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Reconsidering the Early History of Leprosy in Light of Advances in Palaeopathology

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Part of the book series: Palgrave Series in Indian Ocean World Studies ((IOWS))

Abstract

Despite advances in DNA and molecular studies, relatively little is known about the early history of leprosy. Fanciful theories about disease transmission across the Indian Ocean world have contributed an element of empty speculation to the literature, and it is necessary to refocus on the actual evidence available. This chapter reviews the palaeopathological, archaeological and literary evidence and argues that DNA analysis has provided a great deal of new data on the history of leprosy, but the interpretation of this new evidence has proven to be problematic. Given the limitations of this rapidly developing DNA sequencing technology, there are still many unanswered questions about the role of the Indian Ocean world in the early history of leprosy. This chapter first defines leprosy, then evaluates the hypotheses for the early history of leprosy based on the literary and archaeological evidence, third analyses the claim that DNA evidence can fill some of the gaps in the literary and archaeological record and finally examines recent hypotheses that attempt to reconcile the literary, archaeological and DNA evidence for the early history of leprosy.

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References

  • Anastasiou, Evilena, and Piers D. Mitchell. 2013. Evolutionary Anthropology and Genes: Investigating the Genetics of Human Evolution from Excavated Skeletal Remains. Gene 528: 27–32.

    Google Scholar 

  • Andam, Cheryl P., Colin J. Worby, Qiuzhi Chang, and Michael G. Campana. 2016. Microbial Genomics of Ancient Plagues and Outbreaks. Trends in Microbiology 24: 978–989.

    Google Scholar 

  • Andersen, Johannes G. 1969. Studies in the Medieval Diagnosis of Leprosy in Denmark: An Osteoarchaeological, Historical, and Clinical Study. Copenhagen: Costers Bogtrykkeri.

    Google Scholar 

  • Andersen, Johannes G., Keith Manchester, and Charlotte Roberts. 1994. Septic Bone Changes in Leprosy: A Clinical, Radiological and Paleopathological Review. International Journal of Osteoarchaeology 4: 21–30.

    Google Scholar 

  • Arrizabalaga, Jon. 2002. Problematizing Retrospective Diagnosis in the History of Disease. Asclepio 54: 51–70.

    Google Scholar 

  • Beckett, D.W. 1987. The Striking Hand of God: Leprosy in History. New Zealand Medical Journal 12: 494–497.

    Google Scholar 

  • Bhishagranta, Kaviraj Kunja Lal, trans. 1907. An English Translation of the Sushruta Samhita, Vol. 1 Sutrasthanam. Calcutta: Wilkins Press.

    Google Scholar 

  • Bodde, Derk. 1982. Forensic Medicine in Pre-Imperial China. Journal of the American Oriental Society 102: 1–15.

    Google Scholar 

  • Briggs, Helen. 2017. Skeleton Offers Clues to Medieval Spread of Leprosy. BBC News. http://www.bbc.com/news/science-environment–38748911. Accessed 1 Feb 2017.

  • Britton, Warwick J. 2017. Leprosy. In Infectious Diseases, ed. Jonathan Cohen, William G. Powderly, and Steven M. Opal, 954–960. Elsevier.

    Google Scholar 

  • Brooks, E. Bruce, and A. Taeko Brooks. 1998. The Original Analects: Sayings of Confucius and His Successors. New York: Columbia University Press.

    Google Scholar 

  • Browne, Stanley G. 1975. Some Aspects of the History of Leprosy: The Leprosie of Yesterday. Proceedings of the Royal Society of Medicine 68: 485–493.

    Google Scholar 

  • Carmichael, Ann G. 1993. Leprosy. In The Cambridge World History of Human Disease, ed. Kenneth F. Kiple, 834–839. Cambridge: Cambridge University Press.

    Google Scholar 

  • Chakravorty, Ranes C. 1993. Diseases of Antiquity in South Asia. In The Cambridge World History of Human Disease, ed. Kenneth F. Kiple, 408–413. Cambridge: Cambridge University Press.

    Google Scholar 

  • Cole, Stewart, and Pushpendra Singh. 2012. History and Phylogeography of Leprosy. In Leprosy: A Practical Guide, ed. Enrico Nunzi and Cesare Massone, 3–18. Milan: Springer–Verlag Mailand.

    Google Scholar 

  • Cunningham, Andrew. 2002. Identifying Disease in the Past: Cutting the Gordian Knot. Asclepio 54: 13–34.

    Google Scholar 

  • Demaitre, Luke E. 2007. Leprosy in Premodern Medicine: A Malady of the Whole Body. Baltimore: Johns Hopkins University Press.

    Google Scholar 

  • Dharmendra. 1967. Notes on Leprosy. 2nd ed. New Delhi: Government of India Ministry of Health.

