail.2006.05.009.
Suh S, Kim DK. Subclinical hypothyroidism and cardiovascular disease. Endocrinol Metab. 2015;30(3):246–51. https://doi.org/10.3803/EnM.2015.30.3.246.
Beyer C, Plank F, Friedrich G, Wildauer M, Feuchtner G. Effects of hyperthyroidism on coronary artery disease: a computed tomography angiography study. Can J Cardiol. 2017;33(10):1327–34. https://doi.org/10.1016/j.cjca.2017.07.002.
Ilic S, Tadic M, Ivanovic B, Caparevic Z, Trbojevic B, Celic V. Left and right ventricular structure and function in subclinical hypothyroidism: the effects of one-year levothyroxine treatment. Med Sci Monit. 2013;19:960–8. https://doi.org/10.12659/msm.889621.
Brenta G, Thierer J, Sutton M, Acosta A, Vainstein N, Brites F, et al. Low plasma triiodothyronine levels in heart failure are associated with a reduced anabolic state and membrane damage. Eur J Endocrinol. 2011;164(6):937–42. https://doi.org/10.1530/eje-11-0094.
Arikan S, Tuzcu A, Gokalp D, Bahceci M, Danis R. Hyperthyroidism may affect serum N-terminal pro-B-type natriuretic peptide levels independently of cardiac dysfunction. Clin Endocrinol. 2007;67(2):202–7. https://doi.org/10.1111/j.1365-2265.2007.02861.x.
Adamopoulos S, Gouziouta A, Mantzouratou P, Laoutaris ID, Dritsas A, Cokkinos DV, et al. Thyroid hormone signalling is altered in response to physical training in patients with end-stage heart failure and mechanical assist devices: potential physiological consequences? Interact Cardiovasc Thorac Surg. 2013;17(4):664–8. https://doi.org/10.1093/icvts/ivt294.
Pinelli M, Bindi M, Cassetti G, Moroni F, Pandolfo C, Rosada J, et al. Relationship between low T3 syndrome and NT-proBNP levels in non-cardiac patients. Acta Cardiol. 2007;62(1):19–24. https://doi.org/10.2143/ac.62.1.2019366.
Utku U, Gokce M, Ozkaya M. Changes in cerebral blood flow velocity in patients with hypothyroidism. Eur J Endocrinol. 2011;165(3):465–8. https://doi.org/10.1530/eje-11-0254.
Pingitore A, Galli E, Barison A, Iervasi A, Scarlattini M, Nucci D, et al. Acute effects of triiodothyronine (T3) replacement therapy in patients with chronic heart failure and low-T3 syndrome: a randomized, placebo-controlled study. J Clin Endocrinol Metab. 2008;93(4):1351–8. https://doi.org/10.1210/jc.2007-2210.
Shatynska-Mytsyk I, Rodrigo L, Cioccocioppo R, Petrovic D, Lakusic N, Compostella L, et al. The impact of thyroid hormone replacement therapy on left ventricular diastolic function in patients with subclinical hypothyroidism. J Endocrinol Invest. 2016;39(6):709–13. https://doi.org/10.1007/s40618-015-0262-2.
Gerdes AM, Iervasi G. Thyroid replacement therapy and heart failure. Circulation. 2010;122(4):385–93. https://doi.org/10.1161/circulationaha.109.917922.
Pingitore A, Nicolini G, Kusmic C, Iervasi G, Grigolini P, Forini F. Cardioprotection and thyroid hormones. Heart Fail Rev. 2016;21(4):391–9. https://doi.org/10.1007/s10741-016-9545-8.
Zhang Y, Dedkov EI, Lee B 3rd, Li Y, Pun K, Gerdes AM. Thyroid hormone replacement therapy attenuates atrial remodeling and reduces atrial fibrillation inducibility in a rat myocardial infarction-heart failure model. J Card Fail. 2014;20(12):1012–9. https://doi.org/10.1016/j.cardfail.2014.10.003.
Curotto Grasiosi J, Peressotti B, Machado RA, Filipini EC, Angel A, Delgado J et al. [Improvement in functional capacity after levothyroxine treatment in patients with chronic heart failure and subclinical hypothyroidism]. Endocrinol Nutr. 2013;60(8):427–32. https://doi.org/10.1016/j.endonu.2013.01.013.
Arcopinto M, Salzano A, Isgaard J, Cittadini A. Hormone replacement therapy in heart failure. Curr Opin Cardiol. 2015;30(3):277–84. https://doi.org/10.1097/hco.0000000000000166.
Deladoey J, Harrington K. Has triiodothyronine treatment of children after cardiopulmonary bypass surgery any long-term effects? Horm Res Paediatr. 2015;84(2):137–8. https://doi.org/10.1159/000380782.
Carney RM, Freedland KE, Steinmeyer B, Rubin EH, Mann DL, Rich MW. Cardiac risk markers and response to depression treatment in patients with coronary heart disease. Psychosom Med. 2016;78(1):49–59. https://doi.org/10.1097/psy.0000000000000245.
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The authors disclose no conflict of interest, except Julius Burkauskas who has served as a consultant at Cogstate Ltd.
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Burkauskas, J., Pranckeviciene, A., Bunevicius, A. (2020). Thyroid Hormones, Brain, and Heart. In: Iervasi, G., Pingitore, A., Gerdes, A., Razvi, S. (eds) Thyroid and Heart . Springer, Cham. https://doi.org/10.1007/978-3-030-36871-5_25
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