Abstract
Microfluidic devices are now one of the most promising tools to mimic in vivo like conditions, either in normal or disease scenarios, such as tumorigenesis or pathogenesis. Together with the potential of biomaterials, its combination with microfluidics represents the ability to more closely mimic cells’ natural microenvironment concerning its three-dimensional (3D) nature and continuous perfusion with nutrients and cells’ crosstalk. Due to miniaturization and increased experimental throughput, microfluidics have generated significant interest in the drug discovery and development domain. Herein, the most recent advances in the field of microfluidics for drug discovery are overviewed, and the role of biomaterials in 3D in vitro models and the contribution of organ-on-a-chip technologies highlighted.
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Acknowledgments
This chapter is a result of the project FROnTHERA (NORTE-01-0145-FEDER-000023), supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). Mariana Carvalho acknowledges her PhD scholarship NORTE-08-5369-FSE-000044, funded by Programa Operacional Regional do Norte, Fundo Social Europeu, Norte2020 TERM&SC and EMBO Short-Term Fellowship 7232 J. M. Oliveira thanks FCT for his distinction attributed under the FCT Investigator program (IF/01285/2015).
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Carvalho, M.R., Truckenmuller, R., Reis, R.L., Oliveira, J.M. (2020). Biomaterials and Microfluidics for Drug Discovery and Development. In: Oliveira, J., Reis, R. (eds) Biomaterials- and Microfluidics-Based Tissue Engineered 3D Models. Advances in Experimental Medicine and Biology, vol 1230. Springer, Cham. https://doi.org/10.1007/978-3-030-36588-2_8
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