    Google Scholar 

  • Dols, Michael W. 1979. Leprosy in Medieval Arabic Medicine. Journal of the History of Medicine and Allied Sciences 36: 314–333.

    Google Scholar 

  • Donoghue, Helen D., Mark Spigelman, Justin O’Grady, Ildikó Szikossy, Ildikó Pap, Oona Y.-C. Lee, Houdini H.T. Wu, Gurdyal S. Besra, and David E. Minnikin. 2015a. Ancient DNA Analysis – An Established Technique in Charting the Evolution of Tuberculosis and Leprosy. Tuberculosis 95 (Supplement 1): S140–S144.

    Google Scholar 

  • Donoghue, Helen D., G. Michael Taylor, Antónia Marcsik, Erika Molnár, Gyorgy Pálfi, Ildikó Pap, Maria Teschler-Nicola, et al. 2015b. A Migration–Driven Model for the Historical Spread of Leprosy in Medieval Eastern and Central Europe. Infection, Genetics and Evolution 31: 250–256.

    Google Scholar 

  • Drancourt, Michel, and Didier Raoult. 2005. Palaeomicrobiology: Current Issues and Perspectives. Nature Reviews Microbiology 3: 23–35.

    Google Scholar 

  • Dzierzykray-Rogalski, T. 1980. Paleopathology of the Ptolemaic Inhabitants of Dakhleh Oasis (Egypt). Journal of Human Evolution 9: 71–74.

    Google Scholar 

  • Ebbell, B. 1935. A Contribution to the Earliest History of Leprosy. International Journal of Leprosy 3: 257–263.

    Google Scholar 

  • Engler, Steven. 2003. ‘Science’ vs. ‘Religion’ in Classical Ayurveda. Numen 50: 416–463.

    Google Scholar 

  • Gelber, Robert H. 2015. Leprosy. In Harrison’s Principles of Internal Medicine, ed. James F. Shanahan and Kim J. Davis, 19th ed. McGraw-Hill. http://accessmedicine.mhmedical.com/book.aspx?bookid=1130.

  • Harkins, Kelly M., and Anne C. Stone. 2015. Ancient Pathogen Genomics: Insights into Timing and Adaptation. Journal of Human Evolution 79: 137–149.

    Google Scholar 

  • Hulse, E.V. 1972. Leprosy and Ancient Egypt. The Lancet 2 (7785): 1024–1025.

    Google Scholar 

  • ———. 1975. The Nature of Biblical ‘Leprosy’ and the Use of Alternative Medical Terms in Modern Translations of the Bible. Palestine Exploration Quarterly 107: 87–105.

    Google Scholar 

  • Inskip, Sarah A., G. Michael Taylor, Sonia R. Zakrzewski, Simon A. Mays, Alistair W.G. Pike, Gareth Llewellyn, Christopher M. Williams, et al. 2015. Osteological, Biomolecular and Geochemical Examination of an Early Anglo-Saxon Case of Lepromatous Leprosy. PLOS ONE. https://doi.org/10.1371/journal.pone.0124282.

  • Jones, Lori, and Richard Nevell. 2016. Plagued by Doubt and Viral Misinformation: The Need for Evidence-Based Use of Historical Disease Images. The Lancet 16: e235–e240.

    Google Scholar 

  • Larson, Gerald James. 1987. Āyurveda and the Hindu Philosophical Systems. Philosophy East and West 37: 245–259.

    Google Scholar 

  • Lechat, Michael F. 1999. The Paleoepidemiology of Leprosy: An Overview. International Journal of Leprosy and Other Mycobacterial Diseases 67: 460–470.

    Google Scholar 

  • Leung, Angela Ki Che. 2009. Leprosy in China: A History. New York: Columbia University Press.

    Google Scholar 

  • Lloyd Davies, Margaret, and T.A. Lloyd Davies. 1989. Biblical Leprosy: A Comedy of Errors. Journal of the Royal Society of Medicine 82: 622–623.

    Google Scholar 

  • Lovell, Nancy C. 2016. Bioarchaeology of the Indus Valley Civilization: Biological Affinities, Paleopathology, and Chemical Analyses. In A Companion to South Asia in the Past, ed. Gwen Robbins Schug and Subhas R. Walimbe, 169–186. Malden, MA: Wiley Blackwell.

    Google Scholar 

  • Lowe, John. 1947. Comments on the History of Leprosy. Leprosy Review 18: 54–64.

    Google Scholar 

  • Lu, Gwei-Djen, and Joseph Needham. 1967. Records of Diseases in Ancient China. In Diseases in Antiquity: A Survey of the Diseases, Injuries and Surgery of Early Populations, ed. Don Brothwell and A.T. Sandison, 222–237. Springfield, IL: Charles C. Thomas.

    Google Scholar 

  • Manchester, Keith. 1984. Tuberculosis and Leprosy in Antiquity: An Interpretation. Medical History 28: 162–173.

    Google Scholar 

  • Mark, Samuel. 2002. Alexander the Great, Seafaring, and the Spread of Leprosy. Journal of the History of Medicine and Allied Sciences 57: 285–311.

    Google Scholar 

  • McClish, Mark. 2012. Is the Artaśāstra a Mauryan Document? In Reimagining Aśoka: Memory and History, ed. Patrick Olivelle, Janice Leoshko, and Himanshu Prabha Ray, 280–309. Oxford: Oxford University Press.

    Google Scholar 

  • Mendum, Tom A., Verena J. Schuenemann, Simon Roffey, G. Michael Taylor, Huihai Wu, Pushpendra Singh, Katie Tucker, et al. 2014. Mycobacterium leprae Genomes from a British Medieval Leprosy Hospital: Towards Understanding an Ancient Epidemic. BMC Genomics. https://doi.org/10.1186/1471–2164-15–270.

  • Menon, I.A., and H.F. Haberman. 1969. Dermatological Writings of Ancient India. Medical History 13: 387–392.

    Google Scholar 

  • Miller, Timothy S., and John W. Nesbitt. 2014. Walking Corpses: Leprosy in Byzantium and the Medieval West. Ithaca, NY: Cornell University Press.

    Google Scholar 

  • Mitchell, Piers D. 2011. Retrospective Diagnosis and the Use of Historical Texts for Investigating Disease in the Past. International Journal of Paleopathology 1: 81–88.

    Google Scholar 

  • Møller-Christensen, Vilhelm. 1967. Evidence of Leprosy in Earlier Peoples. In Diseases in Antiquity: A Survey of the Diseases, Injuries and Surgery of Early Populations, ed. Don Brothwell and A.T. Sandison, 295–306. Springfield, IL: Charles C. Thomas.

    Google Scholar 

  • Monot, Marc, Nadine Honoré, Thierry Garnier, Romulo Araoz, Jean-Yves Coppée, Céline Lacroix, Samba Sow, et al. 2005. On the Origin of Leprosy. Science 308: 1040–1042.

    Google Scholar 

  • Monot, Marc, Nadine Honoré, Thierry Garnier, Nora Zidane, Diana Sherafi, Alberto Paniz-Mondolfi, Masanori Matsuoka, et al. 2009. Comparative Genomic and Phylogeographic Analysis of Mycobacterium leprae. Nature Genetics 41: 1282–1289.

    Google Scholar 

  • Mukharji, Projit Bihari. 2014. Vishalyakarani and Eupatorium ayapana: Retro-botanizing, Embedded Traditions and Multiple Historicities of Plants in Colonial Bengal, 1890–1940. The Journal of Asian Studies 73: 65–87.

    Google Scholar 

  • Needham, Joseph with Lu, Gwei-Djen. 2000. Science and Civilization in China, Volume 6 Biology and Biological Technology, Part VI: Medicine. Ed. Nathan Sivin. Cambridge: Cambridge University Press.

    Google Scholar 

  • Nutton, Vivian. 2004. Ancient Medicine. New York: Routledge.

    Google Scholar 

  • Olivelle, Patrick, ed. 2013. King, Governance, and Law in Ancient India: Kauṭilya’s Artaśāstra. Oxford: Oxford University Press.

    Google Scholar 

  • Ortner, Donald J. 2002. Observations on the Pathogenesis of Skeletal Disease in Leprosy. In The Past and Present of Leprosy: Archaeological, Historical, Paleopathological and Clinical Approaches, ed. Charlotte A. Roberts, Mary E. Lewis, and K. Manchester, 73–80. BAR International Series 1054.

    Google Scholar 

  • Robbins Schug, Gwen. 2016. Begotten of Corruption? Bioarchaeology and ‘Othering’ of Leprosy in South Asia. International Journal of Paleopathology 15: 1–9.

    Google Scholar 

  • Robbins Schug, Gwen, K. Elaine Blevins, Brett Cox, Kelsey Gray, and V. Mushrif-Tripathy. 2013. Infection, Disease, and Biosocial Processes at the End of the Indus Civilization. PLOS ONE. https://doi.org/10.1371/journal.pone.0084814.

  • Robbins, Gwen, V. Mushrif Tripathy, V.N. Misra, R.K. Mohanty, V.S. Shinde, Kelsey M. Gray, and Malcolm D. Schug. 2009. Ancient Skeletal Evidence for Leprosy in India (2000 B.C.). PLOS ONE. https://doi.org/10.1371/journal.pone.0005669.

  • Roberts, Charlotte, and Keith Manchester. 2005. The Archaeology of Disease. 3rd ed. Ithaca: Cornell University Press.

    Google Scholar 

  • Rubini, Mauro, Yilmaz S. Erdal, Mark Spigelman, Paola Zaio, and Helen D. Donoghue. 2012. Paleopathological and Molecular Study on Two Cases of Ancient Childhood Leprosy from the Roman and Byzantine Empires. International Journal of Osteoarchaeology 24: 570–582.

    Google Scholar 

  • Schuenemann, Verena J., Pushpendra Singh, Thomas A. Mendum, Ben Krause-Kyora, Günter Jäger, Kirsten I. Bos, Alexander Herbig, et al. 2013. Genome-Wide Comparison of Medieval and Modern Mycobacterium leprae. Science 341: 179–183.

    Google Scholar 

  • Sinha, A.K., B.G. Banerjee, and S. Singh. 2010. Leprosy and Its Socio-Cultural Perception in Indian Religions and Ancient Texts. Indian Journal of Leprosy 82: 1–21.

    Google Scholar 

  • Skinsnes, Olaf K. 1973. Notes from the History of Leprosy I. Interpretive Chronology of Leprosy Concept and Practice. International Journal of Leprosy 41: 220–233.

    Google Scholar 

  • Stannard, David E. 1993. Disease, Human Migration, and History. In The Cambridge World History of Human Disease, ed. Kenneth F. Kiple, 35–42. Cambridge: Cambridge University Press.

    Google Scholar 

  • Stein, Claudia. 2014. ‘Getting’ the Pox: Reflections by an Historian on How to Write the History of Early Modern Disease. Nordic Journal of Science and Technology Studies 2: 53–60.

    Google Scholar 

  • Stone, Anne C., Alicia K. Wilbur, Jane E. Buikstra, and Charlotte A. Roberts. 2009. Tuberculosis and Leprosy in Perspective. Yearbook of Physical Anthropology 52: 66–94.

    Google Scholar 

  • Taylor, G. Michael, Soren Blau, Simon Mays, Marc Monot, Oona Y.-C. Lee, David E. Minnikin, Gurdyal S. Besra, Stewart T. Cole, and Paul Rutland. 2009. Mycobacterium leprae Genotype Amplified from an Archaeological Case of Lepromatous Leprosy in Central Asia. Journal of Archaeological Science 36: 2408–2414.

    Google Scholar 

  • Taylor, G. Michael, Katie Tucker, Rachel Butler, Alistair W.G. Pike, Jamie Lewis, Simon Roffey, Philip Marter, et al. 2013. Detection and Strain Typing of Ancient Mycobacterium leprae from a Medieval Leprosy Hospital. PLOS ONE. https://doi.org/10.1371/journal.pone.0062406.

  • Unschuld, Paul U. 1985. Traditional Chinese Medical Theory and Real Nosological Units: The Case of Hansen’s Disease. Medical Anthropology Quarterly 17: 5–8.

    Google Scholar 

  • ———. 2003. Huang Di Nei Jing Su Wen: Nature, Knowledge, Imagery in an Ancient Chinese Medical Text. Berkeley and Los Angeles: University of California Press.

    Google Scholar 

  • Virmond, Marcos, Andrzej Grzybowski, and Luiza Virmond. 2015. Leprosy: A Glossary. Clinics in Dermatology 33: 8–18.

    Google Scholar 

  • Wilbur, Alicia K., and Anne C. Stone. 2012. Using Ancient DNA Techniques to Study Human Disease. In The Global History of Paleopathology, ed. Jane E. Buikstra and Charlotte A. Roberts, 703–717. Oxford: Oxford University Press.

    Google Scholar 

  • Willerslev, Eske, and Alan Cooper. 2006. Reply. Pathogenic Microbial Ancient DNA: A Problem or an Opportunity? Proceedings of the Royal Society B 273: 643.

    Google Scholar 

  • World Health Organization. 2003, January. Leprosy. Fact Sheet 101. https://web-beta.archive.org/web/20030210102100/http://who.int/mediacentre/factsheets/fs101/en. Accessed 6 Feb 2017.

  • ———. 2016, October. Leprosy. Fact Sheet 101. http://who.int/mediacentre/factsheets/fs101/en. Accessed 16 Jan 2016.

  • Zimmerman, Susan. 2008. Leprosy in the Medieval Imaginary. Journal of Medieval and Early Modern Studies 38: 559–587.

    Google Scholar 

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Strahorn, E.A. (2020). Reconsidering the Early History of Leprosy in Light of Advances in Palaeopathology. In: Campbell, G., Knoll, EM. (eds) Disease Dispersion and Impact in the Indian Ocean World. Palgrave Series in Indian Ocean World Studies. Palgrave Macmillan, Cham. https://doi.org/10.1007/978-3-030-36264-5_4

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  • DOI: https://doi.org/10.1007/978-3-030-36264-5_4

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